mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Scientific Papers found: Click to Expand⟱
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
1387- BBR,    Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
- in-vitro, Thyroid, CAL-62
TumCG↓, Apoptosis↑, LC3B↑, ROS↑, PI3K↓, Akt↓, mTOR↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
2707- BBR,    Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7
GLUT1↓, Akt↓, mTOR↓, ATP↓, GlucoseCon↓, TumCP↓, Warburg↓, selectivity↑, TumCCA↑, Glycolysis↓,
2708- BBR,    Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells
- in-vitro, CRC, HCT116
TumCG↓, GlucoseCon↓, GLUT1↓, LDHA↓, HK2↓, Hif1a↓, mTOR↓, Glycolysis↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, necrosis↑, AQPs↓, PTEN↑, PI3K↓, Akt↓, p‑Akt↓, mTOR↓, p‑mTOR↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
5181- BBR,  Cisplatin,    Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
tumCV↓, MDR1↓, ChemoSen↑, PI3K↓, Akt↓, mTOR↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2↓, ACC↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
5729- BF,    Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling
- in-vitro, Lung, NA
TumCCA↑, Apoptosis↑, TumCG↓, EGFR↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1↓, RadioS↑, PhotoS↑, toxicity↝,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
5691- BRU,    Brusatol Inhibits Proliferation, Migration, and Invasion of Nonsmall Cell Lung Cancer PC-9 Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, H1975
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EGFR↓, β-catenin/ZEB1↓, Akt↓, STAT3↓, TumMeta↓, ChemoSen↑, NRF2↓, Akt↓, mTOR↓,
5699- BRU,  BJ,    Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay
- in-vitro, Lung, A549
EGFR↓, ChemoSen↑, NRF2↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ROCK1↓, Hif1a↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1101- CA,  Tras,    Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells
- in-vitro, BC, NA
ChemoSen↑, HER2/EBBR2↓, PI3K↓, Akt↓, mTOR↓, p62↑,
2017- CAP,    Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease
- Review, Var, NA
RenoP↑, AntiTum↑, AMPK↑, mTOR↑, PD-1↓, PD-L1↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
1580- Citrate,    Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway
- in-vitro, Pca, PC3 - in-vivo, PC, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, WPMY-1
Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1↑, TumAuto↑, CaMKII ↓,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
2315- Citrate,    Why and how citrate may sensitize malignant tumors to immunotherapy
- Review, Var, NA
Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,
4773- CoQ10,    Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway
- in-vitro, Nor, NA
*other↓, *PI3K↑, *Akt↑, *mTOR↑, *ROS↓,
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
3631- Cro,    Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease
- in-vitro, AD, HT22 - in-vivo, AD, NA
*ROS↓, *Ca+2↓, *BAX↓, *BAD↓, *Casp3↓, *cognitive↑, *memory↑, *Aβ↓, *GPx↑, *SOD↑, *ChAT↑, *Ach↑, *AChE↓, *ROS↓, *p‑Akt↑, *p‑mTOR↑, *neuroP↑,
140- CUR,    Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
- in-vitro, Pca, PC3
CAFs/TAFs↓, EMT↓, ROS↓, CXCR4↓, IL6↓, MAOA↓, mTOR↓, HIF-1↓,
123- CUR,    Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells
- in-vitro, Colon, LoVo - in-vitro, Colon, COLO205 - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
NF-kB↓, ATF3↑, HO-1↑, Wnt↓, Akt↓, mTOR↓, PTEN↑, Apoptosis↑, TGF-β↓, PPARγ↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
476- CUR,    The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
- in-vitro, PC, PATU-8988 - in-vitro, PC, PANC1
TumCMig↓, TumCI↓, Apoptosis↑, NEDD9↓, p‑Akt↓, p‑mTOR↓, PTEN↑, p73↑, β-TRCP↑,
471- CUR,    Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↑,
435- CUR,    Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549
Apoptosis↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1↑, p62↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, p‑mTOR↓,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
425- CUR,    Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
CDC25↓, cDC2↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑,
452- CUR,    Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells
- vitro+vivo, HNSCC, SCC9 - vitro+vivo, HNSCC, FaDu - vitro+vivo, HNSCC, HaCaT
TumCCA↑, PI3k/Akt/mTOR↓, Casp3↑, EGFR↓, EGF↑, PRKCG↑, p‑Akt↓, p‑mTOR↓, RPS6KA1↓, EIF4E↓, proCasp3↓,
445- CUR,    Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, HCT8 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
p‑AMPK↑, p‑ACC-α↑, NBR2↑, p‑S6K↓, mTOR↓,
168- CUR,    Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism
- in-vitro, Pca, PC3
Akt↓, mTOR↓, AMPK↑, TAp63α↑, TumCP↓,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,

Showing Research Papers: 51 to 100 of 288
Prev Page 2 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 288

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 4,   MDA↑, 1,   NADPH/NADP+↓, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↝, 1,   PARK2↑, 1,   ROS↓, 3,   ROS↑, 19,   ROS↝, 1,   SOD2↓, 1,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   mt-ATP↓, 1,   BOK↑, 1,   CDC2↓, 1,   CDC25↓, 4,   EGF↑, 1,   MMP↓, 4,   MMP↑, 1,   mtDam↑, 1,   PINK1↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   p‑ACC-α↑, 1,   ACLY↓, 1,   ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 10,   AMPK↝, 1,   p‑AMPK↑, 2,   ATG7↑, 1,   cMyc↓, 2,   FASN↑, 1,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 4,   Glycolysis↓, 7,   HK2↓, 3,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 1,   LDL↓, 1,   MCU↓, 1,   PDK1↓, 3,   PDK3↑, 1,   PFK1↓, 1,   PFK2↓, 1,   PFKP↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   Pyruv↓, 1,   p‑S6K↓, 1,   SIRT1↑, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 27,   Akt↝, 1,   p‑Akt↓, 11,   APAF1↑, 1,   Apoptosis↑, 18,   Apoptosis↝, 1,   BAD↓, 1,   BAX↑, 7,   BAX↝, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-2↝, 1,   Bcl-xL↓, 5,   Bcl-xL↝, 1,   BID↑, 1,   Casp↑, 3,   Casp1↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 11,   Casp3↝, 1,   cl‑Casp3↑, 4,   proCasp3↓, 1,   Casp7↑, 1,   Casp8↑, 5,   Casp9↑, 7,   cFLIP↓, 1,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   Diablo↑, 2,   DR5↑, 1,   FADD↑, 1,   Fap1↓, 1,   Fas↑, 2,   FasL↑, 2,   Ferroptosis↑, 2,   hTERT/TERT↓, 1,   IAP1↓, 1,   ICAD↓, 1,   iNOS↓, 2,   JNK↑, 1,   JNK↝, 1,   MAPK↓, 1,   Mcl-1↓, 5,   MDM2↓, 1,   NAIP↓, 1,   necrosis↑, 1,   p27↑, 2,   survivin↓, 4,   Telomerase↓, 2,   TRAIL↑, 1,   TRPV1↑, 2,   β-TRCP↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 2,   HER2/EBBR2↓, 2,   SOX9↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,   other↓, 1,   PhotoS↑, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   ERStress↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 2,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 2,   ATG5↑, 3,   Beclin-1↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↓, 1,   LC3II↑, 4,   LC3s↑, 1,   p62↓, 4,   p62↑, 2,   TumAuto↑, 8,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 3,   DNMT1↓, 2,   DNMT3A↓, 1,   NBR2↑, 1,   P53↓, 1,   P53↑, 5,   P53↝, 1,   p73↑, 1,   PARP↑, 3,   cl‑PARP↑, 5,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

p‑CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   Cyc↝, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 4,   P21↝, 1,   RB1↑, 1,   p‑RB1↓, 1,   TAp63α↑, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 2,   cDC2↓, 1,   CSCs↓, 1,   EIF4E↓, 1,   EMT↓, 5,   EMT↑, 1,   ERK↓, 3,   p‑ERK↓, 1,   FOXM1↓, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC∅, 1,   IGF-1R↓, 1,   IGFBP1↑, 1,   Let-7↑, 1,   mTOR↓, 36,   mTOR↑, 2,   mTOR↝, 2,   mTOR∅, 1,   p‑mTOR↓, 8,   NOTCH1↑, 2,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 15,   PI3K↝, 1,   PRKCG↑, 1,   PTCH1↓, 1,   PTEN↑, 4,   PTEN↝, 1,   RAS↓, 1,   RPS6KA1↓, 1,   STAT3↓, 7,   p‑STAT3↓, 2,   p‑STAT3↑, 1,   TOP1↓, 2,   TOP2↓, 1,   TumCG↓, 7,   Wnt↓, 3,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   AP-1↝, 1,   Ca+2↓, 3,   Ca+2↑, 3,   i-Ca+2?, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   CLDN1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 2,   FAK↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   Ki-67↓, 2,   miR-139-5p↑, 1,   miR-29b↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 7,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 1,   MMP9↓, 9,   MMP9↑, 1,   MMPs↓, 2,   N-cadherin↓, 1,   NEDD9↓, 1,   Rho↓, 2,   ROCK1↓, 4,   Slug↓, 1,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 2,   TumCI?, 1,   TumCI↓, 5,   TumCMig↓, 7,   TumCP↓, 11,   TumMeta↓, 5,   Twist↓, 1,   uPA↓, 2,   Vim↓, 2,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 9,   EGFR↝, 1,   HIF-1↓, 2,   Hif1a↓, 9,   VEGF↓, 8,   VEGF↝, 1,  

Barriers & Transport ⓘ

AQPs↓, 1,   BBB↑, 1,   GLUT1↓, 4,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 7,   COX2↑, 2,   COX2↝, 1,   CXCR4↓, 2,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 3,   IL6↝, 1,   Inflam↓, 2,   JAK1↓, 1,   JAK2↓, 2,   p‑JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 9,   NF-kB↝, 1,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 3,   PSA↝, 1,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,   TNF-α↝, 1,  

Synaptic & Neurotransmission ⓘ

MAOA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   AR↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 3,   ChemoSen↑, 11,   Dose?, 1,   Dose↑, 1,   Dose↝, 1,   eff↓, 6,   eff↑, 16,   eff↝, 1,   Half-Life↓, 1,   MDR1↓, 1,   MRP1↓, 1,   RadioS↑, 3,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 3,   AR↝, 1,   EGFR↓, 9,   EGFR↝, 1,   FOXM1↓, 1,   GutMicro↑, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 3,   IL6↝, 1,   Ki-67↓, 2,   LDH↓, 1,   PD-L1↓, 2,   PSA↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 4,   cardioP↑, 1,   chemoPv↑, 3,   neuroP↑, 1,   RenoP↑, 3,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 344

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx?, 1,   antiOx↑, 2,   Catalase↑, 4,   GPx↑, 5,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 9,   SOD↑, 5,  

Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,  

Cell Death ⓘ

Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↓, 1,   BAD↓, 1,   BAX↓, 1,   Casp3↓, 1,   Casp3∅, 1,   Cyt‑c∅, 1,   iNOS↓, 2,   JNK↓, 1,   p‑JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   HSP90↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   mTOR↓, 1,   mTOR↑, 2,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   P70S6K↓, 2,   PI3K↑, 1,  

Migration ⓘ

5LO↓, 1,   APP↓, 1,   Ca+2↓, 1,   CD31↑, 1,   MMP3↓, 1,   N-cadherin↑, 1,   TGF-β1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 3,   IL10↑, 2,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 7,   NF-kB↓, 3,   PGE2↓, 1,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   ChAT↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 2,   AST↓, 3,   BG↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 2,   hepatoP↑, 3,   memory↑, 3,   neuroP↑, 6,   Obesity↓, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 86

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
17 Curcumin
14 Berberine
14 Quercetin
13 Baicalein
12 Fisetin
9 Thymoquinone
8 Apigenin (mainly Parsley)
8 Magnetic Fields
8 Honokiol
8 Resveratrol
8 Shikonin
7 Alpha-Lipoic-Acid
7 Artemisinin
7 EGCG (Epigallocatechin Gallate)
6 diet FMD Fasting Mimicking Diet
6 Lycopene
6 Sulforaphane (mainly Broccoli)
6 Urolithin
5 Chemotherapy
5 Magnolol
5 Piperlongumine
5 Rosmarinic acid
5 Silymarin (Milk Thistle) silibinin
4 Ashwagandha(Withaferin A)
4 Citric Acid
4 Metformin
4 Piperine
4 Pterostilbene
3 5-fluorouracil
3 Coenzyme Q10
3 Astragalus
3 Cisplatin
3 brusatol
3 Capsaicin
3 Chrysin
3 salinomycin
3 diet Short Term Fasting
3 Gambogic Acid
3 Hydrogen Gas
3 Magnetic Field Rotating
3 Naringin
2 Auranofin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Betulinic acid
2 Brucea javanica
2 Boswellia (frankincense)
2 Propolis -bee glue
2 Ursolic acid
2 Dichloroacetate
2 Deguelin
2 Ellagic acid
2 HydroxyTyrosol
2 itraconazole
2 Juglone
2 Luteolin
2 Niclosamide (Niclocide)
2 doxorubicin
2 Plumbagin
2 Vitamin D3
1 Andrographis
1 2-DeoxyGlucose
1 Baicalin
1 Biochanin A
1 Bufalin/Huachansu
1 Butyrate
1 Carnosic acid
1 Trastuzumab
1 Crocetin
1 diet Methionine-Restricted Diet
1 Emodin
1 Ferulic acid
1 flavonoids
1 Garcinol
1 HydroxyCitric Acid
1 Huperzine A/Huperzia serrata
1 Ivermectin
1 Sorafenib (brand name Nexavar)
1 Laetrile B17 Amygdalin
1 Methylene blue
1 MCToil
1 Oleuropein
1 Oleocanthal
1 sericin
1 Phenethyl isothiocyanate
1 Parthenolide
1 Gold NanoParticles
1 Selenium
1 Selenium NanoParticles
1 Formononetin
1 acetazolamide
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:209  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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