Beclin-1/ATG6 Cancer Research Results

Beclin-1/ATG6, Beclin-1 (BECN1 gene): Click to Expand ⟱
Source:
Type: Protein Coding gene
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown.
A key biomarker of autophagy is Beclin-1. Beclin-1 stimulates LC3-I’s lipidation to produce LC3-II, which localizes to the autophagosome membrane to activate the development of autophagosomes.
-BECN1 = the official gene symbol (human gene name)
-Beclin-1 = the protein name encoded by the BECN1 gene

BECN1 - Beclin 1

Abbreviation: BECN1, Beclin 1

Alternative Names: ATG6, VPS30

Type: Autophagy regulator / class III PI3K complex component

Function: Beclin 1 is a core component of the VPS34/class III PI3K complex and promotes phosphatidylinositol-3-phosphate production required for autophagosome nucleation and membrane trafficking.

Cancer: ↕ Context-dependent. Reduced BECN1 expression can contribute to tumor initiation and genomic instability, supporting a tumor-suppressive role in some tissues. However, established cancers can also exploit Beclin 1-dependent autophagy for survival under metabolic and therapeutic stress.
Scientific Papers found: Click to Expand⟱
1962- GamB,  HCQ,    Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
- in-vitro, PC, NA
LC3II↑, Beclin-1/ATG6↑, p62↓, MMP↓, ROS↑, TumAuto⇅, Synergy↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1/ATG6↑, *p62↓, *mTOR↓,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7353- HibSad,    Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy
- in-vitro, Melanoma, A375
cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
7794- ISQ,    Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
5118- JG,    Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1/ATG6↑,
1917- JG,    Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion
- in-vitro, AML, HL-60
selectivity↑, LC3I↑, LC3II↑, Beclin-1/ATG6↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,
8098- KAE,    Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
8074- KAE,    Dose-dependent tuning of HSP70-Beclin-1 by kaempferol governs autophagy and chemosensitivity
- in-vitro, SCC, KYSE150 - in-vitro, SCC, KYSE450 - in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
ChemoSen⇅, HSP70/HSPA5↑, Beclin-1/ATG6⇅, Dose↝, TumVol⇅, TumW⇅,
9062- L-THE,    Therapeutic Role of l‑Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose?, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
9009- L-THE,    Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose↝, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8369- LT,    Luteolin inhibits proliferation of lung cancer A549 cells by increasing ROS production and inhibiting the AKT/mTOR signaling pathway and HO-1 expression
- in-vitro, Lung, A549
tumCV↓, TumCP↓, ROS↑, BAX↑, cl‑Casp9↑, Beclin-1/ATG6↑, LC3B-II↑, Bcl-2↓, p62↓, TumAuto↑, p‑Akt↓, p‑mTOR↓, HO-1↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
8492- MAG,    Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway
- in-vivo, AD, NA
*Apoptosis↑, *cl‑Casp9↓, *BAX↓, *Bcl-2↓, *p62↓, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ULK1/ATG1↑,
8534- Matr,    Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, MRC-5
TumCP↓, selectivity↑, Apoptosis↑, BAX↑, Bcl-2↓, TumAuto?, LC3II↑, Beclin-1/ATG6↑, p62↓, Cavin3↓, p‑PI3K↓, p‑Akt↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
227- MFrot,  MF,    Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway
- in-vivo, Lung, A549 - in-vitro, Lung, A549
TumCG↓, miR-486↑, BCAP↓, Apoptosis↑, ROS↑, TumAuto↑, LC3II↑, ATG5↑, Beclin-1/ATG6↑, p62↑, TumCP↓,
8661- MLT,    Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway
- in-vitro, BC, NA - in-vitro, Ovarian, NA
PTEN↓, PI3K↓, Akt↓, mTOR↓, mTORC1↓, MDM2↓, BAD↑, Bcl-xL↑, P53↓, TumAuto↑, ULK1/ATG1↑, p‑Beclin-1/ATG6↑,
8891- MOR,  Cisplatin,    Morin Hydrate Sensitizes Hepatoma Cells and Xenograft Tumor towards Cisplatin by Downregulating PARP-1-HMGB1 Mediated Autophagy
- in-vitro, Liver, HepG2
PARP1↓, HMGB1↓, Beclin-1/ATG6?,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,
2076- PB,    Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
TumCP↓, TumAuto↑, Apoptosis↑, ER Stress↑, BID↑, CHOP/DDIT3↑, PDI↑, IRE1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, LC3B↑, Beclin-1/ATG6↑, other↝, other↝,
9016- Phyco,    Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy
- vitro+vivo, PC, PANC1 - in-vitro, PC, Capan1 - in-vitro, Liver, HepG2 - in-vitro, Lung, H460 - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, Beclin-1/ATG6↑, p38↑, JNK↑, ERK↓, PI3K↓, Akt↓, mTOR↓, selectivity↑, Dose↝, toxicity↓, TumW↓, TumVol↓, TumAuto↑,
1993- PTL,    Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer
- in-vitro, Cerv, HeLa
tumCV↓, TumAuto↑, Casp3↑, BAX↑, Beclin-1/ATG6↑, ATG3↑, ATG5↑, Bcl-2↓, mTOR↓, PI3K↓, Akt↓, PTEN↑, ROS↑, MMP↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
2983- RES,    Resveratrol Improves Diabetic Retinopathy via Regulating MicroRNA-29b/Specificity Protein 1/Apoptosis Pathway by Enhancing Autophagy
- in-vitro, Nor, NA
*Beclin-1/ATG6↑, *p62↓, *Sp1/3/4↓, *Apoptosis↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
4729- Se,    Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers
- in-vivo, Nor, NA
*ROS↓, *NRF2↑, *GPx1↑, *NQO1↑, *mTOR↑, *Beclin-1/ATG6↓, *ATG5↓, *LC3s↓, *hepatoP↑,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF7
LC3II↑, Beclin-1/ATG6↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
2229- SK,    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways
- in-vitro, Melanoma, A375
Apoptosis↑, TumAuto↑, TumCP↓, TumCCA↑, P21↑, cycD1/CCND1↓, ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, cl‑Casp3↑, p38↑, LC3B-II↑, Beclin-1/ATG6↑, ROS↑, eff↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1/ATG6↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,

Showing Research Papers: 51 to 100 of 105
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 105

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 3,   Catalase↑, 4,   Fenton↑, 1,   GPx↓, 2,   GPx↑, 1,   GPx1↓, 1,   GPx4↓, 5,   GSH↓, 7,   GSH↑, 3,   GSR↑, 2,   GSTs↑, 2,   H2O2↑, 1,   HNE↑, 1,   HO-1↓, 3,   HO-1↑, 3,   Iron↑, 2,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 3,   MDA↓, 4,   MDA↑, 5,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 4,   ROS↓, 6,   ROS↑, 46,   ROS⇅, 2,   ROS↝, 1,   m-ROS↑, 1,   mt-ROS↑, 4,   SOD↓, 5,   SOD↑, 5,   SOD1↑, 2,   Trx1↑, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC25↓, 6,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 7,   OXPHOS↓, 1,   OXPHOS↑, 1,   PINK1↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 1,   AMPK↑, 7,   ATGL/PNPLA2↓, 1,   ATP↓, 7,   ATP↑, 1,   ATP↝, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 2,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   HK1↓, 1,   HK2↓, 4,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PKM2↓, 2,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 5,   Apoptosis↑, 48,   mt-Apoptosis↑, 1,   BAD↑, 5,   p‑BAD↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 24,   Bax:Bcl2↑, 10,   Bcl-2↓, 32,   Bcl-xL↓, 3,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 2,   BIM↑, 2,   BNIP3?, 1,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 5,   Casp↝, 1,   cl‑Casp↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 27,   cl‑Casp3↑, 9,   proCasp3↓, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 8,   Casp9↑, 21,   cl‑Casp9↑, 4,   proCasp9↓, 1,   CellShr↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 17,   Diablo↑, 1,   DR5↑, 8,   Endon↑, 1,   FADD↑, 3,   Fas↓, 1,   Fas↑, 12,   FasL↑, 4,   Ferroptosis↓, 1,   Ferroptosis↑, 4,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 4,   Mcl-1↓, 5,   MDM2↓, 4,   MOMP↑, 1,   NAIP↓, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 6,   TNFR 1↑, 1,   TRAIL↑, 2,   TumCD↑, 4,   XIAP↓, 5,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 27,   Akt↑, 2,   p‑Akt↓, 14,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   BCAP↓, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CK2↓, 2,   cMET↓, 2,   p‑cMET↑, 1,   EGFR↓, 4,   p‑EGFR↓, 1,   ERK↓, 7,   ERK↑, 1,   p‑ERK↓, 3,   p‑ERK↑, 2,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 2,   IGF-1R↑, 1,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 7,   p‑JNK↑, 1,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 7,   MAPK↑, 6,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 22,   p‑mTOR↓, 8,   p‑mTOR↑, 1,   mTORC2↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   PDE3B↓, 1,   PDGFRB↓, 1,   PI3K↓, 29,   p‑PI3K↓, 1,   p‑PIK3R1↓, 1,   p‑PKA↓, 1,   PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 3,   Raf↓, 1,   RAS↓, 2,   Rictor↓, 1,   Sp1/3/4↓, 1,   STAT3↓, 10,   STAT3↝, 1,   p‑STAT3↓, 3,   STAT5↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 4,   DNMT1↓, 2,   DNMT3B↓, 1,   DNMTs↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↑, 2,   FOXO4↓, 1,   FOXO4↑, 1,   p‑H3↓, 1,   HATs↓, 1,   HDAC↓, 3,   HDAC1↓, 1,   HES1↓, 1,   HMTs↓, 1,   miR-107↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-486↑, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 1,   other↓, 1,   other↝, 2,   SOX2↓, 1,   TFE3↑, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 8,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 10,   ERStress↑, 2,   GRP78/BiP↑, 7,   GRP94↑, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   IRE1↓, 1,   IRE1↑, 2,   PDI↑, 1,   PERK↑, 3,   UPR↑, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 6,   ATG5↓, 1,   ATG5↑, 20,   ATG5↝, 1,   ATG7↑, 8,   autolysosome↑, 1,   AVOs↑, 1,   Beclin-1/ATG6?, 1,   Beclin-1/ATG6↓, 13,   Beclin-1/ATG6↑, 71,   Beclin-1/ATG6⇅, 1,   Beclin-1/ATG6↝, 1,   p‑Beclin-1/ATG6↑, 2,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3A↑, 1,   LC3B↑, 3,   LC3B-II↓, 1,   LC3B-II↑, 7,   LC3I↓, 2,   LC3I↑, 2,   LC3II↓, 2,   LC3II↑, 24,   LC3s↓, 1,   LC3s↑, 5,   LC3s↝, 1,   MitoP↑, 1,   p62↓, 20,   p62↑, 10,   PARK2↑, 2,   RUBCN↓, 1,   TumAuto?, 1,   TumAuto↑, 54,   TumAuto⇅, 1,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 10,   DNArepair↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 3,   p16↑, 1,   P53↓, 4,   P53↑, 19,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 7,   cl‑PARP↑, 14,   PARP1↓, 1,   PCNA↓, 6,   POLD1↓, 1,   Telomerase↓, 1,   TP53↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 8,   CDK2↑, 1,   CDK4↓, 6,   CDK6↓, 3,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 3,   E2Fs↓, 1,   Ki-67↓, 7,   mitA↑, 1,   P21↑, 8,   p27/CDKN1B↑, 1,   p‑pRB↓, 1,   TumCCA↑, 30,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   CD133↓, 1,   CSCs↓, 5,   EIF4E↓, 1,   FGF↓, 2,   HH↓, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   JAG1↓, 1,   Ki-67↓, 7,   mTORC1↓, 3,   NOTCH↓, 4,   NOTCH↑, 1,   NOTCH1↓, 3,   NOTCH3↓, 2,   Shh↓, 1,   TumCG↓, 16,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 38,   tyrosinase↓, 1,   Wnt↓, 9,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   AP-1↑, 1,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 7,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Chl↑, 1,   COL1↓, 1,   COL4A3↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 8,   EMT↓, 13,   FAK↓, 2,   Fibronectin↓, 2,   ITGA5↓, 1,   LAMs↓, 1,   MMP-10↓, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 10,   MMP3↓, 3,   MMP7↓, 2,   MMP9↓, 16,   MMPs↓, 4,   N-cadherin↓, 5,   PAK1↓, 1,   PCBP1↓, 1,   PDGF↓, 2,   Rho↓, 1,   Slug↓, 6,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 5,   TGF-β↓, 3,   TIMP1↑, 2,   TIMP2↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCI↓, 11,   TumCMig↓, 9,   TumMeta↓, 8,   TumMeta↑, 1,   Twist↓, 4,   uPA↓, 5,   uPAR↓, 1,   Vim?, 1,   Vim↓, 9,   Zeb1↓, 4,   Zeb1↑, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 2,   Hif1a↓, 11,   NO↓, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 1,   VEGF↓, 19,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   GLUT1↓, 4,   MMP↓, 19,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   CD8+↑, 2,   COX2/PTGS2↓, 9,   CXCL1↓, 1,   CXCL6/GCP-2↓, 1,   CXCR4↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 2,   IL10↓, 2,   IL12↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL2↑, 1,   IL4↓, 2,   IL6↓, 4,   Imm↑, 5,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 1,   MCT1↓, 1,   MyD88↑, 1,   NF-kB↓, 18,   NF-kB↑, 1,   NK cell↑, 1,   p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   RAGE↓, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 6,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 21,   ChemoSen⇅, 1,   CYP1B1↑, 1,   Dose↑, 1,   Dose↝, 12,   eff↓, 12,   eff↑, 11,   GSTP1/GSTπ↓, 1,   Half-Life↓, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   RadioS↑, 5,   selectivity↑, 11,   Synergy?, 1,   Synergy↑, 14,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 1,   AST↓, 1,   BG↓, 1,   CRP↓, 2,   EGFR↓, 4,   p‑EGFR↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 3,   IL6↓, 4,   LDH↑, 1,   Myc↓, 2,   PD-L1↓, 2,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiD↑, 1,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 3,   chemoP↑, 5,   chemoPv↑, 4,   ChemoSideEff↓, 1,   hepatoP↑, 2,   neuroP↑, 2,   NP/CIPN↓, 1,   Pain↓, 1,   QoL↑, 1,   RenoP↑, 3,   Risk↓, 2,   toxicity↓, 2,   toxicity↝, 3,   TumVol↓, 5,   TumVol⇅, 1,   TumW↓, 4,   TumW⇅, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 569

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 16,   Catalase↑, 7,   GPx↑, 6,   GPx1↑, 1,   GSH↑, 9,   GSR↑, 1,   GSTs↑, 2,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 6,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 7,   MDA↓, 10,   MPO↓, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 12,   ROS↓, 27,   ROS↑, 2,   mt-ROS?, 1,   SOD↑, 11,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mitResp↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 7,   ATP↓, 1,   ATP↑, 1,   glucose↓, 2,   GSK‐3β↓, 1,   LDHA↑, 1,   LDL↓, 1,   NAD↓, 1,   PLA2↓, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 3,   Apoptosis↑, 1,   BAX↓, 4,   Bcl-2↓, 2,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 6,   Casp9↓, 2,   cl‑Casp9↓, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 1,   iNOS↓, 4,   p38↓, 2,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 6,   p‑Akt↓, 2,   p‑Akt↑, 1,   CREB↑, 2,   IκB?, 1,   JAK2↑, 1,   JNK↓, 3,   MAPK↓, 2,   mTOR↓, 2,   mTOR↑, 6,   p‑mTOR↓, 2,   PI3K↓, 1,   PI3K↑, 4,   PKCδ↑, 1,   PP2A↑, 1,   Sp1/3/4↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 2,   HOTAIR↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   ER Stress↓, 4,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG5↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 13,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 3,   LC3II↓, 2,   LC3II↑, 6,   LC3s↓, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 1,   PARK2↑, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Migration(tgid=13) ⓘ

Ca+2?, 1,   LRP1↑, 1,   TGF-β↓, 1,   TregCell↑, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   MMP↓, 1,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   HMGB1↓, 2,   IFN-γ↓, 2,   IL10↓, 3,   IL10↑, 2,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 5,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 9,   IL8↓, 1,   Imm↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 27,   pol-M2 MC↑, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 11,   NLRP3↓, 3,   PGE2↓, 3,   TLR3↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   TRAF6↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 5,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 5,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 4,   tau↓, 2,   p‑tau↓, 3,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 7,   BioAv↝, 3,   Dose?, 1,   Dose↝, 3,   Half-Life↝, 3,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 1,   AST↓, 6,   BG↓, 1,   BloodF↑, 1,   colonLen↑, 1,   creat↓, 1,   IL6↓, 9,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 3,   antiAll↑, 5,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 5,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 6,   hepatoP↑, 10,   Learn↑, 2,   memory↑, 10,   Mucositis↓, 2,   neuroP↑, 17,   NP/CIPN↓, 2,   Obesity↓, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   Strength↑, 1,   Stroke↓, 2,   toxicity↓, 8,   toxicity↑, 1,   toxicity↝, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 5,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  
Total Targets: 216

Scientific Paper Hit Count for: Beclin-1/ATG6, Beclin-1 (BECN1 gene)
7 Curcumin
6 Luteolin
5 Matrine
3 Berberine
3 Kaempferol
2 Silver-NanoParticles
2 Magnetic Fields
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Cisplatin
2 Bromelain
2 Coenzyme Q10
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Ferulic acid
2 Formononetin
2 Gambogic Acid
2 Hibiscus sabdariffa
2 Ivermectin
2 Juglone
2 L-Theanine
2 Morin
2 Resveratrol
2 Selenite (Sodium)
2 Thymoquinone
1 3-bromopyruvate
1 cetuximab
1 Astragalus
1 Allyl isothiocyanate
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Baicalein
1 Berbamine
1 Beta-Caryophyllene
1 Cannabidiol
1 Betulinic acid
1 borneol
1 Radiotherapy/Radiation
1 Boron
1 Citric Acid
1 Copper and Cu NanoParticles
1 Cynaropicrin
1 Dichloroacetophenone(2,2-)
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Dandelion Root
1 Fisetin
1 Fucoidan
1 Gallic acid
1 hydroxychloroquine
1 Genistein (soy isoflavone)
1 Geraniol
1 Hydrogen Gas
1 Honokiol
1 isoorientin
1 isoquercitrin
1 Isovitexin
1 Licochalcone A
1 Licorice
1 Magnolol
1 Magnetic Field Rotating
1 Melatonin
1 doxorubicin
1 Nimbolide
1 Phenylbutyrate
1 Phycocyanin
1 Parthenolide
1 Quercetin
1 Rutin
1 buckwheat sprouts
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:30  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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