XIAP Cancer Research Results

XIAP, X-linked inhibitor of apoptosis protein (XIAP) baculoviral IAP repeat-containing protein 4 (BIRC4): Click to Expand ⟱
Source:
Type:
Also known as BIRC4. XIAP is inhibited by DIABLO (Smac) and HTRA2 (Omi), two death-signaling proteins released into the cytoplasm by the mitochondria.
High proportions of XIAP may function as a tumor marker. In developing prostate cancer, XIAP is one of four IAPs overexpressed in the prostatic epithelium.

XIAP functions predominantly as a protumorigenic protein in the context of cancer. Its upregulation is commonly observed in various tumor types and is associated with poor patient outcomes and resistance to therapy due to its potent inhibition of apoptosis.
Scientific Papers found: Click to Expand⟱
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, Var, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7550- HYP,    Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway
- in-vitro, BC, MCF7 - in-vitro, BC, 4T1
*Inflam↓, AntiCan↑, tumCV↓, TumCMig↓, Apoptosis↑, Bcl-2↓, XIAP↓, BAX↑, cl‑Casp3↑, ROS↓, NF-kB↓, TumVol↓,
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,
7774- IBC,    Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, BAX↑, XIAP↓, survivin↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, GSK‐3β↓,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
8152- lamb,  TRAIL/rTRAIL,    Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis via Inhibition of XIAP/NF-κB and Activation of Caspases and Death Receptor 4
- in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
TumCD↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, cFLIP↓, XIAP↓, BID↑, DR4↑, p‑NF-kB↓, p‑IκB↓,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8557- Matr,    Effects of matrine in combination with cisplatin on liver cancer
- in-vivo, Liver, HepG2
ChemoSen?, TumW↓, TumVol↓, survivin↓, XIAP↓, Casp3↑, Casp7↑, Casp9↑,
8648- MBZ,    Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
- Review, Var, NA
angioG↓, MMPs↓, MDR1↓, TubPol↓, RadioS?, ChemoSen?, TumCG↓, TumMeta?, OS↑, BioAv↓, BioAv↑, BBB↑, mitA↑, HH↓, Shh↓, Synergy↑, Gli1↓, PTCH2↓, XIAP↓, cl‑PARP↑, Casp3↑, BRAF↓, MEK↓, SYN1↑, Cyt‑c↑, TumVol↓, VEGFR2/KDR/Flk1↓, VEGF↓, VCAM-1↓, DYRK1B↓, QoL↑, Dose↝,
8720- MeJa,    Methyl jasmonate downregulates expression of proliferating cell nuclear antigen and induces apoptosis in human neuroblastoma cell lines
- in-vitro, neuroblastoma, SK-N-SH
PCNA↓, TumCCA↑, XIAP↓, survivin↓,
9073- MGF,    Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase
- in-vitro, MM, NA
TumVol↓, Apoptosis↑, Casp3↑, MMP↓, NF-kB↓, IκB↑, XIAP↓, survivin↓, Bcl-xL↓,
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8968- mushLions,    Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells
- in-vitro, lymphoma, U937
Ingr?, Apoptosis↑, TumCP↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, XIAP↓, IAP1↓, Cyt‑c↑, MMP↓, cl‑PARP↑,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,
8963- PatchO,    The Effect of Patchouli Oil (Pogostemon cablin) on Apoptosis through NF-κB Inhibition in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
NF-kB↓, tumCV↓, cl‑Casp3↑, Bcl-2↓, XIAP↓, cFLIP↓,
4935- PEITC,    Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo
- in-vivo, Pca, LNCaP - in-vivo, Pca, PC3
Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27/CDKN1B↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
1746- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, ROS↓, Casp↑, NF-kB↓, IκB↓, p50↓, p65↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Apoptosis↑,
3009- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, NF-kB↓, ROS↓, IAP1↓, IAP2/BIRC3↓, XIAP↓,
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓, Nanog↓, TumCG↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, Synergy↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2/PTGS2↓, PGE1↓,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
2121- TQ,    Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
p‑p38↑, ROS↑, TumCP↓, ChemoSen↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

Showing Research Papers: 51 to 100 of 109
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 109

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 13,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 3,   p‑NRF2↓, 1,   ROS↓, 6,   ROS↑, 45,   ROS⇅, 4,   i-ROS↑, 1,   SOD↓, 4,   SOD↑, 2,   SOD2↓, 1,   TAC↓, 1,   Trx↑, 1,   ox-Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Bfl-1↓, 1,   CDC2↓, 2,   CDC25↓, 5,   compI↓, 1,   compIII↓, 2,   ETC↓, 1,   HSP60/HSPD1↓, 2,   HTRA2/Omi/PARK13↑, 1,   mtDam↑, 2,   OCR↓, 3,   OXPHOS↓, 2,   PDH↝, 1,   PGC-1α↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ACSL4↑, 1,   ALAT↓, 1,   AMACR↓, 1,   AMPK↑, 6,   ATP↓, 3,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 3,   lactateProd↓, 1,   LDHA↓, 2,   LDL↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 3,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 4,   Apoptosis↓, 1,   Apoptosis↑, 56,   ASC↓, 1,   ASK1↑, 1,   aSmase↝, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 6,   BAX↓, 1,   BAX↑, 24,   BAX⇅, 1,   Bax:Bcl2↑, 8,   Bcl-2↓, 58,   Bcl-xL↓, 31,   BID↓, 1,   BID↑, 4,   BIM↑, 3,   BOK↑, 1,   Casp↑, 9,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 47,   cl‑Casp3↑, 6,   Casp7↑, 7,   Casp8↑, 23,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 35,   cl‑Casp9↑, 1,   cFLIP↓, 6,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 31,   Diablo↑, 7,   DR5↑, 12,   FADD↑, 2,   Fas↓, 1,   Fas↑, 14,   FasL↑, 5,   IAP1↓, 18,   IAP2/BIRC3↓, 10,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 5,   Mcl-1↓, 20,   MDM2↓, 4,   MDM2↑, 2,   p‑MDM2↓, 1,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 4,   p38↓, 3,   p38↑, 7,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 5,   Pyro↑, 1,   survivin↓, 65,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 2,   TumCD↑, 1,   XIAP?, 1,   XIAP↓, 105,   XIAP↑, 2,   XIAP↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 39,   Akt↑, 5,   p‑Akt↓, 9,   AKT1↓, 1,   Akt2↓, 1,   BRAF↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 1,   p‑CREB↑, 1,   cSrc↓, 2,   DYRK1B↓, 1,   EGFR↓, 10,   EGFR↑, 2,   EphB4↓, 1,   ERK↓, 12,   ERK↑, 1,   p‑ERK↓, 1,   p‑ERK↑, 1,   FLT4↓, 1,   HER2/EBBR2↓, 6,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 5,   IκB↓, 2,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 9,   JNK↓, 4,   JNK↑, 5,   p‑JNK↑, 1,   MAPK↓, 9,   MAPK↑, 3,   p‑MAPK↑, 1,   MEK↓, 2,   mTOR↓, 20,   p‑mTOR↓, 2,   P70S6K↓, 3,   PDGFRA↓, 1,   PI3K↓, 26,   PI3K↑, 1,   p‑PI3K↓, 2,   PIAS-3↑, 1,   PKCδ↓, 5,   PTEN↓, 2,   PTEN↑, 11,   Raf↓, 1,   RAS↓, 2,   RIP1↓, 1,   p‑RSK↑, 1,   SHP1↑, 2,   Sp1/3/4↓, 3,   Src↓, 2,   p‑Src↓, 1,   STAT3↓, 26,   STAT3↑, 1,   p‑STAT3↓, 4,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 2,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 19,   DNMT1↓, 3,   DNMTs↓, 4,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↑, 4,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   H3↓, 1,   H4↓, 1,   H4↑, 1,   HATs↓, 1,   HDAC↓, 11,   HDAC1↓, 1,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 2,   miR-124-3p↓, 1,   miR-134↑, 1,   miR-200b↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   miR-340↑, 1,   miR-34a↑, 1,   Myc↓, 3,   OCT4↓, 9,   other↓, 3,   other↝, 2,   SOX2↓, 4,   SOX9?, 1,   SPP1↓, 1,   SUV39H↓, 1,   tumCV↓, 12,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 10,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 6,   GRP78/BiP↑, 1,   Hsc70↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HTRA↓, 2,   IRE1↑, 2,   PERK↑, 5,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 6,   LC3A↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 5,   p62↓, 2,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 2,   ATR↑, 1,   BRCA1↓, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 1,   DNAdam↑, 11,   hTERT/TERT↓, 4,   p16↑, 4,   P53↑, 32,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↑, 5,   PARP↝, 1,   cl‑PARP↑, 33,   PARP1↓, 1,   PCNA↓, 9,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 6,   TOP1↓, 3,   TOP2↓, 2,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 11,   CDK2↑, 2,   CDK4↓, 15,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 2,   CDK8↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 30,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 9,   E2F4↑, 1,   E2Fs↓, 1,   GADD45A↑, 1,   Ki-67↓, 7,   MAD↓, 1,   mitA↑, 1,   P21↓, 1,   P21↑, 19,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 10,   pRB↑, 1,   RB1↑, 2,   p‑RB1↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA↓, 2,   TumCCA↑, 41,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH1A1↓, 1,   CD133↓, 3,   CD34↓, 2,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 13,   FBXW7↝, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 2,   Jun↓, 1,   Ki-67↓, 7,   Let-7↑, 1,   Nanog↓, 7,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH2↑, 1,   PTCH1↓, 1,   PTCH2↓, 2,   SCF↓, 2,   Shh↓, 4,   Smo↓, 3,   TumCG↓, 17,   TumCG↑, 1,   TumCP↓, 31,   Wnt↓, 6,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 4,   AXL↓, 1,   Ca+2↑, 6,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 12,   EM↑, 1,   EMT↓, 19,   EMT↑, 1,   FAK↓, 8,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 3,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 26,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 29,   MMP9↑, 1,   MMPs↓, 6,   MTA1↓, 1,   MUC4↓, 3,   N-cadherin↓, 7,   NM23↑, 1,   PDGF↓, 2,   Rac1↓, 2,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 10,   SMAD3↓, 1,   Snail↓, 16,   TET1↓, 1,   TET1↑, 1,   TGF-β↓, 6,   TGF-β↑, 2,   TIMP1↓, 1,   TIMP2↓, 2,   TIMP2↑, 3,   TSP-1↑, 1,   TumCI↓, 20,   TumCMig↓, 14,   TumMeta?, 1,   TumMeta↓, 11,   TumMeta↑, 2,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 5,   uPAR↓, 1,   Vim↓, 13,   Vim↑, 1,   Zeb1↓, 6,   α-SMA↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 15,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 30,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   HIF-1↓, 2,   Hif1a↓, 16,   VCAM-1↓, 2,   VEGF↓, 39,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 2,   GLUT1↓, 1,   MMP↓, 28,   MMP↑, 2,   NHE1↓, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 5,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 26,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 6,   DR4↑, 5,   FOXP3↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 2,   IL12↓, 2,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL6↓, 15,   IL8↓, 3,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 10,   MCP1/CCL2↓, 2,   NF-kB↓, 56,   NF-kB↑, 2,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 4,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 2,   RAGE↓, 1,   T-Cell↑, 1,   TCF↓, 3,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 15,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 5,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 9,   BioAv↑, 9,   BioAv↝, 1,   ChemoSen?, 2,   ChemoSen↑, 34,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↝, 18,   Dose∅, 2,   eff↓, 5,   eff↑, 17,   eff↝, 4,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   NAT↓, 1,   P-gp/ABCB1↓, 4,   P450↓, 4,   RadioS?, 1,   RadioS↑, 12,   selectivity↑, 16,   selectivity↝, 1,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 1,   ALP↓, 1,   AR↓, 5,   BG↓, 1,   BRAF↓, 1,   BRCA1↓, 1,   CEA↓, 2,   EGFR↓, 10,   EGFR↑, 2,   EZH2↓, 2,   FOXM1↓, 1,   HEC1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 4,   IL6↓, 15,   LDH↓, 2,   Myc↓, 3,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 2,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 6,   ChemoSideEff↓, 1,   hepatoP↑, 1,   IMPDH1↓, 1,   IMPDH2↓, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↑, 3,   PFS↑, 1,   QoL↑, 3,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 2,   toxicity↓, 4,   TumVol↓, 11,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,  
Total Targets: 611

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 18,   Catalase↑, 7,   GPx↑, 3,   GPx1↑, 1,   GSH↑, 10,   GSR↑, 1,   GSTs↑, 2,   HO-1?, 1,   HO-1↑, 4,   Keap1↑, 1,   lipid-P↓, 4,   MDA↓, 5,   MPO↓, 1,   MPO↑, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 6,   ROS↓, 19,   ROS∅, 3,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 2,   TBARS↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   5LO↝, 1,   ALAT↓, 5,   AMPK↑, 2,   ATP↑, 2,   glucose↝, 1,   LDHA↑, 1,   LDL↓, 1,   NADPH↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 2,   Cyt‑c↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 4,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑CREB↑, 1,   ERK↑, 1,   JAK2↑, 1,   p‑JNK↓, 1,   mTOR↓, 1,   PI3K↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   other↓, 1,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MMP13↓, 1,   PAI-1/SERPINE1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TXNIP↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CD31/PECAM-1↓, 1,   E-sel↓, 1,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 1,   MMP↑, 2,   MUC5AC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 2,   CD8+↑, 1,   COX2/PTGS2↓, 5,   Eos↓, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IL10↑, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 5,   IL2↓, 1,   IL4↓, 1,   IL6↓, 6,   IL6↑, 1,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 18,   Inflam↑, 1,   LPS↓, 1,   NF-kB↓, 6,   NLRP3↓, 2,   TLR4↓, 1,   TNF-α↓, 7,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 4,   Dose↝, 4,   eff↓, 1,   eff↑, 4,   GSTA1↑, 1,   Half-Life↝, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   AST↓, 6,   BUN↓, 1,   creat↓, 2,   IL6↓, 6,   IL6↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 3,   antiD↓, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 6,   chemoP↑, 1,   chemoPv↑, 3,   cognitive↑, 2,   hepatoP↑, 10,   memory↑, 2,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 12,   Obesity↓, 2,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 3,   Stroke↓, 2,   toxicity↓, 5,   toxicity↝, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 5,   Bacteria↑, 1,   Diar↓, 1,   GutMicro↑, 2,   Sepsis↓, 2,  
Total Targets: 162

Scientific Paper Hit Count for: XIAP, X-linked inhibitor of apoptosis protein (XIAP) baculoviral IAP repeat-containing protein 4 (BIRC4)
12 Thymoquinone
6 Benzyl isothiocyanate
6 EGCG (Epigallocatechin Gallate)
4 Ashwagandha(Withaferin A)
4 Phenethyl isothiocyanate
4 Chrysin
4 Curcumin
4 Sulforaphane (mainly Broccoli)
4 Luteolin
4 Quercetin
3 Allyl isothiocyanate
3 Baicalein
3 Fisetin
3 lambertianic acid
3 Matrine
2 Apigenin (mainly Parsley)
2 Berberine
2 Beta-Caryophyllene
2 Isothiocyanates
2 chaetocin
2 Ellagic acid
2 Resveratrol
2 Emodin
2 Fucoidan
2 Hyperoside
2 Indole-3-carbinol
2 Nimbolide
2 Rosmarinic acid
1 Silver-NanoParticles
1 Andrographis
1 Gemcitabine (Gemzar)
1 immunotherapy
1 Brucea javanica
1 Bromelain
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 Chemotherapy
1 Cinnamon
1 Hydroxycinnamic-acid
1 Cucurbitacin
1 Genistein (soy isoflavone)
1 Evodiamine
1 Ferulic acid
1 Gambogic Acid
1 Garcinol
1 Hydrogen Gas
1 Isobavachalcone
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Licochalcone A
1 Magnolol
1 mebendazole
1 Methyl Jasmonate
1 Mangiferin
1 Morin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Neem
1 Orlistat
1 Patchouli Oil (Pogostemon cablin)
1 isoflavones
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:396  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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