XIAP Cancer Research Results

XIAP, X-linked inhibitor of apoptosis protein (XIAP) baculoviral IAP repeat-containing protein 4 (BIRC4): Click to Expand ⟱
Source:
Type:
Also known as BIRC4. XIAP is inhibited by DIABLO (Smac) and HTRA2 (Omi), two death-signaling proteins released into the cytoplasm by the mitochondria.
High proportions of XIAP may function as a tumor marker. In developing prostate cancer, XIAP is one of four IAPs overexpressed in the prostatic epithelium.

XIAP functions predominantly as a protumorigenic protein in the context of cancer. Its upregulation is commonly observed in various tumor types and is associated with poor patient outcomes and resistance to therapy due to its potent inhibition of apoptosis.
Scientific Papers found: Click to Expand⟱
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,
4935- PEITC,    Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo
- in-vivo, Pca, LNCaP - in-vivo, Pca, PC3
Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
1746- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, ROS↓, Casp↑, NF-kB↓, IκB↓, p50↓, p65↓, IAP1↓, IAP2↓, XIAP↓, Apoptosis↑,
3009- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, NF-kB↓, ROS↓, IAP1↓, IAP2↓, XIAP↓,
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓, Nanog↓, TumCG↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
2121- TQ,    Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
p‑p38↑, ROS↑, TumCP↓, eff↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2085- TQ,    Anticancer Activities of Nigella Sativa (Black Cumin)
- Review, Var, NA
MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, eff↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, survivin↓, COX2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2↓, MMP9↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
4839- Uro,    Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP
tumCV↓, Apoptosis↓, P53↑, P21↑, PUMA↑, NOXA↑, MDM2↓, XIAP↓,

Showing Research Papers: 51 to 82 of 82
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 82

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ATF3↑, 1,   Catalase↓, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GPx↓, 1,   GSH↓, 6,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 3,   MPO↓, 1,   NQO1↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 14,   ROS⇅, 4,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 1,   BOK↑, 1,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 6,   mtDam↑, 1,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 31,   XIAP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMACR↓, 1,   AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 6,   CYP3A4↓, 1,   Glycolysis↓, 1,   PKM2↓, 2,   PPARγ↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↓, 1,   Akt↓, 11,   Akt↑, 2,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 11,   aSmase↝, 1,   BAD↑, 1,   BAX↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 4,   Bcl-2↓, 17,   Bcl-xL↓, 9,   BID↓, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 2,   Casp1↓, 1,   Casp10↑, 1,   cl‑Casp12↑, 1,   Casp3↑, 15,   Casp7↑, 3,   Casp8↑, 6,   Casp9↓, 1,   Casp9↑, 10,   CSR1↑, 1,   Cyt‑c↑, 10,   Diablo↑, 3,   DR4↑, 3,   DR5↑, 5,   FADD↑, 2,   Fas↓, 1,   Fas↑, 6,   FasL↑, 2,   HGF/c-Met↓, 1,   hTERT/TERT↓, 2,   IAP1↓, 8,   IAP2↓, 7,   IAP2↑, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 2,   p‑MAPK↑, 1,   Mcl-1↓, 6,   MDM2↓, 1,   p‑MDM2↓, 1,   Myc↓, 1,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 1,   p27↑, 3,   p38↑, 4,   p‑p38↑, 2,   PUMA↑, 2,   survivin↓, 20,   Telomerase↓, 3,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   H3↓, 1,   H4↓, 1,   H4↑, 1,   other↓, 1,   other↝, 1,   SPP1↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   Hsc70↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 2,   LC3II↑, 3,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   CYP1B1↑, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↑, 1,   DNMT1↓, 2,   GADD45A↑, 1,   p16↑, 2,   P53↑, 13,   PARP↑, 1,   cl‑PARP↑, 9,   PARP1↓, 1,   PCNA↓, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 4,   CDK4↓, 7,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 11,   cycE/CCNE↓, 3,   E2Fs↓, 1,   P21↑, 6,   TumCCA↓, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD34↓, 2,   CD44↓, 2,   cFos↑, 1,   cMET↓, 1,   CSCs↓, 4,   EMT↓, 8,   ERK↓, 5,   FBXW7↝, 1,   FOXO↑, 2,   Gli1↓, 1,   GSK‐3β↓, 2,   HDAC↓, 5,   HDAC1↓, 1,   HDAC4↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   Jun↓, 1,   miR-34a↑, 1,   mTOR↓, 8,   Nanog↓, 1,   NOTCH↓, 3,   NOTCH1↓, 2,   OCT4↓, 1,   P70S6K↓, 1,   PDGFRA↓, 1,   PI3K↓, 11,   p‑PI3K↓, 2,   PTEN↓, 2,   PTEN↑, 5,   RAS↓, 1,   Shh↓, 1,   Smo↓, 1,   p‑Src↓, 1,   STAT3↓, 9,   p‑STAT6↓, 1,   TCF↓, 1,   TumCG↓, 3,   TumCG↑, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Akt2↓, 1,   AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 4,   EphB4↓, 1,   FAK↓, 2,   GLI2↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   Ki-67↓, 3,   LEF1↓, 3,   MET↓, 1,   p‑MET↓, 1,   MMP2↓, 7,   MMP7↓, 2,   MMP9↓, 9,   MMP9↑, 1,   MMPs↓, 3,   MUC4↓, 3,   N-cadherin↓, 5,   NM23↑, 1,   Rac1↓, 2,   RAGE↓, 1,   Rho↓, 1,   Slug↓, 5,   Snail↓, 6,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 5,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 5,   Twist↓, 4,   Tyro3↓, 1,   VCAM-1↓, 1,   Vim↓, 5,   Vim↑, 1,   Zeb1↓, 3,   ZO-1↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 1,   EGFR↓, 3,   EGFR↑, 1,   FLT4↓, 1,   Hif1a↓, 4,   VEGF↓, 13,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

NHE1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2↓, 12,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 4,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 4,   IL1↓, 1,   IL10↓, 1,   IL12↓, 2,   IL1β↓, 1,   IL2↑, 2,   IL6↓, 4,   IL8↓, 2,   Inflam↓, 4,   IκB↓, 2,   JAK2↓, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 23,   p50↓, 2,   p65↓, 4,   p‑p65↓, 2,   PD-1↓, 1,   PGE1↓, 1,   TNF-α↓, 6,  

Cellular Microenvironment(tgid=17) ⓘ

PLC↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 8,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose↓, 1,   Dose↝, 4,   eff↓, 2,   eff↑, 6,   eff↝, 1,   P450↓, 2,   RadioS↑, 3,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   CEA↓, 1,   EGFR↓, 3,   EGFR↑, 1,   HEC1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 4,   Ki-67↓, 3,   Myc↓, 1,   NOS2↓, 1,   NSE↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   cachexia↓, 1,   chemoP↑, 3,   chemoPv↑, 2,   hepatoP↑, 1,   IMPDH1↓, 1,   IMPDH2↓, 1,   OS↑, 1,   Risk↓, 1,   TumVol↓, 1,  
Total Targets: 336

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 2,   GPx↑, 1,   GPx1↑, 1,   GSH↑, 4,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MPO↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 5,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDHA↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,  

Migration(tgid=13) ⓘ

5LO↝, 1,   AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL10↑, 1,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 2,   eff↑, 1,   Half-Life↝, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 3,   radioP↑, 2,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↑, 1,  
Total Targets: 45

Scientific Paper Hit Count for: XIAP, X-linked inhibitor of apoptosis protein (XIAP) baculoviral IAP repeat-containing protein 4 (BIRC4)
12 Thymoquinone
6 EGCG (Epigallocatechin Gallate)
4 Ashwagandha(Withaferin A)
4 Chrysin
4 Curcumin
4 Luteolin
4 Quercetin
3 Baicalein
3 Sulforaphane (mainly Broccoli)
3 Fisetin
2 Apigenin (mainly Parsley)
2 Berberine
2 Beta-Caryophyllene
2 chaetocin
2 Ellagic acid
2 Resveratrol
2 Emodin
2 Fucoidan
2 Nimbolide
2 Phenethyl isothiocyanate
2 Rosmarinic acid
1 Silver-NanoParticles
1 Andrographis
1 Gemcitabine (Gemzar)
1 immunotherapy
1 Brucea javanica
1 Bromelain
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 Chemotherapy
1 Cinnamon
1 Hydroxycinnamic-acid
1 Cucurbitacin
1 Genistein (soy isoflavone)
1 Evodiamine
1 Gambogic Acid
1 Garcinol
1 Magnolol
1 Neem
1 Orlistat
1 isoflavones
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:396  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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