IGF-1 Cancer Research Results

IGF-1, insulin-like growth factor-1: Click to Expand ⟱
Source:
Type:
Higher blood levels of IGF-1, a growth factor, are linked to increased risk of several types of cancer, including thyroid, melanoma and myeloma. IGF-1 is what some call "a growth-promoter" because it has been shown to promote the growth of cancer cells.
The IGF-1 signaling pathway promotes cancer progression; its downregulation is associated with lowered risk.
Scientific Papers found: Click to Expand⟱
5056- Ex,    Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis
- Review, Nor, NA
*IGF-1↑,
5058- Ex,    IGF-1_Signaling_During_Physical_Exercise_A_Systematic_Review">The Role of Insulin-Like Growth Factor (IGF-1) Signaling During Physical Exercise: A Systematic Review
- Review, Nor, NA
*IGF-1↑,
5064- Ex,    Effect Of Exercise Intervention On Insulin, Igfs And Igfbps In Cancer Patients
- Review, Var, NA
IGF-1↓, IGF-2↓, Insulin↓,
5063- Ex,    A randomized controlled trial on the efficacy of supervised exercise training in reducing IGF-1 levels in breast cancer survivors of the Movis’ cohort
- Trial, BC, NA
IGF-1↓, IGFBP3↓,
5062- Ex,    The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives
- Review, Var, NA
IGF-1↑,
5061- Ex,    Role of physical exercise in modulating the insulin-like growth factor system for improving breast cancer outcomes: A meta-analysis
- Review, BC, NA
IGF-2↓, IGFBP1↓, HOMA↓, glucose∅, IGF-1∅, eff↑,
5060- Ex,    Exercise-induced modulation of IGF-1 in healthy, obese, and cancer populations: a systematic review and meta-analysis
- Review, Var, NA
*IGF-1↑, IGF-1↓, IGFBP3↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
6991- Form,    Formononetin-induced apoptosis of human prostate cancer cells through ERK1/2 mitogen-activated protein kinase inactivation
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
TumCCA↑, IGF-1↓, PI3K↓, Akt↓, TumCP↓, ERK↓, MAPK↓, BAX↑, Apoptosis↑,
6964- Form,    Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo
- vitro+vivo, BC, MCF7
IGF-1↓, IGFR↓, PI3K↓, Akt↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, TumCG↓, Dose↝,
6971- Form,    In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa
- vitro+vivo, Cerv, HeLa
p‑Akt↓, Apoptosis↑, TumCG↓, Dose↝, PI3K↓, eff↑, ATP↓, OCR↓, TumCCA↑, IGF-1↓, angioG↓, TumCI↓,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
7609- I3C,    Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives
- Review, Var, NA
AntiCan↑, tumCV↓, HIF-1↓, NF-kB↓, IGF-1↓, PI3K↓, Akt↓, Wnt↓, EstroRS/ERS↓,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8418- Lyco,  docx,    A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
- Trial, Pca, NA
Dose↝, BioEnh↑, angioG↓, IGF-1↓, ChemoSen↑, BioAv↑, CEC↝,
4532- MAG,  Cisplatin,    Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
- in-vivo, Var, NA
cachexia↓, *IGF-1↑, chemoP↑, *M2 MC↑,
3497- MFrot,  MF,    The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets
- Human, Nor, NA
*PDGFR-BB↑, *TGF-β↑, *IGF-1↑, *FGF↑, *angioG↑, *Inflam↓, *ROS↓,
8777- MSM,  Tam,    The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
tumCV↓, TumCMig↓, JAK2↓, STAT5↓, ChemoSen↑, cycD1/CCND1↓, VEGF↓, IGF-1↓, IGF-1R↓, MMP2↓, MMP3↓, MMP9↓, TumVol↓, STAT3↓,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,
3255- PBG,    Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2
- in-vivo, Nor, NA
*IGF-1↓, *MMP2↑, *ROS↓, *Inflam↓, *IL10↓, *NRF2∅,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
78- QC,    Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
- in-vitro, Pca, PC3
IGF-1↓, IGF-2↓, IGFBP3↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Apoptosis↑, BAX↑, DNAdam↑,
86- QC,  PacT,    Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)
- vitro+vivo, Pca, PC3
BAD↑, IGFBP3↑, Cyt‑c↑, cl‑Casp9↑, Casp10↑, cl‑PARP↑, Casp3↑, IGF-1R↓, PI3K↓, p‑Akt↓, cycD1/CCND1↓, IGF-1↓, IGF-2↓, IGF-1R↓, MMP↓, Apoptosis↑, NA?,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2/PTGS2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
3028- RosA,    Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer’s disease
- in-vitro, AD, HT22 - in-vivo, NA, NA
*Aβ↓, *Apoptosis↓, *antiOx↑, *neuroP↑, *Ingr↝, *IGF-1↑, *MMP9↑, *Src↓, *MAPK↓, *MMP↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
4204- SIL,    Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels
- in-vivo, Stroke, NA
*OS↑, *BDNF↑, *IGF-1↑,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, VEGFR2/KDR/Flk1↓, p‑IGF-1↓, PI3K↓, Akt↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,

Showing Research Papers: 51 to 88 of 88
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 88

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 1,   Catalase↑, 1,   GPx↑, 2,   GSH↓, 2,   GSH↑, 3,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 3,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NRF2↓, 2,   NRF2↑, 3,   ROS↑, 23,   SAM-e↝, 1,   SOD↓, 2,   SOD↑, 3,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 10,   OCR↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   adiP↑, 2,   AMPK↑, 4,   ATGL/PNPLA2↓, 1,   ATP↓, 3,   ATP↑, 1,   CRM↑, 1,   FASN↓, 2,   FASN↑, 1,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose∅, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 5,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PFK↓, 1,   polyA↓, 1,   Pyruv↓, 1,   SIRT1↑, 3,   TS↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 16,   BAD↑, 1,   Bak↑, 2,   BAX↑, 11,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-xL↓, 4,   BID↑, 1,   BNIP3↑, 1,   Casp↑, 2,   Casp10↑, 1,   Casp12↑, 1,   Casp3↑, 13,   cl‑Casp3↑, 3,   Casp7↑, 1,   cl‑Casp7↑, 2,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 2,   Cyt‑c↑, 9,   Diablo↑, 2,   DR5↑, 1,   Fas↓, 1,   Fas↑, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MDM2↑, 1,   necrosis↑, 1,   p38↑, 3,   PUMA↑, 1,   survivin↓, 1,   TumCD↑, 2,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 17,   Akt↑, 1,   p‑Akt↓, 5,   BRAF↝, 1,   Brk/PTK6↓, 1,   CK2↓, 4,   EGFR↓, 7,   ERK↓, 8,   ERK↑, 1,   p‑ERK↓, 1,   HER2/EBBR2↓, 4,   HGF/c-Met↓, 1,   IGF-1R↓, 4,   IGFR↓, 2,   IKKα↓, 1,   IR↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↝, 1,   p‑MEK↓, 1,   mTOR↓, 10,   p‑mTOR↓, 1,   p‑p70S6↓, 1,   PDE3B↓, 1,   PI3K↓, 16,   PI3K↑, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   p‑PKA↓, 1,   PKCδ↓, 1,   PTEN↑, 3,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 3,   Rictor↓, 1,   Src↑, 1,   STAT↓, 1,   STAT3↓, 5,   STAT5↓, 3,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cMyc↓, 2,   DNMTs↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO4↓, 1,   H3↓, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC3↓, 1,   miR-106b↓, 1,   miR-21↓, 1,   Myc↓, 1,   other↑, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 2,   HSPs↓, 1,   HSPs↑, 1,   PSMB5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LAMP2↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 5,   P53?, 1,   P53↓, 1,   P53↑, 8,   PARP↓, 1,   cl‑PARP↑, 8,   PCNA↓, 1,   POLD1↓, 1,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 6,   CDK6↓, 4,   Cyc↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 8,   CycD3↓, 1,   cycE/CCNE↓, 2,   Ki-67↓, 4,   P21↓, 1,   P21↑, 8,   p27/CDKN1B↑, 7,   p‑pRB↓, 2,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD24↓, 1,   CSCs↓, 4,   GH↓, 1,   Gli↓, 1,   IGF-1?, 1,   IGF-1↓, 59,   IGF-1↑, 3,   IGF-1↝, 1,   IGF-1∅, 1,   p‑IGF-1↓, 1,   IGF-2↓, 4,   IGFBP1↓, 1,   IGFBP1↑, 5,   IGFBP3↓, 1,   IGFBP3↑, 6,   Ki-67↓, 4,   mTORC1↓, 2,   TumCG↓, 12,   TumCP↓, 11,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   cal2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 6,   EMT↓, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB4↓, 1,   MMP1↓, 2,   MMP2↓, 7,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 10,   MMPs↓, 3,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   serineP↓, 1,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TIMP1↑, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumMeta↓, 6,   Twist↓, 3,   uPA↓, 1,   Vim?, 1,   Vim↓, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   HIF-1↓, 3,   Hif1a↓, 11,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 13,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT2↓, 1,   LAT↓, 1,   MMP↓, 7,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↓, 1,   CD44↓, 1,   CD8+↑, 3,   COX2/PTGS2↓, 8,   CXCR4↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 3,   IL4↑, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 1,   M2 MC↓, 2,   NF-kB↓, 12,   NK cell↑, 2,   p50↓, 1,   PD-1↓, 1,   PGE1↓, 1,   PGE2↓, 3,   PSA↓, 9,   PSA∅, 1,   Resistin↓, 1,   Th1 response↑, 1,   TNF-α↓, 6,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   EstroRS/ERS↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 2,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 18,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   Dose↑, 3,   Dose↝, 9,   eff↓, 3,   eff↑, 24,   eff↝, 6,   Half-Life↓, 1,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 7,   selectivity↑, 2,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   BG↓, 5,   BMD↑, 2,   BRAF↝, 1,   BRCA1↑, 1,   CEC↝, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EstroRS/ERS↓, 1,   Ferritin↓, 1,   HER2/EBBR2↓, 4,   HOMA↓, 1,   IL6↓, 7,   Myc↓, 1,   PSA↓, 9,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 11,   AntiTum↓, 1,   BowelM↑, 1,   cachexia↓, 1,   chemoP↑, 4,   chemoPv↑, 4,   ChemoSideEff↓, 6,   neuroP↑, 1,   OS↑, 8,   QoL↑, 6,   QoL∅, 1,   radioP↑, 1,   Risk↓, 7,   Strength∅, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 7,   Weight↓, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 367

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 9,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 7,   GSR↑, 2,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 3,   NRF2∅, 1,   ROS↓, 10,   mt-ROS↓, 1,   SAM-e↑, 1,   SOD↑, 7,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 2,   mtDam↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   adiP↑, 2,   AMPK↑, 1,   ATP↝, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 3,   Glycolysis↑, 1,   Glycolysis↝, 1,   H2S↑, 1,   HK2↑, 2,   LDHA↑, 1,   LDL↓, 5,   lipidLev↓, 1,   NAD↝, 1,   PFK↑, 1,   PKM2↑, 2,   SCD1↓, 1,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   CREB↑, 1,   ERK↑, 1,   IGFR↓, 1,   IKKα↓, 1,   MAPK↓, 4,   mTOR↓, 1,   PDGFR-BB↑, 1,   PI3K↓, 1,   PKCδ↓, 1,   RAS↓, 1,   Src↓, 1,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   other↓, 1,   other↑, 1,   other↝, 1,   other∅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   FGF↑, 1,   GH↑, 1,   IGF-1↓, 9,   IGF-1↑, 16,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   Cartilage↑, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   MMP9↑, 1,   serineP↓, 1,   TGF-β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   MMP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 14,   M2 MC↑, 1,   NF-kB↓, 4,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 6,   VitD↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   EndoR↑, 1,   GABA↑, 1,   monoA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 2,   PPARα↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   BioAv↝, 1,   BioAv∅, 1,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 7,   Dose∅, 1,   eff↓, 1,   eff↑, 2,   GSTA1↑, 1,   Half-Life↝, 2,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   BP↓, 2,   Calcium↑, 2,   colonLen↑, 1,   CRP↓, 2,   hs-CRP↓, 2,   IL6↓, 2,   IRes↓, 1,   LDH↓, 1,   Mag↑, 2,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 4,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 5,   hepatoP↑, 2,   memory↓, 1,   memory↑, 4,   motorD↓, 1,   motorD↑, 2,   neuroP↑, 9,   OS↑, 4,   Pain↓, 1,   QoL↑, 2,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 176

Scientific Paper Hit Count for: IGF-1, insulin-like growth factor-1
16 Exercise
14 diet FMD Fasting Mimicking Diet
7 Boron
5 diet Methionine-Restricted Diet
5 diet Short Term Fasting
5 Resveratrol
4 Formononetin
3 EGCG (Epigallocatechin Gallate)
3 Methylsulfonylmethane
2 Apigenin (mainly Parsley)
2 Curcumin
2 Chemotherapy
2 Lycopene
2 Quercetin
1 Alpha-Lipoic-Acid
1 Berberine
1 Betulinic acid
1 Vitamin D3
1 Cinnamon
1 Coenzyme Q10
1 Selenium
1 Vitamin C (Ascorbic Acid)
1 Bortezomib
1 D-limonene
1 Piperine
1 Fisetin
1 Flaxseed/Linseed
1 Indole-3-carbinol
1 Inositol
1 SDG/lignans
1 Luteolin
1 Docetaxel
1 Magnolol
1 Cisplatin
1 Magnetic Field Rotating
1 Magnetic Fields
1 tamoxifen
1 Propolis -bee glue
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rosmarinic acid
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:415  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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