P-gp Cancer Research Results

P-gp, permeability-glycoprotein: Click to Expand ⟱
Source:
Type:
P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).
Scientific Papers found: Click to Expand⟱
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp↓, ATP↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
106- RT,    Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
- in-vivo, BC, MCF-7
P-gp↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,
3327- SIL,    Effects of silymarin on HIF‑1α and MDR1 expression in HepG‑2 cells under hypoxia
- in-vitro, Liver, HepG2
MDR1↓, Hif1a↓, P-gp↓,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
5328- TFdiG,    Study on mechanism of low bioavailability of black tea theaflavins by using Caco-2 cell monolayer
- in-vitro, NA, Caco-2
BioAv↓, P-gp↑, MRP1↑, ROS↑, *BioAv↓,
1822- VitK2,    Vitamin K: A novel cancer chemosensitizer
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumCCA↑, P-gp↓,

Showing Research Papers: 51 to 59 of 59
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 59

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Fenton↑, 1,   GSH↓, 1,   ROS↓, 1,   ROS↑, 5,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Bax:Bcl2↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

SOX9↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 2,   EMT↓, 1,   FOXO4↑, 1,   HH↓, 1,   Shh↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 1,   MMP2↓, 1,   MMP9↓, 1,   Snail↓, 1,   TumCP↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 8,   P-gp↑, 1,   sonoP↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   chemoR↓, 1,   ChemoSen↑, 4,   Dose↝, 1,   eff↓, 1,   eff↑, 3,   eff↝, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1↑, 1,   RadioS↑, 2,   selectivity↑, 3,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,  
Total Targets: 55

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 2,   H2O2↑, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

Cell Death ⓘ

JNK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL10↓, 1,   IL4↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

CardioT↓, 1,   hepatoP↑, 1,   RenoP↑, 1,  
Total Targets: 26

Scientific Paper Hit Count for: P-gp, permeability-glycoprotein
8 borneol
6 Biochanin A
6 Quercetin
4 Baicalein
4 Rosmarinic acid
3 Astragalus
3 Silymarin (Milk Thistle) silibinin
3 Honokiol
2 Disulfiram
2 Gambogic Acid
2 doxorubicin
2 Magnetic Fields
2 Naringin
1 Omeprazole
1 Artemisinin
1 Berbamine
1 Genistein (soy isoflavone)
1 Kaempferol
1 Bacopa monnieri
1 Boswellia (frankincense)
1 Capsaicin
1 Piperine
1 Chemotherapy
1 Curcumin
1 immunotherapy
1 Copper and Cu NanoParticles
1 Zinc
1 EGCG (Epigallocatechin Gallate)
1 Fisetin
1 itraconazole
1 Atorvastatin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Docetaxel
1 Paclitaxel
1 tamoxifen
1 Rutin
1 salinomycin
1 SonoDynamic Therapy UltraSound
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:232  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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