PSA Cancer Research Results

PSA, prostate-specific antigen: Click to Expand ⟱
Source:
Type:
Prostate-Specific Antigen (PSA) is a protein produced by both normal and malignant cells of the prostate gland. PSA testing is commonly used as a screening tool for prostate cancer.
Elevated levels of PSA in the blood can indicate the presence of prostate cancer, but they can also be caused by other conditions, such as benign prostatic hyperplasia (BPH) or prostatitis (inflammation of the prostate).

PSA is a clinical biomarker.
Scientific Papers found: Click to Expand⟱
7742- Lyco,  isoFl,    Lycopene and soy isoflavones in the treatment of prostate cancer
- Trial, Pca, NA
Risk↓, PSA↓, Dose↝, eff↝,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8820- MCP,    Effect of pectasol-c modified citrus pectin (P-MCP) treatment (tx) on PSA dynamics in non- metastatic biochemically relapsed prostate cancer (BRPC) patients (pts): Primary outcome analysis of a prospective phase II study.
- Trial, Pca, NA
toxicity↝, SD↝, PSA↓, PSADT↓, TumMeta∅,
8814- MCP,    Modified Citrus Pectin Treatment in Non-Metastatic Biochemically Relapsed Prostate Cancer: Long-Term Results of a Prospective Phase II Study
- Trial, Pca, NA
*toxicity↓, Gal-3?, PSADT↑, Dose↝, PSA↓, PSADT↑,
8824- MCP,    Clinical Benefit in Patients with Advanced Solid Tumors Treated with Modified Citrus Pectin: A Prospective Pilot Study
- Trial, Var, NA
toxicity↓, Dose↝, CR↑, QoL↑, SD↑, PSA↓,
8825- MCP,    modified citrus pectin supplement
- Review, Var, NA
Gal-3↓, *antiOx↑, Imm↑, IronCh↑, TumMeta↓, TumCP↓, PSA↓, NK cell↑, T-Cell↑,
8746- MeSA,    Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action
- in-vitro, Nor, LAPC-4 - in-vitro, Pca, LNCaP
AR↓, GSH↝, PSA↓,
8745- MeSA,    Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers
- in-vitro, Pca, LNCaP
AR↓, PSA↓, AntiCan↑, DHCR24↓,
6936- MF,  Ex,    Pulsed electromagnetic field with or without exercise therapy in the treatment of benign prostatic hyperplasia
- Trial, BPH, NA
*eff↑, *Synergy↑, *BloodF↑, *Diff↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *UFR↑, *UR↓, *PSA↓, *other↑, *Inflam↓,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2/PTGS2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
8982- PCorn,    Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways
- vitro+vivo, Pca, LNCaP
TumCP↓, cycD1/CCND1↓, TumCCA↑, Dose↝, TumCG↓, Ki-67↓, ERK↓, MAPK↓, Ingr↝, PSA↓,
9111- Pomi-T,    A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer—the UK NCRN Pomi-T study
- Trial, Pca, NA
Ingr↝, antiNeop↑, angioG↓, Apoptosis↑, TumCP↓, Dose?, PSA↓, Ingr↝,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
70- QC,    Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
PSA↓, AR↓, NKX3.1↓, HK2↓,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓, TumCP↓, chemoPv↑, TumCMig↓,
75- QC,  ENZ,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, PSA↓, NKX3.1↓, FKBP5↓, UBE2C↓, AR-FL↓, AR-V7↑, AR↓, eff↑, TumVol↓, BioAv↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, Synergy↑,
3033- RosA,    Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP - vitro+vivo, NA, NA
ER Stress↑, selectivity↑, AR↓, TumCG↓, TumCCA↑, CHOP/DDIT3↑, PERK↓, GRP78/BiP↑, PSA↓,
9188- SFN,    Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside
- Review, Pca, NA
chemoPv↑, antiNeop↑, Risk↓, Ingr↝, NRF2↑, NQO1↑, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, STAT3↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, HDAC↓, DNMTs↓, HDAC3↓, HDAC6↓, Akt↓, TumCG↓, BioAv↑, Half-Life↝, PSA↓, PSADT↑,
2446- SFN,  CAP,    The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor
- in-vitro, Pca, LNCaP
AR↓, Bcl-xL↓, TumCP↓, Glycolysis↓, HK2↓, PKA↓, Hif1a↓, PSA↓, ECAR↓, BioAv↑, BioAv↓, *toxicity↓,
1509- SFN,    Combination therapy in combating cancer
- Review, Var, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, ChemoSen↑, PSA↓, P53↑, Hif1a↓, CAIX/CA9↓, chemoR↓, 5HT↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
616- VitC,    Suppression of alkaline phosphatase in prostate cancer patients by high dose intravenous Vitamin C Treatment: Three cases
- Case Report, Pca, NA
PSA↓, ALP↓,
9126- ZYF,  Bical,    Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP
AR↓, NKX3.1↓, PSA↓, Synergy↑,
9124- ZYF,    Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer
- in-vitro, Pca, NA
AntiCan↑, TumCG↓, eff↑, p‑Akt↓, PSA↓, HDAC↓, AR↓,
9123- ZYF,    Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial
- Trial, Pca, NA
PSA↓, CRP↓, NF-kB↓, toxicity↓,

Showing Research Papers: 51 to 82 of 82
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 82

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE/EpRE↑, 1,   Catalase↓, 2,   Catalase↑, 1,   GPx↓, 1,   GPx↑, 2,   GSH↓, 5,   GSH↑, 1,   GSH↝, 1,   HO-1↑, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 5,   NRF2↝, 1,   ROS↓, 1,   ROS↑, 17,   ROS⇅, 1,   ROS↝, 1,   SAM-e↝, 1,   SOD↓, 2,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   EGF↓, 1,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↑, 1,   AMPK↑, 2,   ATP↓, 2,   CAIX/CA9↓, 1,   DHCR24↓, 1,   ECAR↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HK2↓, 3,   NAD↝, 1,   SIRT1↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 13,   Apoptosis↝, 1,   BAD↓, 1,   BAX↑, 9,   BAX↝, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-2↝, 1,   Bcl-xL↓, 3,   Bcl-xL↝, 1,   BID↑, 1,   Casp↑, 2,   Casp3↑, 6,   Casp3↝, 1,   cl‑Casp3↑, 6,   cl‑Casp7↑, 3,   cl‑Casp8↑, 2,   Casp9↑, 4,   cl‑Casp9↑, 3,   Cyt‑c↑, 6,   Cyt‑c↝, 1,   DR5↑, 1,   Fas↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 1,   MDM2↓, 1,   PUMA↓, 2,   survivin↓, 3,   TumCD↑, 1,   XIAP↓, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↝, 1,   p‑Akt↓, 6,   Akt2↓, 1,   AMPKα↓, 1,   BRAF↝, 1,   CK2↓, 2,   EGFR↓, 8,   EGFR↝, 1,   ERK↓, 6,   p‑ERK↓, 1,   HER2/EBBR2↓, 2,   JNK↝, 1,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 1,   MAPK↝, 1,   p‑MEK↓, 1,   mTOR↓, 7,   mTOR↝, 1,   p‑mTOR↓, 2,   p‑P70S6K↓, 1,   PI3K↓, 7,   PI3K↝, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKA↓, 1,   PRAS40↓, 1,   PTEN↑, 3,   PTEN↝, 2,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT3↓, 6,   p‑STAT3↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 1,   cMyc↓, 5,   DNMTs↓, 1,   EZH2↓, 3,   FOXM1↓, 3,   FOXO3↓, 1,   HATs↑, 1,   HDAC↓, 5,   HDAC3↓, 2,   HDAC6↓, 1,   miR-106b↓, 1,   miR-148a↓, 1,   miR-19b↓, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-34a↓, 1,   miR-34a↑, 1,   MTA2↓, 2,   other↑, 1,   other↝, 4,   SD↑, 1,   SD↝, 1,   SOX4↓, 2,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 3,   eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 2,   HSP70/HSPA5↑, 1,   HSPs↓, 1,   PERK↓, 1,   PERK↑, 1,   Proteasome↓, 1,   PSMB5↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

SESN2↑, 1,   TumAuto↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   DNAdam↓, 1,   DNAdam↑, 1,   NKX3.1↓, 3,   NKX3.1↑, 1,   P53↓, 2,   P53↑, 8,   P53↝, 1,   p‑P53↓, 1,   PARP↑, 1,   cl‑PARP↑, 6,   PARP1↑, 1,   PCNA↓, 2,   Telomerase↓, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 5,   CDK4↓, 10,   CDK4/6↓, 1,   CDK6↓, 2,   CDKN1C/p57↓, 1,   Cyc↓, 2,   Cyc↝, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 11,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 3,   Ki-67↓, 3,   P21↓, 2,   P21↑, 11,   P21↝, 1,   p27/CDKN1B↓, 4,   p27/CDKN1B↑, 4,   p‑pRB↓, 2,   RB1↑, 1,   Securin↓, 1,   TumCCA↑, 21,   UBE2C↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CSCs↓, 1,   Gli1↓, 1,   HH↓, 4,   IGF-1↓, 9,   IGFBP3↑, 2,   Ki-67↓, 3,   Let-7↓, 1,   Let-7↑, 1,   NOTCH↓, 1,   NOTCH1↓, 3,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 12,   TumCP↓, 17,   Wnt↓, 6,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AntiAg↑, 2,   AP-1↝, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   cal2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 6,   EMT↓, 3,   EMT↑, 1,   FAK↓, 2,   p‑FAK↓, 1,   hnRNPA1↓, 1,   ITGB4↓, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↝, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 6,   MMPs↓, 3,   N-cadherin↓, 2,   PDGF↓, 2,   Rho↓, 1,   serineP↓, 1,   Slug↓, 1,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 7,   TumMeta↓, 5,   TumMeta∅, 1,   TumPF↓, 1,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 3,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   HIF-1↓, 1,   Hif1a↓, 8,   LOX1↓, 1,   VEGF↓, 11,   VEGF↝, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

LAT↓, 1,   MMP↓, 9,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 7,   COX2/PTGS2↝, 1,   CXCR4↓, 1,   Gal-3?, 1,   Gal-3↓, 1,   IFN-γ↓, 1,   IL1↓, 4,   IL10↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 4,   IL6↝, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 2,   IRAK1↓, 2,   Neut↑, 1,   NF-kB↓, 13,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   ac‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 3,   PSA↓, 77,   PSA↝, 1,   PSA∅, 1,   T-Cell↑, 1,   TCF↓, 1,   TNF-α↓, 5,   TNF-α↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 28,   AR↝, 2,   AR-FL↓, 1,   AR-V7↑, 1,   ER-α36↓, 1,   FKBP5↓, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,   RANKL↓, 1,   testos∅, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 7,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 10,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↑, 5,   Dose↝, 19,   eff?, 1,   eff↑, 12,   eff↝, 2,   eff∅, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   MDR1↓, 1,   P-gp/ABCB1↓, 3,   RadioS↑, 2,   selectivity↑, 5,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   AR↓, 28,   AR↝, 2,   BRAF↝, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 8,   EGFR↝, 1,   EZH2↓, 3,   FOXM1↓, 3,   HER2/EBBR2↓, 2,   IL6↓, 4,   IL6↝, 1,   PD-L1↓, 1,   PSA↓, 77,   PSA↝, 1,   PSA∅, 1,   PSADT↓, 1,   PSADT↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 3,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 4,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 1,   CR↑, 1,   hepatoP↑, 2,   memory↑, 1,   OS↑, 5,   Pain↓, 1,   Pin1↓, 1,   QoL↑, 2,   QoL↝, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 8,   Risk↝, 1,   toxicity↓, 4,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 8,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 368

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 11,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 3,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 3,   SAM-e↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   AMPK↑, 1,   ATP↝, 1,   LDL↓, 3,   NAD↝, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AKT1↓, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↑, 1,   JNK↓, 1,   MAPK↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 1,   other↑, 1,   other↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   Diff↝, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2↝, 2,   serineP↓, 1,   TIMP1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   IL1↓, 1,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 2,   Inflam↓, 12,   NF-kB↓, 3,   PGE2↓, 1,   PSA↓, 2,   PSA∅, 1,   TNF-α↓, 4,   VitD↑, 2,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

DHT↓, 1,   testos↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 4,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↑, 1,   Dose↝, 9,   eff↑, 3,   Half-Life↝, 2,   selectivity↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BMD↑, 2,   Calcium↑, 2,   EGFR↓, 1,   hs-CRP↓, 1,   IL6↓, 2,   Mag↑, 2,   PSA↓, 2,   PSA∅, 1,   UFR↑, 1,   UR↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 3,   memory↓, 1,   memory↑, 3,   motorD↓, 1,   neuroP↑, 3,   Obesity↓, 1,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 100

Scientific Paper Hit Count for: PSA, prostate-specific antigen
8 Lycopene
8 Boron
8 Curcumin
4 isoflavones
4 Diindolylmethane
4 itraconazole
4 Modified Citrus Pectin
4 Quercetin
3 Silymarin (Milk Thistle) silibinin
3 Sulforaphane (mainly Broccoli)
3 Zyflamend
2 Apigenin (mainly Parsley)
2 Bicalutamide
2 Capsaicin
2 Fisetin
2 Juglone
2 lambertianic acid
2 methylseleninic acid
2 Resveratrol
2 Rosmarinic acid
1 Alpha-Lipoic-Acid
1 HydroxyCitric Acid
1 Astaxanthin
1 Vitamin D3
1 Carnosic acid
1 Catechins
1 Ursolic acid
1 Indole-3-carbinol
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Eurycomanone
1 Flaxseed/Linseed
1 Genistein (soy isoflavone)
1 Gold NanoParticles
1 Photodynamic Therapy
1 Isothiocyanates
1 Phenethyl isothiocyanate
1 Ivermectin
1 SDG/lignans
1 Chemotherapy
1 Magnetic Fields
1 Exercise
1 Oleocanthal
1 Purple Corn / Purple Maize
1 Pomi-T
1 Arctigenin
1 enzalutamide
1 Selenite (Sodium)
1 Radiotherapy/Radiation
1 Aflavin-3,3′-digallate
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:264  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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