Snail Cancer Research Results

Snail, SNAI1, Snail Family Transcriptional Repressor 1: Click to Expand ⟱
Source:
Type:
Scientific Papers found: Click to Expand⟱
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, Synergy↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, Var, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
7243- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathwa
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, *toxicity↓,
7254- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, tumCV↓, Dose↝, N-cadherin↓, Vim↓, EMT↓,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
2880- HNK,    Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vivo, NA, NA
tumCV↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, TumMeta↓, p‑eIF2α↑,
2882- HNK,    Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling
- in-vitro, PC, PANC1
TumCI↓, TumCMig↓, p‑SMAD2↓, p‑SMAD3↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, Snail↓, Slug↓, Rho↓, ROCK1↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2884- HNK,    Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP
- in-vitro, Lung, A549 - in-vitro, Lung, H460
EMT↓, cFLIP↓, N-cadherin↓, Snail↓, p‑SMAD2↓, p‑SMAD3↓, IKKα↑, TumCMig↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
7711- IBC,    Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo
- vitro+vivo, BC, NA
SIRT2↓, Dose↝, Snail↓, MMPs↓, STAT3↓, cMyc↓, ROS↑,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
9253- ISO, IH,    Progress in the antitumor molecular mechanisms of Isorhamnetin
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiTum↑, TumCP↓, Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, ChemoSen↑, PI3K↓, Akt↓, TumCCA↑, MAPK↓, TumCG↓, CDK2↑, PPARγ↑, PTEN↓, CAIX/CA9↓, Casp8↑, Casp9↑, Casp3↑, ROS↑, ER Stress↑, UPR↑, BAX↑, Cyt‑c↑, cl‑PARP↑, Bcl-2↓, MMP↓, N-cadherin↓, Vim↓, Snail↓, E-cadherin↑, EMT↓, MMP2↓, MMP9↓,
9177- ITCs,  SFN,    Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
- Review, Var, NA
CSCs↓, GutMicro↑, Bacteria↓, TumCCA↑, Apoptosis↑, TumAuto↑, angioG↓, TumCI↓, TumMeta↓, NRF2↑, Glycolysis↓, Wnt↓, β-catenin/ZEB1↓, HH↓, NOTCH↓, NK cell↑, EMT↓, angioG↓, BioAv↓, BioAv↑, AntiBio↑, Bacteria↓, HK2↓, PDH↓, OXPHOS↓, AKT1↓, ACC1↓, FASN↓, ACC-α↓, ACLY↓, SREBP1/SREBF1↓, OCT4↓, Nanog↓, YAP/TEAD↓, miR-21↓, miR-29b↓, ALDH1A1↓, miR-140↑, CD44↓, BMI1↓, miR-200c↑, TumCG↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, α-SMA↓, Slug↓, Snail↓, Twist↓, DNAdam⇅, BioAv↓, ChemoSen↑,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
1121- JG,    Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3β/Snail signaling pathway
- in-vitro, Pca, LNCaP
E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, GSK‐3β↑,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
9004- L-THE,    L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail
- vitro+vivo, Pca, PC3 - in-vitro, Pca, DU145
TumCI↓, TumCMig↓, EMT↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, E-cadherin↑, ERK↓, NF-kB↓, TumMeta↓, Dose↝, Dose↝,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
4535- MAG,  5-FU,    Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
- in-vitro, Cerv, NA
ChemoSen↑, TumCP↓, vinculin↓, TumCA↓, TumCMig↓, TumCI↓, p‑Akt↓, p‑PI3K↓, mTOR↓, E-cadherin↑, β-catenin/ZEB1↑, Snail↓, Slug↓,
8530- Matr,    Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCI↓, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, EMT↓, PIP3↑, PTEN↑, p‑Akt↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8628- MBZ,    Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, p‑JAK2↓, p‑STAT3↓, eff↓, TumCG?, Bcl-xL↓, EMT↓, Snail↓, Twist↓,
2378- MET,    Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway
- in-vitro, SCC, CAL27 - in-vivo, NA, NA
TumCP↓, TumCMig↓, TumCI↓, EMT↓, mTOR↓, Hif1a↓, PKM2↓, STAT3↓, E-cadherin↑, Vim↓, Snail↓, STAT3↓,
8662- MLT,    Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis
- vitro+vivo, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, HNSCC, UM-SCC-1
Glycolysis↓, ENO1↓, ROS↑, TumCP↓, TumMeta↓, TumCCA↑, Casp3↑, BIM↑, Bcl-2↓, γH2AX↑, EMT↓, N-cadherin↓, MMP9↓, Snail↓, Akt↓, eff↓, TumVol↓, PPARγ↓,
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,
1129- NarG,    Naringenin Attenuated Prostate Cancer Invasion via Reversal of Epithelial-to-Mesenchymal Transition and Inhibited uPA Activity
- in-vitro, Pca, PC3
E-cadherin↓, Vim↓, Snail↓, Twist↓, EMT↓, uPA↓,
9049- PatchO,    Inhibitory effects of patchouli alcohol on hepatocellular carcinoma growth through accumulation of oxidative stress and inactivation of androgen receptor signaling
- vitro+vivo, HCC, HepG2 - in-vivo, Liver, HUH7
ROS?, MMP↓, DNAdam↑, TumCCA↑, Apoptosis↑, P53↑, P21↑, Fas↑, FasL↑, Casp8↑, BAX↑, Casp9↑, ChemoSen↑, AR↓, TumCP↓, selectivity↑, eff↓, Snail↓, Twist↓, ICAM-1↓, VCAM-1↓, MMP9↓, EMT↓, toxicity↓, chemoP↑,
4926- PEITC,    PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT
- in-vitro, CRC, SW48
TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, Synergy↑, E-cadherin↑, N-cadherin↓, Vim↓,
5211- PI,    Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition
- in-vitro, CRC, NA
TumCMig↓, TumCI↓, EMT↓, Snail↓, STAT3↓,
1258- PI,    Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
- in-vivo, CRC, NA
COX2/PTGS2↓, IL6↓, EMT↓, β-catenin/ZEB1↓, Snail↓, Symptoms∅,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
9115- PRO,    Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
- Trial, BC, NA
Dose↝, Snail↓, Slug↓, NF-kB↓, ADRB2↓, TumMeta↓,
1236- PTS,    Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumMeta↓, EMT↓, E-cadherin↑, Zeb1↓, Snail↓, β-catenin/ZEB1↓, CD44↓, MMPs↓, CSCs↓,
4699- PTS,    Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vivo, BC, MDA-MB-231
TumCMig↓, TumCI↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, Zeb1↑, miR-205↑, Src↓, TumCG↓, FAK↓, EMT↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
65- QC,    Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB
- in-vitro, BC, NA
HSP27↓, EMT↓, NF-kB↓, Snail↓, Vim↓, E-cadherin↑, CSCs↓,

Showing Research Papers: 51 to 100 of 129
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 129

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 7,   GSH↑, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   Iron↑, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 6,   NRF2↑, 6,   p‑NRF2↓, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 42,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 4,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC25↓, 3,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 2,   mtDam↑, 5,   OCR↓, 3,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 2,   ALAT↓, 2,   ALAT↝, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 8,   GSK‐3β↓, 8,   GSK‐3β↑, 3,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 5,   lactateProd↓, 2,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 3,   PFK↓, 1,   PFK1↓, 1,   PFK2↓, 1,   PIP3↑, 1,   PKM2↓, 3,   SIRT1↓, 3,   SIRT1↑, 2,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis↓, 1,   Apoptosis↑, 39,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 2,   BAX↑, 22,   Bax:Bcl2↑, 1,   Bcl-2↓, 32,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 2,   BIM↑, 6,   BNIP3↑, 1,   Casp↑, 2,   Casp1↓, 1,   Casp10↑, 1,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 37,   Casp3∅, 1,   cl‑Casp3↑, 6,   Casp6↑, 1,   Casp7↑, 9,   Casp8↑, 14,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 24,   cl‑Casp9↑, 3,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 24,   Diablo↑, 5,   DR5↑, 8,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↑, 1,   HEY1↓, 2,   iNOS↓, 6,   Mcl-1↓, 12,   MDM2↓, 3,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 4,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 22,   TNFR 1↑, 2,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 7,   XIAP↓, 16,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 40,   Akt↑, 1,   p‑Akt↓, 18,   AKT1↓, 2,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   EGFR↓, 14,   EGFR↑, 1,   p‑EGFR↓, 2,   ERK↓, 9,   p‑ERK↓, 7,   ERK5↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 5,   IKKα↑, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 3,   MEK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 34,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 8,   RAS↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 20,   p‑STAT3↓, 7,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 2,   p‑ATF4↝, 1,   cJun↓, 2,   cMyc↓, 14,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-126↑, 1,   miR-127-5p↑, 2,   miR-139-5p↑, 1,   miR-140↑, 1,   miR-182-5p↓, 1,   miR-200c↑, 1,   miR-205↑, 1,   miR-21↓, 2,   miR-29b↓, 1,   miR-339-5p↝, 1,   miR-375↑, 1,   miR-592↑, 1,   Myc↓, 4,   OCT4↓, 12,   other↓, 2,   other↑, 1,   other↝, 1,   SOX2↓, 6,   SOX4↓, 1,   SOX9↓, 1,   tumCV↓, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 10,   p‑CHOP/DDIT3↝, 1,   eIF2α↓, 1,   p‑eIF2α↑, 4,   p‑eIF2α↝, 1,   ER Stress↑, 9,   Erlin1↑, 1,   GRP78/BiP↑, 3,   HSP27↓, 3,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 2,   PDI↑, 1,   PERK↑, 2,   p‑PERK↝, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 4,   PARK2↑, 2,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 2,   DNAdam↓, 1,   DNAdam↑, 10,   DNAdam⇅, 1,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↑, 17,   p‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↑, 9,   cl‑PARP↑, 15,   PARP1↑, 1,   PCNA↓, 9,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 2,   UHRF1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1/2/5/9↓, 1,   CDK2↓, 15,   CDK2↑, 2,   CDK4↓, 11,   CDK4/6↓, 1,   CDK6↓, 9,   CDK8↓, 2,   CHK1↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 5,   E2Fs↓, 2,   Ki-67↓, 6,   MAD↓, 1,   P21↑, 15,   p27/CDKN1B↑, 6,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 27,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 2,   CD133↓, 4,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 3,   cFos↑, 1,   CSCs↓, 24,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 9,   HH↓, 9,   IGF-1↓, 2,   JAG1↓, 1,   Ki-67↓, 6,   LRP6↓, 3,   p‑LRP6↓, 2,   Nanog↓, 10,   NOTCH↓, 10,   NOTCH1↓, 7,   NOTCH1↑, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 2,   PTCH2↓, 1,   Shh↓, 8,   Smo↓, 6,   TumCG?, 1,   TumCG↓, 18,   TumCP↓, 33,   TumCP↑, 2,   Wnt↓, 20,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 3,   AXL↓, 2,   Ca+2↑, 10,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   Cdc42↓, 1,   CDH1↑, 2,   Cofilin↓, 1,   COL1↓, 3,   COL1A1↓, 3,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 12,   E-cadherin↑, 68,   EM↑, 1,   EMT↓, 84,   EpCAM↓, 1,   FAK↓, 4,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 8,   Fibronectin↑, 1,   GLI2↓, 5,   ITGA5↓, 1,   ITGA5↑, 3,   ITGB1↓, 2,   ITGB1↑, 3,   ITGB3↓, 1,   LAMA5↑, 3,   LEF1↓, 3,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP2↓, 45,   MMP2↝, 1,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 45,   MMP9↝, 1,   MMPs↓, 9,   N-cadherin↓, 50,   N-cadherin↑, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 3,   Sharpin↓, 2,   Slug?, 1,   Slug↓, 42,   Smad1↓, 3,   SMAD2↓, 3,   p‑SMAD2↓, 4,   SMAD3↓, 5,   p‑SMAD3↓, 3,   p‑SMAD4↓, 1,   Snail?, 2,   Snail↓, 119,   Snail↑, 6,   TET1↑, 1,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 48,   TumCI↑, 1,   TumCMig↓, 42,   TumMeta↓, 31,   Twist↓, 27,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 8,   Vim?, 1,   Vim↓, 71,   Vim↑, 3,   vinculin↓, 1,   Zeb1↓, 25,   Zeb1↑, 4,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 35,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   NO↓, 1,   NO↝, 1,   VCAM-1↓, 3,   VEGF↓, 27,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   GLUT1↓, 2,   MMP↓, 27,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TRPV1↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 10,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 4,   IL2↑, 2,   IL4↓, 1,   IL6↓, 17,   IL8↓, 4,   Imm↑, 2,   Inflam↓, 7,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 33,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 3,   NLRP3↓, 1,   p50↓, 2,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 5,   RAGE↓, 1,   TCF↓, 3,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α∅, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AR↓, 3,   AR↑, 1,   ER-α36↓, 1,   PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 3,   ChemoSen↑, 30,   CompStab↑, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose↝, 11,   Dose∅, 3,   eff↓, 6,   eff↑, 15,   eff↝, 1,   Half-Life↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 10,   selectivity↑, 10,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 28,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 3,   AR↑, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   EGFR↑, 1,   p‑EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 17,   LDH↓, 2,   LDH↑, 1,   Myc↓, 4,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiD↑, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cachexia↓, 2,   cardioP↑, 3,   chemoP↑, 6,   chemoPv↑, 4,   ChemoSideEff↓, 2,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 3,   Risk↓, 5,   Symptoms∅, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 4,  
Total Targets: 645

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   Catalase↑, 5,   DPPH↓, 1,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 4,   HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 6,   Prx↑, 1,   RNS↓, 1,   ROS↓, 15,   SOD↓, 1,   SOD↑, 4,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   DGAT1↓, 1,   FASN↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   Casp3?, 1,   Casp3↓, 3,   Cyt‑c↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   mTOR↑, 2,   PI3K↑, 2,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   RUNX2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   cal2↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   F-actin↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   Snail↑, 1,   TregCell↑, 1,   TumCMig↓, 1,   Twist↑, 1,   Vim↓, 1,   Vim↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 7,   NeuroI↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 1,   CYP2E1↓, 1,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   creat↓, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 3,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 6,   Obesity↓, 1,   PDE4↓, 1,   toxicity↓, 7,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiViral↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 108

Scientific Paper Hit Count for: Snail, SNAI1, Snail Family Transcriptional Repressor 1
9 Sulforaphane (mainly Broccoli)
7 Resveratrol
7 Quercetin
6 EGCG (Epigallocatechin Gallate)
6 Honokiol
5 Apigenin (mainly Parsley)
4 Ellagic acid
4 Luteolin
3 Boron
3 Curcumin
3 Cyclopamine
3 Eugenol
3 Fisetin
3 HydroxyTyrosol
3 Matrine
3 Urolithin
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Benzyl isothiocyanate
2 Chrysin
2 Ginkgetin
2 Isothiocyanates
2 Phenethyl isothiocyanate
2 Kaempferol
2 Piperine
2 Pterostilbene
1 1,8-Cineole
1 Astragalus
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Cisplatin
1 Artemisinin
1 Baicalin
1 Betulinic acid
1 Butyrate
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cannabidiol
1 Chlorogenic acid
1 Citric Acid
1 Diindolylmethane
1 Genistein (soy isoflavone)
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 phytic acid, Inositol hexakisphosphate
1 Isorhamnetin
1 Allyl isothiocyanate
1 Juglone
1 L-Theanine
1 Magnolol
1 5-fluorouracil
1 mebendazole
1 Metformin
1 Melatonin
1 Morin
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Propranolol
1 isoflavones
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 salinomycin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Taurine
1 Thymoquinone
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:376  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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