CDK1 Cancer Research Results

CDK1, Cyclin-dependent kinase 1: Click to Expand ⟱
Source:
Type:
CDK1, (Cyclin-dependent kinase 1) same as p34 (cdc2) kinase activity
Mitotic Gatekeeper, Essential Cell-Cycle Engine, and Therapeutic Vulnerability
Cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival.
CDK1 is a significant biomarker in various cancers, with its overexpression often correlating with aggressive tumor characteristics and poor prognosis. Targeting CDK1 may offer therapeutic potential, especially in cancers where its expression is linked to unfavorable outcomes.
Scientific Papers found: Click to Expand⟱
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,

Showing Research Papers: 51 to 53 of 53
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 53

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSTA1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Casp3↑, 3,   Casp8↑, 1,   pro‑Casp8↑, 1,   Casp9↑, 3,   Cyt‑c↑, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   hTERT/TERT↓, 1,   p‑JNK↓, 1,   Mcl-1↓, 2,   p27↑, 1,   p‑p38↓, 1,   survivin↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 1,   cycD1/CCND1↑, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 2,   EMT↓, 2,   p‑ERK↓, 1,   FOXM1↓, 1,   HDAC↓, 1,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   OCT4↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 1,   STAT3↓, 2,   TumCG↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   E-cadherin↑, 1,   MMP2↓, 2,   MMP9↓, 1,   N-cadherin↓, 1,   TGF-β↓, 1,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 2,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CXCR4↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 1,   eff↑, 4,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   radioP↑, 1,  
Total Targets: 89

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   HDAC3↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  
Total Targets: 7

Scientific Paper Hit Count for: CDK1, Cyclin-dependent kinase 1
8 Quercetin
4 Sulforaphane (mainly Broccoli)
3 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Hydroxycinnamic-acid
2 Curcumin
2 Fisetin
2 Silymarin (Milk Thistle) silibinin
1 Allicin (mainly Garlic)
1 Andrographis
1 Artemisinin
1 Astaxanthin
1 Aloe anthraquinones
1 Berbamine
1 Berberine
1 Biochanin A
1 Boswellia (frankincense)
1 Caffeic acid
1 Chlorogenic acid
1 Chrysin
1 Cinnamon
1 Docetaxel
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Fenbendazole
1 Formononetin
1 Gallic acid
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Juglone
1 Laetrile B17 Amygdalin
1 Nimbolide
1 Propolis -bee glue
1 Phenethyl isothiocyanate
1 Paclitaxel/Taxol
1 Piperlongumine
1 Plumbagin
1 Sulfasalazine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:382  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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