PGE2 Cancer Research Results

PGE2, Prostaglandin E2: Click to Expand ⟱
Source:
Type:
Prostaglandin E2 (PGE2) is a lipid compound that plays a significant role in various physiological processes, including inflammation, immune response, and regulation of cell growth. PGE2 is often found at elevated levels in various types of cancer, including colorectal, breast, and lung cancers. It can promote tumor growth by enhancing cell proliferation, inhibiting apoptosis (programmed cell death), and promoting angiogenesis (the formation of new blood vessels).
- PGE2 is a pain-inducing factor. It is able to sensitize primary sensory neurons and leads to central sensitization and also facilitate the release of pain-related neuropeptides
-Upregulated in AD brain; promotes inflammatory cytokine release, increase ROS, may increase Aβ deposition
Scientific Papers found: Click to Expand⟱
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2859- FIS,    The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
- in-vitro, Liver, HepG2 - NA, Colon, Caco-2
TumCG↓, other↝, Casp3↑, Casp7↑, PGE2↓, GSTs↓, Wnt↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, P53↑, P21↑, P450↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6995- Form,    Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia
- Review, Nor, BV2
*TNF-α↓, *IL6↓, *IL1β↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *neuroP↑, *Inflam↓,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
4030- FulvicA,    Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes
- Review, Nor, NA
*Inflam↓, TNF-α↓, *COX2/PTGS2↓, *PGE2↓, *ROS↓, *GutMicro↑, *BioEnh↑, *BioEnh↑, *SOD↑, *Catalase↑, *GPx↑,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
7090- GAR,    Garcinol
- in-vitro, Var, NA
AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
7238- GBE,    Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells
- in-vitro, Nor, RAW264.7
*NO↓, *PGE2↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
7107- GEN,    Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
- Trial, Pca, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
COX2/PTGS2↓, P21↑, PGE2↓, other↑, Dose↝,
7108- GEN,    Genistein: A Review on its Anti-Inflammatory Properties
- Review, Nor, NA
*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,
7268- GGB,    Ginkgolide B inhibits the neurotoxicity of prions or amyloid-beta1-42
- in-vitro, AD, NA
*PGE2↓, *Casp3↓, *neuroP↑, *PAF↑,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2/PTGS2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,
7151- GI,    A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, RAW264.7
MMP9↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7338- Gra,    Pharmacological Activities of Soursop (Annona muricata Lin.)
- Review, Var, NA
AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7111- GSL,    In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens
- in-vitro, Nor, NA
*NO↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓, *Inflam↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
1087- HNK,    Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, H226
TumCMig↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, p65↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
7641- Ins,    Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
- Review, CRC, NA
AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7884- isoO,    Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
- in-vitro, Nor, RAW264.7
*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8221- LCA,    Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects
- in-vitro, Nor, NA
*Inflam↓, *AntiBio↑, *PGE2↓, *IL6↓, *TNF-α↓,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8273- LE,    A Systematic Review of the Effect of Licorice on Head and Neck Chemotherapy- and Radiotherapy-Induced Mucositis
- Review, HNSCC, NA
radioP↑, chemoP↑, *Pain↓, *Inflam↓, IL1β↓, PGE2↑, COX2/PTGS2↓, *toxicity↝, *Mucositis↓,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8188- LGE,    Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells
- in-vitro, BC, MCF7
TumCG↓, TumCCA↑, Apoptosis↑, PGE2↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
1084- LT,  CHr,    Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells
- in-vitro, Nor, RAW264.7
*COX2/PTGS2↓, *COX2/PTGS2∅, *PGE2↓, *ROS↓,

Showing Research Papers: 51 to 100 of 144
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 144

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 2,   GPx↑, 4,   GSH↓, 2,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↓, 1,   NRF2↑, 5,   ROS↓, 13,   ROS↑, 34,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↑, 2,   Trx↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 4,   ETC↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 3,   OCR↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 5,   ACC↑, 1,   ALAT↓, 1,   AMPK↓, 2,   AMPK↑, 7,   AMPK↝, 1,   ATP↓, 3,   glucose↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 3,   HK2↓, 1,   lactateProd↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PLA2↓, 1,   SIRT1↓, 1,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 30,   ASC↑, 1,   BAD↑, 2,   Bak↑, 1,   BAX↓, 2,   BAX↑, 15,   Bax:Bcl2↑, 5,   Bcl-2↓, 18,   Bcl-2↑, 2,   Bcl-xL↓, 9,   BID↑, 1,   BIM↑, 3,   BNIP3↑, 2,   BNIP3↝, 1,   Casp↑, 5,   Casp1↓, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 30,   cl‑Casp3↑, 2,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 2,   Casp8↑, 8,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 20,   cl‑Casp9↑, 2,   proCasp9↑, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 17,   Diablo↑, 4,   DR5↑, 6,   FADD↑, 1,   Fas↑, 4,   FasL↑, 3,   Ferroptosis↑, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 7,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 2,   MDM2↑, 1,   oncosis↑, 1,   p38↑, 6,   p‑p38↓, 1,   survivin↓, 12,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 34,   p‑Akt↓, 9,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 5,   HER2/EBBR2↓, 2,   Hippo↑, 1,   IGF-2R↑, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   JAK1↓, 3,   JAK2↓, 2,   p‑JAK2↓, 1,   JNK↓, 2,   JNK↑, 6,   p‑JNK↓, 2,   LIMK1↓, 1,   MAPK↓, 6,   MAPK↑, 1,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 23,   mTOR↝, 2,   p70S6↓, 1,   PI3K↓, 26,   p‑PI3K↓, 2,   PKCδ↓, 1,   PTEN↑, 7,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 3,   RAS↑, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   STAT↓, 1,   STAT3↓, 20,   p‑STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 10,   DNMT1↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   FOXO1↓, 1,   FOXO3↓, 1,   H3↑, 1,   H4↑, 1,   HATs↓, 3,   HATs↑, 2,   HDAC↓, 6,   HDAC1↓, 1,   HDAC2↓, 1,   miR-106b↓, 1,   miR-19b↓, 1,   miR-203↑, 1,   miR-34a↓, 2,   n-MYC↓, 1,   OCT4↓, 1,   other↓, 1,   other↑, 4,   other↝, 2,   SOX2↓, 2,   SOX4↓, 1,   SOX9↓, 1,   TCF-4↓, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 2,   IRE1↑, 2,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 4,   p62↓, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 16,   HR↓, 1,   hTERT/TERT↓, 1,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 16,   p‑P53↑, 1,   PARP↑, 3,   cl‑PARP↑, 15,   PCNA↓, 10,   RAD51↓, 1,   Telomerase↓, 3,   TOP1↓, 2,   TOP2↓, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   p‑CDK1↓, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 16,   CDK4/6↓, 2,   CDK6↓, 5,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 20,   cycE/CCNE↓, 8,   cycE/CCNE↑, 1,   cycE1↓, 1,   Ki-67↓, 4,   P21?, 1,   P21↑, 15,   p27/CDKN1B↑, 8,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 2,   TumCCA↓, 1,   TumCCA↑, 36,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMPs↑, 1,   CD133↓, 3,   cFos↓, 3,   CSCs↓, 7,   Diff↓, 1,   EP2↓, 1,   EP4/PTGER4↓, 1,   Gli1↓, 1,   IGF-1↓, 4,   IGFBP3↑, 1,   Ki-67↓, 4,   mTORC1↓, 2,   p‑mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 3,   NOTCH↓, 3,   NOTCH1↓, 3,   NOTCH1↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 1,   TumCG↓, 15,   TumCP↓, 17,   Wnt↓, 16,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 2,   CA↓, 1,   Ca+2↑, 7,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   Cofilin↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 14,   EMT↓, 25,   EMT↑, 1,   FAK↓, 4,   p‑FAK↓, 1,   fascin↓, 2,   Fibronectin↓, 3,   GIT1↓, 1,   ITGB1↑, 1,   MMP-10↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 26,   MMP3↓, 5,   MMP7↓, 6,   MMP9↓, 32,   MMP9↑, 1,   MMPs↓, 9,   N-cadherin↓, 9,   NCAM↑, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 4,   serineP↓, 1,   Slug?, 1,   Slug↓, 5,   Smad1↑, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 1,   TGF-β↓, 5,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 2,   pol-TregCell↓, 1,   TRIB3↑, 1,   TumCI↓, 17,   TumCMig↓, 17,   TumMeta↓, 18,   TumMeta↑, 3,   Twist↓, 7,   uPA↓, 8,   uPAR↓, 1,   Vim↓, 11,   Zeb1↓, 4,   α-SMA↓, 1,   β-catenin/ZEB1↓, 16,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 1,   Hif1a↓, 13,   NO↓, 5,   NO↑, 1,   NO↝, 1,   PGI2↓, 1,   TXA2↓, 1,   VEGF↓, 28,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   MMP↓, 21,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 1,   CD44↓, 1,   CD8+↑, 1,   COX1↓, 4,   COX1↑, 1,   COX2/PTGS2↓, 55,   COX2/PTGS2↑, 2,   CXCR4↓, 6,   FOXP3↓, 1,   FOXP3↑, 1,   FoxP3+↓, 1,   GM-CSF↓, 2,   HMGB1↓, 1,   ICAM-1↓, 3,   IL1↓, 5,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 7,   IL2↑, 1,   IL4↑, 2,   IL6↓, 16,   IL6↑, 1,   IL8↓, 3,   Imm↑, 3,   Inflam↓, 17,   MCP1/CCL2↓, 3,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 2,   MyD88↓, 1,   NF-kB↓, 43,   NF-kB↑, 3,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 3,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 64,   PGE2↑, 1,   PSA↓, 3,   PSA∅, 1,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 3,   TNF-α↓, 15,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   ADAM10?, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 3,   GR↑, 1,   PPARα↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 13,   BioAv↝, 1,   ChemoSen↑, 32,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↑, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 4,   Dose↝, 16,   eff↓, 2,   eff↑, 7,   eff↝, 5,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 6,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 4,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 10,   selectivity↑, 10,   Synergy↑, 32,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 3,   EGFR↓, 14,   EZH2↓, 1,   FOXM1↓, 3,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 16,   IL6↑, 1,   LDH↓, 2,   PD-L1↓, 3,   PSA↓, 3,   PSA∅, 1,   TF-Ag↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 13,   AntiTum↑, 4,   cardioP↑, 6,   chemoP↑, 12,   chemoPv↑, 6,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 2,   OS↑, 4,   Pain↓, 1,   QoL↑, 3,   radioP↑, 3,   RenoP↑, 2,   Risk↓, 7,   toxicity↓, 5,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 502

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 40,   ARE↑, 1,   Bil↑, 2,   Catalase↑, 29,   DPPH↓, 1,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 1,   GPx↑, 15,   GPx3↑, 1,   GSH↑, 25,   GSR↓, 1,   GSR↑, 6,   GSSG↓, 1,   GSTs↑, 10,   H2O2↓, 1,   HO-1↑, 21,   Keap1↓, 1,   lipid-P↓, 23,   MDA↓, 21,   MPO↓, 5,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 4,   NRF2↓, 1,   NRF2↑, 29,   RNS↓, 3,   ROS?, 1,   ROS↓, 62,   SOD↓, 1,   SOD↑, 37,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 2,   Thiols↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mitResp↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   5LO↓, 11,   ACC↓, 1,   ALAT↓, 13,   AMPK↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 3,   cAMP↑, 2,   cPLA2↓, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   Eic↓, 1,   FASN↓, 2,   GlutMet↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   H2S↑, 1,   LDL↓, 2,   lipidLev↓, 2,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PLA2↓, 1,   SIRT1↑, 6,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 6,   BAX↓, 7,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 12,   Casp8↓, 1,   Casp9↓, 7,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 31,   iNOS↑, 1,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 4,   p‑Akt↓, 1,   Akt2↓, 1,   p‑CREB↑, 1,   ERK↓, 3,   ERK↑, 2,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   JAK2↑, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 8,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↑, 2,   mTOR↝, 1,   PI3K↓, 3,   PI3K↑, 4,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   cJun↓, 1,   p‑cJun↓, 1,   p‑cMyc↑, 1,   OCT4↓, 1,   other↑, 13,   other↝, 3,   RUNX2↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP70/HSPA5↑, 3,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   LC3II↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 1,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Choline↑, 1,   Diff↑, 1,   Ki-67↓, 1,   MSCs↑, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 7,   AP-1↓, 5,   Ca+2↓, 6,   Ca+2↑, 2,   Cartilage↑, 1,   COL1↓, 1,   COL1↑, 1,   COL2A1↑, 1,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 5,   MMP2↓, 4,   MMP2↑, 1,   MMP3↓, 4,   MMP3↑, 1,   MMP9↓, 7,   MMPs↓, 3,   MMPs↑, 1,   MUC1↑, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   Snail↑, 1,   TGF-β↓, 2,   TGF-β↑, 3,   TIMP1↓, 2,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Twist↑, 1,   Vim↑, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   angioG↝, 1,   E-sel↓, 1,   eNOS↓, 1,   NO↓, 28,   NO↑, 3,   TXA2↓, 3,   VCAM-1↓, 6,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   CLDN1↑, 1,   CLDN3↑, 1,   GastroP↑, 2,   IBI↑, 1,   MMP↑, 6,   MMP∅, 1,   MUC19↓, 1,   MUC2↓, 1,   OATPs↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPV3↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 54,   COX2/PTGS2∅, 1,   CXCc↓, 1,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 8,   IFN-γ↑, 1,   IL1↓, 3,   IL10↓, 6,   IL10↑, 8,   IL12↓, 4,   IL17↓, 4,   IL18↓, 2,   IL1β↓, 34,   IL2↓, 6,   IL2↑, 1,   IL22↓, 1,   IL4↓, 6,   IL4↑, 2,   IL5↓, 3,   IL6↓, 42,   IL8↓, 9,   Imm↓, 1,   Imm↑, 1,   INF-γ↓, 2,   Inflam↓, 63,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP2↓, 1,   NF-kB↓, 46,   NF-kB↑, 2,   NLRP3↓, 8,   PAF↑, 1,   PGD2↓, 1,   PGE2↓, 78,   PGE2↑, 3,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 8,   TNF-α↓, 49,   TNF-α↑, 1,   Treg lymp↝, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 2,   AChE↓, 5,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 5,   BrainVol↑, 1,   ChAT↑, 2,   DA↑, 1,   GABA↑, 1,   MAOA↓, 4,   MAOA↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   PPARγ↓, 2,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 18,   BioAv↝, 7,   BioEnh↑, 6,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 2,   CYP3A2↓, 1,   Dose↓, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 14,   eff↑, 7,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 4,   P-gp/ABCB1↓, 2,   P450↑, 1,   P450↝, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 1,   AST↓, 14,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 2,   BP↓, 3,   Calcium↑, 1,   creat↓, 2,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 42,   LDH↓, 5,   Mag↑, 1,   NOS2↓, 1,   SpO2↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll?, 1,   antiAll↑, 11,   AntiArt↑, 2,   AntiCan↑, 7,   AntiDiabetic↓, 1,   AntiDiabetic↑, 8,   AntiTum↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 18,   chemoP↑, 3,   chemoPv↑, 3,   cognitive↑, 17,   cough?, 1,   hepatoP↑, 20,   memory↑, 9,   Mucositis↓, 2,   neuroP↑, 43,   Obesity↓, 3,   OS↑, 1,   Pain↓, 4,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 8,   SoreThr?, 1,   Stroke↓, 3,   toxicity↓, 16,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 3,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 7,   AntiFungal↓, 1,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 4,   Bacteria↓, 4,   Diar↓, 2,   GutMicro↑, 9,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 362

Scientific Paper Hit Count for: PGE2, Prostaglandin E2
7 Fisetin
6 Curcumin
6 Lycopene
5 Honokiol
5 Thymoquinone
4 Ginger/6-Shogaol/Gingerol
4 Eugenol
4 Licorice
4 Magnetic Fields
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Aspirin
3 Baicalein
3 Berberine
3 Boswellia (frankincense)
3 Chrysin
3 Garcinol
3 Rosmarinic acid
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Capsaicin
2 Artemisinin
2 Betulinic acid
2 Carvacrol
2 Chocolate
2 Diclofenac
2 Echinacea
2 Emodin
2 Ferulic acid
2 Ginkgo biloba
2 Genistein (soy isoflavone)
2 Grapeseed extract
2 Inositol
2 Kaempferol
2 Licochalcone A
2 Luteolin
2 Morin
2 Propolis -bee glue
2 Piperlongumine
2 Resveratrol
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 Baicalin
1 Biochanin A
1 Boron
1 Celecoxib
1 Celastrol
1 Chlorogenic acid
1 Lecithin
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Diindolylmethane
1 Formononetin
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgolide B
1 Ginkgetin
1 Graviola
1 Proanthocyanidins
1 Siegesbeckia glabrescens
1 Hydrogen Gas
1 phytic acid, Inositol hexakisphosphate
1 isoorientin
1 Lemongrass Extract/Citral
1 Magnolol
1 Melatonin
1 Moringa oleifera
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sesame seeds and Oil
1 Terpinen-4-ol / Tea Tree Oil
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:248  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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