MMPs Cancer Research Results

MMPs, Matrix metalloproteinases: Click to Expand ⟱
Source:
Type:
Family of zinc-dependent proteolytic enzymes that play a key role in degrading the extracellular matrix (ECM).; are metalloproteinases that are calcium-dependent zinc-containing endopeptidases;[1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.[2]
MMP secretion: matrix metalloproteinase (MMP) is a kind of enzymes secreted.
by tumor cell to degrade ECM, facilitating the migration of tumor cells.

MMPs are generally considered protumorigenic due to their role in promoting tumor invasion, metastasis, and angiogenesis. They facilitate the breakdown of the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant sites.
Scientific Papers found: Click to Expand⟱
5210- PI,    Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells
- in-vitro, Melanoma, B16-BL6
IL1β↓, TNF-α↓, MMPs↓, p65↓, p50↓, NF-kB↓, ATF2↓, cFos↓, CREB↓,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *eff↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
1236- PTS,    Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumMeta↓, EMT↓, E-cadherin↑, Zeb1↓, Snail↓, β-catenin/ZEB1↓, CD44↓, MMPs↓, CSCs↓,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
56- QC,    Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988
EMT↓, MMPs↓, MMP2↓, MMP7↓, STAT3↓, TumCI↓, TumMeta↓, tumCV↓,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
*ROS↓, ROS↑, DNAdam↑, Apoptosis↑, Hif1a↑, Casp3↑, Casp9↑, Cyt‑c↑, Dose↝, MMPs↓, MMP2↓, MMP9↓, EMT↓, E-cadherin↑, N-cadherin↓, AR↓,
3077- RES,    Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways
- in-vitro, Chon, HTB94
MMP2↓, MMP9↓, SOX9↑, MMPs↓, p‑p38↑, p‑JNK↓, NF-kB↓, HO-1↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3027- RosA,    Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway
- in-vitro, HCC, SMMC-7721 cell
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, TumCMig↓, MMPs↓, Vim↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
3188- SFN,    Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells
- in-vitro, BC, NA
TNF-α↓, TumCI↓, TumMeta↓, MMPs↓, MMP2↓, MMP9↓, MMP13↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, NA, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31↓, Hif1a↓, VEGFR2↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
2094- TQ,    Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies
- Review, Var, NA
ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2↓, ER Stress↑, IRE1↑, JNK↑, CHOP↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,
3129- VitC,    Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis
- in-vivo, Stroke, NA
*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,

Showing Research Papers: 51 to 81 of 81
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 81

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   GSH↓, 1,   GSH↑, 3,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 3,   ROS↑, 12,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↑, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↑, 1,   EGF↓, 2,   FGFR1↓, 1,   MEK↓, 1,   MMP↓, 5,   OCR↓, 1,   Raf↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 9,   CREB↓, 1,   ECAR↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 4,   HK2↓, 2,   lactateProd↓, 4,   LDH↑, 2,   NADPH↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 2,   SIRT1↑, 2,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 9,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 10,   ATF2↓, 2,   Bak↑, 2,   BAX↑, 8,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BIM↓, 1,   Casp↑, 2,   Casp10↑, 1,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 9,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 7,   cFLIP↓, 2,   Cyt‑c↑, 5,   Diablo↑, 1,   DR5↑, 3,   Endon↑, 1,   Fas↑, 1,   FasL↑, 1,   GRP58↓, 1,   iNOS↓, 2,   JNK↑, 2,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 1,   MAPK↝, 1,   Necroptosis↑, 1,   p27↑, 3,   p38↑, 3,   p‑p38↑, 2,   RIP1↓, 1,   survivin↓, 5,   TNFR 1↑, 1,   TRAILR↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   SOX9↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↑, 1,   miR-21↓, 1,   miR-21↑, 1,   other↓, 2,   other↑, 1,   p‑pRB↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 4,   ER Stress↑, 2,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   LC3II↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   DFF45↑, 1,   DNAdam↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↑, 8,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 3,   PARP1↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↑, 1,   CDK4↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   P21↑, 3,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD44↓, 2,   cFos↓, 1,   CSCs↓, 4,   EMT↓, 12,   ERK↓, 3,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 4,   FGF↓, 1,   GSK‐3β↓, 2,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC4↓, 1,   IGFBP3↑, 1,   mTOR↓, 8,   p‑mTOR↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 10,   PTEN↑, 5,   RAS↓, 2,   Shh↓, 2,   Src↓, 1,   STAT3↓, 7,   TumCG↓, 3,   Wnt↓, 3,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

AntiAg↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   CD31↓, 1,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 3,   FAK↓, 3,   Ki-67↓, 1,   LEF1↓, 1,   MMP13↓, 1,   MMP2↓, 10,   MMP7↓, 3,   MMP9↓, 7,   MMP9:TIMP1↓, 1,   MMPs↓, 26,   N-cadherin↓, 2,   PDGF↓, 2,   PKA↓, 1,   PKCδ↓, 1,   RAGE↓, 1,   RIP3↓, 1,   Slug↓, 2,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 3,   TIMP2↑, 1,   TSP-1↑, 3,   TumCI↓, 7,   TumCMig↓, 5,   TumCP↓, 8,   TumMeta↓, 13,   Twist↓, 3,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 4,   Zeb1↓, 2,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 9,   angioG↑, 1,   EGFR↓, 5,   Hif1a↓, 6,   Hif1a↑, 1,   NO↓, 1,   VEGF↓, 12,   VEGFR2↓, 4,  

Barriers & Transport ⓘ

GLUT1↓, 2,   P-gp↓, 2,   P-gp↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 7,   CRP↓, 1,   CXCR4↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 2,   IL10↓, 5,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 6,   IL8↓, 1,   Inflam↓, 4,   MDSCs↓, 1,   NF-kB↓, 7,   p‑NF-kB↑, 1,   p50↓, 1,   p65↓, 1,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 6,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 3,   BioEnh?, 1,   ChemoSen↓, 1,   ChemoSen↑, 6,   Dose↝, 4,   eff↑, 12,   Half-Life↑, 1,   MDR1↓, 2,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 5,   HER2/EBBR2↓, 1,   IL6↓, 6,   Ki-67↓, 1,   LDH↑, 2,   Maspin↑, 1,   PSA↓, 1,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cardioP↑, 1,   chemoP↑, 3,   ChemoSideEff↓, 1,   hepatoP↑, 2,   neuroP↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity∅, 1,   TumVol↓, 1,  
Total Targets: 265

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 9,   Catalase↑, 6,   GPx↑, 1,   GSH↑, 4,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 2,   HO-1↑, 2,   lipid-P↓, 5,   MDA↓, 1,   NRF2↑, 5,   Prx↑, 1,   ROS↓, 13,   ROS↑, 1,   SOD↑, 6,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   CYP3A2↓, 1,   LDL↓, 1,   NADPH↓, 1,   PPARα↑, 1,  

Cell Death ⓘ

iNOS↓, 3,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↝, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

OCT4↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   CLDN1↝, 1,   E-sel↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 5,   PKCδ↓, 1,   TXNIP↓, 1,   ZO-1↝, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   OATPs↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 5,   CRP↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1β↓, 4,   IL2↓, 2,   IL4↓, 2,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 7,   MCP1↓, 1,   NF-kB↓, 3,   PGE2↓, 4,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 2,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

cortisol↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↑, 1,   Half-Life↝, 1,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BG↓, 1,   BP↓, 2,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 3,   hepatoP↑, 5,   memory↑, 3,   motorD↓, 1,   neuroP↑, 6,   toxicity↓, 3,   Weight↓, 1,  
Total Targets: 96

Scientific Paper Hit Count for: MMPs, Matrix metalloproteinases
9 Quercetin
4 Curcumin
4 EGCG (Epigallocatechin Gallate)
4 Resveratrol
4 Thymoquinone
3 Apigenin (mainly Parsley)
3 Baicalein
3 Propolis -bee glue
3 Rosmarinic acid
2 Astaxanthin
2 Biochanin A
2 Betulinic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Coenzyme Q10
2 Honokiol
2 Lycopene
2 Magnetic Fields
2 Piperine
2 Pterostilbene
2 Silymarin (Milk Thistle) silibinin
2 Vitamin C (Ascorbic Acid)
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Ashwagandha(Withaferin A)
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Berberine
1 Boswellia (frankincense)
1 Carnosic acid
1 Carvacrol
1 Chlorophyllin
1 Lecithin
1 diet FMD Fasting Mimicking Diet
1 Fisetin
1 Garcinol
1 Gemcitabine (Gemzar)
1 HydroxyTyrosol
1 Luteolin
1 Magnetic Field Rotating
1 Proanthocyanidins
1 Phenethyl isothiocyanate
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:204  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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