NK cell Cancer Research Results

NK cell, NK cell activity: Click to Expand ⟱
Source: HalifaxProj(promote)
Type:
Natural Killer (NK) cells are a type of lymphocyte in the immune system that play a crucial role in the body's defense against tumors and virally infected cells.
NK cells can directly kill cancer cells through the release of cytotoxic granules containing perforin and granzymes. Perforin forms pores in the target cell membrane, allowing granzymes to enter and induce apoptosis (programmed cell death).
NK cells produce various cytokines, such as interferon-gamma (IFN-γ), which can enhance the immune response and promote the activation of other immune cells, including macrophages and T cells.
-Monoclonal Antibodies: Using antibodies that engage NK cells to target and kill cancer cells.
-Cytokine Therapy: Administering cytokines like IL-2 or IL-15 to boost NK cell activity.
Scientific Papers found: Click to Expand⟱
1281- SK,    Enhancement of NK cells proliferation and function by Shikonin
- in-vivo, Colon, Caco-2
Perforin↑, GranB/GZMB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5082- SSE,    Rationale for the treatment of cancer with sodium selenite
- Review, Var, NA
Risk↑, antiOx↑, ROS↑, Imm↑, NK cell↑, angioG↓, toxicity↓,
5087- SSE,    Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System
- Trial, BC, NA
eff↑, Inflam↓, Imm↑, ROS↑, *NK cell↑,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
4834- Uro,    Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer
- Human, Pca, NA
eff↑, NK cell↑,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, Synergy↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,

Showing Research Papers: 51 to 57 of 57
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 4,   HO-1↑, 1,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NRF2↑, 5,   Prx↑, 1,   ROS↓, 1,   ROS↑, 18,   ROS⇅, 2,   mt-ROS↑, 1,   SOD↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   Insulin↓, 1,   mtDam↓, 1,   mtDam↑, 2,   OXPHOS↓, 2,   PDH↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 1,   AMPK↑, 3,   ATP↓, 2,   CAIX/CA9↑, 1,   FASN↓, 2,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   GSK‐3β↑, 1,   HK2↓, 5,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 1,   lipoGen↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   SCD1↓, 2,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↑, 17,   BAX↑, 4,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Casp↑, 2,   Casp3↑, 9,   Casp7↑, 4,   Casp8↑, 2,   Casp9↑, 4,   Cyt‑c↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   GranB/GZMB↑, 1,   cl‑GSDME↑, 1,   IAP2/BIRC3↓, 1,   necrosis↑, 1,   Perforin↑, 1,   Pyro↑, 1,   XIAP↓, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   p‑Akt↓, 1,   p‑Akt↑, 1,   AKT1↓, 1,   AMPKα↑, 1,   ERK↓, 4,   p‑ERK↑, 1,   IGF-1R↓, 1,   IGFR↓, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 4,   mTOR↓, 1,   PI3K↓, 7,   PI3K↑, 1,   PI3K/Akt↑, 1,   PKCδ↓, 1,   PTEN↑, 1,   RAS↓, 2,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMT3B↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   HDAC↓, 2,   miR-124-3p↓, 1,   miR-140↑, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-29b↓, 1,   OCT4↓, 1,   other↑, 2,   other↝, 5,   SD↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 4,   DNAdam⇅, 1,   DNArepair↑, 2,   hTERT/TERT↓, 2,   P53↑, 5,   cl‑PARP↑, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 3,   CDK6↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 4,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   pRB↓, 1,   p‑pRB↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   BMI1↓, 1,   CSCs↓, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   TumCG↓, 9,   TumCG↑, 2,   TumCP↓, 8,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   Cofilin↓, 1,   E-cadherin↑, 5,   EMT↓, 5,   fascin↓, 1,   MALAT1↓, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP9↓, 4,   MMPs↓, 7,   N-cadherin↓, 3,   NFAT↑, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 3,   TIMP1↑, 1,   TregCell↓, 1,   pol-TregCell↓, 1,   TumCI↓, 5,   TumCMig↓, 3,   TumMeta↓, 7,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 1,   Vim↓, 3,   Zeb1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   angioG↑, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 11,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,   CLDN2↑, 1,   EPR↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP↓, 3,   MPT↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPV2↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↓, 1,   CD4+↑, 3,   CD44↓, 1,   CD47↓, 1,   CD8+↑, 6,   COX1↓, 1,   COX2/PTGS2↓, 7,   COX2/PTGS2↑, 1,   CR3↝, 1,   DCells↑, 1,   Eos↑, 1,   FOXP3↓, 1,   Gal-3↓, 1,   IFN-γ↑, 5,   Igs↑, 1,   IL10↓, 1,   IL10↑, 1,   IL12↑, 1,   IL15↑, 1,   IL18↑, 2,   IL1β↓, 1,   IL1β↑, 1,   IL2↑, 1,   IL6↓, 3,   IL6↑, 1,   IL8↓, 1,   IL8↑, 1,   Imm↑, 16,   Inflam↓, 3,   MCT1↓, 1,   MDSCs↓, 1,   Neut↑, 2,   NF-kB↓, 7,   NF-kB↑, 2,   NK cell↑, 42,   NK cell⇅, 1,   PD-L1↓, 1,   PGE1↓, 1,   PGE2↓, 3,   PSA↓, 1,   Resistin↓, 1,   T-Cell↑, 4,   Th1 response↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,   ER(estro)↓, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 16,   DDS↑, 2,   Dose?, 1,   Dose↑, 2,   Dose↝, 17,   Dose∅, 2,   eff↓, 2,   eff↑, 17,   eff↝, 3,   Half-Life↑, 2,   MDR1↓, 1,   RadioS↑, 4,   selectivity↑, 8,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   BMD↑, 1,   BRCA1↑, 1,   CRP↓, 1,   EZH2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 3,   IL6↑, 1,   IRes↓, 1,   NOS2↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↑, 9,   antiNeop↑, 1,   AntiTum↑, 5,   APG↓, 1,   BowelM↑, 1,   chemoP↑, 5,   ChemoSideEff↓, 1,   fatigue∅, 1,   NP/CIPN↓, 1,   OS↑, 6,   Pain↓, 1,   PFS↑, 2,   QoL↑, 5,   QoL∅, 1,   radioP↑, 5,   Remission↑, 2,   Risk↓, 6,   Risk↑, 1,   toxicity↓, 7,   toxicity↑, 2,   toxicity↝, 1,   TumVol↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 315

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 12,   Catalase↑, 6,   GPx↑, 6,   GSH↑, 4,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 3,   lipid-P↓, 6,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 4,   ROS↓, 10,   SOD↑, 7,   TAC↑, 1,   VitC↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACSL4↓, 1,   ALAT↓, 1,   ATP↑, 2,   LDL↓, 3,   SCFAs↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp12↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑JNK↓, 1,   mTOR↓, 1,   PI3K↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   cJun↓, 1,   other↓, 1,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   TGF-β↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   IBI↑, 1,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 4,   IFN-γ↓, 1,   IFN-γ↑, 2,   IL10↑, 3,   IL1β↓, 3,   IL4↓, 1,   IL6↓, 4,   Imm↑, 13,   Imm⇅, 1,   Inflam↓, 10,   LPS↓, 1,   Neut↑, 1,   NF-kB↓, 3,   NK cell↑, 14,   NLRP3↓, 1,   PGE2↓, 1,   Th1 response↑, 1,   TNF-α↓, 4,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

EndoR↑, 1,   monoA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARγ↑, 1,   testos↑, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 2,   Dose↝, 8,   eff↑, 1,   GSTA1↓, 1,   P450↓, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   BP↝, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 4,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 4,   cognitive↑, 3,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 1,   RenoP↑, 1,   Stroke↓, 1,   toxicity↓, 6,   toxicity↝, 2,   Weight↓, 1,   Weight↝, 1,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 1,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 130

Scientific Paper Hit Count for: NK cell, NK cell activity
7 Echinacea
4 chitosan
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Fucoidan
3 Inositol
3 Lactoferrin/Talactoferrin
3 Selenite (Sodium)
2 3-bromopyruvate
2 Curcumin
2 Chlorella (Chlorella vulgaris)
2 Cichoric acid / Chicoric acid
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 phytic acid, Inositol hexakisphosphate
2 Melatonin
1 Auranofin
1 Allicin (mainly Garlic)
1 Aloe anthraquinones
1 beta-glucans
1 Cannabidiol
1 Docetaxel
1 Chyawanprash
1 Spirulina(Arthrospira/Limnospira)
1 diet FMD Fasting Mimicking Diet
1 Exercise
1 Hydrogen Gas
1 Isorhamnetin
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 Modified Citrus Pectin
1 methylseleninic acid
1 Moringa oleifera
1 Mushroom Maitake
1 Mushroom Reishi
1 Bicarbonate(Sodium)
1 Propolis -bee glue
1 Psoralidin
1 Shikonin
1 Thymoquinone
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:219  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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