Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
255- AL,    Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Apoptosis↑, P53↑, Casp3↑, P53↑, TPM4↓, TumCCA↑, THBS1↑,
241- AL,    Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells
- in-vitro, neuroblastoma, SK-N-SH
Casp3↑, Casp9↑, p38↑, MAPK↑, Cyt‑c↑, Apoptosis↑,
239- AL,    Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways
- in-vitro, GC, SGC-7901
Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
233- AL,  5-FU,    Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway
- in-vivo, Liver, NA
ROS↑, MMP↓, Casp3↑, PARP↑, Bcl-2↓,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
3448- ALA,    Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line
*Inflam↓, *ROS↓, *GSH↑, *GPx↑, *Casp3↓, *Casp9↓, *MMP↑,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
277- ALA,    α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B
ROS↑, Hif1a↑, JNK↑, Casp3↑, P21↑, BAX↑, Bcl-xL↓, cFos↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
296- ALA,    Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo
- vitro+vivo, neuroblastoma, SK-N-SH - vitro+vivo, BC, SkBr3
TumCG↓, Casp3↑,
304- ALA,    alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation
- in-vitro, Colon, HT-29
mt-ROS↑, Apoptosis↑, Casp3↑, DNAdam↑, Bcl-xL↓, Dose↝,
258- ALA,    Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells
- in-vitro, BC, MDA-MB-231
TumCG↓, p‑Akt↓, Akt↓, HER2/EBBR2↓, Bcl-2↓, BAX↑, Casp3↑,
5320- ALC,    l-Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer
- in-vivo, Var, NA
Strength↑, *Casp3↓, cachexia↓, *Dose↝,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1351- And,  MEL,    Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
- in-vitro, CRC, T84 - in-vitro, CRC, COLO205 - in-vitro, CRC, HT-29 - in-vitro, CRC, DLD1
eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,
1301- Api,    Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways
- in-vitro, neuroblastoma, NA
BAX↑, Bcl-2↓, Cyt‑c↑, cal2↑, Casp3↑,
1553- Api,    Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
- Review, NA, NA
Dose∅, TumVol↓, Dose∅, COX2↓, Hif1a↓, TumCCA↑, P53↑, P21↑, Casp3↑, DNAdam↑, TumAuto↝,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1536- Api,    Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells
- in-vitro, MM, MSTO-211H - in-vitro, MM, H2452
tumCV↓, ROS↑, MMP↓, ATP↓, Apoptosis↑, Necroptosis↑, DNAdam↑, TumCCA↑, Casp3↑, cl‑PARP↑, MLKL↑, p‑RIP3↑, Bax:Bcl2↑, eff↓, eff↓,
1560- Api,    Apigenin as an anticancer agent
- Review, NA, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
2632- Api,    Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress
- in-vitro, EC, NA
TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,
2634- Api,    Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells
- in-vitro, CRC, HCT116
TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,
2637- Api,    Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells
- in-vitro, Diabetic, NA
*other↝, *Insulin↑, ER Stress↓, *CHOP↓, *cl‑Casp3↓, *ROS↓, *Inflam↓, *TXNIP↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
584- Api,  Cisplatin,    Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms
- in-vivo, Var, NA
Beclin-1↑, Casp3↑, Casp9↑, JNK↑, Mcl-1↓, Ki-67↓,
586- Api,  5-FU,    5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma
- in-vivo, HCC, NA
ROS↑, MMP↓, Bcl-2↓, Casp3↑, PARP↑,
591- Api,  doxoR,    Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
- in-vitro, AML, Jurkat - in-vitro, AML, THP1
ATP↓, Casp3↑, γH2AX↑,
310- Api,    Apigenin inhibits renal cell carcinoma cell proliferation
- vitro+vivo, RCC, ACHN - in-vitro, RCC, 786-O - in-vitro, RCC, Caki-1 - in-vitro, RCC, HK-2
TumCCA↑, p‑ATM↑, p‑CHK1↑, p‑CDC25↑, p‑cDC2↑, P53↑, BAX↑, Casp9↑, Casp3↑,
176- Api,    Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells
- in-vitro, BC, BT474
cl‑Casp8↑, cl‑Casp3↑, p‑JAK1↓, p‑JAK2↓, p‑STAT3↓, P53↑, VEGF↓, Hif1a↓, MMP9↓, TumCG↓, TumCCA↑, cl‑PARP↑,
243- Api,    Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
p‑FAK↓, ERK↓, Casp3↑, PARP↑, ITGA5↓,
178- Api,    Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells
- in-vivo, BC, MDA-MB-231 - in-vitro, BC, T47D
Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, BAX↑,
179- Api,    Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells
- in-vitro, BC, SkBr3
cl‑Casp8↑, cl‑Casp3↑, VEGF↓, TumCG↓, TumCCA↑, cl‑PARP↑, p‑STAT3↓, p‑JAK2↓,
180- Api,    Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells
- in-vitro, BC, MDA-MB-231
cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, BAX∅, Bcl-2∅, Bcl-xL∅, p‑STAT3↓, P53↑, P21↑, p‑JAK2↓, VEGF↓,
206- Api,    Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, Melanoma, A375 - in-vitro, Lung, H2030 - in-vitro, CRC, SW480
Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,
270- Api,    Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK
- in-vivo, AML, U937
Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,
268- Api,    Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
- in-vitro, AML, HL-60
Casp3↑, PARP↑,
173- Api,    Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
- in-vitro, Colon, HCT116
CycB/CCNB1↓, cDC2↓, CDC25↓, P53↑, P21↑, cl‑PARP↑, proCasp8↓, proCasp9↓, proCasp3↓,
242- Api,    Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, C8161
ERK↓, PI3k/Akt/mTOR↓, Casp3↑, PARP↑, p‑mTOR↓, p‑Akt↓,
240- Api,    The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, CD44+
P21↑, p27↑, Casp3↑, Casp8↑, Slug↓, Snail↓, NF-kB↓, PI3K↓, Akt↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, NA, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
5131- ART/DHA,    Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells
- in-vitro, NSCLC, ASTC-a-1
Apoptosis↑, MMP↓, Casp3↑, TumCP↓,
5130- ART/DHA,    Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, eff↓, Apoptosis↑, Casp3↑, ROS↑, Cyt‑c↑, MMP↓, Bcl-2↓, BAX↑, MOMP↑, TumCG↓,
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,

Showing Research Papers: 51 to 100 of 692
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 692

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   frataxin↑, 1,   GPx4↓, 1,   GSH↓, 1,   HK1↓, 1,   lipid-P↑, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 18,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 3,   CDC25↓, 2,   p‑CDC25↑, 1,   MMP↓, 12,   MPT↑, 1,   mtDam↑, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALDOA↓, 1,   cMyc↓, 2,   p‑CREB↓, 1,   ENO1↓, 1,   FASN↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   NADPH↓, 3,   NADPH↑, 1,   PGK1↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   PPP↓, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 4,   APAF1↑, 1,   Apoptosis↑, 15,   Bak↑, 1,   BAX↑, 15,   BAX∅, 1,   Bax:Bcl2↑, 5,   Bcl-2↓, 12,   Bcl-2∅, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 5,   Bcl-xL∅, 1,   cl‑BID↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 35,   Casp3∅, 1,   cl‑Casp3↑, 7,   proCasp3↓, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 6,   Casp8∅, 1,   cl‑Casp8↑, 5,   proCasp8↓, 1,   Casp9↑, 14,   cl‑Casp9↑, 3,   proCasp9↓, 1,   p‑Chk2↓, 1,   CK2↓, 3,   Cyt‑c↑, 14,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   cl‑IAP2↑, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 1,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 1,   Necroptosis↑, 2,   p27↑, 3,   p38↓, 1,   p38↑, 2,   p‑p38↓, 1,   p‑RSK↓, 1,   survivin↓, 2,   Telomerase↓, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 3,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   p‑pRB↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↓, 2,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSPs↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 2,   TumAuto↝, 1,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑CHK1↑, 1,   DNA-PK↑, 1,   DNAdam↑, 6,   MGMT↓, 1,   p16↑, 1,   P53↓, 1,   P53↑, 11,   p‑P53↑, 1,   PARP↑, 5,   p‑PARP↑, 1,   cl‑PARP↑, 11,   PARP1↑, 1,   PCNA↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 4,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 3,   CycD3↓, 1,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↑, 9,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

cDC2↓, 1,   p‑cDC2↑, 1,   cFos↓, 2,   CREB2↓, 1,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 4,   p‑ERK↓, 2,   FOXO3↑, 1,   Gli↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC3↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   PI3K↓, 4,   STAT3↓, 3,   p‑STAT3↓, 3,   p‑STAT5↓, 1,   TOP2↓, 1,   TPM4↓, 1,   TumCG↓, 7,   TumCG↑, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 4,   cal2↑, 2,   Cdc42↑, 1,   E-cadherin↑, 4,   FAK↓, 3,   p‑FAK↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 2,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 7,   MMPs↓, 2,   PKCδ↓, 1,   RIP3↑, 1,   p‑RIP3↑, 2,   Slug↓, 2,   Snail↓, 3,   THBS1↑, 1,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 2,   Twist↓, 2,   uPA↓, 3,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 1,   EGFR↓, 1,   Hif1a↓, 7,   Hif1a↑, 1,   NO↓, 1,   VEGF↓, 9,  

Barriers & Transport ⓘ

GLUT1↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   CRP↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 3,   Inflam↓, 1,   p‑JAK1↓, 1,   p‑JAK2↓, 3,   NF-kB↓, 7,   p50↓, 1,   PSA↓, 1,   SOCS1↑, 1,   TNF-α↓, 1,   TNF-α∅, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 5,   Dose↝, 1,   Dose∅, 4,   eff↓, 7,   eff↑, 8,   eff↝, 2,   Half-Life↓, 2,   selectivity↓, 1,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

AR↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   Ferritin↓, 1,   HER2/EBBR2↓, 3,   IL6↓, 2,   Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cachexia↓, 1,   chemoPv↑, 3,   RenoP↑, 1,   Strength↑, 1,   toxicity↑, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 255

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   GPx↑, 2,   GSH↑, 3,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 5,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

cAMP↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Casp3↓, 4,   cl‑Casp3↓, 1,   Casp9↓, 3,   iNOS↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Migration ⓘ

PKCδ↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL6↓, 2,   INF-γ↓, 1,   Inflam↓, 6,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   ChAT↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↓, 1,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cognitive↑, 2,   neuroP↑, 2,   toxicity↓, 2,   toxicity∅, 1,  
Total Targets: 48

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
34 Silver-NanoParticles
33 Quercetin
29 Thymoquinone
29 Curcumin
26 Apigenin (mainly Parsley)
22 Sulforaphane (mainly Broccoli)
21 Baicalein
21 Berberine
17 EGCG (Epigallocatechin Gallate)
17 Shikonin
15 Fisetin
14 Artemisinin
14 Allicin (mainly Garlic)
14 Propolis -bee glue
14 Honokiol
13 Magnetic Fields
13 Ashwagandha(Withaferin A)
13 Chrysin
12 Betulinic acid
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 Emodin
10 Cisplatin
10 Luteolin
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Graviola
9 Magnolol
9 Phenylbutyrate
8 Citric Acid
8 Garcinol
8 Lycopene
7 Capsaicin
7 Gambogic Acid
7 Juglone
7 Phenethyl isothiocyanate
7 Piperlongumine
7 Rosmarinic acid
6 5-fluorouracil
6 doxorubicin
6 Radiotherapy/Radiation
6 Bufalin/Huachansu
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 Ursolic acid
5 salinomycin
5 Ellagic acid
5 Magnetic Field Rotating
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Melatonin
4 Astaxanthin
4 Bromelain
4 borneol
4 chitosan
4 Dichloroacetate
4 Paclitaxel
4 Naringin
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Auranofin
3 Berbamine
3 Photodynamic Therapy
3 Biochanin A
3 Brucea javanica
3 Crocetin
3 Chemotherapy
3 Hydroxycinnamic-acid
3 Laetrile B17 Amygdalin
3 Nimbolide
3 Psoralidin
3 Pterostilbene
3 Vitamin C (Ascorbic Acid)
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Andrographis
2 Metformin
2 Aloe anthraquinones
2 brusatol
2 Caffeic acid
2 diet FMD Fasting Mimicking Diet
2 Electrical Pulses
2 Ferulic acid
2 Gallic acid
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Magnesium
2 Docetaxel
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
1 5-Aminolevulinic acid
1 entinostat
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 D-limonene
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Butyrate
1 Carvacrol
1 Chlorogenic acid
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 Deguelin
1 Date Fruit Extract
1 diet Methionine-Restricted Diet
1 Fucoidan
1 carboplatin
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 Orlistat
1 Hyperthermia
1 itraconazole
1 lambertianic acid
1 Lutein
1 Iron
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 isoflavones
1 Hyperoside
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Osimertinib
1 Adagrasib
1 Taurine
1 triptolide
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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