TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
5505- Ba,    Baicalein inhibits the progression of thyroid cancer by suppressing the TPL2/MEK2/ERK2 pathway
- in-vitro, Thyroid, NA
ERK↓, PI3K↓, Akt↓, Apoptosis↑, TumAuto↑, NF-kB↑, MEK↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, Synergy↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
1528- Ba,    Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma
- in-vitro, OS, CAL27
Apoptosis↑, ROS↑, eff↓, TumAuto↑, cl‑PARP↑, Bax:Bcl2↑, Beclin-1/ATG6↑, p62↓,
2608- Ba,    Baicalein sensitizes hepatocellular carcinoma cells to 5-FU and Epirubicin by activating apoptosis and ameliorating P-glycoprotein activity
- in-vitro, HCC, Bel-7402
Apoptosis↑, TumAuto↑, P-gp/ABCB1↓, Bcl-xL↓, ChemoSen↑,
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
1374- BBR,  PDT,    Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells
- in-vitro, RCC, 786-O - in-vitro, RCC, HK-2
ROS↑, TumAuto↑, Apoptosis↑, Casp3↑, eff↑,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,
5585- BetA,    Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response
- in-vitro, Cerv, HeLa - in-vitro, lymphoma, U937
mtDam↑, TumAuto↑,
2720- BetA,    Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo
- in-vitro, Cerv, HeLa
Keap1↝, ROS↑, Ca+2↑, Beclin-1/ATG6↓, GRP78/BiP↑, LC3II↑, p62↑, ERStress↑, TumAuto↑,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
5715- BF,    Bufalin for an innovative therapeutic approach against cancer
- Review, Var, NA
selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,
9165- BITC,    Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review
- Review, Var, NA
Ingr↝, Apoptosis↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, TumAuto↑,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1/ATG6↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
765- Bor,    High concentrations of boric acid induce autophagy in cancer cell lines
- in-vitro, Var, NA
p62↓, LC3II↑, TumAuto↑,
725- Bor,    Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway
- in-vitro, HCC, NA
tumCV↓, Apoptosis↑, TumAuto↑, p‑Akt↓,
9285- BR, BRJ,    Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells
- in-vitro, BC, MCF7
other↝, TumCP↓, tumCV↓, BAD↑, TRAILR↑, Fas↑, P53↑, MMP↓, TumAuto↑,
6545- BSB,    The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes
- in-vitro, Cerv, HeLa - in-vitro, AML, Jurkat
MPT↑, Casp↑, TumAuto↑, Apoptosis↑, TumCD↑, Dose↝, MMP↓, ROS↑, mtDam↑,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
5838- CAP,    Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway
- in-vitro, NPC, NA
TumCG↓, TumCCA↑, TumAuto↑, Casp3↑, Ca+2↑, ROS↑, MMP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, p62↓, Fap1↓, PI3K↓, DNAdam↑,
5856- CAP,    Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumAuto↑, angioG↓, TumCG↓, TumMeta↓, P-gp/ABCB1↝, ERK↝, NF-kB↝, STAT3↝, Synergy↑,
5851- CAP,    Capsaicin Potentiates Anticancer Drug Efficacy Through Autophagy-Mediated Ribophorin II Downregulation and Necroptosis in Oral Squamous Cell Carcinoma Cells
- in-vitro, Oral, NA
ChemoSen↑, TumAuto↑, ER Stress↑, P-gp/ABCB1↓,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
5953- Cela,  CUR,    The Combination of Celastrol and Curcumin Enhances the Antitumor Effect in Nasopharyngeal Carcinoma by Inducing Ferroptosis
- vitro+vivo, NPC, NA
eff↑, TumCP↓, GPx4↓, eff↑, TumAuto↑, Ferroptosis↑, Dose↝, ACSL4↑, toxicity↓,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓, CompStab?,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6653- Cen,    Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway
- in-vitro, Melanoma, KM3/BTZ
TumCG↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Casp↑, ROS↑, TumCMig↓, TumCI↓, STAT3↓,
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, Synergy↑, *toxicity↓,
7168- CHA,    The anticancer effect of chaetocin is enhanced by inhibition of autophagy
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HepG3 - in-vitro, Liver, HUH7
Apoptosis↓, TumAuto↑, ROS↑, Hif1a↓, SUV39H↓, cl‑PARP↑, eff↑, eff↑,
4479- Chit,    Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, HCC, SMMC-7721 cell
TumAuto↑, ROS↑, eff↓,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, Synergy↑, Synergy↑, *Synergy↑, RadioS↑, Synergy↑, ChemoSen↑, eff↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
1580- Citrate,    Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway
- in-vitro, Pca, PC3 - in-vivo, PC, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, WPMY-1
Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑, TumAuto↑, CaMKII ↓,
4772- CoQ10,    The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1/ATG6↑, TumAuto↑, ROS↑,
9273- CRAN,    Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation
- vitro+vivo, ESCC, NA
AntiCan↑, Casp↑, TumAuto↑, necrosis↑, PI3K↓, Akt↓, mTOR↓, BAX↑, Bcl-xL↑, Cyt‑c↑, PARP↑, TumCG↓, toxicity↓,
9272- CRAN,    Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
- Review, Var, NA
TumCD↑, Apoptosis↑, necrosis↑, TumAuto↑, TumCP↓, ROS↝, tumCV↓, lipid-P↓, TNF-α↓, IL6↓, ROS↓, TumCCA↑, ROS↑, H2O2↑, PI3K↓, Akt↓, mTOR↓, Ingr↝,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, Var, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1/ATG6↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
872- CUR,  RES,    New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
- in-vitro, BC, TUBO - in-vitro, BC, SALTO
TumCP↓, tumCV↓, p62↓, p62↑, TumAuto↑, TumAuto↓, ROS↑, ROS↓, CHOP/DDIT3↑,
471- CUR,    Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↑,
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
TumAuto↑, LC3II↑, Beclin-1/ATG6↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1 / PDPK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1/ATG6↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
404- CUR,    Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1/ATG6↑, LC3s↑, p62↓, Ferroptosis↑,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,
435- CUR,    Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549
Apoptosis↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, p‑mTOR↓,

Showing Research Papers: 51 to 100 of 320
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 320

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↓, 1,   Catalase↓, 4,   Catalase↑, 5,   DJ-1↓, 1,   Fenton↑, 3,   GPx↓, 1,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 14,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 2,   H2O2↑, 8,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 3,   Iron↑, 9,   i-Iron↓, 1,   i-Iron↑, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 7,   MDA↓, 2,   MDA↑, 5,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 4,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PrxII↓, 1,   ROS↓, 14,   ROS↑, 169,   ROS⇅, 2,   ROS↝, 2,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 4,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TKT↓, 1,   TrxR↓, 2,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 6,   FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   SFXN2↓, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 8,   compI↓, 4,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 27,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 5,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PDH↓, 2,   PDH↝, 1,   PINK1↑, 5,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AApath↓, 1,   ACC↓, 1,   ACC-α↓, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↑, 26,   p‑AMPK↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 26,   ATP↝, 1,   CRM↑, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   GAPDH↓, 1,   GLS↑, 1,   glucose↓, 2,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK1↓, 1,   HK2↓, 15,   HK2↑, 1,   HMG-CoA↓, 3,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 12,   lactateProd↑, 1,   LDHA↓, 4,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 10,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SCP2↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   SREBP1/SREBF1↓, 2,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 4,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 183,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 1,   BAX↓, 1,   BAX↑, 50,   Bax:Bcl2↑, 15,   Bcl-2↓, 57,   Bcl-2↑, 1,   Bcl-xL↓, 12,   Bcl-xL↑, 2,   BID↑, 2,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   BNIP3↝, 2,   Casp↑, 16,   cl‑Casp↑, 1,   Casp1↓, 2,   proCasp1↓, 1,   Casp12↑, 2,   Casp3↓, 2,   Casp3↑, 62,   cl‑Casp3↑, 29,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   proCasp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 7,   proCasp9↑, 1,   CellShr↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 41,   DR5↑, 9,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 20,   GRP58↓, 1,   IAP1↓, 4,   ICD↑, 2,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 5,   Necroptosis↑, 4,   necrosis↑, 8,   NOXA↑, 1,   oncosis↑, 2,   P2X7↓, 1,   p38↓, 4,   p38↑, 11,   p‑p38↑, 3,   Paraptosis↑, 2,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 20,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 18,   XIAP↓, 7,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 87,   Akt↑, 4,   p‑Akt↓, 21,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 3,   BCAP↓, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 2,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 13,   ERK↓, 17,   ERK↑, 3,   ERK↝, 2,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   GNAI1↓, 1,   HER2/EBBR2↓, 6,   Hippo↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 2,   JAK3↓, 1,   JNK↓, 3,   JNK↑, 18,   p‑JNK↑, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 14,   MAPK↑, 11,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   MEK↑, 1,   MKK4↓, 1,   mTOR↓, 75,   mTOR↑, 7,   mTOR∅, 1,   p‑mTOR↓, 13,   p‑mTOR↑, 1,   mTORC2↓, 2,   p‑p70S6↓, 2,   P70S6K↓, 6,   P70S6K↑, 1,   p‑P70S6K↓, 1,   p‑P70S6K↑, 1,   PDE3B↓, 1,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 64,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3k/Akt/mTOR↓, 2,   PIK3CA↑, 1,   p‑PIK3R1↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 3,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 5,   Rictor↓, 1,   RIP1↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   STAT↓, 2,   STAT3↓, 19,   STAT3↑, 3,   STAT3↝, 2,   p‑STAT3↓, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 7,   cJun↓, 1,   cJun↑, 2,   cMyc↓, 10,   cMyc↑, 2,   p‑cMyc↑, 1,   COMP↓, 1,   CREBBP↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↓, 1,   FOXO1↓, 1,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   FOXO4↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC∅, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 1,   HMTs↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-199↓, 1,   miR-200c↑, 1,   miR-21↓, 4,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-486↑, 1,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 2,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 4,   other↝, 17,   SOX2↓, 1,   SOX4↓, 2,   SUV39H↓, 1,   TFAP2A↓, 1,   TFE3↑, 2,   tumCV?, 1,   tumCV↓, 41,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 19,   CHOP/DDIT3↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 50,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 10,   HSP90↑, 1,   HSPs↑, 1,   IRE1↓, 1,   IRE1↑, 2,   p‑IRE1↑, 1,   PDI↑, 2,   PERK↑, 7,   Proteasome↓, 1,   UPR↑, 6,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1,   ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 5,   ATG5↑, 17,   ATG5↝, 1,   ATG7↑, 7,   autoF↓, 2,   autolysosome↑, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 49,   Beclin-1/ATG6↝, 1,   p‑Beclin-1/ATG6↑, 2,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   CTSZ↓, 1,   LAMP1?, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 14,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↓, 1,   LC3B-II↑, 11,   LC3I↓, 1,   LC3I↑, 2,   LC3II↑, 41,   LC3s↓, 1,   LC3s↑, 3,   LC3s↝, 1,   lysoM↓, 1,   LysoPr↑, 1,   lysosome↓, 3,   MitoP↑, 3,   p62↓, 28,   p62↑, 11,   PARK2↑, 4,   RUBCN↓, 1,   TFEB↑, 1,   TumAuto?, 1,   TumAuto↓, 16,   TumAuto↑, 299,   TumAuto⇅, 2,   TumAuto↝, 3,   mt-TumAuto↑, 2,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   DFF45↑, 1,   DNAdam↑, 31,   DNAdam⇅, 1,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 3,   P53↑, 45,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 10,   p‑PARP↑, 1,   cl‑PARP↑, 34,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 5,   RAD51↓, 1,   Telomerase↓, 4,   TP53↓, 1,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 6,   CDK2↑, 2,   CDK4↓, 6,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 4,   CDK6↑, 1,   CDK7↓, 1,   CDKN1C/p57↓, 1,   p‑CHK1↑, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 18,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 11,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 8,   RB1↑, 1,   TumCCA↓, 3,   TumCCA↑, 96,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 3,   ALDH↓, 2,   ALDH1A1↓, 1,   BMI1↓, 3,   BMP2↓, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CD24↓, 1,   cFos↓, 1,   cMYB↓, 1,   CSCs↓, 24,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 2,   EIF4E↓, 1,   Gli1↓, 2,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 3,   JAG1↓, 1,   p‑Jun↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LGR5↓, 1,   mTORC1↓, 9,   Nanog↓, 4,   NICD↓, 1,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 1,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 60,   TumCG↑, 1,   TumCG⇅, 1,   TumCP?, 1,   TumCP↓, 106,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 23,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AP-1↓, 2,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 19,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Chl↑, 1,   COL1↓, 2,   COL2A1↓, 1,   COL4A3↓, 1,   COL9A3↓, 1,   E-cadherin↑, 14,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 5,   FAK↑, 1,   Fibronectin↓, 1,   GLI2↓, 1,   GP1BB↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 2,   LAMA5↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 5,   MMP9↓, 34,   MMP9:TIMP1↓, 1,   MMPs↓, 7,   MTA1↓, 1,   N-cadherin↓, 7,   NCAM↑, 1,   PAK1↓, 3,   PAK1↑, 1,   RECK↑, 1,   Rho↓, 1,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   Smad1↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 9,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 6,   TGF-β↑, 2,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 4,   TSC1↑, 1,   TumCA↓, 2,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 49,   TumCMig↓, 42,   TumMeta↓, 37,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 6,   uPAR↓, 1,   Vim↓, 14,   Zeb1↓, 3,   ZEB2↓, 1,   α-SMA↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 19,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 50,   angioG↑, 2,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   NO↓, 2,   NO↑, 3,   TYMP/ECGF1↓, 1,   VCAM-1↓, 1,   VEGF↓, 30,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 72,   MMP↑, 1,   MPT↑, 5,   TRPM7↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 6,   CD59↑, 1,   COX2/PTGS2↓, 25,   COX2/PTGS2↑, 1,   CXCL6/GCP-2↓, 1,   CXCR4↓, 3,   DR4↑, 4,   FOXP3↑, 2,   Gal1↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   Igs↑, 1,   IL1↓, 4,   IL10↓, 3,   IL17↓, 1,   IL1β↓, 6,   IL1β↑, 1,   IL2↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 14,   Imm↝, 3,   Inflam↓, 20,   Inflam↝, 1,   IRAK1↓, 1,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 51,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 2,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 7,   PSA↓, 1,   RAGE↓, 2,   T-Cell↑, 1,   TCF↓, 1,   TCF↝, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 11,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   e-pH↑, 2,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 4,   CYP19↓, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 22,   BioAv↑, 19,   BioAv↝, 5,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 77,   CompStab?, 1,   CompStab↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 32,   Dose∅, 7,   eff↓, 46,   eff↑, 57,   eff↝, 5,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 3,   MDR1↓, 7,   P-gp/ABCB1↓, 12,   P-gp/ABCB1↝, 1,   P450↓, 1,   RadioS↑, 27,   selectivity↓, 1,   selectivity↑, 37,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 57,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 4,   AST↓, 2,   BRCA1↓, 1,   BRCA1↝, 1,   CA19-9↓, 1,   CEA↓, 1,   EGFR↓, 13,   EZH2↓, 2,   Ferritin↓, 6,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 4,   IL6↓, 13,   LDH↓, 8,   LDH↑, 2,   p‑LDH↓, 1,   Myc↓, 2,   PD-L1↓, 4,   PSA↓, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 33,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 4,   CardioT↑, 1,   chemoP↑, 11,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 1,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↑, 9,   OS∅, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 9,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 3,   TumVol↓, 21,   TumW↓, 13,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 896

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 27,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 7,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 3,   HO-1?, 1,   HO-1↑, 4,   i-Iron↓, 1,   lipid-P↓, 8,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 11,   ROS↓, 29,   ROS↑, 1,   SOD↑, 10,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   mtDam↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   glucose↓, 2,   glucose↝, 1,   H2S↑, 1,   LDL↓, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 2,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   HOTAIR↑, 1,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Cartilage↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 31,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NLRP3↓, 3,   NLRP3↑, 2,   PGE2↓, 2,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 4,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 5,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   Dose⇅, 2,   Dose↝, 10,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 1,   BP↓, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 9,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 8,   AntiTum↑, 4,   cardioP↑, 17,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 6,   cough?, 1,   hepatoP↑, 11,   memory↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 21,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   RenoP↑, 4,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 6,   Stroke↝, 1,   toxicity?, 1,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 11,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 6,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 178

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
7 Ivermectin
6 Magnetic Fields
6 Baicalein
6 Kaempferol
5 Celastrol
5 Eugenol
5 Spermidine
5 itraconazole
5 Licochalcone A
5 Luteolin
5 Matrine
5 Melatonin
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 hydroxychloroquine
4 Ginkgetin
4 Hyperoside
4 Juglone
4 Phenethyl isothiocyanate
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 Cynaropicrin
3 Dichloroacetate
3 diet Short Term Fasting
3 Fisetin
3 Hibiscus sabdariffa
3 Isoliquiritigenin
3 Sulforaphane (mainly Broccoli)
3 Isovitexin
3 Licorice
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Metformin
2 Ashwagandha(Withaferin A)
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Cranberry
2 Resveratrol
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 Formononetin
2 Paclitaxel/Taxol
2 Cisplatin
2 Gossypol/AT-101
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 isoquercitrin
2 Methyl Jasmonate
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Propolis -bee glue
2 Phycocyanin
2 Psoralidin
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Allyl isothiocyanate
1 Alpha-Lipoic-Acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chaetocin
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Ellagic acid
1 Bortezomib
1 Estrogen
1 Beta-Caryophyllene
1 5-fluorouracil
1 Evodiamine
1 Ferulic acid
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Gemcitabine (Gemzar)
1 Helleborus niger extracts – Christmas Rose
1 Isobavachalcone
1 isoorientin
1 Isothiocyanates
1 Vitexin
1 Magnolol
1 mebendazole
1 immunotherapy
1 Magnetic Field Rotating
1 Magnesium
1 Morin
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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