β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱
Source: HalifaxProj (inactivate)
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β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.
Scientific Papers found: Click to Expand⟱
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, Synergy↑, *toxicity↓,
6040- CGA,    Protective effect of chlorogenic acid on cognitive impairment in rats with early Alzheimer's disease via Wnt signaling pathway
- in-vivo, AD, NA
*neuroP↑, *Dose↝, *GSK‐3β↓, *tau↓, *β-catenin/ZEB1↑, *Wnt↑, *memory↑, *cognitive↑, *NRF2↑, *ROS↓,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
6628- Cic,    The Prevention and Treatment of Colorectal Cancer by Traditional Plants
- Review, CRC, NA
tumCV↓, Telomerase↓, Casp9↑, cl‑PARP↑, TumCP↓, β-catenin/ZEB1↓,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑, CompStab↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *CompStab↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, Synergy↑,
6229- CUR,    Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells
- in-vitro, Cerv, NA
TumCI↓, TumCP↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1 / PDPK1↓, Beclin-1/ATG6↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6217- CUR,    Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PPARγ↑, Akt↓, *ROS↓, *Inflam↓, Bcl-2↓, GSK‐3β↑, NF-kB↓, COX2/PTGS2↓,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
420- CUR,    Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Vim↓, Fibronectin↓, β-catenin/ZEB1↓, E-cadherin↓, CD44↑, CD24↓, OCT4↓, Nanog↓, SOX2↓,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
455- CUR,    Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin
- in-vitro, GC, SGC-7901
Shh↓, Gli1↓, FOXM1↓, β-catenin/ZEB1↓, TumCMig↓, Apoptosis↑, TumCCA↑, Wnt↓, EMT↓, E-cadherin↑, Vim↓,
449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
TumCP↓, β-catenin/ZEB1↓, TCF↓, miR-21↓, NKD2↑, miR-130a↓,
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
DNMT1↓, DNMT3A↓, N-cadherin↓, Vim↓, Wnt↓, Snail↓, Twist↓, β-catenin/ZEB1↓, E-cadherin↑, EMT↓, CDX2↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
126- CUR,    Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
miR-34a↑, β-catenin/ZEB1↓, cMyc↓, P21↑, cycD1/CCND1↓, PCNA↓, TumCG↓,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, Synergy↑,
165- CUR,    Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, β-catenin/ZEB1↓, p‑Akt↓, GSK‐3β↓, p‑β-catenin/ZEB1↑, cycD1/CCND1↓, cMyc↓, chemoPv↑, TumCP↓,
4671- CUR,    Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy
- in-vitro, CRC, NA
CSCs↓, TumCG↓, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, Shh↓, NOTCH↓, DNMT1↓, STAT3↓, NF-kB↓, EGFR↓, IGFR↓, TumCCA↓, cl‑PARP↑, BAX↑, ECM/TCF↓,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-99↑, JAK↓, STAT↓, cycD1/CCND1↓, P21↑, ChemoSen↑, miR-192-5p↑, cMyc↓, Wnt↓, β-catenin/ZEB1↓, miR-130a↓,
3861- CUR,    Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?
- Review, Var, NA
*antiOx↑, *Inflam↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, NF-kB↓, HH↓, NOTCH↓, JAK↓, STAT3↓, ADAM10↓,
6248- Cyc,    The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
- in-vitro, CRC, NA
HH↓, Apoptosis↑, Slug↓, Snail↓, Twist↓, EMT↓, β-catenin/ZEB1↓, E-cadherin↑, TumCI↓,
6675- Deg,    Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway
- in-vitro, BC, MCF7 - in-vitro, BC, BT474 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, TNF-α↓, PI3K↓, Akt↓,
6703- DFC,    Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics.
- Analysis, Var, NA
*Inflam?, *COX1↓, *COX2/PTGS2↓, GLUT1↓, MCT4↓, LDHA↓, ABCG2↓, MDM2↓, MRP1/ABCC1↓, SOD2↓, Myc↓, β-catenin/ZEB1↓, VEGF↓, IKKα↓, cJun↓, E2Fs↓,
1183- DHA,    Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo
- in-vitro, BC, 4T1 - in-vitro, BC, MCF7 - in-vivo, BC, NA
TumCG↓, TumCCA↑, β-catenin/ZEB1↓, TCF↓, LEF1↓, cMyc↓, cycD1/CCND1↓, Wnt/(β-catenin)↓, TumMeta↓,
8852- DIM,    3,3'-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway
- in-vitro, ESCC, TE1 - in-vitro, ESCC, KYSE-30
AhR↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Vim↓, Slug↓, CLDN1↑, COX2/PTGS2↓, PGE2↓, ROCK1↓, ROCK1↓, EMT↓,
6729- Dipy,    Dipyridamole prevents triple-negative breast-cancer progression
- Trial, BC, MDA-MB-231
TumCG↓, TumMeta↑, β-catenin/ZEB1↓, *AntiAg↑, TumCCA↑, Wnt↓, NF-kB↓,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Ingr↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
6611- Ech,    Proliferative activity of a blend of Echinacea angustifolia and Echinacea purpurea root extracts in human vein epithelial, HeLa, and QBC-939 cell lines, but not in Beas-2b cell lines
- in-vitro, Cerv, HeLa - in-vitro, Nor, BEAS-2B - in-vitro, Nor, HUVECs
Imm↑, TumCP↑, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓,
6606- Ech,  Cic,    Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓, eff↑,
3243- EGCG,    (−)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway
- in-vitro, CRC, NA
CD133↓, CSCs↓, TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
21- EGCG,    Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice
- in-vivo, Liver, NA
HH↓, PTCH1↓, Smo↓, Gli1↓, CD44↓, β-catenin/ZEB1↓,
1012- EGCG,    Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations
- in-vitro, Nor, HEK293
*H2O2↑, *β-catenin/ZEB1↓, *TCF-4↓,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, Lung, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2/PTGS2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,
688- EGCG,  GEM,    Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine
- in-vitro, PC, NA
Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,
4682- EGCG,    Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate
- Review, Var, NA
CSCs↓, EMT↓, ChemoSen↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, TumCP↓, Apoptosis↑, p‑GSK‐3β↓, GSK‐3β↑, β-catenin/ZEB1↓, cMyc↓, XIAP↓, Bcl-2↓, survivin↓, Vim↓, Slug↓, Snail↓,
4683- EGCG,    Epigallocatechin-3-gallate inhibits self-renewal ability of lung cancer stem-like cells through inhibition of CLOCK
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vivo, Lung, A549
CSCs↓, CD133↓, CLOCK↓, Wnt↓, β-catenin/ZEB1↓, CD44↓, SOX2↓, Nanog↓, OCT4↓,
2992- EGCG,    Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity
- Review, Var, NA
AP-1↓, Sp1/3/4↓, NF-kB↓, ERK↓, P-gp/ABCB1↓, HSP27↓, β-catenin/ZEB1↓, MMPs↓, TNF-α↓, IL1β↓, MMP2↓,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓, *antiAll↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,

Showing Research Papers: 51 to 100 of 255
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 255

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 2,   Catalase↑, 1,   ENOX2↓, 1,   GPx↓, 1,   GPx↑, 4,   GPx4↓, 6,   GPx4↝, 1,   GSH↓, 13,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 9,   HO-2↑, 1,   Iron↑, 2,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 6,   lipid-P↑, 5,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 5,   NRF2↑, 9,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 13,   ROS↑, 73,   ROS⇅, 4,   ROS↝, 2,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 4,   SOD2↓, 2,   TAC?, 1,   TrxR↓, 3,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 3,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 3,   mtDam↑, 5,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 2,   ALAT↝, 1,   AMACR↓, 1,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 19,   ATP↓, 4,   CAIX/CA9↓, 1,   ECAR↓, 1,   FAO↓, 1,   FASN↓, 4,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   Glycolysis↓, 15,   GSK‐3β↓, 16,   GSK‐3β↑, 9,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 9,   HK1↓, 1,   HK2↓, 8,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   lipoGen↓, 1,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PKM2:PKM1↓, 2,   SCD1↓, 1,   SIRT1↓, 7,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 85,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASK1↑, 2,   aSmase↝, 1,   BAD↑, 2,   Bak↑, 4,   BAX↓, 2,   BAX↑, 37,   BAX↝, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 44,   Bcl-2↑, 4,   Bcl-2↝, 1,   Bcl-xL↓, 6,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   BIM↓, 1,   BIM↑, 5,   Casp↓, 1,   Casp↑, 15,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 48,   Casp3↝, 1,   cl‑Casp3↑, 13,   proCasp3↓, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 30,   cl‑Casp9↑, 5,   cFLIP↓, 3,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 33,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 17,   FADD↑, 1,   Fas↓, 1,   Fas↑, 11,   FasL↑, 2,   Ferroptosis↑, 9,   HEY1↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 2,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   MDM2↓, 4,   p‑MDM2↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 10,   p‑p38↑, 2,   PUMA↑, 1,   PUMA⇅, 1,   Pyro↑, 1,   survivin↓, 32,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 5,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↝, 1,   p‑Akt↓, 17,   AKT1↓, 1,   AMPKα↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   CREB↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   EphB4↓, 1,   ERK↓, 25,   ERK↑, 5,   p‑ERK↓, 7,   FGFR1↓, 1,   FLT4↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 7,   JAK↓, 6,   JAK1↓, 3,   JAK2↓, 4,   JNK↓, 4,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 9,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   Mst1↑, 1,   mTOR↓, 51,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   NRAS↓, 1,   p‑p42↓, 1,   p‑p42↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 3,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 62,   PI3K↝, 1,   p‑PI3K↓, 3,   PIAS-3↑, 1,   PKCδ↓, 4,   PKCδ↑, 1,   PP2A↑, 2,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 13,   PTEN↝, 1,   Raf↓, 3,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 6,   Sp1/3/4↓, 8,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 49,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 6,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 41,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 4,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO4↑, 1,   H3↓, 1,   H3↑, 2,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 1,   miR-200c↑, 2,   miR-205↑, 1,   miR-21↓, 6,   miR-210↓, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-224↓, 2,   miR-29b↓, 1,   miR-340↓, 2,   miR-34a↑, 5,   miR-384↑, 1,   miR-422a↑, 2,   miR-592↑, 1,   miR-99↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 9,   other↓, 2,   other↑, 2,   other↝, 3,   PCAF↓, 1,   Shc↓, 1,   SOX2↓, 7,   SOX4↓, 3,   SOX4↑, 1,   SPP1↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 20,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 23,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 10,   LC3s↓, 1,   p62↓, 3,   p62↑, 2,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 17,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 1,   DNAdam↑, 19,   DNArepair↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 3,   p16↑, 2,   P53?, 1,   P53↓, 3,   P53↑, 31,   P53↝, 1,   ac‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 26,   proPARP↓, 1,   PARP1↓, 1,   PARP1↑, 2,   PCNA↓, 12,   PCNA↑, 1,   SIRT6↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 19,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 2,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 58,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   E2Fs↓, 4,   Ki-67↓, 11,   MAD↓, 1,   P21?, 1,   P21↑, 28,   P21↝, 1,   p27/CDKN1B↑, 10,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   Securin↓, 2,   TAp63α↑, 1,   TumCCA↓, 3,   TumCCA↑, 75,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↓, 1,   AXIN1↑, 2,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 14,   CD24↓, 3,   CD34↓, 1,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 6,   cFos↑, 1,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 49,   CSCs↑, 1,   Diff↑, 3,   EP2↓, 1,   EP4/PTGER4↓, 1,   FBXW7↝, 1,   Gli↓, 2,   Gli1↓, 9,   HH↓, 10,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 11,   Let-7↑, 2,   LRP6↓, 6,   p‑LRP6↓, 2,   mTORC1↓, 5,   Nanog↓, 9,   Nestin↓, 3,   NKD2↑, 2,   NOTCH↓, 17,   NOTCH⇅, 1,   NOTCH1↓, 8,   NOTCH1↝, 1,   NOTCH2↓, 2,   NOTCH3↓, 3,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 8,   Smo↓, 5,   STAT1↓, 1,   p‑STAT1↓, 1,   TOPflash↓, 2,   TumCG↓, 40,   TumCP?, 1,   TumCP↓, 76,   TumCP↑, 1,   Wnt↓, 122,   Wnt↑, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 12,   AP-1↝, 2,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 10,   Ca+2↝, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Chl↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 43,   EMT↓, 69,   F-actin↓, 1,   FAK↓, 7,   p‑FAK↓, 1,   fascin↓, 2,   Fibronectin↓, 3,   GLI2↓, 3,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB4↓, 1,   KRAS↓, 1,   LEF1↓, 5,   MALAT1↓, 4,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP14↓, 1,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 44,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 48,   MMPs↓, 18,   N-cadherin↓, 28,   N-cadherin↑, 1,   NCAM↓, 1,   NM23↑, 1,   p‑p44↓, 1,   p‑p44↑, 1,   p‑pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 3,   SMAD3↓, 2,   p‑SMAD3↓, 2,   Snail↓, 36,   TET1↑, 2,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 55,   TumCMig↓, 57,   TumCMig↑, 1,   TumMeta↓, 39,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 47,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 15,   ZEB2↑, 1,   β-catenin/ZEB1↓, 234,   β-catenin/ZEB1↑, 6,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 35,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   ECM/TCF↓, 1,   HIF-1↓, 1,   Hif1a↓, 25,   Hif1a↝, 1,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 47,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 1,   BBB∅, 1,   CLDN1↓, 5,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   GLUT1↓, 8,   MMP↓, 35,   MPT↑, 3,   NHE1↓, 1,   ZO-1↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 19,   CD44↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 46,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 12,   DR4↑, 6,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 3,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 6,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↝, 1,   IL8↓, 3,   Imm↑, 10,   Imm↝, 1,   Inflam↓, 16,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   NF-kB?, 2,   NF-kB↓, 79,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PGE2↓, 14,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   TCF↓, 10,   TCF↑, 1,   TCF7/TCF1↓, 2,   TNF-α↓, 11,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 10,   AR↝, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 14,   BioAv↑, 13,   BioAv↝, 6,   BioEnh?, 1,   BioEnh↑, 3,   ChemoSen↑, 75,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↑, 3,   Dose↝, 17,   Dose∅, 4,   eff↓, 9,   eff↑, 27,   eff↝, 5,   GSTA1↑, 1,   Half-Life↓, 6,   Half-Life↝, 2,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P450↓, 2,   P450↝, 1,   RadioS↑, 26,   selectivity↑, 26,   selectivity↝, 1,   Synergy↑, 42,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALB↑, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 10,   AR↝, 1,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 2,   DBIL↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HEC1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 19,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   Myc↓, 3,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 4,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   TBIL↓, 1,   TP53↑, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 22,   antiD↑, 1,   antiNeop↑, 3,   AntiTum↑, 7,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 13,   chemoPv↑, 14,   ChemoSideEff↓, 4,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 3,   IMPDH1↓, 1,   IMPDH2↓, 1,   Mucositis↓, 1,   neuroP↑, 3,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 7,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 8,   Sleep↑, 1,   Symptoms∅, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 7,   TumVol∅, 1,   TumW↓, 5,   TumW∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 869

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 28,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 6,   GPx4↑, 2,   GSH↑, 7,   GSTs↑, 4,   H2O2↑, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 10,   i-Iron↓, 1,   lipid-P↓, 7,   MDA↓, 7,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↑, 18,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 30,   ROS↑, 2,   mt-ROS↓, 1,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   GSK‐3β↓, 5,   LDL↓, 1,   NADPH↓, 1,   SIRT1↑, 1,   SIRT1↝, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 2,   Ferroptosis↓, 2,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 4,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PI3K↑, 2,   PKCδ↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   miR-34b-5p↓, 1,   other↝, 1,   RUNX2↑, 1,   TCF-4↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↑, 1,   Diff↑, 2,   FGF↑, 1,   Ki-67↑, 1,   TumCP↓, 1,   Wnt↓, 2,   Wnt↑, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   E-cadherin↑, 1,   EMT↓, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 3,   MUC1↑, 1,   OPN↑, 1,   Smad1↑, 1,   Smad7↑, 1,   STAC2↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 10,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 5,   GLUT4↓, 1,   IBI↑, 1,   MMP↑, 1,   MUC19↓, 1,   MUC2↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 4,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 34,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 10,   p‑NF-kB↓, 1,   NLRP3↓, 2,   PGE2↓, 3,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 6,   BDNF↑, 6,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 2,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 9,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 7,   eff↑, 4,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   ALP↑, 1,   AST↓, 4,   BMD↑, 3,   CRP↓, 1,   IL6↓, 7,   IRes↑, 1,   LDH↓, 1,   LDH↑, 1,   OCN↑, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 7,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 4,   chemoP↑, 1,   chemoPv↑, 5,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 12,   Learn↑, 1,   memory↑, 11,   motorD↑, 1,   neuroP↑, 23,   Obesity↓, 2,   OS↑, 1,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 3,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity↓, 13,   toxicity∅, 2,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 4,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 264

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1
21 Curcumin
11 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Matrine
9 Resveratrol
7 Apigenin (mainly Parsley)
7 Fisetin
7 Honokiol
6 Luteolin
6 Sulforaphane (mainly Broccoli)
6 salinomycin
5 Astragalus
5 Berberine
5 Ivermectin
5 Lycopene
5 Magnetic Fields
4 Ashwagandha(Withaferin A)
4 Garcinol
4 isoquercitrin
4 Kaempferol
4 Thymoquinone
3 Allicin (mainly Garlic)
3 Boswellia (frankincense)
3 5-fluorouracil
3 Ginkgetin
3 HydroxyTyrosol
3 phytic acid, Inositol hexakisphosphate
3 Naringin
3 Nimbolide
3 Piperine
2 Cisplatin
2 Isovitexin
2 Artemisinin
2 Baicalein
2 Caffeic acid
2 Propolis -bee glue
2 Capsaicin
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Ursolic acid
2 Dandelion Root
2 Echinacea
2 Hydrogen Gas
2 Indole-3-carbinol
2 isoorientin
2 itraconazole
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Magnolol
2 Melatonin
2 Morin
2 Niclosamide (Niclocide)
2 Piperlongumine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Chemotherapy
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Bromelain
1 Boron
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Gemcitabine (Gemzar)
1 Emodin
1 Ferulic acid
1 flavonoids
1 Fucoidan
1 Grapeseed extract
1 Isobavachalcone
1 Inositol
1 Isoliquiritigenin
1 Vitexin
1 lambertianic acid
1 methylseleninic acid
1 Magnetic Field Rotating
1 Zeolite
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 L-Theanine
1 Orlistat
1 isoflavones
1 Rutin
1 buckwheat sprouts
1 Shikonin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Urolithin
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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