NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
1149- Api,    Apigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
- vitro+vivo, IBD, NA
COX2↓, MPO↓, NF-kB↓, STAT3↓, Inflam↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1560- Api,    Apigenin as an anticancer agent
- Review, NA, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
1564- Api,    Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
- in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
MDM2↓, NF-kB↓, p65↓, P21↑, ROS↑, GSH↓, MMP↓, Cyt‑c↑, Apoptosis↑, P53↑, eff↓, Bcl-xL↓, Bcl-2↓, BAX↑, Casp↑, TumCG↓, TumVol↓, TumW↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2319- Api,    Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis
- in-vitro, GBM, NA
Glycolysis↓, NF-kB↓, p65↓, Hif1a↓, GLUT1↓, GLUT3↓, PKM2↓, RadioS↑, TumVol↓, TumW↓,
2318- Api,    Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems
- Review, Nor, NA
*ROS↓, *PKM2↓, *Hif1a↓, *TGF-β↓, *AMPK↑, *Inflam↓, *PI3K↓, *Akt↑, *NRF2↑, *NF-kB↓,
1095- Api,    Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway
- Analysis, Colon, NA
Snail↓, EMT↓, NF-kB↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
589- Api,  5-FU,    Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro
- in-vitro, PC, Bxpc-3
GSK‐3β↓, NF-kB↓,
211- Api,    Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
- in-vivo, Pca, NA
IKKα↓, NF-kB↓, cycD1/CCND1↓, COX2↓, Bcl-2↓, Bcl-xL↓, VEGF↓, PCNA↓, BAX↑,
171- Api,    Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
- Review, Var, NA
PI3K/Akt↓, NF-kB↓, CK2↓, FOXO↓, MAPK↝, ERK↓, p‑JAK↓, Wnt/(β-catenin)↓, ROS↑, CDC25↓, p‑STAT↓, DNAdam↑,
240- Api,    The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, CD44+
P21↑, p27↑, Casp3↑, Casp8↑, Slug↓, Snail↓, NF-kB↓, PI3K↓, Akt↓,
237- Api,    Apigenin blocks IKKα activation and suppresses prostate cancer progression
- in-vivo, Pca, PC3 - in-vivo, Pca, 22Rv1 - in-vivo, Pca, LNCaP - in-vivo, Pca, DU145
IKKα↓, NF-kB↓,
416- Api,    In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma
- vitro+vivo, NA, NA
Bax:Bcl2↑, P53↑, ROS↑, Casp9↑, Casp8↑, cl‑PARP1↑, p‑ERK⇅, p‑JNK↓, p‑p38↑, p‑Akt↓, cJun↓, NF-kB↓, EGFR↓, TumCCA↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3385- ART/DHA,    Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study
- Study, NA, NA
*NF-kB↑, *Catalase↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3392- ART/DHA,    Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways
- in-vitro, Nor, Hep3B - in-vivo, NA, NA
*Inflam↓, *NF-kB↓, *ROS↓, *p‑p38↓, *p‑ERK↓,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
3666- ART/DHA,    Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
- NA, AD, NA
*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2↓, *cognitive↑,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1↓, *MIP2↓, *TGF-β↑, *Inflam↓,
5136- ART/DHA,    Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis
- in-vitro, Var, NA
angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
5134- ART/DHA,    Dihydroartemisinin induces autophagy by suppressing NF-κB activation
- in-vitro, Var, NA
TumAuto↑, NF-kB↓, ChemoSen↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
2324- ART/DHA,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
PKM2↓, GLUT1↓, Glycolysis↓, Akt↓, mTOR↓, Hif1a↓, HK2↓, LDH↓, NF-kB↓,
5793- ASA,    Aspirin Recapitulates Features of Caloric Restriction
- in-vitro, Nor, NA
*CRM↑, *HATs↓, *NF-kB↓, *EP300↓,
1142- Ash,    Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
- Review, BC, MCF-7 - NA, BC, MDA-MB-231 - NA, Nor, HMEC
Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, NA, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
3689- Ash,    Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells
- in-vitro, NA, NRK52E
*RenoP↑, *NF-kB↓, *MCP1↓, *RANTES↓,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
1362- Ash,  GEM,    Synergistic Inhibition of Pancreatic Cancer Cell Growth and Migration by Gemcitabine and Withaferin A
- in-vitro, PC, PANC1 - in-vitro, PC, Hs766t
ChemoSen↑, ROS↑, Apoptosis↑, TumCMig↓, F-actin↓, YMcells↓, NF-kB↓,
1181- Ash,    Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCMig↓, TumCI↓, EMT↓, p‑SMAD2↓, p‑SMAD3↓, p‑NF-kB↓,
1177- Ash,    Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
- in-vivo, EC, NA
TumVol↓, MMP2↓, MMP9↓, NF-kB↓, COX2↓, NO↓, IL1β↓, IL6↓,
5170- Ash,    Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ
- Review, Var, NA
NF-kB↓, Inflam↓, IKKα↓,
5174- Ash,    Withaferin A is a potent inhibitor of angiogenesis
- in-vitro, Nor, HUVECs
Inflam↓, *TumCP↓, cycD1/CCND1↓, NF-kB↓, angioG↓,
4820- ASTX,    Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
- in-vitro, NPC, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, Bcl-2↓, P21↑, BAX↑, PI3K↓, Akt↓, NF-kB↓, miR-29b↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
147- ATG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF-7
Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓, chemoPv↑, TumCP↓, TumCCA↑, TumCMig↓,

Showing Research Papers: 51 to 100 of 790
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 790

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   ATF3↑, 1,   Catalase↓, 1,   Ferroptosis↑, 3,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 3,   GSR↑, 1,   HO-1↑, 3,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 2,   OXPHOS↓, 2,   ROS↓, 1,   ROS↑, 16,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC2↑, 1,   CDC25↓, 2,   mitResp↓, 1,   MMP↓, 5,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMP↓, 1,   AMPK↑, 1,   cMyc↓, 4,   FASN↓, 1,   Glycolysis↓, 4,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 2,   LDHA↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PI3K/Akt↓, 2,   PKM2↓, 2,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 12,   p‑Akt↓, 5,   APAF1↑, 1,   Apoptosis↑, 11,   Bak↑, 1,   BAX↑, 8,   BAX⇅, 1,   Bax:Bcl2↑, 4,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 5,   Casp3∅, 1,   cl‑Casp3↑, 2,   Casp8↑, 4,   Casp8∅, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   CK2↓, 3,   Cyt‑c↑, 6,   DR5↑, 3,   Ferroptosis↑, 3,   HEY1↓, 1,   IAP1↓, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 2,   MAPK↝, 1,   Mcl-1↓, 1,   MDM2↓, 2,   Myc↓, 1,   oncosis↑, 2,   p27↑, 4,   p38↑, 3,   p‑p38↑, 1,   Paraptosis↑, 1,   survivin↓, 6,   Telomerase↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   RET↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   H3↑, 1,   pRB↑, 1,   YMcells↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   eIF2α↓, 1,   ER Stress↓, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP90↓, 6,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   DNAdam↑, 5,   HR↓, 1,   p16↑, 2,   P53↑, 7,   PARP↑, 1,   cl‑PARP↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 4,   RAD51↓, 1,   SIRT6↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 4,   CDK4↓, 5,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 7,   CycD3↓, 1,   cycE/CCNE↓, 2,   cycE1↓, 1,   E2Fs↓, 1,   P21↑, 7,   p‑RB1↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD44↓, 1,   cMET↓, 2,   CREBBP↓, 1,   CSCs↓, 7,   EMT↓, 8,   EMT↑, 1,   ERK↓, 5,   p‑ERK⇅, 1,   FOXO↓, 1,   FOXO↑, 1,   FOXO3↑, 4,   Gli↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   mTOR↓, 5,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 9,   SOX2↓, 1,   STAT↓, 1,   p‑STAT↓, 1,   STAT3↓, 8,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 2,   Wnt/(β-catenin)↑, 1,  

Migration ⓘ

AP-1↓, 4,   Ca+2↑, 1,   Cdc42↑, 1,   CDK4/6↓, 2,   E-cadherin↑, 4,   ER-α36↓, 2,   F-actin↓, 1,   FAK↓, 2,   ITGB1↑, 1,   LysoPr↑, 1,   miR-29b↑, 1,   MMP2↓, 10,   MMP7↓, 1,   MMP9↓, 8,   MMPs↓, 2,   N-cadherin↓, 2,   NCAM↑, 1,   PDGF↓, 1,   PKCδ↓, 1,   Sharpin↓, 1,   Slug↓, 3,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 5,   TGF-β↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 3,   TumCMig↓, 6,   TumCP↓, 7,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 6,   Vim↓, 2,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature ⓘ

angioG↓, 9,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 5,   KDR/FLK-1↓, 1,   NO↓, 2,   PDGFR-BB↓, 1,   VEGF↓, 7,  

Barriers & Transport ⓘ

GLUT1↓, 3,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 9,   CXCR4↓, 1,   ICAM-1↓, 1,   IKKα↓, 4,   IL1↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL6↓, 5,   IL8↓, 3,   Inflam↓, 5,   JAK↓, 1,   p‑JAK↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 36,   p‑NF-kB↓, 1,   p50↓, 1,   p65↓, 2,   PGE2↓, 1,   TNF-α↓, 4,   TNF-α∅, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   BioEnh↑, 1,   ChemoSen↑, 8,   Dose↝, 2,   Dose∅, 1,   eff↓, 4,   eff↑, 14,   eff↝, 2,   Half-Life↓, 2,   Half-Life↝, 1,   RadioS↑, 4,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

E6↓, 4,   E7↓, 4,   EGFR↓, 2,   Ferritin↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 5,   LDH↓, 2,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   chemoP↑, 2,   chemoPv↑, 3,   neuroP↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↑, 1,   TumVol↓, 4,   TumW↓, 2,  
Total Targets: 274

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Catalase↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 4,   Prx↑, 1,   ROS↓, 8,   ROS∅, 3,   SOD↑, 3,   SOD2↑, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 3,   CRM↑, 1,   PKM2↓, 1,   p‑PPARγ↓, 1,  

Cell Death ⓘ

Akt↑, 2,   Casp3?, 1,   iNOS↓, 3,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   AntiThr↑, 1,   HATs↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

HSPs↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   PI3K↓, 1,  

Migration ⓘ

AntiAg↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IFN-γ↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL6↓, 5,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 9,   Inflam↑, 1,   MCP1↓, 2,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   NF-kB↑, 1,   PGE2↓, 1,   RANTES↓, 1,   TLR4↓, 2,   TNF-α↓, 6,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   ChAT↑, 2,   MAOA↓, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 2,   Dose↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

IL6↓, 5,  

Functional Outcomes ⓘ

AntiDiabetic↓, 2,   cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 2,   memory↑, 4,   neuroP↑, 5,   RenoP↑, 1,   toxicity↓, 1,   Wound Healing↑, 1,  
Total Targets: 79

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
70 Curcumin
43 Thymoquinone
27 Resveratrol
24 Propolis -bee glue
22 Quercetin
22 Lycopene
20 EGCG (Epigallocatechin Gallate)
20 Betulinic acid
20 Fisetin
19 Baicalein
19 Silymarin (Milk Thistle) silibinin
18 Sulforaphane (mainly Broccoli)
16 Ashwagandha(Withaferin A)
15 Alpha-Lipoic-Acid
15 Apigenin (mainly Parsley)
14 Eugenol
14 Shikonin
13 Boswellia (frankincense)
12 Silver-NanoParticles
12 Artemisinin
12 Chrysin
11 Cisplatin
11 Berberine
11 Caffeic Acid Phenethyl Ester (CAPE)
11 Honokiol
11 Rosmarinic acid
10 Luteolin
9 Magnetic Fields
9 Radiotherapy/Radiation
9 Garcinol
8 Capsaicin
8 Chlorogenic acid
8 Crocetin
8 Hydrogen Gas
8 Phenethyl isothiocyanate
7 Selenite (Sodium)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Disulfiram
7 Parthenolide
7 Pterostilbene
7 Vitamin K2
6 Dandelion Root
6 Copper and Cu NanoParticles
6 Magnolol
5 Anethole/trans-Anethole
5 Boron
5 Celastrol
5 Cinnamon
5 Ellagic acid
5 Piperine
5 Graviola
5 Piperlongumine
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Astaxanthin
4 Docetaxel
4 Berbamine
4 borneol
4 Chemotherapy
4 Hydroxycinnamic-acid
4 Ursolic acid
4 Emodin
3 Auranofin
3 Astragalus
3 Citric Acid
3 Gemcitabine (Gemzar)
3 beta-glucans
3 Bromelain
3 Butyrate
3 Carnosic acid
3 Carvacrol
3 Cat’s Claw
3 Celecoxib
3 Chocolate
3 Cucurbitacin
3 Ginger/6-Shogaol/Gingerol
3 Deguelin
3 Ferulic acid
3 Gambogic Acid
3 Orlistat
3 HydroxyTyrosol
3 Oleuropein
3 Rutin
3 Sulfasalazine
2 Ajoene (compound of Garlic)
2 5-fluorouracil
2 immunotherapy
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 brusatol
2 Zinc
2 Chlorophyllin
2 Photodynamic Therapy
2 CUSP9
2 D-limonene
2 Paclitaxel
2 Proanthocyanidins
2 Melatonin
2 Methylsulfonylmethane
2 Naringin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 xanthohumol
2 Plumbagin
2 Psoralidin
2 salinomycin
2 Selenium NanoParticles
2 Aflavin-3,3′-digallate
1 2-DeoxyGlucose
1 Anthocyanins
1 alpha Linolenic acid
1 Andrographis
1 Aspirin
1 Arctigenin
1 Aloe anthraquinones
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosine
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Galantamine
1 Lecithin
1 Oxygen, Hyperbaric
1 methylseleninic acid
1 Cyclopamine
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Evodiamine
1 Ascorbyl Palmitate
1 Genistein (soy isoflavone)
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Grapeseed extract
1 HydroxyCitric Acid
1 Juglone
1 Magnetic Field Rotating
1 Moringa oleifera
1 Mushroom Chaga
1 Nimbolide
1 Oroxylin A
1 Propyl gallate
1 temozolomide
1 Kaempferol
1 Perilla
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Taurine
1 Tomatine
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin D3
1 probiotics
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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