OS Cancer Research Results

OS, overall survival: Click to Expand ⟱
Source:
Type:
Overall survival
Scientific Papers found: Click to Expand⟱
5516- BEV,  immuno,  Chemo,    Targeting vascular normalization: a promising strategy to improve immune–vascular crosstalk in cancer immunotherapy
- Review, Var, NA
OS↑, eff↑,
5595- BEV,  Chemo,    Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
- Human, CRC, NA
OS↑,
5596- BEV,    Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
- Study, GBM, NA
QoL↑, OS∅,
5717- BF,  Chemo,  GEM,    Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas
- Trial, Var, NA
OS∅,
5716- BF,    Pilot Study of Huachansu in Patients with Hepatocellular Carcinoma, Non-Small Cell Lung Cancer, or Pancreatic Cancer
- Trial, NSCLC, NA - Trial, PC, NA - Trial, HCC, NA
Dose↝, toxicity↓, other↓, QoL↑, OS?,
5623- Bif,    Bifidobacterium breve predicts the efficacy of anti-PD-1 immunotherapy combined with chemotherapy in Chinese NSCLC patients
- Study, NSCLC, NA
GutMicro↑, OS↑, eff↑,
5628- Bif,  immuno,    Bifidobacterium modulation of tumor immunotherapy and its mechanism
- Review, Var, NA
Imm↑, Risk↓, GutMicro↑, AntiTum↑, OS↑, selectivity↑, Synergy↑,
5692- BJ,    Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells
- vitro+vivo, AML, NA
Apoptosis↑, Akt↓, P53↑, FOXO1↑, GSK‐3β↑, TumVol↓, QoL↑, BBB↑, OS↑, Dose↝, MMP↓, ROS↑, XIAP↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, TumCCA↑,
3695- BM,    Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans
- in-vitro, AD, HT22
*OS↑, *mt-ROS↓, *ROS↓, *neuroP↑, *ER Stress↓,
753- Bor,    Boron Intake and decreased risk of mortality in kidney transplant recipients
- in-vivo, Nor, NA
OS↑,
8970- BRice,    Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway
- Study, CRC, NA
Ingr↑, TumVol↓, OS↑, GutMicro↑, IBI↑, Risk↓, Ki-67↓, PCNA↓, AhR↑,
5736- Buty,    Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug
- Trial, Var, NA
Dose↝, BioAv↝, toxicity↓, OS↝,
1205- Caff,  immuno,    Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody
- in-vivo, Melanoma, B16-F10
OS↑, CD4+↑, CD8+↑, AntiTum↑, TNF-α↑, IFN-γ↑,
8702- CAP,    Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy
- Review, Var, NA
Apoptosis↑, TumCMig↓, Synergy↑, ROS↑, RNS↑, selectivity↑, TumCG↓, TumVol↓, OS↑, E-cadherin↑, ChemoSen↑, Ingr↝, eff↓, angioG↓, TumMeta↓, EMT↓, TumCCA↑, Glycolysis↓, HK2↓, PFK1↓, LDH↓, GLUT2↓, PI3K↓, Akt↓, GAPDH↓, CSCs↓, ChemoSen↑,
8701- CAP,    Comparative assessment of direct and indirect cold atmospheric plasma effects, based on helium and argon, on human glioblastoma: an in vitro and in vivo study
- vitro+vivo, GBM, GBM - in-vitro, GBM, U87MG
Apoptosis↑, TumCG↓, TumCMig↓, ROS↑, TAC↓, eff↝, TumVol↓, OS↑, GFAP↓, P53↑, motorD↑,
5754- CAPE,  Rad,    The radiosensitizing effect of Caffeic Acid Phenethyl Ester in breast cancer is dependent on p53 status
- in-vivo, BC, MDA-MB-231
tumCV↓, eff⇅, RadioS↑, OS↑,
5822- capec,    Capecitabine as Adjuvant Treatment for Stage III Colon Cancer
- Trial, Colon, NA
OS↑, eff↑,
5821- capec,  docx,    Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results
- Trial, BC, NA
eff↑, OS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5891- CAR,  SRF,    Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7
- in-vivo, HCC, NA
Synergy↑, OS↑, hepatoP↑, AFP↓, NOTCH↓, cycD1/CCND1↓, Bcl-xL↑, Casp3↑, TRPM7↓, Dose↝,
5812- CBD,    Cannabidiol oil or placebo in advanced cancer-disease progression and survival: a secondary analysis
- Trial, Var, NA
other∅, OS∅, other∅,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
5972- CET,  Rad,    Retrospective Trial on Cetuximab Plus Radiotherapy in Elderly Patients with Head and Neck Squamous Cell Cancer
- Trial, HNSCC, NA
OS↑,
5970- CET,    Cetuximab
- Review, CRC, NA - Review, HNSCC, NA
EGFR↓, OS↑, QoL↑, Dose↝,
5968- CET,    Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer
- in-vitro, CRC, NA
eff↑, Half-Life↑, Half-Life↑, EGFR↓, OS↑, QoL↑, eff↑, KRAS↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6030- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, Nor, MCF10
NF-kB↓, AntiTum↑, tumCV↓, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, TumCG↓, OS↑, TumMeta↓, CD4+↑, CD8+↑, Imm↑,
7171- CHA,    Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201
- vitro+vivo, GBM, DIPG
TumCG↓, TumCP↓, Apoptosis↓, OS↑, H3K9↓, SUV39H↓, Synergy↑, CSCs↓, SOX9↓, HGF/c-Met↓, FGF21↓, EGFR↓, PDGFR-BB↓, Wnt↓, MYCN↑, OLIG2↓, AURKB↓, HO-1↑, P21↑,
7170- CHA,    Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A–GATA3–STAT3 Circuit
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, selectivity↑, CSCs↓, SUV39H↓, GATA3↓, STAT3↓, TumCG↓, OS↑,
5985- Chit,  immuno,    Immunomodulatory potential of chitosan-based materials for cancer therapy: a systematic review of in vitro, in vivo and clinical studies.
- Review, Var, NA
TumCP↓, TumW↓, OS↑, eff↑,
6091- CHOC,    Chocolate Consumption in Relation to All-Cause and Cause-Specific Mortality in Women: The Women's Health Initiative
- Study, Nor, NA
*Risk↓, *cardioP↑, *OS↑,
6151- Chol,    Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study
- Study, GBM, NA
OS↑,
6106- Chol,    Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study
- Study, HCC, NA
OS↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
9116- Cim,    Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells
- Trial, CRC, NA
eff↑, Dose↝, OS↑, E-sel↓, TumCA↓,
9117- Cim,    Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression
- vitro+vivo, CRC, NA
OS↑, TumCA↓, TumMeta↓, E-sel↑,
9118- Cim,    Cimetidine inhibits angiogenesis and suppresses tumor growth
- vitro+vivo, CRC, NA
OS↑, angioG↓,
1582- Citrate,    Clinical report: A patient with primary peritoneal mesothelioma that has improved after taking citric acid orally
- Case Report, PerC, NA
Dose∅, Weight↑, OS↑,
1581- Citrate,    Hypothesis proved. . .citric acid (citrate) does improve cancer:A case of a patient suffering from medullary thyroid cancer
- Case Report, Thyroid, NA
OS↑, Weight↑, Dose∅, eff↑,
6153- CoQ10,    High levels of ubidecarenone (oxidized CoQ10) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells
- vitro+vivo, GBM, U251
eff↑, selectivity↑, ROS↑, OS↑, TumCCA↑,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
5783- CUR,  EGCG,    The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice
- in-vivo, Nor, NA
*OS↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2/PTGS2↓,
1510- CUR,  Chemo,    Combination therapy in combating cancer
- Review, Var, NA
*NRF2↑, *GSH↑, *ROS↓, ChemoSideEff↓, ChemoSen↑, OS↓, chemoP↑,
6421- CUR,    Curcumin simultaneously improves mitochondrial dynamics and myocardial cell bioenergy after sepsis via the SIRT1-DRP1/PGC-1α pathway
- in-vivo, Nor, NA
*SIRT1↓, *PGC-1α↑, *NRF2↑, *DRP1/DNM1L↓, *Sepsis↓, *OS↑, *cardioP↑,
2579- CUR,  ART/DHA,    Curcumin-Artemisinin Combination Therapy for Malaria
- in-vivo, Nor, 1-
OS↑, toxicity↓,

Showing Research Papers: 51 to 100 of 364
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 364

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   Copper↓, 1,   CoQ10↑, 1,   cystine↓, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 10,   GSH↑, 1,   GSH/GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 4,   HO-1↑, 4,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 3,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 5,   NRF2↝, 1,   RNS↑, 1,   ROS↓, 3,   ROS↑, 69,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 5,   SOD2↑, 1,   TAC↓, 1,   TAC↑, 1,   TKT↓, 1,   Trx↓, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   compI↓, 2,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 2,   mitResp↓, 2,   mtDam↑, 7,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 3,   PINK1↑, 1,   PleEff↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   adiP↑, 1,   ALAT↓, 2,   ALAT↑, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↑, 1,   CRM↑, 2,   ECAR↓, 1,   FAO↑, 1,   GAPDH↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 10,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 3,   HMG-CoA↓, 2,   KeyT↑, 1,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 1,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   MethCyc↓, 1,   NAD↓, 1,   PDK1 / PDPK1↓, 2,   PDKs↓, 2,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 5,   Pyruv↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   TCA?, 1,   TS↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 36,   Bak↑, 2,   BAX↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-xL↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↓, 1,   Casp3↑, 18,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 7,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 3,   ICD↑, 1,   iNOS↓, 1,   iNOS↑, 1,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 3,   p38↑, 2,   p‑p38↑, 1,   Pyro↑, 1,   RIP3↑, 1,   survivin↓, 1,   TumCD↑, 9,   XIAP↓, 2,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   p‑Akt↓, 3,   p‑Akt↑, 1,   BRAF↓, 2,   CaMKII ?, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 5,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 1,   ERK5↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JNK↑, 3,   MAPK↓, 5,   MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 12,   mTOR↑, 1,   OR13G1?, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 12,   PI3K↑, 1,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 2,   c-Raf↓, 1,   RAS↓, 3,   RIP1↑, 1,   Sp1/3/4↓, 1,   STAT3↓, 7,   p‑STAT3↑, 1,   TK1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 2,   cJun↑, 1,   cMyc↓, 5,   FOXM1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   GATA3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↑, 1,   HDAC↓, 7,   HDAC8↓, 1,   KISS1↑, 1,   miR-34a↑, 1,   Myc↓, 1,   MYCN↑, 1,   OCT4↓, 1,   OLIG2↓, 1,   other?, 1,   other↓, 2,   other↑, 2,   other⇅, 1,   other↝, 17,   other∅, 2,   OV6↓, 1,   SD↑, 1,   SOX2↓, 1,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 2,   tumCV↓, 8,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSPs↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   LC3B↑, 1,   LC3I↑, 1,   LC3II↑, 2,   LC3s↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 13,   DNArepair↓, 3,   DNArepair↑, 2,   hTERT/TERT↓, 2,   P53?, 1,   P53↓, 1,   P53↑, 16,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 9,   PCNA↓, 6,   Telomerase↓, 1,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 6,   CDKN1C/p57↑, 1,   CHK1↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 10,   E2Fs↓, 1,   Ki-67↓, 11,   mitA↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↑, 3,   p‑pRB↓, 1,   p‑RB1↓, 1,   TubPol↓, 2,   TumCCA↑, 31,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   AXIN1↑, 2,   CD133↓, 3,   CSCs↓, 6,   Diff↑, 1,   EP2↓, 1,   GH↓, 1,   Gli1↓, 5,   HH↓, 9,   HMGCR↓, 1,   IGF-1↓, 9,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 11,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   PTCH2↓, 1,   Shh↓, 2,   Smo↓, 1,   TumCG↓, 64,   TumCG↑, 1,   TumCG⇅, 1,   TumCG↝, 1,   TumCP↓, 32,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↑, 1,   Ca+2↑, 4,   Cofilin↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 9,   EMT↓, 11,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 2,   fascin↓, 1,   GLI2↓, 1,   GLI3↑, 1,   KRAS↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 7,   MMPs↓, 5,   N-cadherin↓, 6,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TSP-1↑, 1,   TumCA↓, 2,   TumCI↓, 11,   TumCMig↓, 17,   TumMeta?, 1,   TumMeta↓, 22,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 1,   Vim↓, 4,   Zeb1↓, 2,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   CD31/PECAM-1↓, 1,   E-sel↓, 1,   E-sel↑, 1,   eNOS↑, 1,   Hif1a↓, 10,   Hif1a↝, 1,   Hypoxia↓, 2,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 19,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CellMemb↑, 1,   CLDN1↓, 1,   EPR↑, 2,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP↓, 15,   MMP↑, 2,   MPT↑, 1,   SVCT-2∅, 1,   TRPM7↓, 1,   TRPV1↓, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 7,   CD44↓, 1,   CD8+↑, 8,   COX2/PTGS2↓, 11,   CXCc↓, 1,   CXCL12↓, 1,   CXCL9↓, 1,   DCells↓, 1,   DCells↑, 3,   FOXP3↓, 1,   FOXP3↑, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↑, 2,   IL17↑, 1,   IL18↑, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 14,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↑, 17,   Imm↝, 2,   Inflam↓, 12,   pol-M1↝, 1,   Macrophages↑, 1,   NF-kB↓, 14,   NF-kB↑, 1,   NK cell↑, 6,   NLRP3↑, 1,   p65↓, 2,   p65↑, 1,   PD-L1↓, 4,   PDT+↓, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 4,   PSA∅, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF7/TCF1↓, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 12,   TNF-α↑, 3,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↑, 1,   pH↝, 3,   e-pH↑, 3,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 2,   PPARγ↑, 1,   RANKL↓, 1,   testos∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 10,   BioAv↝, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 53,   ChemoSen∅, 1,   Dose?, 1,   Dose↓, 3,   Dose↑, 12,   Dose↝, 85,   Dose∅, 15,   eff↓, 13,   eff↑, 58,   eff⇅, 1,   eff↝, 15,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 3,   Half-Life∅, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 4,   RadioS?, 1,   RadioS↑, 21,   selectivity↑, 36,   Synergy↑, 39,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 7,   ALAT↓, 2,   ALAT↑, 1,   AR↓, 1,   ascitic↓, 1,   AST↓, 1,   AST↑, 1,   BG↓, 2,   BloodF↑, 2,   BMD↑, 5,   BRAF↓, 2,   BRCA1↑, 1,   CA125↓, 2,   CA19-9↓, 1,   CEA↓, 1,   CRP↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 5,   EstroRS/ERS↑, 1,   Ferritin↓, 2,   FOXM1↓, 1,   hTERT/TERT↓, 2,   IL6↓, 14,   IL6↑, 1,   KeyT↑, 1,   KRAS↓, 1,   LDH↓, 4,   Myc↓, 1,   PD-L1↓, 4,   PSA↓, 4,   PSA∅, 1,   TP53↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AEs∅, 1,   AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 12,   antiNeop↑, 3,   AntiTum↓, 1,   AntiTum↑, 15,   Appetite↑, 2,   BowelM↑, 3,   breath↑, 2,   cachexia↓, 2,   cardioP↑, 5,   chemoP↑, 16,   chemoPv↑, 2,   ChemoSideEff↓, 5,   cognitive↑, 2,   CR↑, 3,   DCR↑, 3,   EFS↑, 1,   fatigue↓, 4,   hepatoP↑, 4,   LC↑, 4,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 4,   ORR↑, 2,   ORR∅, 1,   OS?, 4,   OS↓, 5,   OS↑, 294,   OS⇅, 1,   OS↝, 2,   OS∅, 16,   Pain↓, 8,   PFS?, 1,   PFS↓, 1,   PFS↑, 3,   PFS∅, 2,   QoL↑, 31,   QoL∅, 3,   radioP↑, 13,   Remission↓, 1,   Remission↑, 9,   RFS↑, 1,   Risk↓, 18,   Risk↑, 1,   Risk↝, 1,   Risk∅, 3,   Sleep↑, 2,   Strength↑, 4,   toxicity↓, 24,   toxicity↑, 4,   toxicity↝, 10,   toxicity∅, 4,   TR↑, 1,   TTP↑, 1,   TumVol↓, 32,   TumVol↑, 2,   TumW↓, 5,   Weight↓, 4,   Weight↑, 13,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 6,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 582

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 21,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 7,   GSH↑, 9,   GSR↑, 3,   GSTs↑, 1,   HDL↑, 1,   HO-1↑, 6,   Iron↝, 1,   lipid-P↓, 7,   MDA↓, 5,   MDA↑, 1,   MPO↓, 2,   NFE2L2↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 2,   NRF2↑, 12,   RNS↓, 1,   ROS↓, 36,   mt-ROS↓, 2,   selenoP↑, 2,   SOD↑, 13,   SOD1↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   EGF↓, 1,   Insulin↓, 1,   mtDam↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 2,   ALAT∅, 1,   AMPK↑, 7,   CRM↑, 1,   glucose↓, 4,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 3,   H2S↑, 1,   HK2↑, 1,   LDL↓, 3,   NADPH↓, 2,   PFK↑, 1,   PKM2↑, 1,   SIRT1↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   ASC?, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 3,   Casp9↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   AMPKα↑, 1,   CREB↑, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 1,   PTEN↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↑, 1,   other↓, 1,   other↑, 4,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 3,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSF1↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↓, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 2,   IGF-1↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   MMP9↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GLUT4↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   GM-CSF↑, 1,   HMGB1↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL17↑, 1,   IL18↓, 1,   IL1β↓, 5,   IL23↓, 2,   IL4↑, 1,   IL6↓, 6,   Imm↑, 1,   Inflam↓, 27,   IP-10/CXCL-10↓, 1,   IP-10/CXCL-10↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3?, 1,   mPGES-1↓, 1,   Neut↑, 1,   NF-kB↓, 11,   NLRP3↓, 3,   NLRP3↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 11,   Treg lymp↝, 1,   TREM-1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 4,   EndoR↑, 1,   monoA↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   Aβ42↓, 1,   BACE/β-secretase↓, 2,   p‑tau↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 2,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 4,   BioEnh↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↑, 10,   Half-Life?, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 3,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT∅, 1,   ALP↓, 2,   AST↓, 3,   AST∅, 1,   BG↓, 1,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 1,   IL6↓, 6,   IRes↓, 1,   LDH↓, 2,   SpO2↑, 1,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 2,   AntiDiabetic↑, 4,   cachexia↓, 1,   cardioP↑, 15,   chemoP↑, 1,   cognitive↑, 13,   hepatoP↑, 6,   memory↑, 12,   memory∅, 1,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 20,   neuroP↝, 1,   Obesity↓, 2,   OS↓, 1,   OS↑, 46,   Pain↓, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 4,   Strength↑, 2,   Stroke↓, 3,   toxicity?, 1,   toxicity↓, 12,   toxicity↝, 5,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 3,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↓, 1,   GutMicro↑, 8,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,  
Total Targets: 235

Scientific Paper Hit Count for: OS, overall survival
18 Chemotherapy
18 Magnetic Fields
18 Magnetic Field Rotating
14 Vitamin C (Ascorbic Acid)
14 Hydrogen Gas
13 Radiotherapy/Radiation
9 diet Methionine-Restricted Diet
8 Silver-NanoParticles
8 Hyperthermia
8 immunotherapy
8 beta-glucans
8 Dichloroacetate
8 Selenium
8 MCT, metronomic chemo
7 Alpha-Lipoic-Acid
7 capecitabine
7 Curcumin
7 diet Plant based
7 itraconazole
7 Melatonin
5 HydroxyCitric Acid
5 cetuximab
5 diet FMD Fasting Mimicking Diet
5 mebendazole
5 Metformin
5 Bicarbonate(Sodium)
5 Phenylbutyrate
4 Bevacizumab (brand Avastin)
4 EGCG (Epigallocatechin Gallate)
4 Gemcitabine (Gemzar)
4 Fucoidan
4 Phenethyl isothiocyanate
4 Ramucirumab (CYRAMZA)
4 Selenite (Sodium)
3 3-bromopyruvate
3 Lycopene
3 low dose naltrexone
3 almonertinib
3 Anti-oxidants
3 Aspirin
3 Arsenic trioxide
3 Atorvastatin
3 Carvacrol
3 Cimetidine
3 Oxygen, Hyperbaric
3 Quercetin
3 Exercise
3 diet Short Term Fasting
3 Honokiol
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 iodine
3 Juglone
3 nivolumab
3 Mistletoe/Viscum album Extracts
3 nicotinamide adenine dinucleotide
3 Sulfasalazine
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
3 Urolithin
2 Acetyl-l-carnitine
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Bufalin/Huachansu
2 Bifidobacterium
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Docetaxel
2 Chlorogenic acid
2 chaetocin
2 Choline
2 Citric Acid
2 Calorie Restriction Mimetics
2 Resveratrol
2 Spermidine
2 diet Fermented Foods
2 Sulforaphane (mainly Broccoli)
2 Disulfiram
2 eicosapentaenoic acid
2 Flaxseed/Linseed
2 Orlistat
2 hydroxychloroquine
2 imatinib
2 isoflavones
2 Lapatinib
2 Lactoferrin/Talactoferrin
2 ipilimumab
2 Patchouli Oil (Pogostemon cablin)
2 Propolis -bee glue
2 Piperine
2 doxorubicin
2 EMF
2 Spirulina(Arthrospira/Limnospira)
2 Thymoquinone
2 VitK3,menadione
1 2-DeoxyGlucose
1 Auranofin
1 Astragalus
1 Akkermansia
1 Baicalein
1 Berberine
1 Brucea javanica
1 Bacopa monnieri
1 Boron
1 Black Rice, Oryza sativa
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celastrol
1 chitosan
1 Chocolate
1 Chrysin
1 Coenzyme Q10
1 Hydroxycinnamic-acid
1 Artemisinin
1 Dasatinib/Phyrago
1 Cisplatin
1 salinomycin
1 Deguelin
1 Bortezomib
1 diet Ketogenic
1 D-limonene
1 Copper and Cu NanoParticles
1 Echinacea
1 Emodin
1 Electrical Pulses
1 Folic Acid, Vit B9
1 Formononetin
1 Garcinol
1 Geraniol
1 5-fluorouracil
1 Ginkgolide B
1 Gossypol/AT-101
1 Paclitaxel/Taxol
1 Isoliquiritigenin
1 Isovitexin
1 Vitexin
1 Trastuzumab
1 Licochalcone A
1 SDG/lignans
1 Luteolin
1 Mung Bean Sprouts
1 Lutein
1 Magnolol
1 Magnesium
1 Mangiferin
1 Helleborus niger extracts – Christmas Rose
1 Naringin
1 Noscapine
1 Piperlongumine
1 Radio Frequency
1 Shankhpushpi
1 Iron
1 Salvia miltiorrhiza
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitamin K2
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:229  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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