TGF-β Cancer Research Results

TGF-β, transforming growth factor-beta: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS TCGA
Type:
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses.
Anti-inflammatory cytokine.
In normal tissues, TGF-β plays an essential role in cell cycle regulation, immune function, and tissue remodeling.
- In early carcinogenesis, TGF-β typically acts as a tumor suppressor by inhibiting cell proliferation and inducing apoptosis.

In advanced cancers, cells frequently become resistant to the growth-inhibitory effects of TGF-β.
- TGF-β then switches roles and promotes tumor progression by stimulating epithelial-to-mesenchymal transition (EMT), cell invasion, metastasis, and immune evasion.

Non-canonical (Smad-independent) pathways, such as MAPK, PI3K/Akt, and Rho signaling, also contribute to TGF-β-mediated responses.

Elevated levels of TGF-β have been detected in many advanced-stage cancers, including breast, lung, colorectal, pancreatic, and prostate cancers.
 - The switch from a tumor-suppressive to a tumor-promoting role is often associated with increased TGF-β production and activation in the tumor microenvironment.

High TGF-β expression or signaling activity is frequently correlated with aggressive disease features, resistance to therapy, increased metastasis, and poorer overall survival in many cancer types.
Scientific Papers found: Click to Expand⟱
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
1246- EMD,    Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation
- in-vivo, BC, NA
TGF-β↓, EMT↓, CSCs↓,
6580- EU,    Eurycomanone Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition, Migration, and Invasion Pathways in Human Non-Small Cell Lung Cancer Cells by Targeting Smad and Non-Smad Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-1
TumCMig↓, MMP2↓, EMT↓, E-cadherin↑, Akt↓, N-cadherin↓, TGF-β↓, Smad1↓,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, Var, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
822- GAR,    Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
- vitro+vivo, HNSCC, NA
ROS↑, STAT3↓, cSrc↓, JAK1↓, JAK2↓, NF-kB↓, TGF-β↓, TumCG↓,
1117- GBE,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CCN2/CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
941- Gos,  Rad,    The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis
- in-vivo, Var, NA
lactateProd↓, other↓, TGF-β↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
1649- HCAs,    Anticancer Properties of Hydroxycinnamic Acids -A Review
- Review, Var, NA
*antiOx↑, MMP2↓, MMP9↓, VEGF↓, TGF-β↓, Bax:Bcl2↑, TumCCA↑, COX2/PTGS2↓, NF-kB↓,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
7749- ISL,    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
- in-vitro, GBM, U87MG
angioG↓, COX2/PTGS2↓, mPGES-1↓, CYP4A/CYP4A11/CYP4A22↓, FGF21↓, TGF-β↓, VEGF↓, miR-194↑, NEAT1↓,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
1122- LF,  MTX,    Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition
- in-vivo, Colon, Caco-2
TGF-β↓, EMT↓,
1060- LT,  BTZ,    Luteolin inhibits the TGF-β signaling pathway to overcome bortezomib resistance in multiple myeloma
- vitro+vivo, Melanoma, NA
ALDH1A1↓, TGF-β↓, ChemoSen↑,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
4520- MAG,    Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF-β/Smad Signaling
- vitro+vivo, PC, PANC1
Vim↓, E-cadherin↑, EMT↓, N-cadherin↓, p‑SMAD2↓, p‑SMAD3↓, TumCP↓, TumCMig↓, TumCI↓, TGF-β↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
2386- MET,    Mechanisms of metformin inhibiting cancer invasion and migration
- Review, Var, NA
OS↑, AMPK↑, EMT↓, TGF-β↓, mTOR↓, P70S6K↓, PKM2↓, Hif1a↓, ChemoSen↑,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, Nor, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1/CCL2↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
3536- MF,    Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
- Review, Arthritis, NA - Review, Stroke, NA
*Inflam↓, *Diff↑, *toxicity∅, *other↑, *SOX9↑, *COL2A1↑, *NO↓, *PGE2↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *angioG↑, *MSCs↑, *VEGF↑, *TGF-β↑, *angioG↝, *VEGF↓, Ca+2↝,
3478- MF,    One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study
- Trial, BC, NA - in-vitro, BC, MCF7 - in-vitro, Nor, C2C12
TumCP↓, TumCMig↓, TumCI↓, *toxicity∅, TGF-β↓, Twist↓, Slug↓, β-catenin/ZEB1↓, Vim↓, p‑SMAD2↓, p‑SMAD3↓, angioG↓, VEGF↓, selectivity↑, LIF↑,
3497- MFrot,  MF,    The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets
- Human, Nor, NA
*PDGFR-BB↑, *TGF-β↑, *IGF-1↑, *FGF↑, *angioG↑, *Inflam↓, *ROS↓,
201- MFrot,  MF,    Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-468
CCDC150↓, TGF-β↓, SMAD3↓,
1798- NarG,    Naringenin: A potential flavonoid phytochemical for cancer therapy
- Review, Var, NA
*Inflam↓, *antiOx↓, neuroP↑, hepatoP↑, AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, ROS↝, SOD↑, TGF-β↓, Treg lymp↓, IL1β↓, *BioAv↝, ChemoSen↑, cardioP↑,
2048- PB,    Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo
- in-vitro, OS, CAL27 - in-vitro, Oral, HSC3 - in-vitro, OS, SCC4 - in-vivo, NA, NA
*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, ChemoSen↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, Nor, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2/PTGS2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓, *antiAll↑,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1681- PBG,    Propolis: Its Role and Efficacy in Human Health and Diseases
- Review, Nor, NA
*Inflam↓, *AntiCan↑, *antiOx↑, *hyperG↓, *BG↓, *HbA1c↓, *NF-kB↓, *ROS↓, *TGF-β↑, *selectivity↑,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
103- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- vitro+vivo, BC, 4T1
ROS↑, MMP↓, Bcl-2↓, BAX↑, Casp9↑, T-Cell↑, TGF-β↓,
878- RES,    Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression
- vitro+vivo, CRC, LoVo
TumMeta↓, E-cadherin↑, Vim↓, TGF-β↓, SMAD2↓, EMT↓, SMAD3↓,
3619- RosA,    Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion
- Review, AD, NA
*BioAv↓, *BBB↝, *monoA↑, *TGF-β↓, *Aβ↓,
7381- RS,    In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
- in-vitro, BC, MCF7
AntiCan↑, Apoptosis↑, DNAdam↑, Bcl-2↓, TGF-β↓, Dose↝,
7378- RS,    Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling
- in-vitro, Oral, NA
*antiOx↑, *AntiBio↑, TGF-β↓, p‑SMAD3↓, p‑SMAD2↓, p‑SMAD4↓, SMAD3↓, Snail↓, ERCC1↓, ERCC4/XPF↓, Ku70/XRCC6↓, PCNA↓, cycD1/CCND1↓, Hif1a↓, IL6↓, Mcl-1↓, BAX↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, PARP↑, DNArepair↓, TumCP↓, TumCI↓,
4485- Se,    Selenium stimulates the antitumour immunity: Insights to future research
- Review, Var, NA
*antiOx↑, chemoPv↑, ROS↑, Imm↑, selenoP↑, *IL2↑, *IL4↑, *TNF-α↓, *TGF-β↓, *EMT↓, Risk↓, *GPx↑, *TrxR↑,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3294- SIL,    Silymarin: a review on paving the way towards promising pharmacological agent
- Review, Nor, NA - Review, Arthritis, NA
*hepatoP↑, *Inflam↓, *chemoP↑, *glucose↓, *antiOx↑, *ROS↓, *ACC↓, *FASN↓, *radioP↑, *NF-kB↓, *TGF-β↓, *AST↓, *α-SMA↝, *Synergy↑, *neuroP↑, Synergy↑, ROS↓,

Showing Research Papers: 51 to 100 of 115
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 115

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 4,   HO-2↓, 1,   lipid-P↓, 1,   MDA↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 2,   NRF2↝, 1,   ROS↓, 8,   ROS↑, 33,   ROS↝, 1,   selenoP↑, 1,   SOD↑, 2,   SOD2↓, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 2,   EGF↓, 2,   mtDam↑, 2,   OCR↓, 1,   PDH↝, 1,   PGC-1α↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   ALAT↓, 1,   AMPK↑, 4,   ATP↓, 5,   i-ATP↓, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↝, 1,   FASN↓, 2,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 4,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HK2↓, 1,   lactateProd↓, 5,   PDK1 / PDPK1?, 2,   PFK↓, 1,   PKM2↓, 5,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 30,   BAD↓, 2,   Bak↑, 2,   BAX↑, 18,   Bax:Bcl2↑, 4,   Bcl-2↓, 19,   Bcl-xL↓, 4,   Casp↓, 1,   Casp↑, 3,   Casp10↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 20,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 7,   Casp9↑, 17,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 14,   Diablo↑, 2,   DR5↑, 6,   FADD↑, 1,   Fas↑, 8,   FasL↑, 2,   Ferroptosis↑, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 5,   MDM2↓, 2,   Necroptosis↑, 1,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 2,   p38↑, 4,   p‑p38↓, 2,   PUMA↑, 1,   survivin↓, 8,   TNFR 1↑, 1,   TRAILR↑, 1,   XIAP↓, 7,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 26,   Akt↑, 3,   Akt↝, 1,   p‑Akt↓, 3,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   cSrc↓, 1,   EGFR↓, 11,   ERK↓, 7,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 4,   FGFR1↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   IKKα↓, 1,   p‑IKKα↓, 1,   IR↓, 1,   IκB↓, 1,   JAK↓, 3,   JAK↝, 1,   JAK1↓, 1,   JAK2↓, 4,   JNK↓, 1,   JNK↑, 5,   JNK↝, 1,   p‑JNK↓, 1,   MAPK↓, 10,   MAPK↑, 3,   MAPK↝, 1,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 16,   p‑mTOR↓, 1,   mTORC2↓, 1,   P70S6K↓, 1,   P90RSK↓, 1,   PAK↓, 1,   PI3K↓, 22,   PI3K↝, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 4,   PTEN↑, 6,   Raf↓, 1,   RAS↓, 2,   Sp1/3/4↓, 2,   Src↓, 2,   STAT3↓, 15,   p‑STAT3↓, 2,   i-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 1,   CBP↓, 1,   cJun↓, 1,   cMyc↓, 9,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 2,   FOXO3↑, 1,   FOXO4↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 3,   miR-124-3p↓, 1,   miR-145↑, 1,   miR-194↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-34a↑, 1,   Myc↓, 1,   NEAT1↓, 1,   OCT4↓, 3,   other↓, 3,   other↝, 1,   SOX2↓, 3,   SOX9?, 1,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 3,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   i-CRT↓, 1,   ER Stress↓, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 2,   IRE1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↓, 2,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 14,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   HR↓, 1,   Ku70/XRCC6↓, 1,   p16↑, 2,   P53↑, 11,   p‑P53↑, 1,   i-P53↓, 1,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 7,   PARP1↑, 1,   PCNA↓, 7,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 2,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 4,   CDK2↑, 2,   CDK4↓, 7,   CDK4/6↓, 1,   CDK6↓, 8,   CDK6↑, 2,   CDK8↓, 2,   p‑CHK1↑, 1,   p‑Chk2↑, 1,   CycB/CCNB1↓, 3,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 15,   cycE/CCNE↓, 5,   cycE1↓, 1,   Ki-67↓, 8,   MAD↓, 1,   P21↑, 7,   p27/CDKN1B↑, 2,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 30,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 1,   CSCs↓, 10,   FGF↓, 3,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 8,   Let-7↑, 1,   LRP6↓, 2,   p‑LRP6↓, 1,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 7,   NOTCH1↓, 7,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   STAT1↓, 1,   TumCG↓, 9,   TumCP↓, 25,   Wnt↓, 10,   Wnt/(β-catenin)↓, 3,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AP-1↓, 1,   ATPase↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 6,   Ca+2↝, 3,   CAFs/TAFs↓, 1,   CCDC150↓, 1,   CCN2/CTGF↓, 2,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 16,   EMT↓, 32,   EMT↑, 2,   FAK↓, 6,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 1,   Fibrosis↓, 1,   ITGB1↑, 1,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP1:TIMP1↑, 1,   MMP13↓, 1,   MMP2↓, 20,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 22,   MMPs↓, 5,   MUC4↓, 1,   N-cadherin↓, 6,   NCAM↑, 1,   NEDD9↓, 1,   PDGF↓, 3,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 7,   Smad1↓, 2,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 9,   p‑SMAD2↓, 9,   SMAD3↓, 15,   p‑SMAD3↓, 7,   SMAD4↓, 5,   p‑SMAD4↓, 2,   Snail?, 1,   Snail↓, 10,   STAC2↓, 1,   TGF-β↓, 76,   TGF-β↑, 6,   TGF-β↝, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TSP-1↑, 3,   TumCA↓, 1,   TumCI↓, 21,   TumCMig↓, 22,   TumMeta↓, 17,   Twist↓, 6,   uPA↓, 7,   uPAR↓, 1,   Vim?, 1,   Vim↓, 15,   Zeb1↓, 6,   ZEB2↓, 2,   α-SMA↓, 3,   β-catenin/ZEB1↓, 12,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 14,   NO↓, 2,   VEGF↓, 29,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   GLUT1↓, 3,   MMP↓, 16,   NHE1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD44↓, 1,   CD47↓, 1,   CD8+↑, 4,   COX1↓, 2,   COX2/PTGS2↓, 20,   CXCL12↓, 2,   CXCR4↓, 3,   DCells↑, 1,   DR4↑, 1,   i-HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 2,   IL1↓, 4,   IL10↓, 3,   IL12↓, 1,   IL12↑, 2,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 14,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 7,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 30,   NF-kB↑, 1,   NF-kB↝, 1,   NK cell↑, 1,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE2↓, 4,   PSA↓, 2,   RAGE↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 8,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER(estro)↓, 1,   FGF21↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 3,   ChemoSen↑, 28,   CompStab↓, 1,   CYP1A1↑, 1,   Dose↝, 7,   Dose∅, 1,   eff↑, 12,   eff⇅, 1,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 2,   P-gp/ABCB1↓, 4,   P450↓, 1,   RadioS↑, 11,   selectivity↑, 7,   Synergy↑, 23,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   AST↓, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 11,   EZH2↓, 2,   HER2/EBBR2↓, 6,   IL6↓, 14,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   PD-L1↓, 2,   PSA↓, 2,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   antiNeop↑, 1,   AntiTum↑, 2,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 491

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 20,   Catalase↑, 12,   GPx↓, 1,   GPx↑, 6,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 10,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 7,   hyperG↓, 1,   Keap1↓, 2,   lipid-P↓, 5,   MDA↓, 11,   MDA↑, 1,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 14,   Prx↑, 1,   ROS↓, 30,   SOD↑, 12,   SOD2↑, 1,   TOS↓, 1,   Trx1↑, 1,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   mtDam↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 4,   ATP↑, 2,   FASN↓, 1,   glucose↓, 1,   GSK‐3β↓, 1,   LDL↓, 3,   lipidLev↓, 1,   NH3↓, 1,   PKM2↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 3,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 5,   Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 3,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 4,   Akt↝, 1,   ERK↓, 1,   IκB↑, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 1,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   PDGFR-BB↑, 1,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↑, 1,   STAT3↓, 1,   STAT3↑, 1,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   cMyc↓, 1,   HDAC↓, 2,   other↑, 3,   other↝, 4,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 2,   FGF↑, 2,   IGF-1↑, 1,   MSCs↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   ARG1/2↑, 1,   Ca+2↑, 1,   Cartilage↑, 1,   COL1↓, 2,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   Fibronectin↓, 1,   LRP1↑, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP7↓, 1,   MMP9↓, 5,   MUC1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   TGF-β↓, 21,   TGF-β↑, 12,   TIMP1↓, 2,   TumCI↓, 1,   Vim↓, 1,   α-SMA↓, 6,   α-SMA↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 3,   angioG↝, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 3,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 2,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 2,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 2,   MUC19↓, 1,   MUC2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 8,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 8,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 12,   IL2↑, 1,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 17,   IL6↑, 1,   IL8↓, 4,   Imm↑, 2,   Inflam↓, 31,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↑, 1,   MIP2↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 16,   NLRP3↓, 3,   PGE2↓, 5,   PGE2↑, 1,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 15,   TNF-α↑, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   monoA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 5,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 8,   BioAv↝, 3,   BioEnh↑, 2,   ChemoSen↑, 1,   CYP2E1↓, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 4,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALB↑, 1,   AST↓, 8,   BG↓, 1,   BMD↑, 2,   creat↓, 1,   CRP↓, 2,   HbA1c↓, 1,   IL6↓, 17,   IL6↑, 1,   LDH↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 6,   AntiDiabetic↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 10,   chemoP↑, 2,   cognitive↑, 6,   diuretic↑, 1,   hepatoP↑, 13,   memory↑, 4,   neuroP↑, 15,   Obesity↓, 3,   Pain↓, 1,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 3,   Stroke↓, 1,   toxicity↓, 4,   toxicity↝, 2,   toxicity∅, 5,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   AntiViral↑, 3,   Bacteria↓, 5,   GutMicro↑, 6,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 260

Scientific Paper Hit Count for: TGF-β, transforming growth factor-beta
10 Curcumin
6 Magnetic Fields
6 Thymoquinone
5 Artemisinin
5 Ellagic acid
5 Quercetin
5 Emodin
4 Apigenin (mainly Parsley)
3 Baicalein
3 Radiotherapy/Radiation
3 EGCG (Epigallocatechin Gallate)
3 Garcinol
3 Propolis -bee glue
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
2 Allicin (mainly Garlic)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Piperine
2 HydroxyTyrosol
2 Magnolol
2 Magnetic Field Rotating
2 Rauwolfia serpentina/Indian Snakeroot
1 1,8-Cineole
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Andrographis
1 Isovitexin
1 Berbamine
1 Betulinic acid
1 Boron
1 Caffeine
1 Celecoxib
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 Date Fruit Extract
1 D-limonene
1 Gemcitabine (Gemzar)
1 Docetaxel
1 Tetrahydroxystilbene glucoside
1 Eurycomanone
1 Fisetin
1 Shilajit/Fulvic Acid
1 Cisplatin
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Gossypol/AT-101
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Isoliquiritigenin
1 isoorientin
1 Kaempferol
1 Lactoferrin/Talactoferrin
1 methotrexate
1 Luteolin
1 Bortezomib
1 Lycopene
1 Matrine
1 MCT oil
1 Metformin
1 Naringin
1 Phenylbutyrate
1 Rosmarinic acid
1 Selenium
1 Salvia miltiorrhiza
1 doxorubicin
1 Ursolic acid
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:304  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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