ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Scientific Papers found: Click to Expand⟱
5819- CBD,    The potential role of cannabidiol (CBD) in lung cancer therapy: a systematic review of preclinical and clinical evidence
- Review, Lung, NA
Apoptosis↑, PPARγ↓, mtDam↑, ROS↑, EMT↓, CD8+↑, NK cell↑, ChemoSen↑, ATP↓, glucose↓, Ca+2↑, TRPV2↑,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6129- CHr,    A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
- vitro+vivo, Melanoma, NA
ATP↓, TumCCA↑, CDK2↓, CDK4↓, TumW↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2315- Citrate,  immuno,    Why and how citrate may sensitize malignant tumors to immunotherapy
- Review, Var, NA
Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, NA, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, NA, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
1577- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet
- in-vivo, PC, NA - in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988 - in-vitro, PC, MIA PaCa-2
Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,
6146- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high‐fat diet
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCG↓, SPARC↑, Glycolysis↓, OCR↓, ATP↓, NF-kB↓, Ca+2↑,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6298- Cro,    Crocetin Prevents RPE Cells from Oxidative Stress through Protection of Cellular Metabolic Function and Activation of ERK1/2
- in-vitro, AMD, RPE-1
*ATP↑, *antiOx↑, *ROS↓,
6293- Cro,    Crocetin: an agent derived from saffron for prevention and therapy for cancer
- Review, Var, NA
*toxicity↓, *lipid-P↓, *neuroP↑, *BloodF↑, *BP↓, *RenoP↑, *ATP↑, AntiCan↑, TumCP↓, Apoptosis↑, lipid-P↓, ROS↓, GSTs↑, Catalase↑, SOD↑,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
6203- Cuc,  immuno,    Isocucurbitacin B targets STAT3 to induce ferroptosis and promote anti-PD1 immunotherapy responses in breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, 4T1
Ferroptosis↑, STAT3↓, GPx4↓, Imm↑, PD-L1↓, TumCG↓, ATP↓, OXPHOS↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
409- CUR,    Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity
- in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
GLO-I↓, GSH↓, ATP↓,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
5010- DSF,  Cu,  Rad,    Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma
- in-vivo, Melanoma, B16-F10
Apoptosis↑, ICD↑, HMGB1↑, ATP↓, TumCG↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
3241- EGCG,    Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, eff↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
5495- EP,    Irreversible electroporation in focal therapy for prostate cancer: current status and future directions
- Review, Pca, NA
Ca+2↑, ATP↓, mtDam↑, ROS↑, CellMemb↑,
4251- FA,    Antidepressant-Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity
- in-vivo, NA, NA
*BDNF↑, *ATP↑, *Mood↑,
935- Gallo,    Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
LDH↓, ROS↑, TumCP↓, Glycolysis↓, ATP↓, ER-α36↓, Apoptosis?,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, NA, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
840- Gra,    Evaluation of cytotoxicity of aqueous extract of Graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-Yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at G2M phase of cell cycle by flow cytometry: An in vitro study
- in-vitro, SCC, SCC25
TumCCA↑, ATP↓,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, NA, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, asthmatic, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF-7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1↓, Apoptosis↑, LDHA↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
886- HPT,    Impact of hyper- and hypothermia on cellular and whole-body physiology
- Analysis, NA, NA
MMP↓, OXPHOS↓, ATP↓, ROS↑, Apoptosis↑, Cyt‑c↑,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
2913- LT,    Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells
- in-vitro, GC, HGC27 - in-vitro, BC, MCF-7 - in-vitro, GC, MKN45
TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
1780- MEL,    Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing
- Review, Var, NA
*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,
1778- MEL,    Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
- Review, Var, NA - Review, AD, NA
*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,

Showing Research Papers: 51 to 100 of 180
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 180

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   CYP1A1↑, 1,   Fenton↑, 1,   Ferroptosis↑, 5,   GPx4↓, 2,   GSH↓, 2,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 2,   ICD↑, 2,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MDA↑, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   OXPHOS↓, 5,   OXPHOS↑, 2,   OXPHOS↝, 1,   ROS↓, 2,   ROS↑, 29,   ROS↝, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 35,   ATP↑, 2,   ATP↝, 1,   i-ATP↓, 1,   i-ATP↑, 1,   mt-ATP↓, 1,   ETC↓, 2,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   MMP↓, 8,   MPT↑, 2,   mtDam↑, 3,   OCR↓, 4,   OCR↑, 3,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   adiP↑, 1,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP:AMP↓, 1,   cMyc↓, 2,   ECAR↓, 3,   FASN↓, 2,   FBPase↑, 1,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucoNG↑, 1,   glucose↓, 1,   GlucoseCon↓, 8,   GlucoseCon↑, 1,   GLUT2↓, 1,   GlutaM↓, 1,   glyC↓, 1,   Glycolysis↓, 15,   HK2↓, 10,   lactateProd↓, 5,   lactateProd↑, 1,   LDH↓, 3,   LDHA↓, 8,   lipoGen↓, 1,   MCU↓, 1,   NADPH↓, 1,   PDH↓, 1,   PDH↑, 1,   PDK1↓, 3,   PDK3↑, 1,   PFK↓, 2,   PFK1↓, 4,   PFK2↓, 1,   PKM2↓, 1,   PPARγ↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   SCD1↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,   β-oxidation↓, 1,  

Cell Death ⓘ

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis?, 1,   Apoptosis↑, 22,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 3,   Casp↑, 3,   Casp∅, 1,   Casp2↑, 1,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 4,   Cupro↑, 1,   Cyt‑c↑, 4,   Ferroptosis↑, 5,   p‑JNK↓, 1,   MAPK↓, 2,   Mcl-1↓, 4,   MCT1↓, 1,   necrosis↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

FOXD3↑, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,   TRPV2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↓, 1,   other↑, 2,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

i-CRT↓, 1,   ER Stress↑, 4,   NQO2↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   ATG5↝, 1,   Beclin-1↓, 1,   Beclin-1↑, 1,   Beclin-1↝, 1,   LAMP2↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   mt-DNAdam↑, 1,   DNMTs↓, 1,   P53↑, 2,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 4,   ERK↓, 2,   p‑ERK↓, 1,   HDAC↓, 2,   IGF-1↓, 2,   IGF-1R↓, 1,   IGFBP1↑, 1,   mTOR↓, 5,   mTORC1↓, 1,   NOTCH↓, 1,   NOTCH1↑, 1,   PI3K↓, 6,   PTEN↑, 2,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT5↓, 1,   p‑STAT5↓, 1,   TOP1↓, 1,   TumCG↓, 7,   TumCG↑, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   i-Ca+2↑, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   p‑FAK↓, 2,   Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMP9↑, 1,   MMPs↓, 2,   MUC4↓, 1,   PKA↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   SPARC↑, 2,   STAC2↓, 1,   TGF-β↓, 2,   TIMP1↑, 1,   Treg lymp↓, 1,   TumCI↓, 4,   TumCI↑, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 12,   TumCP↑, 1,   TumMeta↓, 4,   TumMeta↑, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   angioG↑, 1,   EGFR↓, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 10,   VEGF↓, 5,  

Barriers & Transport ⓘ

BBB↑, 1,   CellMemb↑, 1,   GLUT1↓, 9,   GLUT4↓, 4,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   DCells↑, 1,   HMGB1↑, 1,   i-HMGB1↓, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL1β↓, 1,   IL2↑, 1,   Imm↑, 2,   Inflam↓, 1,   JAK↓, 1,   JAK2↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   pol-M2 MC↓, 1,   NF-kB↓, 8,   p‑NF-kB↓, 1,   NK cell↑, 2,   p65↓, 1,   PD-L1↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 13,   DDS↑, 1,   Dose↑, 3,   Dose↝, 2,   Dose∅, 1,   eff↓, 2,   eff↑, 14,   Half-Life↓, 2,   RadioS↑, 2,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   BG↓, 2,   EGFR↓, 1,   GutMicro↑, 3,   HER2/EBBR2↓, 1,   Ki-67↓, 1,   LDH↓, 3,   PD-L1↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 2,   neuroP↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  

Infection & Microbiome ⓘ

CD8+↑, 3,  
Total Targets: 274

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 6,   Catalase↑, 4,   GPx↑, 3,   GSH↑, 2,   GSR↓, 1,   H2O2↓, 1,   HO-1↑, 3,   lipid-P↓, 4,   MDA↓, 3,   NRF2↑, 6,   OXPHOS↑, 1,   ROS↓, 11,   SOD↑, 4,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 10,   mitResp↑, 2,   MMP↑, 1,   mtDam↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   AMPK↑, 1,   CREB↑, 1,   Glycolysis↑, 1,   LDH↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 2,   Bax:Bcl2↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Casp9↑, 1,   iNOS↓, 2,   MAPK↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO3↑, 1,   GSK‐3β↓, 2,   miR-34a↓, 1,   p‑mTOR↑, 1,   PI3K↓, 1,   RAS↓, 1,   STAT↓, 1,  

Migration ⓘ

APP↓, 1,   SMAD3↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL10↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 1,   INF-γ↓, 1,   Inflam↓, 7,   NF-kB↓, 2,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 3,   tau↓, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 2,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   BioEnh↑, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

BloodF↑, 2,   BP↓, 1,   BP∅, 1,   IL6↓, 3,   LDH↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 3,   CardioT↓, 1,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 4,   memory↑, 2,   Mood↑, 1,   neuroP↑, 6,   RenoP↑, 1,   toxicity↓, 4,   toxicity∅, 1,  
Total Targets: 99

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
11 3-bromopyruvate
9 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
6 Berberine
6 Citric Acid
6 Shikonin
5 Silver-NanoParticles
5 Alpha-Lipoic-Acid
5 Quercetin
5 salinomycin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Graviola
4 Resveratrol
3 2-DeoxyGlucose
3 Apigenin (mainly Parsley)
3 Propolis -bee glue
3 immunotherapy
3 Crocetin
3 Copper and Cu NanoParticles
3 Curcumin
3 diet FMD Fasting Mimicking Diet
3 EGCG (Epigallocatechin Gallate)
3 Honokiol
3 Luteolin
3 Melatonin
3 Metformin
3 Rosmarinic acid
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
3 Ursolic acid
3 Urolithin
2 Radiotherapy/Radiation
2 Allicin (mainly Garlic)
2 Chrysin
2 Cucurbitacin
2 Docosahexaenoic Acid
2 Chemotherapy
2 Galloflavin
2 Hydrogen Gas
2 Pachymic acid
2 Phenethyl isothiocyanate
2 Thymoquinone
2 Vitamin B5,Pantothenic Acid
2 Vitamin K2
1 Sorafenib (brand name Nexavar)
1 cetuximab
1 Anthocyanins
1 Auranofin
1 Acetyl-l-carnitine
1 Andrographis
1 doxorubicin
1 Artemisinin
1 Aloe anthraquinones
1 Betulinic acid
1 Boron
1 Boswellia (frankincense)
1 Carvacrol
1 Cannabidiol
1 Celecoxib
1 Chlorogenic acid
1 Disulfiram
1 Emodin
1 Electrical Pulses
1 Ferulic acid
1 Hyperthermia
1 Ivermectin
1 Methylene blue
1 MCToil
1 Magnesium
1 Methylglyoxal
1 Pterostilbene
1 Radio Frequency
1 EMF
1 SonoDynamic Therapy UltraSound
1 triptolide
1 Vitamin B1/Thiamine
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin B2,Riboflavin
1 Arsenic trioxide
1 probiotics
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:21  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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