mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Scientific Papers found: Click to Expand⟱
2618- Ba,    Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer
- in-vitro, Lung, H1299 - in-vivo, Lung, A549
TumCG↓, TumCP↓, Apoptosis↑, GLUT1↓, GLS↓, mTOR↓, *toxicity∅, cl‑Casp9↓, cl‑Casp3↓, GSH↓, GlutMet↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, Var, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, Synergy↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2/PTGS2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
1387- BBR,    Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
- in-vitro, Thyroid, CAL-62
TumCG↓, Apoptosis↑, LC3B↑, ROS↑, PI3K↓, Akt↓, mTOR↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
2707- BBR,    Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
GLUT1↓, Akt↓, mTOR↓, ATP↓, GlucoseCon↓, TumCP↓, Warburg↓, selectivity↑, TumCCA↑, Glycolysis↓,
2708- BBR,    Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells
- in-vitro, CRC, HCT116
TumCG↓, GlucoseCon↓, GLUT1↓, LDHA↓, HK2↓, Hif1a↓, mTOR↓, Glycolysis↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, necrosis↑, AQPs↓, PTEN↑, PI3K↓, Akt↓, p‑Akt↓, mTOR↓, p‑mTOR↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
5181- BBR,  Cisplatin,    Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
tumCV↓, MDR1↓, ChemoSen↑, PI3K↓, Akt↓, mTOR↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6514- BCP,    Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells
- in-vitro, BC, NA
TumCP↓, CB2 / CNR2↓, STAT3↓, mTOR↓, Akt↓, Hypoxia↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
- in-vitro, Var, NA
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6498- BCP,    β-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, 5637
tumCV↓, ROS↑, Apoptosis↑, MMP↓, TumCMig↓, STAT3↓, mTOR↓, Akt↓,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
5729- BF,    Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling
- in-vitro, Lung, NA
TumCCA↑, Apoptosis↑, TumCG↓, EGFR↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓,
9172- BITC,    Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling
- in-vitro, Pca, PC3
mTOR↓,
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, Var, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2/PTGS2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
5691- BRU,    Brusatol Inhibits Proliferation, Migration, and Invasion of Nonsmall Cell Lung Cancer PC-9 Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, H1975
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EGFR↓, β-catenin/ZEB1↓, Akt↓, STAT3↓, TumMeta↓, ChemoSen↑, NRF2↓, Akt↓, mTOR↓,
5699- BRU,  BJ,    Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay
- in-vitro, Lung, A549
EGFR↓, ChemoSen↑, NRF2↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ROCK1↓, Hif1a↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1101- CA,  Tras,    Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells
- in-vitro, BC, NA
ChemoSen↑, HER2/EBBR2↓, PI3K↓, Akt↓, mTOR↓, p62↑,
5870- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen‐Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF7
ROS↑, cJun↑, p38↑, eff↓, TumCP↓, glucose↓, Apoptosis↑, BAX↑, PARP↑, Bcl-2↓, TumCG↑, Ki-67↓, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, Synergy↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5841- CAP,    The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
- in-vitro, HCC, HepG2
AMPK↑, CaMKII ↑, tumCV↓, Akt↓, mTOR↓, ROS↑,
5846- CAP,    Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell
- in-vitro, HCC, HepG2
Dose↝, miR-126↑, Ki-67↓, PI3K↓, mTOR↓, Akt↑, Synergy↑, Casp3↑,
2017- CAP,    Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease
- Review, Var, NA
RenoP↑, AntiTum↑, AMPK↑, mTOR↑, PD-1↓, PD-L1↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, Synergy↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5940- Cela,    Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
- in-vivo, Pca, PC3
Dose↝, TumVol↓, TumW↓, angioG↓, VEGF↓, TumCMig↓, TumCP↓, TumCI↓, Akt↓, mTOR↓, P70S6K↓,
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, Synergy↑, *toxicity↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,

Showing Research Papers: 51 to 100 of 489
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 489

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 7,   ARE↑, 1,   Catalase↓, 7,   Catalase↑, 3,   Copper↓, 1,   Copper↑, 1,   Fenton↑, 3,   GPx↓, 2,   GPx↑, 1,   GPx4↓, 9,   GSH↓, 23,   GSH↑, 6,   GSR↓, 2,   GSTs↓, 2,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 6,   HO-1↓, 8,   HO-1↑, 19,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 9,   i-Iron↓, 1,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 6,   lipid-P↑, 12,   MDA↓, 4,   MDA↑, 11,   MPO↓, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 3,   NRF2↓, 22,   NRF2↑, 23,   NRF2↝, 3,   p‑NRF2↓, 1,   Prx4↑, 1,   PYCR1↓, 2,   ROS↓, 34,   ROS↑, 214,   ROS⇅, 8,   ROS↝, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD?, 1,   SOD↓, 9,   SOD↑, 8,   mt-SOD↑, 1,   SOD1↑, 2,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 2,   TBARS↑, 1,   Thiols↓, 1,   TKT↝, 1,   Trx↑, 1,   Trx1↑, 2,   TrxR↓, 8,   TrxR↑, 1,   TrxR1↓, 3,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   NCOA4↑, 2,   STEAP3↓, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 8,   CDC25↓, 13,   compI↓, 5,   compIII↓, 3,   compV↓, 1,   EGF↓, 5,   EGF↑, 1,   ETC↓, 4,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 7,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 18,   OCR↓, 9,   OCR↑, 4,   OXPHOS↓, 6,   OXPHOS↑, 7,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↑, 3,   PGC-1α↑, 1,   PINK1↑, 3,   SIRT3↓, 1,   SIRT3↑, 4,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   AApath↓, 1,   ACC↓, 1,   ACC↑, 4,   p‑ACC↑, 1,   p‑ACC-α↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   adiP↑, 1,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 2,   AMPK↓, 4,   AMPK↑, 62,   AMPK↝, 1,   p‑AMPK↑, 10,   ATGL/PNPLA2↓, 1,   ATP↓, 26,   ATP↑, 1,   mt-ATP↓, 2,   CAIX/CA9↓, 2,   CRM↑, 1,   ECAR↓, 5,   ENO1↓, 2,   FABP4↑, 1,   FASN↓, 6,   FASN↑, 1,   FBPase↑, 1,   FDG↓, 1,   FFA/NEFA↓, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 2,   glucoNG↑, 1,   glucose↓, 4,   GlucoseCon↓, 20,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 50,   Glycolysis↝, 1,   p‑GS3Kβ↓, 1,   GSK‐3β↓, 16,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 4,   p‑GSK‐3β↑, 1,   HK1↓, 1,   HK2↓, 21,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 21,   lactateProd↑, 1,   LDHA↓, 11,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↓, 2,   NADPH↓, 3,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 13,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 3,   PFK2↓, 1,   PFKFB3↓, 2,   PFKP↓, 1,   PKM2↓, 28,   PKM2↑, 1,   PKM2:PKM1↓, 1,   Pyruv↓, 1,   R5P↝, 1,   p‑S6↓, 3,   SCD1↓, 2,   SCP2↓, 1,   SIRT1↓, 5,   SIRT1↑, 10,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 3,   TumCM/A↓, 1,   Warburg↓, 18,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 11,   Apoptosis?, 3,   Apoptosis↓, 1,   Apoptosis↑, 193,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD?, 1,   BAD↓, 3,   BAD↑, 11,   Bak↑, 7,   BAX↓, 1,   BAX↑, 104,   BAX↝, 1,   Bax:Bcl2↑, 18,   Bcl-2↓, 112,   Bcl-2↑, 3,   Bcl-2↝, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 25,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 9,   BNIP3↑, 3,   BOK↑, 1,   Casp↓, 1,   Casp↑, 33,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 2,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 114,   Casp3↝, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 26,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   Casp6↓, 1,   Casp7↑, 10,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 26,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 66,   cl‑Casp9↓, 1,   cl‑Casp9↑, 11,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 8,   Cyt‑c↓, 1,   Cyt‑c↑, 67,   Cyt‑c↝, 1,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 22,   FADD↑, 5,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 15,   FasL↑, 10,   Ferroptosis↑, 18,   GRP58↓, 1,   GSDMD↑, 1,   GSDME↑, 1,   IAP1↓, 8,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 12,   Mcl-1↓, 24,   MDM2↓, 10,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 3,   NAIP↓, 1,   Necroptosis↑, 1,   necrosis↑, 5,   oncosis↑, 2,   p38↓, 7,   p38↑, 17,   p‑p38↑, 4,   PUMA↓, 2,   PUMA↑, 3,   Pyro↑, 3,   RIP3↓, 1,   RIP3↑, 1,   survivin↓, 47,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 13,   XIAP↓, 22,   XIAP↑, 1,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 260,   Akt↑, 10,   Akt↝, 2,   p‑Akt↓, 75,   AKT1↓, 3,   AMPKα↑, 5,   CaMKII ↓, 2,   CaMKII ↑, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 2,   EGFR↓, 47,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 36,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 3,   FGFR1↓, 2,   GNAI1↓, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 3,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 7,   JAK1↓, 4,   JAK2↓, 15,   p‑JAK2↓, 1,   JNK↓, 3,   JNK↑, 15,   JNK↝, 1,   p‑JNK↑, 4,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 31,   MAPK↑, 13,   MAPK↝, 3,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 7,   MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR?, 1,   mTOR↓, 353,   mTOR↑, 16,   mTOR⇅, 1,   mTOR↝, 4,   mTOR∅, 1,   p‑mTOR↓, 61,   p‑mTOR↑, 2,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 5,   p70S6↑, 1,   p‑p70S6↓, 2,   P70S6K↓, 17,   P70S6K↑, 1,   p‑P70S6K↓, 7,   p‑P70S6K↑, 1,   p85S6K↓, 1,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PI3K?, 1,   PI3K↓, 192,   PI3K↑, 5,   PI3K↝, 3,   p‑PI3K↓, 13,   PI3K/Akt↓, 5,   PI3k/Akt/mTOR↓, 4,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 5,   PP2A↑, 2,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 5,   PTEN↑, 31,   PTEN↝, 1,   Raf↓, 3,   e-Raf↓, 1,   RAS↓, 13,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 2,   RIP1↑, 1,   RPS6KA1↓, 1,   S6K↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 8,   Src↓, 2,   p‑Src↓, 2,   STAT↓, 6,   STAT3↓, 79,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TSC2↑, 5,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 10,   ATF4↝, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 2,   cMyc↓, 35,   CREBBP↓, 1,   DLEU1↓, 1,   DNMT1↓, 6,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 5,   EZH2↓, 8,   FOXM1↓, 7,   FOXO↑, 1,   FOXO1↓, 3,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 17,   HDAC∅, 1,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 1,   HMTs↓, 1,   JPT1/HN1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 3,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-206↑, 1,   miR-21↓, 6,   miR-21↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-340↓, 2,   miR-34a↓, 2,   miR-34a↑, 5,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   miR-429↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 6,   OCT4↓, 11,   other↓, 5,   other↝, 5,   PhotoS↑, 1,   SOX2↓, 9,   SOX4↓, 4,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFE3↑, 2,   tumCV?, 2,   tumCV↓, 59,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 23,   eIF2α↓, 3,   eIF2α↑, 4,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 37,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 12,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 6,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSP90↑, 1,   IRE1↑, 4,   PERK↑, 6,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 10,   ATG7↑, 5,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 27,   p‑Beclin-1/ATG6↑, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 4,   LC3B-II↑, 7,   LC3I↓, 1,   LC3I↑, 1,   LC3II↑, 22,   LC3s↓, 1,   LC3s↑, 1,   lysoM↓, 1,   LysoPr↑, 1,   lysosome↓, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 18,   p62↑, 6,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto↓, 4,   TumAuto↑, 92,   TumAuto⇅, 1,   ULK1/ATG1↑, 2,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↝, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↑, 45,   DNArepair↓, 2,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   NBR2↑, 1,   p16↑, 3,   P53?, 1,   P53↓, 3,   P53↑, 74,   P53↝, 1,   p‑P53↑, 3,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 3,   PARP↑, 22,   cl‑PARP↑, 55,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 16,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 5,   TOP1?, 1,   TOP1↓, 5,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 3,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 16,   CDK1↑, 3,   p‑CDK1↓, 1,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 36,   CDK4↑, 3,   CDK4/6↓, 2,   CDK6↓, 15,   CDK6↑, 4,   CDKN1C/p57↓, 1,   CHK1↓, 1,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 11,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 25,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 58,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 3,   cycE/CCNE↓, 18,   cycE1↓, 2,   E2Fs↓, 3,   E2Fs↑, 1,   Ki-67↓, 25,   mitA↓, 1,   mitA↑, 1,   p19↑, 2,   P21↓, 2,   P21↑, 53,   P21↝, 1,   p27/CDKN1B↓, 4,   p27/CDKN1B↑, 25,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 3,   TAp63α↑, 1,   TumCCA?, 2,   TumCCA↓, 5,   TumCCA↑, 153,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 4,   4E-BP1↑, 1,   p‑4E-BP1↓, 4,   ALDH↓, 5,   ALDH1A1↓, 1,   Axin2↑, 1,   BMI1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 2,   CD133↓, 6,   CD24↓, 3,   CD34↓, 2,   cFos↓, 9,   cFos↑, 1,   CSCs↓, 37,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 12,   HH↓, 12,   IGF-1↓, 11,   IGFBP1↑, 3,   IGFBP3↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 25,   Let-7↓, 1,   Let-7↑, 2,   mTORC1↓, 9,   Nanog↓, 9,   Nestin↓, 1,   NOTCH↓, 18,   NOTCH↑, 1,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 2,   OGFr↑, 2,   p300↓, 1,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 7,   Smo↓, 7,   STAT1↓, 1,   Sufu↓, 1,   TumCG↓, 81,   TumCG↑, 4,   TumCP?, 2,   TumCP↓, 150,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 49,   Wnt↝, 1,   Wnt/(β-catenin)↓, 8,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 11,   AP-1↝, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↓, 4,   Ca+2↑, 25,   Ca+2↝, 1,   i-Ca+2?, 1,   CAFs/TAFs↓, 2,   Cal1↑, 1,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↓, 1,   Chl↑, 1,   Cofilin↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 44,   EMT↓, 71,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 11,   p‑FAK↓, 1,   Fibronectin↓, 5,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 5,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   KRAS↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 5,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 2,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 77,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 10,   MMP7↓, 10,   MMP9↓, 83,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 26,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 33,   NCAM↑, 1,   NEDD9↓, 1,   PAK1↓, 4,   PAK1↑, 1,   PDGF↓, 3,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 7,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 11,   Smad1↓, 1,   SMAD2↓, 1,   SMAD2↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail↓, 29,   talin↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 2,   TIMP1↓, 2,   TIMP1↑, 4,   TIMP2↓, 3,   TIMP2↑, 3,   TSC1↑, 2,   TSP-1↑, 3,   TumCA↓, 3,   TumCI?, 2,   TumCI↓, 88,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 79,   TumCMig↑, 3,   TumMeta↓, 57,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 20,   Tyro3↓, 1,   uPA↓, 19,   uPAR↓, 3,   Vim?, 1,   Vim↓, 38,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 13,   ZEB2↓, 1,   α-tubulin↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 52,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 3,   CD31/PECAM-1↓, 5,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 1,   HIF-1↓, 9,   Hif1a↓, 63,   Hypoxia↓, 2,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 3,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 91,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↓, 1,   BBB↑, 3,   BBB∅, 2,   CellMemb↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   GLUT1↓, 22,   GLUT2↓, 1,   GLUT4↓, 2,   MMP↓, 86,   MMP↑, 2,   MPT↑, 2,   TRPM7↓, 2,   TRPM7↑, 1,   TRPV1↑, 2,   TRPV1↝, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 57,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 13,   DCells↑, 1,   DR4↑, 2,   FOXP3↑, 2,   HMGB1↓, 1,   ICAM-1↓, 7,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 5,   IL10↓, 8,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 12,   IL2↓, 1,   IL2↑, 5,   IL33↑, 1,   IL6↓, 34,   IL6↑, 1,   IL6↝, 1,   IL8↓, 5,   Imm↑, 10,   Imm↝, 3,   Inflam↓, 20,   IRAK1↓, 2,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB↓, 116,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   p50↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 13,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↑, 1,   T-Cell↑, 1,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR2↓, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 25,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 1,   pH↑, 1,   e-pH↑, 1,   i-pH↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   MAOA↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AhR↓, 2,   AR↓, 13,   AR↝, 1,   CYP19↓, 1,   ER-α36↓, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARγ↓, 3,   PPARγ↑, 7,   RANKL↓, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 33,   BioAv↑, 36,   BioAv↝, 9,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↑, 125,   CompStab↓, 3,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 5,   Dose↝, 43,   Dose∅, 2,   eff?, 1,   eff↓, 32,   eff↑, 57,   eff↝, 8,   eff∅, 3,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life↓, 11,   Half-Life↝, 12,   Half-Life∅, 1,   MDR1↓, 11,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 22,   P450↓, 2,   RadioS↑, 39,   selectivity↑, 58,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 83,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 2,   AR↓, 13,   AR↝, 1,   AST↓, 1,   BG↓, 3,   BRCA1↓, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 47,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 8,   Ferritin↓, 3,   FOXM1↓, 7,   HemoG↓, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 34,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 8,   LDH↑, 3,   Myc↓, 6,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 13,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   TP53↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan?, 1,   AntiCan↑, 42,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 18,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 2,   cardioP↑, 9,   chemoP↑, 22,   chemoPv↑, 11,   ChemoSideEff↓, 3,   fatigue↓, 3,   hepatoP↑, 3,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 1,   OS↑, 12,   OS⇅, 1,   OS∅, 1,   Pain↓, 3,   PFS↑, 1,   PFS∅, 1,   QoL↑, 6,   QoL∅, 1,   radioP↑, 6,   RenoP↑, 7,   Risk↓, 10,   Risk↑, 1,   Sleep↑, 2,   Strength↑, 2,   toxicity↓, 23,   toxicity↝, 10,   toxicity∅, 1,   TumVol↓, 20,   TumVol∅, 1,   TumW↓, 14,   TumW∅, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 8,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 8,  
Total Targets: 1119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 4,   antiOx↑, 67,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 38,   GPx↑, 24,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 22,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 23,   hyperG↓, 1,   hyperG↝, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 22,   MDA↓, 23,   MDA↑, 1,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 7,   NRF2?, 1,   NRF2↑, 47,   RNS↓, 2,   ROS?, 1,   ROS↓, 87,   mt-ROS↓, 2,   SOD↓, 1,   SOD↑, 38,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   p‑DRP1/DNM1L↝, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 4,   MFN1↝, 1,   MFN2↝, 1,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↑, 5,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   adiP↑, 1,   ALAT↓, 11,   AMPK↓, 1,   AMPK↑, 21,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↑, 5,   CRM↑, 1,   cytoP450↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 3,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↑, 1,   LDL↓, 7,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 2,   PFK↑, 1,   PKM2↑, 1,   PLA2↓, 1,   SIRT1↑, 10,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 8,   Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 7,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 2,   Casp3↓, 12,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 2,   cl‑Casp8↓, 1,   Casp9↓, 2,   cl‑Casp9↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 10,   p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 18,   Akt↝, 1,   p‑Akt↓, 6,   p‑Akt↑, 3,   CREB↑, 1,   p‑CREB↑, 1,   ERK↓, 3,   ERK↑, 3,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   JAK2↑, 1,   JNK↓, 2,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 26,   mTOR↑, 19,   mTOR↝, 2,   p‑mTOR↓, 10,   p‑mTOR↑, 3,   p‑p70S6↓, 1,   P70S6K↓, 3,   p‑P70S6K↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 13,   PI3K↝, 1,   p‑PI3K↓, 2,   PKA↑, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTP1B↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 8,   ATF4↓, 1,   ATF4↑, 1,   cJun↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC2↓, 1,   HOTAIR↑, 1,   miR-107↑, 1,   other↓, 4,   other↑, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 2,   HSP70/HSPA5↓, 1,   HSP90↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 4,   LC3s↓, 1,   MitoP↑, 2,   p62↓, 3,   p62↑, 1,   PARK2↑, 2,   TFEB↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   DNArepair↑, 1,   p16↓, 1,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↑, 1,   Diff↑, 1,   Diff↝, 1,   FGF↑, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   MMPs↑, 1,   N-cadherin↑, 1,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TXNIP↓, 1,   Vim↓, 1,   α-SMA↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   CD31/PECAM-1↑, 1,   E-sel↓, 1,   eNOS↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 11,   NO↑, 1,   VEGF↓, 2,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 9,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 3,   MMP↑, 4,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 18,   HMGB1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 4,   IL10↑, 7,   IL17↓, 4,   IL18↓, 1,   IL1β↓, 24,   IL23↓, 2,   IL4↓, 2,   IL5↓, 1,   IL6↓, 30,   IL6↑, 1,   IL8↓, 6,   Imm↑, 5,   Inflam↓, 94,   Inflam↑, 1,   LPS↓, 2,   MCP1/CCL2↓, 2,   MyD88↓, 1,   NeuroI↓, 2,   NF-kB↓, 30,   p‑NF-kB↓, 1,   NLRP3↓, 10,   NLRP3↑, 1,   PGE2↓, 12,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 7,   TNF-α↓, 37,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   Ach↑, 4,   AChE↓, 14,   BChE↓, 1,   BDNF↑, 14,   ChAT↑, 2,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 1,   TrkB↝, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 2,   Aβ↓, 20,   Aβ42↓, 1,   BACE/β-secretase↓, 7,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   CYP19↓, 1,   FGF21↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 23,   BioAv↑, 18,   BioAv↝, 21,   BioEnh↑, 2,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 12,   eff↑, 10,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 12,   Half-Life∅, 2,   P-gp/ABCB1↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALP↓, 4,   AST↓, 13,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 2,   colonLen↑, 1,   creat↓, 3,   CRP↓, 3,   IL6↓, 30,   IL6↑, 1,   LDH↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 9,   antiAll↑, 11,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 14,   antiCG↑, 3,   antiD↓, 1,   AntiDiabetic↑, 13,   antiPs↑, 1,   AntiTum↑, 5,   cardioP↑, 31,   chemoP↑, 4,   chemoPv↑, 4,   cognitive↑, 23,   cough?, 1,   hepatoP↑, 31,   Learn↑, 3,   memory↑, 29,   motorD↑, 3,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 67,   Obesity↓, 10,   OS↑, 4,   Pain↓, 1,   radioP↑, 3,   RenoP↑, 8,   Risk↓, 4,   SoreThr?, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 11,   toxicity↓, 23,   toxicity↑, 3,   toxicity↝, 10,   toxicity∅, 2,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 5,   AntiP↑, 9,   AntiViral↑, 15,   Bacteria↓, 14,   Diar↓, 1,   GutMicro↑, 14,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 403

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
22 Curcumin
19 Fisetin
15 Quercetin
14 Berberine
13 Baicalein
11 Ivermectin
9 Thymoquinone
9 Magnetic Fields
9 Resveratrol
9 Sulforaphane (mainly Broccoli)
9 itraconazole
9 Luteolin
9 Matrine
8 Apigenin (mainly Parsley)
8 EGCG (Epigallocatechin Gallate)
8 Honokiol
8 Isoliquiritigenin
8 Shikonin
7 Alpha-Lipoic-Acid
7 Artemisinin
7 Metformin
6 Chemotherapy
6 diet FMD Fasting Mimicking Diet
6 Isorhamnetin
6 Lycopene
6 Magnolol
6 Melatonin
6 Urolithin
5 Capsaicin
5 Hydrogen Gas
5 Licochalcone A
5 Piperlongumine
5 Rosmarinic acid
5 Silymarin (Milk Thistle) silibinin
4 5-fluorouracil
4 Allyl isothiocyanate
4 Benzyl isothiocyanate
4 Phenethyl isothiocyanate
4 Ashwagandha(Withaferin A)
4 Beta-Caryophyllene
4 Chlorogenic acid
4 Chrysin
4 Cinnamon
4 Citric Acid
4 Dichloroacetate
4 Diindolylmethane
4 Gambogic Acid
4 Hyperoside
4 Isovitexin
4 Vitexin
4 Kaempferol
4 L-Theanine
4 Licorice
4 Magnetic Field Rotating
4 Morin
4 doxorubicin
4 Piperine
4 Pterostilbene
3 Coenzyme Q10
3 Astragalus
3 Cisplatin
3 Isothiocyanates
3 brusatol
3 Carnosic acid
3 salinomycin
3 diet Short Term Fasting
3 Eugenol
3 Ginkgolide B
3 HydroxyTyrosol
3 isoquercitrin
3 Mangiferin
3 Naringin
2 1,8-Cineole
2 Auranofin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Betulinic acid
2 Brucea javanica
2 Boswellia (frankincense)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Propolis -bee glue
2 Hydroxycinnamic-acid
2 Cranberry
2 Calorie Restriction Mimetics
2 Ursolic acid
2 CUSP9
2 Deguelin
2 Dandelion Root
2 Ellagic acid
2 Emodin
2 Ferulic acid
2 Formononetin
2 Garcinol
2 Ginkgetin
2 Juglone
2 Lasiodin
2 low dose naltrexone
2 MCT oil
2 Niclosamide (Niclocide)
2 Plumbagin
2 α-Santalol/Sandalwood oil
2 Vitamin D3
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 2-DeoxyGlucose
1 Baicalin
1 Biochanin A
1 Bufalin/Huachansu
1 Beetroot
1 Butyrate
1 Trastuzumab
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Spermidine
1 Aspirin
1 Crocetin
1 Radiotherapy/Radiation
1 Chlorella (Chlorella vulgaris)
1 diet Methionine-Restricted Diet
1 Indole-3-carbinol
1 flavonoids
1 Fucoidan
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 HydroxyCitric Acid
1 Huperzine A/Huperzia serrata
1 Inulin Prebiotic
1 phytic acid, Inositol hexakisphosphate
1 isoflavones
1 Sorafenib (brand name Nexavar)
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Lactoferrin/Talactoferrin
1 Linalool
1 Methylene blue
1 Mung Bean Sprouts
1 Magnesium
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Oleuropein
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 sericin
1 Phycocyanin
1 Parthenolide
1 Gold NanoParticles
1 Selenium
1 Selenium NanoParticles
1 acetazolamide
1 Spirulina(Arthrospira/Limnospira)
1 Selenite (Sodium)
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Usnic acid
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:209  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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