TumCMig Cancer Research Results

TumCMig, Tumor cell migration: Click to Expand ⟱
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Type:
Tumor cell migration is a critical process in cancer progression and metastasis, which is the spread of cancer cells from the primary tumor to distant sites in the body.
Scientific Papers found: Click to Expand⟱
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
4808- ASTX,    Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer
- in-vitro, Pca, DU145 - in-vivo, NA, NA
TumCP↓, STAT3↓, Apoptosis↑, TumCMig↓, TumCI↓,
4807- ASTX,    An overview of the anticancer activity of astaxanthin and the associated cellular and molecular mechanisms
- Review, Var, NA
*antiOx↑, *neuroP↑, AntiCan↑, TumCG↓, TumCD↑, TumCMig↓, ChemoSen↑, chemoP↑, *BioAv↓, TumCP↓, TumCCA↑, Apoptosis↑, BioAv↑,
147- ATG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF7
Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓, chemoPv↑, TumCP↓, TumCCA↑, TumCMig↓,
4980- ATV,    A review of effects of atorvastatin in cancer therapy
- Review, Var, NA
HMG-CoA↓, TumCP↓, TumCMig↓,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
1098- BA,    Baicalein inhibits fibronectin-induced epithelial–mesenchymal transition by decreasing activation and upregulation of calpain-2
- in-vitro, Nor, MCF10 - in-vivo, NA, NA
*TumCMig↓, *F-actin↓, *E-cadherin↑, *ZO-1↑, *N-cadherin↓, *Vim↓, *Snail↓, *cal2↓, *Ca+2↝,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, Synergy↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
2473- BA,    Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H460
EMT↓, PDK1 / PDPK1↓, Akt↓, TumCMig↓, E-cadherin↑, Vim↓,
2606- Ba,    Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
- Review, HCC, NA
ChemoSen↑, TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, MMPs↓, MAPK↓, TGF-β↓, ZFX↓, p‑MEK↓, ERK↓, MMP2↓, MMP9↓, uPA↓, TIMP1↓, TIMP2↓, NF-kB↓, p65↓, p‑IKKα↓, Fas↑, Casp2↑, Casp3↑, Casp8↑, Casp9↑, Bcl-xL↓, BAX↑, ER Stress↑, Ca+2↑, JNK↑, P53↑, ROS↑, H2O2↑, cMyc↓, CD24↓, 12LOX↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2289- Ba,  Rad,    Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A
- in-vitro, ESCC, KYSE150
TumCP↓, TumCMig↓, Glycolysis↓, cycD1/CCND1↓, CDK4↓, ECAR↓, TumCCA↑, HK1↓, ALDH↓, ALDOA↓, PKM2↓, Hif1a↓,
5536- BBM,    Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
- Review, Var, NA
JAK↝, STAT3↓, p‑CaMKII ↓, TGF-β↑, Smad1↑, ChemoSen↑, RadioS↑, TumCI↓, TumCMig↓, ROS↑, NRF2↓, SOD2↓, GPx1↓, HO-1↓,
5540- BBM,    Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways
- vitro+vivo, NSCLC, NA
TumCMig↓, TumCI↓, PI3K↓, Akt↓, MDM2↓, TumCP↓, TumMeta↓,
5555- BBM,    Berbamine inhibits cell proliferation and invasion by increasing FTO expression in renal cell carcinoma cells
- vitro+vivo, RCC, NA
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, toxicity↓, FTO↑,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
1392- BBR,    Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress
- in-vitro, GC, AGS - in-vitro, GC, MKN45
TumCG↓, TumCMig↓, ROS↑, MDA↑, SOD↓, NRF2↓, HO-1↓, Hif1a↓, EMT↓, Snail↓, Vim↓,
2700- BBR,    Cell-specific pattern of berberine pleiotropic effects on different human cell lines
- in-vitro, GBM, U343 - in-vitro, GBM, MIA PaCa-2 - in-vitro, Nor, HDFa
selectivity↑, TumCCA↑, Casp3↑, TumCI↓, TumCMig↓, N-cadherin?, DNMT1↑,
2702- BBR,    The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
TumCG↓, MAPK↓, FOXO3↑, TumCCA↑, TumCMig↓, TumCI↓, Sp1/3/4↓, PDK1 / PDPK1↓, DNMT1↓, Synergy↑,
2709- BBR,    Berberine inhibits the glycolysis and proliferation of hepatocellular carcinoma cells by down-regulating HIF-1α
- in-vitro, HCC, HepG2
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PKM2↓, LDHA↓,
2711- BBR,    Berberine inhibits the progression of breast cancer by regulating METTL3-mediated m6A modification of FGF7 mRNA
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, FGF↓, IGFBP3↑,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, necrosis↑, AQPs↓, PTEN↑, PI3K↓, Akt↓, p‑Akt↓, mTOR↓, p‑mTOR↓,
1102- BBR,    Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells
- in-vitro, Melanoma, B16-BL6
TumCMig↓, TumCI↓, EMT↓, p‑PI3K↓, p‑Akt↓, RARα↓, RARβ↑, RARγ↑, E-cadherin↑, N-cadherin↓,
5182- BBR,    Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9
- in-vitro, SCC, SCC4
TumCMig↓, TumCI↓, p‑JNK↝, p‑ERK↝, p‑p38↝, IKKα↝, NF-kB↝, MMP2↓, MMP9↓,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
5638- BCA,    Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway
- in-vitro, Oral, NA
tumCV↓, ROS↑, MMP↓, TumCMig↓, TAC↓, lipid-P↓, NF-kB↓, Apoptosis↑,
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, VEGF↓, TumVol↓, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, TumCP↓, TumCMig↓, TumCG↓, Dose↝,
6498- BCP,    β-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, 5637
tumCV↓, ROS↑, Apoptosis↑, MMP↓, TumCMig↓, STAT3↓, mTOR↓, Akt↓,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
2757- BetA,    Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways
- in-vitro, GBM, U251
tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1 / PDPK1↓, PDK1 / PDPK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
2741- BetA,    Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress
- in-vitro, GC, SNU16 - in-vitro, GC, NCI-N87 - in-vivo, NA, NA
TumCG↓, TumCMig↓, TumCI↓, N-cadherin↓, E-cadherin↑, EMT↓, Ki-67↓, MMP2↓,
2742- BetA,    Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, TumCMig↓, TumCI↓, STAT3↑, FAK↓, MMPs↓, MMP2↓, MMP9↓, TIMP2↑,
2756- BetA,    Betulinic acid inhibits growth of hepatoma cells through activating the NCOA4-mediated ferritinophagy pathway
- in-vitro, HCC, HUH7 - in-vitro, HCC, H1299
TumCP↓, ROS↑, antiOx↓, TumCG↓, TumCMig↓, NRF2↓, GPx4↓, HO-1↓, NCOA4↑, FTH1↓, Ferritin↑, Ferroptosis↑, GSH↓, MDA↓,
5515- BEV,    Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro.
- Review, Var, NA
VEGF↓, TumCP↓, tumCV↓, TumCMig↓,
5726- BF,    Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain
- Review, neuroblastoma, SK-N-BE
Apoptosis↑, TumCP↓, TumCMig↓, MMP↓, ROS↑, ETC↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, eff↓, TumCG↓, Ki-67↓, PCNA↓,
5715- BF,    Bufalin for an innovative therapeutic approach against cancer
- Review, Var, NA
selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,
5689- BJ,    Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway
- vitro+vivo, Oral, CAL27
TumCP↓, TumCMig↓, TumCI↓, SOD2↓, H2O2↓, OXPHOS↑, Glycolysis↓, ROS↑, RadioS↑, Hif1a↓, TumCG↓,
5481- BM,    Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies
- in-vitro, HCC, HepG2
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, lipid-P↓,
5477- BM,    The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis.
- in-vitro, Var, NA
AQPs↓, tumCV↓, Apoptosis↑, TumCMig↓,
5476- BM,    In Vitro Synergistic Inhibition of HT-29 Proliferation and 2H-11 and HUVEC Tubulogenesis by Bacopaside I and II Is Associated with Ca2+ Flux and Loss of Plasma Membrane Integrity
- vitro+vivo, CRC, HT29
TumCD↑, TumCMig↓, Ca+2↑,
5684- BML,    Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway
- in-vitro, Cerv, HeLa
ROS↑, Apoptosis↑, P53↑, TumCMig↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
702- Bor,  GEN,  SeMet,  Rad,    Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
- Analysis, Pca, NA
Risk↓, TumCMig↓, Bcl-2↓,
709- Bor,    Cellular changes in boric acid-treated DU-145 prostate cancer cells
- in-vitro, Pca, DU145
Cyc↓, MAPK↓, TumCMig↓, LAMP2↓, p‑ERK⇅, TumCM/A↑,
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,

Showing Research Papers: 51 to 100 of 603
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 603

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 3,   antiOx↑, 5,   ARE↓, 1,   Catalase↓, 3,   ENOX2↓, 1,   ENOX2↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 11,   GSH↓, 23,   GSH↑, 4,   i-GSH↓, 1,   GSR↓, 1,   GSTs↑, 1,   H2O2↓, 2,   H2O2↑, 4,   HO-1↓, 6,   HO-1↑, 5,   Iron↑, 6,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 4,   lipid-P↑, 9,   lipid-P↝, 1,   MDA?, 1,   MDA↓, 1,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 1,   NOX4↓, 1,   NRF2↓, 15,   NRF2↑, 10,   p‑NRF2↑, 1,   p66Shc↓, 1,   PYCR1↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 30,   ROS↑, 165,   ROS⇅, 1,   ROS↝, 3,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 4,   SOD↓, 8,   SOD1↓, 1,   SOD2↓, 3,   SOD2↑, 1,   TAC↓, 3,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 3,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 2,   IronCh↑, 1,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 3,   CDC25↓, 4,   compI↓, 2,   compIII↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 4,   HSP60/HSPD1↓, 1,   MFN2↓, 1,   mitResp↑, 1,   mtDam↑, 18,   OCR↓, 7,   OCR↑, 1,   OXPHOS↓, 3,   OXPHOS↑, 3,   PDH↑, 2,   PDH∅, 1,   PGC-1α↑, 1,   PINK1↑, 3,   SIRT3↓, 1,   SIRT3↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 1,   ACC↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 4,   ALDOA↓, 1,   AMPK↓, 1,   AMPK↑, 18,   AMPK↝, 1,   p‑AMPK↑, 6,   ATP↓, 17,   i-ATP↓, 1,   CAIX/CA9↓, 1,   citrate↓, 1,   ECAR↓, 6,   ENO1↓, 1,   FASN↓, 5,   FDG↓, 1,   G6PD↓, 2,   GALNT10↓, 1,   GAPDH↓, 2,   GlucoseCon↓, 10,   Glycolysis↓, 30,   Glycolysis↑, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   ac‑Histones↑, 1,   HK1↓, 2,   HK2↓, 14,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 13,   LDHA↓, 9,   LDHA∅, 1,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 1,   O-Glc↓, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 7,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 3,   PFK1↓, 1,   PGK1↓, 2,   PGM1↓, 1,   PIP3↑, 1,   PKM2↓, 19,   PKM2∅, 1,   Pyruv↓, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SREBP1/SREBF1↓, 5,   TCA↓, 1,   TumCM/A↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 5,   Apoptosis↓, 9,   Apoptosis↑, 256,   mt-Apoptosis↑, 2,   ASC↑, 1,   BAD↓, 1,   BAD↑, 6,   Bak↑, 5,   BAX↓, 1,   BAX↑, 87,   BAX⇅, 1,   Bax:Bcl2↑, 19,   Bcl-2↓, 101,   Bcl-xL↓, 11,   BID↑, 1,   BIM↑, 2,   BNIP3↑, 2,   Casp↓, 2,   Casp↑, 19,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   cl‑Casp1↑, 1,   Casp10∅, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 2,   Casp3↓, 1,   Casp3↑, 82,   cl‑Casp3↑, 31,   Casp7↑, 9,   cl‑Casp7↑, 1,   Casp8↑, 18,   Casp8∅, 1,   cl‑Casp8↑, 4,   proCasp8↑, 1,   Casp9↑, 41,   cl‑Casp9↑, 11,   cFLIP↓, 4,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 34,   mt-Cyt‑c↓, 1,   DR5↑, 8,   DR5∅, 1,   Endon↑, 1,   FADD↑, 1,   FADD∅, 1,   Fas↓, 2,   Fas↑, 9,   FasL↓, 1,   FasL↑, 1,   Ferroptosis↑, 19,   GRP58↓, 1,   GSDMD↑, 2,   IAP1↓, 5,   IAP2/BIRC3↓, 2,   iNOS↓, 8,   Mcl-1↓, 7,   Mcl-1↑, 1,   MDM2↓, 7,   MDM2↑, 1,   MOMP↓, 2,   MOMP↑, 2,   Necroptosis↑, 2,   necrosis↑, 3,   NOXA↑, 3,   p38↓, 5,   p38↑, 9,   p‑p38↓, 4,   p‑p38↑, 4,   p‑p38↝, 1,   PUMA↓, 1,   PUMA↑, 4,   Pyro↑, 2,   RIP1↓, 2,   RIP3↓, 1,   survivin↓, 27,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 11,   TumCD∅, 1,   XIAP↓, 14,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 117,   Akt↑, 3,   Akt↝, 1,   p‑Akt↓, 50,   AKT1↓, 3,   AKT3↓, 1,   AMPKα↓, 1,   p‑CaMKII ↓, 1,   CK2↓, 3,   cMET↓, 1,   p‑cMET↑, 2,   CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 27,   p‑EGFR↓, 2,   ERK↓, 35,   ERK↑, 7,   ERK↝, 2,   p‑ERK↓, 22,   p‑ERK↑, 1,   p‑ERK⇅, 1,   p‑ERK↝, 1,   ERK5↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 5,   HRAS↓, 1,   IGF-1R↓, 2,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 5,   IKKα↑, 1,   IKKα↝, 1,   p‑IKKα↓, 1,   IR↓, 2,   p‑IκB↓, 2,   p‑IκB↑, 1,   JAK↓, 5,   JAK↝, 1,   JAK2↓, 10,   p‑JAK2↓, 2,   JNK↓, 3,   JNK↑, 9,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   p‑JNK↝, 1,   LATS1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 19,   MAPK↑, 7,   MAPK↝, 1,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MEK↓, 4,   p‑MEK↓, 3,   Mst1↑, 1,   mTOR↓, 57,   mTOR↑, 4,   mTOR↝, 1,   p‑mTOR↓, 16,   mTORC2↓, 2,   mTORC2↑, 1,   NRAS↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 6,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PFKFB2↓, 1,   PI3K↓, 82,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 16,   PI3K/Akt↓, 5,   PI3k/Akt/mTOR↓, 1,   PKA↓, 3,   PKCδ↓, 5,   PKCδ↑, 1,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PTEN↑, 15,   PTK2B / PYK2↓, 1,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 7,   RAS↑, 1,   p‑S6K↓, 1,   SGK1↓, 1,   Sp1/3/4↓, 15,   Src↓, 4,   STAT↓, 2,   p‑STAT↓, 1,   STAT3↓, 51,   STAT3↑, 3,   p‑STAT3↓, 11,   p‑STAT3↑, 3,   i-STAT3↓, 1,   STAT5↓, 3,   STAT6↓, 2,   THEM4/CTMP↑, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF2↓, 2,   ATF3↑, 2,   ATF4↑, 6,   CBP↓, 1,   ChrMod↝, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 27,   DNMT1↓, 4,   DNMT1↑, 1,   DNMTs↓, 1,   EZH2↓, 3,   FOXM1↓, 7,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 5,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↓, 1,   H4↑, 1,   ac‑H4↓, 1,   HATs↓, 2,   HATs↑, 3,   HDAC↓, 11,   HDAC1↓, 5,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 2,   JHDM1D-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   Matr↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-130a↓, 2,   miR-139-5p↑, 2,   miR-143↑, 1,   miR-145↑, 1,   miR-148a↓, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-19b↓, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-206↑, 1,   miR-21↓, 5,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↑, 7,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-542↓, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 2,   Myc↑, 1,   NDRG1↑, 1,   NR1D2↓, 1,   OCT4↓, 10,   other↓, 2,   other↑, 3,   other↝, 11,   PAX2↓, 1,   SBF2-AS1↓, 1,   SOX2↓, 9,   SOX4↓, 2,   SUV39H↓, 1,   TCF-4↓, 1,   TFAP2A↓, 1,   TLE1↓, 1,   tumCV↓, 92,   tumCV↑, 1,   tumCV∅, 1,   YMcells↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 14,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 1,   ER Stress↑, 23,   Erlin1↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 9,   HTRA↓, 1,   IRE1↑, 2,   PDI↑, 1,   PERK↑, 8,   p‑PERK↑, 1,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 5,   LC3s↓, 1,   lysoMP↑, 2,   MitoP↑, 1,   p62↓, 3,   p62↑, 4,   p‑p62↑, 1,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 2,   TumAuto↑, 34,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 3,   ATR↑, 2,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA2↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 35,   DNArepair↓, 2,   ERCC1↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 3,   MGMT↓, 1,   NKX3.1↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 58,   P53↝, 2,   P53∅, 1,   p‑P53↑, 3,   ac‑P53↑, 1,   i-P53↓, 1,   p73↑, 1,   PARP↓, 3,   PARP↑, 7,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 36,   cl‑PARP1↑, 2,   PCNA↓, 21,   PCNA↑, 1,   RAD51↓, 1,   SIRT6↓, 1,   Telomerase↓, 6,   TOP1↓, 3,   TOP2↓, 1,   TOP2↑, 1,   TP53↑, 1,   XRCC1↓, 1,   γH2AX↑, 8,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 6,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 19,   CDK2↑, 2,   CDK4↓, 29,   CDK4↑, 3,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 9,   CDK6↑, 3,   CDK6∅, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 2,   p‑CHK1↑, 1,   Chk2↑, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   cycD1/CCND1↓, 56,   cycD1/CCND1↑, 2,   cycD1/CCND1∅, 1,   CycD3↓, 1,   cycE/CCNE↓, 15,   E2Fs↓, 1,   GADD45A↑, 3,   Ki-67↓, 24,   MKI67↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 37,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 12,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   RRM2↓, 1,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 6,   TumCCA↑, 159,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 7,   ALDH1A1↓, 1,   AXIN1↑, 1,   BMI1↓, 2,   BMPs↑, 2,   CD133↓, 10,   CD24↓, 3,   cFos↓, 5,   CSCs↓, 35,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 9,   GREM1↓, 1,   HH?, 1,   HH↓, 7,   IGF-1↓, 5,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 24,   Let-7↑, 2,   LRP6↓, 4,   p‑LRP6↓, 2,   MCM2↓, 1,   MSCmark↓, 1,   mTORC1↓, 4,   Nanog↓, 10,   Nestin↓, 3,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↝, 1,   NOTCH3↓, 2,   OGFr↑, 2,   p300↓, 2,   PCLAF↓, 1,   Piezo1↑, 1,   PTCH1↓, 3,   PTCH2↓, 1,   Shh↓, 5,   Smo↓, 5,   Sufu↓, 1,   TAZ↓, 2,   TOPflash↓, 1,   TumCG?, 2,   TumCG↓, 115,   TumCG↑, 5,   TumCP?, 2,   TumCP↓, 275,   TumCP↑, 4,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   WDR72↓, 1,   Wnt↓, 32,   Wnt/(β-catenin)↓, 6,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   AntiAg↑, 2,   AP-1↓, 3,   AP-1↝, 1,   CA↓, 1,   Ca+2↑, 24,   i-Ca+2↓, 1,   i-Ca+2↑, 1,   cal2↑, 1,   Cav1↓, 1,   CCAT1↓, 1,   CCN2/CTGF↓, 2,   Cofilin↓, 1,   p‑Cofilin↑, 2,   COL1A1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 8,   E-cadherin↑, 74,   EM↑, 1,   EMT↓, 128,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 4,   FAK↓, 16,   p‑FAK↓, 4,   Fibronectin↓, 4,   Galectin-9↓, 1,   GLI2↓, 2,   IQGAP3↓, 1,   ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 5,   ITGB3↓, 1,   ITGB4↓, 3,   ITGB6↓, 1,   KRAS↓, 2,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP14↓, 2,   MMP16↓, 1,   MMP17↓, 1,   MMP2?, 1,   MMP2↓, 110,   MMP2↝, 1,   MMP3↓, 9,   MMP7↓, 9,   MMP9?, 1,   MMP9↓, 121,   MMP9↑, 1,   MMP9↝, 1,   MMPs↓, 25,   MTA1↓, 2,   N-cadherin?, 1,   N-cadherin↓, 49,   N-cadherin↑, 2,   NCAM↓, 1,   NEDD9↓, 4,   PAI-1/SERPINE1↓, 1,   PAK1↓, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 2,   RHBDD1↓, 1,   Rho↓, 4,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 23,   Smad1↓, 3,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 3,   p‑SMAD2↓, 12,   SMAD3↓, 7,   p‑SMAD3↓, 10,   SMAD4↓, 2,   SMAD4↑, 1,   Snail↓, 38,   T-cadherin↑, 1,   TET1↑, 2,   TGF-β↓, 20,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 4,   THBS1↓, 1,   TIMP1↓, 3,   TIMP1↑, 9,   TIMP2↓, 3,   TIMP2↑, 7,   TIMP3↑, 2,   pol-TregCell↓, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 11,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 345,   TumCI↑, 4,   TumCMig?, 1,   TumCMig↓, 594,   TumCMig↑, 8,   TumCMig⇅, 1,   TumMeta↓, 65,   TumMeta↑, 3,   Twist↓, 16,   TXNIP↑, 1,   uPA↓, 18,   uPAR↓, 5,   Vim↓, 57,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 17,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 1,   α-tubulin↑, 2,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 57,   β-catenin/ZEB1↑, 3,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 77,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 3,   ECM/TCF↓, 1,   EGR1↓, 1,   EGR4↓, 1,   HIF-1↓, 5,   Hif1a↓, 46,   Hif1a↑, 2,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 2,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 72,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 3,   BBB↑, 2,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 7,   GLUT1∅, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3∅, 1,   MMP↓, 66,   MMP↑, 1,   MMP↝, 1,   MMP∅, 1,   MPT↑, 5,   NHE1↓, 1,   TRPM7↓, 2,   TRPM7↑, 1,   TRPV1↑, 3,   ZO-1↓, 1,   ZO-1↑, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD155↓, 1,   CD25+↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 11,   CD47↓, 1,   CD8+↑, 6,   COX1↓, 1,   COX2/PTGS2↓, 36,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL12↓, 1,   CXCR3↓, 1,   CXCR4↓, 9,   DR4↑, 3,   DR4∅, 1,   FOXP3↑, 1,   FoxP3+↓, 1,   Gal-3↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 4,   ICAM-1↓, 5,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 3,   IL10↓, 1,   IL17↓, 1,   IL18↓, 5,   IL1α↓, 1,   IL1β↓, 12,   IL2↓, 2,   IL4↓, 1,   IL6↓, 18,   IL6↑, 1,   IL8↓, 5,   Imm↑, 9,   Imm↝, 1,   Inflam↓, 25,   Inflam↝, 1,   IRAK1↓, 1,   IRAK4↓, 1,   LIF↑, 1,   LTA/TNF-β↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 100,   NF-kB↑, 4,   NF-kB↝, 2,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 2,   NLRP3↓, 8,   NLRP3↑, 2,   p65↓, 7,   p‑p65↓, 3,   PD-1↓, 2,   PD-L1↓, 8,   PD-L1↑, 3,   PD-L2↓, 1,   PGE2↓, 12,   PSA↓, 7,   T-Cell↑, 2,   TCF↓, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 18,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↓, 1,   pH↑, 1,   TAMS↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AhR↑, 1,   AhR↓, 2,   AR↓, 7,   AR↑, 1,   CYP19↓, 1,   ER-α36↓, 2,   ERβ/ESR2↑, 1,   Estro↝, 1,   NR3C2/MR↑, 2,   PPARα↝, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 19,   BioAv↑, 22,   BioAv↝, 5,   BioEnh?, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 101,   CompStab↓, 1,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 6,   Dose↑, 2,   Dose↝, 42,   Dose∅, 5,   eff↓, 26,   eff↑, 42,   eff↝, 7,   GSTP1/GSTπ↓, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 6,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 10,   P450↓, 2,   RadioS↑, 26,   selectivity?, 1,   selectivity↑, 71,   Synergy↑, 54,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALB↑, 1,   ALP↓, 2,   AR↓, 7,   AR↑, 1,   AST?, 1,   AST↓, 3,   B2M↓, 1,   BMD↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   DBIL↓, 1,   EGFR↓, 27,   p‑EGFR↓, 2,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 7,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 18,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 6,   LDH↑, 1,   Maspin↑, 1,   Myc↓, 2,   Myc↑, 1,   PD-L1↓, 8,   PD-L1↑, 3,   PSA↓, 7,   TBIL↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 39,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 23,   cachexia↓, 2,   cardioP↑, 3,   CardioT↓, 1,   chemoP?, 1,   chemoP↓, 1,   chemoP↑, 19,   chemoPv↑, 12,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↓, 1,   FTO↑, 1,   hepatoP↑, 5,   motorD↑, 1,   Mucositis↓, 1,   neuroP↑, 3,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↑, 15,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 3,   radioP↑, 9,   RenoP↑, 2,   Risk↓, 11,   Risk↑, 1,   Sleep↑, 1,   toxicity?, 1,   toxicity↓, 13,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 37,   TumVol↑, 1,   TumW↓, 15,   Weight∅, 2,   Wound Healing↓, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 1044

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 61,   Bil↓, 1,   Catalase↑, 19,   Fenton↓, 1,   GPx↑, 16,   GPx1↑, 3,   GPx4↑, 1,   GSH↑, 15,   GSR↑, 2,   GSTs↑, 7,   H2O2↓, 1,   HDL↓, 1,   HDL↑, 3,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 8,   hyperG↝, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 17,   MDA↓, 11,   MPO↓, 5,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 2,   NRF2↑, 20,   RNS↓, 4,   ROS?, 1,   ROS↓, 49,   ROS↑, 1,   SAM-e↑, 1,   SOD↑, 19,   SOD1↑, 6,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 3,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   HSP60/HSPD1↓, 1,   mitResp↓, 1,   OXPHOS↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 7,   ATP↑, 1,   ATP↝, 1,   glucose↓, 3,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   H2S↑, 1,   HK2↑, 1,   HMG-CoA↓, 1,   LDL↓, 5,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKM↑, 1,   PKM2↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Apoptosis↑, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 4,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 2,   DR5↑, 1,   Fas↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 11,   p38↓, 1,   RIP1↓, 1,   survivin↓, 1,   TNFR 1↑, 1,   TRAIL↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↓, 1,   p‑Akt↑, 1,   ERK↓, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↑, 1,   JAK2↑, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 5,   mTOR↓, 2,   mTOR↑, 2,   PI3K↓, 1,   PI3K↑, 4,   PTEN↑, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 1,   HOTAIR↑, 1,   other↓, 2,   other↑, 3,   other↝, 6,   tumCV↓, 1,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 2,   PCNA↓, 1,   Telomerase↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   Diff↝, 1,   neuroG↑, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   Ca+2↑, 1,   Ca+2↝, 2,   cal2↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   serineP↓, 1,   Snail↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   TumCI↓, 2,   TumCI∅, 1,   TumCMig↓, 4,   TumCMig↑, 1,   TumCMig∅, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 4,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 4,   GastroP↑, 2,   GLUT1↑, 1,   GLUT2↑, 1,   IBI↑, 3,   MMP↑, 1,   MUC5AC↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 13,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 4,   IL1↓, 1,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 13,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 16,   IL8↓, 1,   Imm↑, 6,   Inflam?, 1,   Inflam↓, 61,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 1,   NF-kB↓, 19,   NLRP3↓, 5,   PGE2↓, 5,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 5,   TNF-α↓, 20,   Treg lymp↝, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 1,   AChE↓, 6,   AChE↑, 1,   BChE↓, 2,   BDNF↑, 2,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   NGF↑, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 3,   p‑tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   testos↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 15,   BioAv↑, 23,   BioAv⇅, 1,   BioAv↝, 15,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 7,   eff↑, 7,   Half-Life↓, 3,   Half-Life↝, 4,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 2,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 3,   AST↓, 7,   Bil↓, 1,   BMD↑, 1,   BP↓, 4,   p‑BRCA1↑, 1,   BUN↓, 1,   Calcium↑, 1,   CEA↓, 1,   creat↓, 2,   hs-CRP↓, 1,   IL6↓, 16,   LDH↓, 5,   Mag↑, 1,   NOS2↓, 1,   RAGE↓, 1,   SpO2↑, 1,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 9,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 11,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 14,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 20,   chemoP↑, 2,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 8,   diuretic↑, 1,   hepatoP↑, 20,   Learn↑, 1,   memory↑, 10,   neuroP?, 1,   neuroP↑, 39,   Obesity↓, 5,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 5,   Risk↓, 1,   Stroke↓, 6,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 8,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 5,   Bacteria↓, 17,   GutMicro↑, 11,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 316

Scientific Paper Hit Count for: TumCMig, Tumor cell migration
21 Curcumin
15 Quercetin
15 Matrine
13 Honokiol
13 Shikonin
11 Berberine
11 Luteolin
11 Magnolol
10 Capsaicin
10 Fisetin
10 Magnetic Fields
9 Apigenin (mainly Parsley)
9 Resveratrol
9 EGCG (Epigallocatechin Gallate)
9 Dandelion Root
9 Silymarin (Milk Thistle) silibinin
8 Betulinic acid
8 Sulforaphane (mainly Broccoli)
7 Ashwagandha(Withaferin A)
7 Thymoquinone
7 Kaempferol
7 Licochalcone A
7 Melatonin
7 Urolithin
6 Propolis -bee glue
6 Chlorogenic acid
6 Metformin
6 Diindolylmethane
6 Ferulic acid
6 Piperlongumine
6 Rosmarinic acid
5 Silver-NanoParticles
5 Alpha-Lipoic-Acid
5 Artemisinin
5 Baicalein
5 Radiotherapy/Radiation
5 Carvacrol
5 Indole-3-carbinol
5 Emodin
5 Eugenol
5 Ginkgetin
5 Hyperoside
5 Licorice
5 Phenethyl isothiocyanate
5 Piperine
4 Astragalus
4 Gemcitabine (Gemzar)
4 Astaxanthin
4 Boron
4 Paclitaxel/Taxol
4 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
4 5-fluorouracil
4 Gallic acid
4 Ginkgolide B
4 Isoliquiritigenin
4 Ivermectin
4 Juglone
4 Cisplatin
4 Morin
4 Nimbolide
4 Pterostilbene
3 DTS(dibenzyl trisulphide) from Anamu
3 Berbamine
3 Bacopa monnieri
3 brusatol
3 Caffeic acid
3 Chrysin
3 Cinnamon
3 Crocetin
3 Copper and Cu NanoParticles
3 Cucurbitacin
3 CUSP9
3 Deguelin
3 Evodiamine
3 Formononetin
3 Fucoidan
3 Garcinol
3 Hydrogen Gas
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 Linalool
3 Lycopene
3 mebendazole
3 Methylsulfonylmethane
3 Marjoram (Origanum majorana)
3 salinomycin
3 Aflavin-3,3′-digallate
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Isovitexin
2 Aspirin
2 Arctigenin
2 Baicalin
2 Beta-Caryophyllene
2 Bufalin/Huachansu
2 Genistein (soy isoflavone)
2 Boswellia (frankincense)
2 Carnosic acid
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 chaetocin
2 Chlorophyllin
2 Docetaxel
2 Carvone
2 Disulfiram
2 Ellagic acid
2 Ginkgo biloba-EGb 761
2 Ginkgolic acids
2 Ginkgo biloba
2 Geraniol
2 Grapeseed extract
2 phytic acid, Inositol hexakisphosphate
2 isoflavones
2 isoorientin
2 isoquercitrin
2 itraconazole
2 doxorubicin
2 Plumbagin
2 low dose naltrexone
2 Lutein
2 Methyl Jasmonate
2 Magnetic Field Rotating
2 Magnesium
2 tamoxifen
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Psoralidin
2 Parthenolide
2 α-Santalol/Sandalwood oil
2 Ursolic acid
2 Vitamin C (Ascorbic Acid)
2 VitK3,menadione
1 3-bromopyruvate
1 Auranofin
1 Ajoene (compound of Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bevacizumab (brand Avastin)
1 Brucea javanica
1 Bromelain
1 selenomethionine
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cannabidiol
1 chitosan
1 Selenium NanoParticles
1 Hydroxycinnamic-acid
1 Citric Acid
1 Oxaliplatin
1 Electrical Pulses
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 diet Short Term Fasting
1 D-limonene
1 Mistletoe/Viscum album Extracts
1 Tetrahydroxystilbene glucoside
1 eicosapentaenoic acid
1 erastin
1 Eurycomanone
1 Shilajit/Fulvic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Proanthocyanidins
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 Lapachol
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Modified Citrus Pectin
1 Methyl salicylate / Sweet Birch oil
1 immunotherapy
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Myricetin
1 Naringin
1 Niclosamide (Niclocide)
1 Oroxylin A
1 Orlistat
1 Propyl gallate
1 temozolomide
1 raloxifen
1 Germacranolide sesquiterpene lactone
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 Sanguinarine
1 Sulfasalazine
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Usnic acid
1 Arsenic trioxide
1 Vitexin
1 Zinc
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:326  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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