PDK1 Cancer Research Results

PDK1, Pyruvate dehydrogenase kinase 1: Click to Expand ⟱
Source:
Type:
PDK1 (3-phosphoinositide-dependent protein kinase-1) (PDPK1) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell growth, survival, and metabolism. It is a key component of the PI3K/Akt signaling pathway, which is often dysregulated in cancer.
Overexpression or hyperactivation of PDK1 can lead to increased cell proliferation, survival, and resistance to apoptosis, contributing to tumorigenesis.
Inhibitors of PDK1 are being explored in preclinical and clinical studies as a means to disrupt cancer cell growth and survival.
Scientific Papers found: Click to Expand⟱
2470- SK,    PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism
- in-vitro, Lung, H1299
PKM2↓, PDK1↓, Glycolysis↓,
1003- SSE,    Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression
- vitro+vivo, Lung, NA
NF-kB↓, PDK1↓, p‑p65↑, p‑IκB↑, BAX↑, lactateProd↓, MMP↓, Cyt‑c↑, mitResp↑, Apoptosis↑,
2125- TQ,    Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
- in-vitro, RCC, RCC4 - in-vitro, RCC, Caki-1
Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX↓, PDK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,
1067- VitC,    Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
- in-vivo, CRC, NA
PDK1↓, Hif1a↓, GLUT1↓, ATP↓, MMP↓,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1↓, BNIP3↓,
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,

Showing Research Papers: 51 to 57 of 57
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   i-ATP↓, 1,   mitResp↑, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   CAIX↓, 1,   citrate↓, 1,   ECAR↓, 1,   FASN↓, 1,   Glycolysis↓, 4,   HK2↓, 2,   lactateProd↓, 1,   e-lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 3,   PDH↑, 1,   PDK1↓, 7,   PKM2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 2,   Casp↑, 1,   Cyt‑c↑, 2,   TRAIL↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

uPAR↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 3,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

p‑IκB↑, 1,   NF-kB↓, 1,   p‑p65↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   eff↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  
Total Targets: 39

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDK1, Pyruvate dehydrogenase kinase 1
9 Dichloroacetate
6 Baicalein
4 Betulinic acid
3 Celecoxib
3 Chrysin
3 Curcumin
3 Dichloroacetophenone(2,2-)
3 Vitamin C (Ascorbic Acid)
2 5-fluorouracil
2 Berberine
2 Propolis -bee glue
2 Ellagic acid
2 Eugenol
2 Phenylbutyrate
2 Resveratrol
2 Shikonin
1 Alpha-Lipoic-Acid
1 Baicalin
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Chlorogenic acid
1 Citric Acid
1 gefitinib, erlotinib
1 Quercetin
1 Cisplatin
1 Metformin
1 EGCG (Epigallocatechin Gallate)
1 Honokiol
1 Selenite (Sodium)
1 Thymoquinone
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:246  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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