Synergy Cancer Research Results

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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2789- CHr,    Anticancer Activity of Ether Derivatives of Chrysin
- Review, Var, NA
eff↑, COX2/PTGS2↓, PGE2↓, Synergy↑,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, Synergy↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, ChemoSen↑, eff↑, eff↑, eff↑,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *Synergy↑, *LDL↓, *HDL↑, *Synergy↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, Synergy↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
Synergy↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
1978- CUR,    Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells
- in-vitro, Cerv, HeLa
TrxR1↓, ROS↑, DNA-PK↑, Synergy↑, Trx↓, Trx1↓,
129- CUR,    Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation
- vitro+vivo, Pca, LNCaP
JNK↓, H3K4↓, TumCG↓, Apoptosis↑, Synergy↑,
130- CUR,    Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
BAD↝, BAX↝, Synergy↑,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, Synergy↑,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMPs↓, *Synergy↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *Synergy↑,
3582- CUR,  PI,    Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells
*Synergy↑, *IL6↓, *TGF-β↓, *BioAv↑,
3579- CUR,  AgNPs,    Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin
- Review, NA, NA
*IronCh↑, *BioAv↑, *antiOx↑, *Inflam↓, *BioAv↑, ROS↑, *neuroP↑, *Synergy↑,
3578- CUR,  SIL,    Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferation
- in-vitro, CRC, DLD1
Synergy↑, BioAv↓, TumCG↓,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *Synergy↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, Synergy↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
1878- DCA,  5-FU,    Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
- in-vitro, CRC, LS174T - in-vitro, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
tumCV↓, Synergy↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,
1876- DCA,  Chemo,    In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines
- in-vivo, Lung, H727
Synergy↑, TumCG↓, Glycolysis↓, mitResp↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, Synergy↑, ROS↑, PDK1 / PDPK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1881- DCA,  Chemo,    Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report
- in-vitro, NA, HT1080 - in-vitro, NA, WI38 - Case Report, Var, NA
Synergy↑, selectivity↑, OS↑,
1884- DCA,  Sal,    Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines
- in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116
Synergy↑, pH↓, PDKs↓, Warburg↓,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, Synergy↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, Synergy↑, Dose∅, toxicity∅,
1867- DCA,  Chemo,    Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy
- in-vivo, BC, NA - in-vitro, BC, NA
TumCG↓, Synergy↑, OS↑, PDKs↓, PDH↑,
1866- DCA,  MET,  BTZ,    Targeting metabolic pathways alleviates bortezomib-induced neuropathic pain without compromising anticancer efficacy in a sex-specific manner
- in-vivo, NA, NA
Synergy↑, TumCG↓, Hif1a↓, PDH↑, lactateProd↓, TumVol↓, TumW↓, Glycolysis↑, neuroP↑,
1885- DCA,    Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
SMCT1∅, eff↓, eff↑, Synergy↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1850- dietFMD,    Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
- in-vivo, CRC, NA
TumCP↑, angioG↓, CD8+↑, GutMicro↑, Synergy↑,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, Synergy↑, HO-1↓, DNAdam↑, Synergy↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, Synergy↑, ROS↑, Akt↑, Casp3↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, Synergy↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, Synergy↑,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, Synergy↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
2268- dietMet,    Methionine dependency and cancer treatment
- Review, Var, NA
ChemoSen↑, *eff↑, selectivity↑, Synergy↑,
2264- dietMet,    Methionine restriction for cancer therapy: From preclinical studies to clinical trials
- Review, Var, NA
TumCP↓, *ROS?, ChemoSen↑, RadioS↑, Synergy↑, ROS↑, selectivity↑, TS↓, eff↑,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, Synergy↑, NRF2↑, HO-1↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, Synergy↑,
1503- EGCG,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2/PTGS2↓, NOS2↓, ac‑H3↑, ac‑H4↑, Synergy↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
4143- Ex,    Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, *Synergy↑, *other↓, *eff↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
2498- FBZ,    Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins
- in-vivo, lymphoma, NA
eff↓, Synergy↑, TumVol↓, antiOx↑, Hif1a↓,
2494- FBZ,    Oral Fenbendazole for Cancer Therapy in Humans and Animals
- Review, Var, NA
Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, Synergy↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, eff↑,
1914- Fer,  VitC,  TMZ,  Rad,    Pharmacologic Ascorbate and Ferumoxytol Combined with Temozolomide and Radiation Therapy for the Treatment of Newly Diagnosed Glioblastoma
- Trial, GBM, NA
Synergy↑,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, Synergy↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2856- FIS,    N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells
- in-vitro, Colon, COLO205
Synergy↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,

Showing Research Papers: 51 to 100 of 204
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 204

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 1,   Catalase↑, 2,   CYP1A1↑, 1,   Fenton↑, 3,   Ferroptosis↑, 4,   frataxin↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 1,   GPx4↑, 1,   GSH↓, 9,   GSH↑, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 8,   hyperG↓, 1,   Iron↑, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 6,   MDA↓, 1,   MDA↑, 2,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 9,   NRF2↑, 11,   OXPHOS↓, 5,   OXPHOS↑, 1,   OXPHOS↝, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 14,   ROS↑, 110,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 1,   SOD↑, 3,   Trx↓, 2,   Trx1↓, 1,   TrxR↓, 2,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 1,   ATP↓, 8,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 2,   CDC25↓, 1,   EGF↓, 2,   FGFR1↓, 1,   Insulin↓, 1,   MEK↓, 4,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 35,   MMP↑, 2,   Mortalin↓, 1,   mtDam↑, 5,   OCR↓, 1,   OCR↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 8,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 1,   adiP↑, 1,   ALAT↓, 1,   AMPK↑, 11,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 15,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 23,   Glycolysis↑, 1,   HK2↓, 12,   HMG-CoA↓, 1,   KeyT↑, 1,   lactateProd↓, 7,   lactateProd↑, 1,   LDH↓, 8,   LDHA↓, 4,   LDL↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 6,   PDK3↑, 1,   PDKs↓, 8,   PFK↓, 2,   PFK2?, 1,   PI3K/Akt↓, 1,   PKM2↓, 10,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 2,   p‑S6K↓, 1,   SIRT1↓, 2,   SIRT1↑, 3,   SIRT2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 6,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 48,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 35,   BAX↝, 1,   Bax:Bcl2↑, 9,   Bcl-2↓, 39,   Bcl-2↑, 1,   Bcl-xL↓, 9,   BID↑, 1,   BIM↑, 5,   Casp↑, 11,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 43,   cl‑Casp3↑, 6,   cl‑Casp3⇅, 1,   pro‑Casp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 6,   cl‑Casp8↑, 2,   pro‑Casp8↑, 1,   Casp9↑, 23,   cl‑Casp9↑, 4,   cFLIP↓, 1,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 24,   Diablo↑, 4,   DR4↑, 2,   DR5↑, 9,   FADD↑, 2,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↑, 4,   GSDME-N↑, 1,   HEY1↓, 1,   hTERT/TERT↓, 8,   IAP1↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 4,   iNOS↑, 2,   JNK↓, 2,   JNK↑, 7,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 4,   MAPK↝, 1,   Mcl-1↓, 12,   Mcl-1↑, 1,   MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   Myc↓, 2,   Necroptosis↑, 2,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↑, 6,   p38↓, 1,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 1,   Paraptosis↑, 2,   Proteasome↓, 1,   PUMA↑, 1,   Pyro↑, 2,   survivin↓, 14,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↑, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 35,   Akt↑, 6,   p‑Akt↓, 8,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 4,   p70S6↓, 1,   SOX9?, 1,   Sp1/3/4↓, 7,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 4,   cJun↑, 2,   EZH2↓, 2,   H3↑, 2,   ac‑H3↑, 2,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 1,   HATs↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↓, 2,   other↑, 4,   other↝, 2,   p‑pRB↓, 1,   tumCV↓, 15,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 22,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   GRP78/BiP↝, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 2,   HSP72↑, 1,   HSP90↓, 7,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 7,   p62↓, 4,   p62↑, 5,   SESN2↑, 1,   TumAuto↑, 12,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 2,   DNA-PK↑, 2,   DNAdam↑, 19,   DNArepair↑, 1,   DNMT1↓, 6,   DNMT3A↓, 1,   DNMTs↓, 4,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 1,   P53↑, 22,   p‑P53↑, 2,   PARP↑, 3,   p‑PARP↑, 1,   cl‑PARP↑, 21,   PARP1↑, 1,   PCNA↓, 9,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 2,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK2↓, 15,   CDK4↓, 20,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 7,   cycD1/CCND1↓, 26,   cycE/CCNE↓, 9,   cycE1↓, 1,   P21?, 2,   P21↓, 1,   P21↑, 14,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 3,   TumCCA↑, 45,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CD44↓, 2,   cFos↓, 4,   cMYB↓, 2,   CSCs↓, 14,   Diff↓, 3,   EMT↓, 31,   EMT↑, 1,   ERK↓, 9,   ERK↑, 4,   p‑ERK↓, 7,   FOXM1↓, 2,   FOXO3↓, 1,   FOXO3↑, 5,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 3,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 13,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 5,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   miR-34a↑, 1,   mTOR↓, 19,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 3,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 7,   Nestin↓, 3,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 5,   NOTCH1↑, 3,   NOTCH3↓, 3,   OCT4↓, 5,   P70S6K↓, 1,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 23,   PI3K↑, 3,   p‑PI3K↓, 1,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 8,   RAS↓, 3,   Shh↓, 3,   SHP1↑, 1,   Smo↓, 1,   SOX2↓, 4,   STAT↓, 1,   STAT3↓, 24,   p‑STAT3↓, 5,   p‑STAT3↑, 2,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 1,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 4,   TOP2↓, 2,   TOP2↑, 1,   TumCG↓, 28,   TumCG↑, 2,   Wnt↓, 9,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 4,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 9,   CAFs/TAFs↓, 1,   cal2↑, 1,   CDKN1C/p57↑, 1,   CLDN1↓, 2,   CLDN2↓, 1,   CLDN2↑, 1,   CXCL12↓, 2,   E-cadherin↓, 3,   E-cadherin↑, 17,   ER-α36↓, 2,   FAK↓, 3,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 4,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 9,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 1,   L-sel↑, 1,   LAMs↓, 1,   MALAT1↓, 2,   MET↓, 1,   miR-200b↑, 1,   MMP-10↓, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 25,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 4,   MMP9↓, 27,   MMP9↑, 1,   MMPs↓, 12,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 9,   PAK1↓, 1,   PDGF↓, 1,   PKA↓, 1,   PKCδ↓, 2,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 2,   Slug↓, 6,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 10,   SOX4↓, 1,   STAC2↓, 1,   TET1↑, 3,   TGF-β↓, 9,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 3,   Treg lymp↓, 2,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 15,   TumCMig↓, 16,   TumCMig↑, 1,   TumCP↓, 24,   TumCP↑, 1,   TumMeta↓, 16,   TumMeta↑, 1,   Twist↓, 6,   uPA↓, 9,   uPAR↓, 1,   Vim?, 1,   Vim↓, 14,   Zeb1↓, 8,   Zeb1↑, 1,   ZEB2↓, 1,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 15,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   angioG↑, 1,   ATF4↓, 1,   ATF4↑, 6,   EGFR↓, 11,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 25,   Hif1a↑, 1,   NO↓, 4,   NO↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 37,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT3↑, 1,   P-gp/ABCB1↓, 5,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 2,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 3,   IL10↓, 4,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↑, 3,   IL4↓, 2,   IL4↑, 1,   IL6↓, 15,   IL8↓, 3,   INF-γ↑, 1,   Inflam↓, 9,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 5,   M2 MC↓, 2,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 37,   NF-kB↑, 3,   NK cell↑, 2,   p65↓, 4,   PD-1↓, 1,   PD-L1↓, 3,   PGE1↓, 1,   PGE2↓, 10,   PSA↓, 3,   PSA∅, 1,   T-Cell↑, 1,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TNF-α↓, 8,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   CDK6↓, 6,   CDK6↑, 3,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 16,   BioAv↝, 3,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 68,   ChemoSen⇅, 1,   CYP1A2↓, 1,   CYP2C9↓, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 4,   Dose↝, 12,   Dose∅, 15,   eff↓, 17,   eff↑, 59,   eff↝, 4,   eff∅, 1,   Half-Life↓, 3,   Half-Life↝, 5,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 24,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 36,   Synergy↑, 222,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 1,   ALP↓, 1,   AR↓, 8,   ascitic↓, 1,   BG↓, 3,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 11,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   GutMicro↑, 3,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 8,   IL6↓, 15,   Ki-67↓, 9,   Ki-67↑, 1,   KRAS↓, 1,   LDH↓, 8,   Myc↓, 2,   NOS2↓, 1,   PD-L1↓, 3,   PSA↓, 3,   PSA∅, 1,   TP53↓, 2,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 14,   AntiCan∅, 1,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 2,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 5,   ChemoSideEff↓, 10,   hepatoP↓, 1,   hepatoP↑, 2,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   OS↑, 11,   QoL↑, 3,   radioP↑, 5,   RenoP↑, 3,   Risk↓, 10,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 4,   TumVol↓, 8,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 4,  
Total Targets: 673

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   TRPA1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 30,   Catalase↑, 12,   Copper↓, 1,   Fenton↓, 1,   GPx↑, 10,   GSH↑, 16,   GSR↑, 2,   GSSG↓, 1,   GSSG∅, 1,   GSTs↑, 6,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↑, 9,   Iron↓, 1,   Keap1↓, 3,   lipid-P↓, 12,   MDA↓, 9,   MPO↓, 3,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 17,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 40,   SAM-e↑, 1,   SOD↑, 19,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↝, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALAT↓, 4,   AMPK↑, 3,   p‑cMyc↑, 1,   CYP3A2↓, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   H2S↑, 1,   LDH↓, 2,   LDL↓, 4,   lipidLev↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bax:Bcl2↓, 1,   Casp3?, 1,   Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   iNOS↓, 7,   JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↓, 2,   other↑, 8,   other↝, 1,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 3,  

DNA Damage & Repair(tgid=10) ⓘ

GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   ERK↓, 2,   ERK↑, 2,   GSK‐3β↓, 4,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↑, 1,   PI3K↓, 3,   PI3K↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   TumCG∅, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↝, 3,   Cartilage↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 1,   RAGE↓, 1,   serineP↓, 1,   TGF-β↓, 2,   VCAM-1↓, 3,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   eNOS↓, 1,   NO↓, 6,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 8,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 12,   CRP↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 12,   IL2↓, 2,   IL4↓, 1,   IL6↓, 16,   IL8↓, 2,   Inflam↓, 38,   MCP1/CCL2↓, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 18,   PGE2↓, 6,   TLR2↓, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 20,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 4,   BChE↓, 1,   BDNF↑, 1,   tau↓, 3,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 6,   BACE/β-secretase↓, 3,   NLRP3↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 15,   BioAv↑, 19,   BioAv↝, 5,   BioEnh↑, 3,   Dose↑, 3,   Dose↝, 5,   eff↑, 9,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 6,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 36,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 6,   BMD↑, 1,   BMPs↑, 1,   BP↓, 5,   BP↝, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 2,   GutMicro↑, 2,   hs-CRP↓, 1,   IL6↓, 16,   LDH↓, 2,   Mag↑, 1,   MUC19↓, 1,   RAGE↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↓, 1,   cardioP↑, 17,   CardioT↓, 1,   chemoP↑, 6,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↑, 14,   cognitive↝, 1,   hepatoP↑, 10,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 27,   Pain↓, 2,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 6,   Risk↓, 1,   toxicity↓, 7,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 5,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 1,   IRF3↓, 1,  
Total Targets: 220

Scientific Paper Hit Count for: Synergy, Synergy
14 Curcumin
12 Vitamin C (Ascorbic Acid)
11 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 Quercetin
7 Resveratrol
7 Chrysin
6 Metformin
6 Artemisinin
6 Ashwagandha(Withaferin A)
6 Berberine
6 EGCG (Epigallocatechin Gallate)
6 Silymarin (Milk Thistle) silibinin
6 Chemotherapy
6 Fisetin
6 Thymoquinone
5 Apigenin (mainly Parsley)
5 Lycopene
5 diet FMD Fasting Mimicking Diet
5 Gambogic Acid
5 Rosmarinic acid
5 Vitamin K2
4 Magnetic Fields
4 Alpha-Lipoic-Acid
4 Propolis -bee glue
4 Piperlongumine
4 VitK3,menadione
3 3-bromopyruvate
3 Silver-NanoParticles
3 Piperine
3 Hydrogen Gas
3 Melatonin
3 Hyperthermia
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Andrographis
2 Gemcitabine (Gemzar)
2 Betulinic acid
2 beta-carotene(VitA)
2 Lutein
2 Zeaxanthin
2 5-fluorouracil
2 Citric Acid
2 Ellagic acid
2 diet Methionine-Restricted Diet
2 Fenbendazole
2 Radiotherapy/Radiation
2 HydroxyCitric Acid
2 Honokiol
2 Lecithin
2 Photodynamic Therapy
2 Selenite (Sodium)
2 Vitamin D3
1 2-DeoxyGlucose
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Vitamin B12
1 Folic Acid, Vit B9
1 Trichostatin A
1 5-Aminolevulinic acid
1 Baicalein
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Boron
1 Boswellia (frankincense)
1 Caffeic acid
1 Capsaicin
1 Coenzyme Q10
1 Selenium
1 Copper and Cu NanoParticles
1 salinomycin
1 Bortezomib
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 Emodin
1 Exercise
1 Ferulic acid
1 ferumoxytol
1 temozolomide
1 verapamil
1 hydroxychloroquine
1 doxorubicin
1 Genistein (soy isoflavone)
1 Calorie Restriction Mimetics
1 Spermidine
1 Docosahexaenoic Acid
1 chitosan
1 Matrine
1 immunotherapy
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Phenylbutyrate
1 borneol
1 Auranofin
1 Phosphatidylserine
1 Parthenolide
1 acetaminophen
1 Formononetin
1 acetazolamide
1 Shikonin
1 statins
1 triptolide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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