Bax:Bcl2 Cancer Research Results

Bax:Bcl2, Bax:Bcl2 ratio: Click to Expand ⟱
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Bax and Bcl-2 are the major members of Bcl-2 family that play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction.
Bax/Bcl-2 ratio is typically significantly lower in tumors.
Scientific Papers found: Click to Expand⟱
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1/ATG6↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2/PTGS2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
6291- Cro,    Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
- vitro+vivo, PC, MIA PaCa-2 - vitro+vivo, PC, Bxpc-3 - vitro+vivo, PC, Capan1 - vitro+vivo, PC, AsPC-1
TumCG↓, EGFR↓, Apoptosis↑, Bax:Bcl2↑, TumCP↓, TumCCA↑, Dose↝,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
7410- CS,    Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
- in-vitro, BC, MDA-MB-231
selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,
6176- Cu,    Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells
- in-vitro, Liver, HepG2
ROS↑, P53↑, MMP↓, Bax:Bcl2↑, Apoptosis↑, *Bacteria↓, MDA↑, GSH↓, eff↓, Casp3↑,
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,
1981- CUR,    Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
- in-vitro, Lung, NA
eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6707- DFC,    Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines
- in-vitro, Melanoma, NA
TumCP↓, ROS↑, Bax:Bcl2↑, Casp3↑, SOD2↑, Cyt‑c↑,
6271- DL,    D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- in-vitro, Colon, SW480 - in-vitro, Colon, HT-29
TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,
6274- DL,    Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *Bax:Bcl2↑, *p‑p38↓,
6328- DRE,    Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells
- in-vitro, BC, 4T1
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1/ATG6↑, ATG7↑, Bcl-2↓, NO↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
7219- EGb 761,    Ginkgo biloba Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells
- in-vitro, Nor, SK-N-BE
*MMP↑, *Bax:Bcl2↓, *cl‑PARP↓, *i-antiOx↑, *mt-Apoptosis↓, *neuroP↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
1321- EMD,    Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model
- in-vitro, CRC, LS1034 - in-vivo, NA, NA
tumCV↓, TumCCA↑, ROS↑, Ca+2↑, MMP↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Bax:Bcl2↑,
1318- EMD,    Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species
- in-vitro, Nor, HL7702
*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,
1328- EMD,    Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
- in-vitro, Tong, SCC4
TumCCA↑, P21↑, Chk2↑, CycB/CCNB1↓, cDC2↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Casp3↑, ROS↑, MMP↓, Bax:Bcl2↑, ER Stress↑,
1329- EMD,    Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
- in-vitro, Tong, SCC4
TumCCA↑, eff↓, P53↑, P21↑, p27/CDKN1B↑, cycA1/CCNA1↓, cycE/CCNE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,
1330- EMD,    Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway
- in-vitro, Var, NA
tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
6855- FBZ,    Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study
- vitro+vivo, Ovarian, A2780S - vitro+vivo, Ovarian, SKOV3
TumCP↓, Apoptosis↑, TumCG↓, cl‑Casp3↑, Bax:Bcl2↑, CDK1↓,
6917- FIS,    Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *Dose↝, *Aβ↓, *ASK1↓, *p‑JNK↓, *P53↓, *Cyt‑c↓, *Casp9↓, *Bax:Bcl2↝,
6986- Form,    Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway
- in-vitro, Var, NA
other↝, AntiCan↑, VEGF↓, Apoptosis↑, Bax:Bcl2↑, cl‑Casp3↑, cl‑Casp9↑, Cyt‑c↑, Hif1a↓, MEK↓, ERK↓, VEGFR2/KDR/Flk1↓, angioG↓,
6970- Form,    Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells
- in-vitro, Ovarian, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, Bax:Bcl2↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑ERK↓,
6963- Form,    Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
eff↝, TumCP↓, TumCP∅, MAPK↑, Bax:Bcl2↑, Apoptosis↑,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5149- GamB,    Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells
- in-vitro, lymphoma, JeKo-1
TumCG↓, Apoptosis↑, selectivity↑, MMP↓, Casp3↑, Casp9↑, Casp8↑, Bax:Bcl2↑,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
821- GAR,    Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
- in-vitro, Liver, Hep3B
ROS↑, CHOP/DDIT3↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,
830- GAR,    Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
- in-vitro, CRC, HT-29
TumCI↓, TumCMig↓, Apoptosis↑, p‑FAK↓, Src↓, MAPK↓, ERK↓, PI3K/Akt↓, Bax:Bcl2↑, Cyt‑c↑, MMP7↓,
7233- GAs,    Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis
- in-vitro, Laryn, HEp2
TumCG↓, selectivity↑, Casp3↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, TumCP↓,
7226- GBE,    Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways
- vitro+vivo, Lung, NA
TumCP↓, selectivity↑, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Fas↑, FasL↑, Dose↝, TumCG↓,
7252- Gink,    STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells
- in-vitro, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, SV-HUC-1
tumCV↓, selectivity↑, TumCMig↓, EMT↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, STEAP3↓, Bax:Bcl2↑, cl‑Casp3↑,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, Var, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
1649- HCAs,    Anticancer Properties of Hydroxycinnamic Acids -A Review
- Review, Var, NA
*antiOx↑, MMP2↓, MMP9↓, VEGF↓, TGF-β↓, Bax:Bcl2↑, TumCCA↑, COX2/PTGS2↓, NF-kB↓,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, AD, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
7556- HYP,    Hyperoside induces apoptosis and inhibits growth in pancreatic cancer via Bcl-2 family and NF-κB signaling pathway both in vitro and in vivo
- vitro+vivo, PC, NA
TumCP↓, Apoptosis↑, Bax:Bcl2↑, NF-kB↓, TumCG↓,

Showing Research Papers: 51 to 100 of 169
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 169

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 2,   GPx1↓, 1,   GSH↓, 9,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   GSSG↑, 1,   HO-1↓, 3,   HO-1↑, 2,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 1,   lipid-P↑, 2,   MDA↑, 3,   NRF2↓, 4,   NRF2↑, 4,   NRF2⇅, 1,   p‑NRF2↑, 1,   OSI↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 11,   ROS↑, 68,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   TBARS↑, 1,   TOS↑, 1,   Trx2↓, 1,   TrxR↓, 1,   TrxR1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   CDC25↑, 1,   HSP60/HSPD1↓, 1,   mitResp↓, 1,   mtDam↑, 8,   OCR↓, 1,   mt-OXPHOS↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 1,   AMPK↑, 6,   ATP↓, 5,   CAIX/CA9↓, 1,   CholSyn↓, 1,   ECAR↝, 1,   FASN↓, 2,   GlucoseCon↓, 4,   Glycolysis↓, 8,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 5,   HK2↓, 4,   lactateProd↓, 1,   LDHA↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PKM2↓, 2,   PKM2↑, 1,   PPP↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 93,   mt-Apoptosis↑, 4,   BAD↓, 2,   BAD↑, 1,   BAX↑, 21,   Bax:Bcl2↓, 2,   Bax:Bcl2↑, 149,   Bcl-2↓, 25,   Bcl-xL↓, 8,   Casp↑, 12,   Casp12?, 1,   Casp12↑, 3,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 67,   cl‑Casp3↑, 16,   proCasp3↓, 1,   Casp6↑, 1,   Casp7↑, 5,   cl‑Casp7↑, 2,   Casp8↑, 12,   Casp8∅, 2,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 45,   cl‑Casp9↑, 9,   proCasp9↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 47,   Diablo↑, 2,   DR5↑, 4,   FADD↑, 1,   Fap1↓, 1,   Fas?, 1,   Fas↓, 1,   Fas↑, 5,   FasL↑, 2,   Ferroptosis↑, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 3,   Mcl-1?, 1,   Mcl-1↓, 1,   MDM2↓, 4,   MDM2↑, 1,   MLKL↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 5,   p‑p38↑, 2,   PUMA↑, 2,   Pyro↑, 1,   p‑RIP3↑, 1,   survivin↓, 16,   TRAIL↑, 2,   TumCD↑, 3,   XIAP↓, 8,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 36,   Akt↑, 2,   p‑Akt↓, 17,   AMPKα↓, 1,   CIP2A↓, 1,   CK2↓, 4,   p‑cMET↑, 1,   CREB2↓, 1,   EGFR↓, 12,   ERK↓, 11,   ERK↑, 6,   p‑ERK↓, 6,   p‑ERK↑, 1,   p‑ERK⇅, 1,   e-ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 5,   IKKα↓, 1,   IκB↓, 1,   JAK↓, 1,   JAK2↓, 2,   JAK3↓, 1,   JNK↑, 4,   p‑JNK↓, 3,   LIMK1↓, 1,   MAPK↓, 5,   MAPK↑, 4,   MEK↓, 4,   MKK4↓, 1,   mTOR↓, 11,   p‑mTOR↓, 6,   p70S6↓, 1,   P70S6K↓, 1,   PI3K↓, 23,   p‑PI3K↓, 2,   PI3K/Akt↓, 3,   PKCδ↓, 2,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PTEN↑, 5,   p‑PTEN↓, 1,   Raf↓, 2,   RAS↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 1,   Src↓, 1,   STAT3↓, 17,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   ChrMod↝, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 15,   DNMTs↓, 1,   FOXM1↓, 1,   FOXO3↓, 1,   FOXO3↑, 3,   FOXO4↑, 2,   HATs↓, 2,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HES1↓, 1,   miR-148a↓, 1,   miR-19b↓, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 2,   other↑, 1,   other↝, 3,   PCAF↓, 1,   SOX2↓, 3,   SOX4↓, 1,   tumCV?, 1,   tumCV↓, 25,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 1,   ER Stress↑, 8,   ERStress↑, 1,   HSP90↓, 2,   HSPs↓, 1,   HTRA↓, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 7,   LC3s↑, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 3,   p62↑, 5,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↑, 15,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 22,   mt-DNAdam↑, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 29,   P53∅, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 3,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 37,   cl‑PARP1↑, 2,   PCNA↓, 6,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP2↓, 1,   TP53↑, 1,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 11,   CDK4↓, 14,   CDK4↑, 1,   CDK6↓, 5,   CDK6↑, 1,   CDK8↓, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 30,   CycD3↓, 1,   cycE/CCNE↓, 8,   Ki-67↓, 10,   mitA↑, 1,   p19↑, 1,   P21↓, 1,   P21↑, 35,   p27/CDKN1B↑, 15,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA?, 2,   TumCCA↓, 2,   TumCCA↑, 67,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   BMP2↓, 1,   CD133↓, 3,   cFos↓, 2,   cMYB↓, 1,   CSCs↓, 13,   Diff↓, 1,   Diff↑, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 3,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   p‑Jun↓, 1,   Ki-67↓, 10,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NOTCH↓, 4,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH2↓, 1,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   TumCG?, 1,   TumCG↓, 32,   TumCP↓, 41,   TumCP↑, 1,   TumCP∅, 1,   Wnt↓, 3,   Wnt↑, 1,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   APC↑, 1,   Ca+2↑, 10,   Ca+2↝, 1,   i-Ca+2?, 1,   cal2↑, 2,   Cav1↓, 1,   COL1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 8,   EMT↓, 17,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   p‑FAK↑, 1,   Fibronectin↓, 1,   ITGB4↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP16↓, 1,   MMP2↓, 21,   MMP3↓, 3,   MMP7↓, 2,   MMP9↓, 24,   MMPs↓, 5,   MUC4↓, 1,   N-cadherin↓, 3,   NCAM↓, 1,   SMAD3↓, 2,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 14,   TumCMig↓, 19,   TumCMig↑, 1,   TumMeta↓, 11,   Twist↓, 2,   uPA↓, 2,   Vim↓, 3,   β-catenin/ZEB1↓, 13,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   angioG↑, 1,   Endoglin↑, 1,   HIF-1↓, 2,   Hif1a↓, 13,   NO↓, 1,   NO↑, 1,   VEGF↓, 26,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   CellMemb↑, 1,   CLDN1↑, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT4↓, 2,   IBI↑, 1,   MMP?, 1,   MMP↓, 55,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TJ↑, 1,   TRPV1↑, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 6,   CD59↑, 1,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   DR4↑, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↑, 1,   IL1β↓, 5,   IL2↓, 1,   IL2↑, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 2,   IL8↑, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 7,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 42,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   p65↓, 1,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 7,   PSA↓, 2,   TNF-α↓, 9,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   COMT↓, 2,   ER-α36↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   PPARα↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 9,   BioAv↝, 2,   BioEnh↑, 3,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↑, 34,   CompStab↓, 1,   CompStab↑, 1,   CYP1A1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   Dose∅, 5,   eff↓, 23,   eff↑, 24,   eff↝, 6,   eff∅, 2,   Half-Life↓, 3,   Half-Life↝, 1,   MDR1↓, 4,   MDR1↑, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   RadioS↑, 13,   selectivity↑, 29,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 2,   AR↓, 5,   AST↓, 1,   EGFR↓, 12,   ERα/ESR1↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 4,   IL6↓, 7,   LDH↓, 3,   LDH↑, 1,   LDH↝, 1,   Myc↓, 1,   PD-L1↓, 3,   PSA↓, 2,   TP53↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13,   antiNeop↑, 3,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 9,   ChemoSideEff↓, 4,   hepatoP↑, 4,   memory↑, 1,   OS↑, 2,   Pain↓, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 2,   TumVol↓, 6,   TumVol↑, 1,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 536

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   i-antiOx↑, 1,   Catalase↑, 5,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 3,   GPx4↑, 1,   GSH↑, 6,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 3,   H2O2↑, 1,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↝, 1,   lipid-P↓, 5,   MDA↓, 11,   NOX↓, 1,   NQO1↑, 1,   NQO1↝, 1,   NRF2↑, 11,   p‑NRF2↑, 1,   ROS↓, 23,   ROS↑, 2,   SOD↑, 11,   TAC↑, 1,   Trx1↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   ATP↑, 2,   glucose↓, 1,   GSK‐3β↓, 3,   p‑GSK‐3β↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↓, 1,   PLA2↓, 1,   SCFAs↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   mt-Apoptosis↓, 1,   ASK1↓, 1,   BAX↓, 1,   Bax:Bcl2↓, 14,   Bax:Bcl2↑, 3,   Bax:Bcl2↝, 1,   Bcl-2↑, 3,   Casp↓, 1,   Casp3↓, 4,   Casp3↑, 2,   Casp3∅, 1,   cl‑Casp3↓, 5,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 2,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   Fas↑, 2,   Ferroptosis↓, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 4,   Akt2↓, 1,   CREB↑, 1,   ERK↓, 2,   IKKα↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 4,   PKCδ↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,   P53↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   LAMs↑, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   MMP↓, 2,   MMP↑, 3,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,   TRPC1↓, 1,   ZO-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 4,   IL33↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 17,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   NeuroI↓, 1,   NF-kB↓, 9,   NK cell↑, 1,   NLRP3↓, 2,   p65↓, 1,   PGE2↓, 1,   RAGE↓, 1,   TLR4↓, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   PSD95↑, 3,   SYP↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 6,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 5,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 3,   Half-Life↓, 1,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   BP↝, 1,   CRP↓, 2,   hs-CRP↓, 1,   IL6↓, 7,   LDH↓, 3,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 3,   AntiArt↑, 3,   AntiCan↑, 2,   AntiDiabetic↑, 7,   antiPs↑, 1,   cardioP↑, 9,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 6,   hepatoP↑, 9,   Learn↑, 1,   memory↑, 5,   motorD↑, 1,   Mucositis↓, 1,   neuroP↑, 15,   Obesity↓, 1,   radioP↑, 3,   RenoP↑, 7,   Stroke↓, 1,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 2,   GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 4,  
Total Targets: 215

Scientific Paper Hit Count for: Bax:Bcl2, Bax:Bcl2 ratio
9 Thymoquinone
7 Apigenin (mainly Parsley)
6 Baicalein
6 Berberine
6 Emodin
6 Lycopene
6 Sulforaphane (mainly Broccoli)
5 Quercetin
4 Isoliquiritigenin
4 Luteolin
3 Cisplatin
3 EGCG (Epigallocatechin Gallate)
3 Curcumin
3 Caffeic acid
3 Carvacrol
3 Crocetin
3 Ellagic acid
3 Formononetin
3 Garcinol
3 iodine
3 isoorientin
3 Ivermectin
3 Melatonin
2 Silver-NanoParticles
2 Arctigenin
2 Docetaxel
2 Berbamine
2 Beta-Caryophyllene
2 Propolis -bee glue
2 Chlorogenic acid
2 Coenzyme Q10
2 D-limonene
2 Dandelion Root
2 Gambogic Acid
2 Graviola
2 HydroxyTyrosol
2 Licochalcone A
2 Magnolol
2 Myricetin
2 Phycocyanin
1 2-DeoxyGlucose
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Paclitaxel/Taxol
1 Betulinic acid
1 borneol
1 Boswellia (frankincense)
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Diclofenac
1 Radiotherapy/Radiation
1 Ginkgo biloba-EGb 761
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Flaxseed/Linseed
1 Fucoidan
1 Gallic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginkgetin
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 Indole-3-carbinol
1 isoquercitrin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Juglone
1 Kaempferol
1 Matrine
1 Magnetic Fields
1 Morin
1 Naringin
1 Nimbolide
1 Plumbagin
1 Rosmarinic acid
1 salinomycin
1 Terpinen-4-ol / Tea Tree Oil
1 doxorubicin
1 Thymol-Thymus vulgaris
1 Vitamin D3
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:352  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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