Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.


Scientific Papers found: Click to Expand⟱
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, eff↑, eff↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
6428- FEO,  Eug,    Triggering of apoptosis and cell cycle arrest by fennel and clove oils in Caco-2 cells: the role of combination
- in-vitro, Colon, Caco-2
TumCCA↑, Apoptosis↑, Dose↝, TumCCA↑, Ki-67↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27↓,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
6967- Form,  BTZ,    Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
- in-vivo, Melanoma, U266 - in-vivo, Melanoma, RPMI-8226
eff↑, NF-kB↓, PI3K↓, Akt↓, AP-1↓, COX2↓, MMP9↓, Casp3↑, cl‑PARP↑, Dose↝, Ki-67↓, VEGF↓,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
7041- GA,    Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
- vitro+vivo, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, Nor, HK-2
selectivity↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumVol↓, TumW↓, Ki-67↓, MMP9↓, TumAuto↑, LC3B-II↓, Beclin-1↓, p62↑,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31↓,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
1190- GBE,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, Ki-67↑,
7136- GI,    [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2
- vitro+vivo, NSCLC, H1650
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, EGFR↓, STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, TumCG↓, Ki-67↓, eff↑, Dose↝,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
5049- HPT,    Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
- vitro+vivo, PC, Panc02 - vitro+vivo, PC, Bxpc-3
tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
6481- LIN,    Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
- in-vivo, Pca, 22Rv1
TumCP↓, Apoptosis↑, Ki-67↓, PCNA↓, TumCCA↑, MMP↓, TumCG↓,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1↓, *FASN↓, *ACC↓,
1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, CA125↓, ITGA5↓, ITGB1↓, MMP9↓, FAK↓, EMT↓, MAPK↓, MMP9↓, antiOx↑, Ki-67↓, MAPK↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
1043- MET,  immuno,    Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
- in-vitro, NA, NA
eff↑, PD-L1↓, Ki-67↑, TIM-3↑, L-sel↑,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
4948- PEITC,    Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
4963- PEITC,    Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
5208- PI,    Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- in-vitro, GC, SNU16 - in-vitro, Nor, GES-1
TumCP↓, Apoptosis↑, BAX↑, BAD↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, Bcl-2↓, Bcl-xL↓, p‑PI3K↓, p‑Akt↓, Ki-67↓, toxicity↓, RadioS↑,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
96- QC,  docx,    Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
PI3K/Akt↓, Ki-67↓, BAX↑, Bcl-2↓, EpCAM↓, Twist↓, E-cadherin↑, P-gp↓, TumCP↓, TumCMig↓, TumCI↓,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
EMT↓, E-cadherin↑, N-cadherin↓, Ki-67↓, PI3K/Akt↓, MALAT1↓, TumCG↓,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, eff↑, chemoPv↑, BioAv↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
2440- RES,    Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- in-vitro, Lung, H460 - in-vivo, Lung, NA - in-vitro, Lung, H1650 - in-vitro, Lung, HCC827
AntiTum↑, Glycolysis↓, HK2↓, EGFR↓, Akt↓, ERK↓, GlucoseCon↓, lactateProd↓, TumCG↓, Ki-67↓,
3081- RES,    Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?
- Review, CRC, NA
NF-kB↓, FAK↓, Ki-67↓, MMP9↓, CSCs↓, CD44↓, CD133↓, ALDH1A1↓, EMT↓, ChemoSen↑, Hif1a↓, ITGB1↓, Inflam↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
1140- SIL,    Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
- in-vitro, PC, AsPC-1 - in-vivo, PC, NA - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,
5102- SK,  GEM,    Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway
TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,

Showing Research Papers: 51 to 100 of 109
Prev Page 2 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 109

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0)

CXCR3↓, 1,  

Redox & Oxidative Stress(tgid=1)

antiOx↑, 1,   CYP1A1↓, 1,   Ferroptosis↑, 3,   GPx4↓, 3,   GSH↓, 5,   GSTA1↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 2,   i-Iron↑, 1,   lipid-P↑, 3,   MDA↑, 2,   NOX4↓, 1,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   PARK2↑, 1,   PYCR1↓, 1,   ROS↓, 2,   ROS↑, 21,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 2,   TrxR↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

AIF↑, 1,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 3,   CDC25↝, 1,   FGFR1↓, 1,   MMP↓, 10,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4)

ALAT↓, 1,   CAIX↓, 1,   cMyc↓, 5,   FABP4↑, 1,   FASN↓, 1,   FGF21↓, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 5,   HK2↓, 3,   lactateProd↓, 2,   LDH↓, 2,   LDHA↓, 1,   PCK1↓, 1,   PFK↓, 1,   PI3K/Akt↓, 2,   PKM2↓, 1,   POLD1↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   PPP↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5)

Akt↓, 17,   p‑Akt↓, 3,   Apoptosis↑, 21,   BAD↑, 1,   Bak↑, 1,   BAX↑, 15,   Bax:Bcl2↑, 2,   Bcl-2↓, 11,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 1,   proCasp↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 11,   cl‑Casp3↑, 5,   Casp7↑, 2,   Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   CBP↓, 1,   cFLIP↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   CK2↓, 1,   Cyt‑c↑, 8,   Diablo↑, 3,   DR4↑, 1,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 3,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   IAP2↓, 1,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 3,   p‑MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 1,   p27↓, 1,   p27↑, 1,   p‑p38↓, 1,   survivin↓, 4,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↑, 2,   TUNEL↑, 1,  

Kinase & Signal Transduction(tgid=6)

p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7)

p‑H3↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 1,   HATs↓, 1,   other↝, 2,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8)

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,  

Autophagy & Lysosomes(tgid=9)

ATG5↑, 1,   Beclin-1↓, 2,   Beclin-1↑, 1,   LC3B↑, 1,   LC3B-II↓, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 1,   p62↑, 3,   TumAuto↑, 3,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10)

ATM↑, 1,   CHK1↑, 1,   CHK1↝, 1,   DNAdam↑, 6,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↓, 1,   P53↑, 10,   cl‑PARP↑, 5,   PARP1↑, 1,   PCNA↓, 11,   PCNA↑, 1,   TP53↑, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11)

CDK1↓, 2,   CDK1↑, 1,   CDK1↝, 1,   CDK2↓, 6,   CDK4↓, 5,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 12,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 6,   RB1↓, 1,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12)

ALDH↓, 1,   ALDH1A1↓, 2,   CD133↓, 3,   CD44↓, 2,   CDK8↓, 1,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 6,   Diff↑, 1,   EMT?, 1,   EMT↓, 13,   EpCAM↓, 1,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   Gli1↓, 1,   GSK‐3β↑, 2,   HDAC↓, 4,   HDAC1↓, 1,   HRAS↓, 1,   IGF-1↓, 1,   IGFBP3↓, 1,   MCM2↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   mTORC1↓, 1,   mTORC2↓, 1,   Nanog↓, 2,   NOTCH↓, 2,   NOTCH1↓, 1,   OCT4↓, 2,   p300↓, 1,   PI3K↓, 9,   p‑PI3K↓, 2,   PTEN↑, 3,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 9,   p‑STAT3↓, 1,   STAT6↓, 2,   TOP2↓, 2,   TumCG↓, 24,   tyrosinase↓, 1,   Wnt↓, 2,  

Migration(tgid=13)

AntiAg↓, 1,   AP-1↓, 1,   Ca+2↑, 2,   cal2↑, 1,   CD31↓, 2,   CLDN2↓, 1,   CXCL12↓, 1,   E-cadherin↑, 9,   FAK↓, 2,   Fibronectin↓, 1,   ITGA5↓, 1,   ITGB1↓, 2,   Ki-67↓, 46,   Ki-67↑, 2,   KRAS↓, 1,   L-sel↑, 1,   MALAT1↓, 1,   MMP13↓, 2,   MMP2↓, 7,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 14,   MMPs↓, 4,   N-cadherin↓, 5,   PKCδ↓, 1,   Rho↓, 1,   Slug↓, 3,   SMAD2↓, 2,   SMAD3↓, 2,   Snail↓, 3,   TGF-β↓, 3,   TIMP1↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 16,   TumCMig↓, 11,   TumCMig↑, 1,   TumCP↓, 15,   TumMeta↓, 6,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 2,   uPA↓, 2,   Vim?, 1,   Vim↓, 3,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 7,   ATF4↑, 1,   EGFR↓, 7,   p‑EGFR↓, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 6,   NO↓, 1,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15)

BBB↑, 1,   GLUT1↓, 1,   P-gp↓, 2,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

COX2↓, 2,   CRP↓, 1,   CXCR4↓, 1,   IKKα↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 2,   JAK1↓, 2,   JAK2↓, 3,   NF-kB↓, 12,   NF-kB↑, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   Th1 response↑, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17)

NOX↓, 1,   TIM-3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20)

AR↓, 1,   CDK6↓, 4,   COMT↓, 2,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 4,   BioAv↑, 5,   ChemoSen↑, 12,   Dose↝, 9,   eff↓, 3,   eff↑, 16,   eff↝, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 6,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22)

ALAT↓, 1,   ALP↓, 1,   AR↓, 1,   AST↓, 1,   BMPs↑, 1,   CA125↓, 1,   CRP↓, 1,   EGFR↓, 7,   p‑EGFR↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 46,   Ki-67↑, 2,   KRAS↓, 1,   LDH↓, 2,   PD-L1↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 3,   AntiTum↑, 5,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   K17↓, 1,   neuroP↑, 1,   OS↑, 3,   radioP↑, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↓, 3,   TumVol↓, 5,   TumW↓, 5,   Weight∅, 1,  

Infection & Microbiome(tgid=24)

CD8+↑, 1,  
Total Targets: 346

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↑, 9,   Bil↓, 1,   Catalase↑, 1,   GPx↑, 3,   GSH↑, 5,   GSR↑, 1,   H2O2↓, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 7,   ROS↓, 9,   SOD↑, 5,  

Mitochondria & Bioenergetics(tgid=3)

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4)

ACC↓, 1,   ALAT↓, 3,   AMPK↓, 1,   CREB↑, 1,   FASN↓, 1,   LDH↓, 1,   NAD↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   SREBP1↓, 1,  

Cell Death(tgid=5)

Akt↓, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GADD34↓, 1,   iNOS↓, 2,   MAPK↓, 1,  

Protein Folding & ER Stress(tgid=8)

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9)

Beclin-1↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↓, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11)

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12)

ERK↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   IGF-1↑, 1,  

Migration(tgid=13)

Ca+2↓, 1,   CEA↓, 1,   Ki-67↓, 2,   MMP2↑, 1,   ROCK1↓, 1,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 1,   ATF4↓, 1,   NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

COX2↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 2,   IL22↓, 2,   IL6↓, 3,   Imm↓, 1,   Inflam↓, 8,   Inflam↑, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18)

AChE↑, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   tau↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 1,   Dose↑, 1,   Dose↝, 2,   Half-Life↓, 1,   P450↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22)

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   Bil↓, 1,   CEA↓, 1,   IL6↓, 3,   Ki-67↓, 2,   LDH↓, 1,  

Functional Outcomes(tgid=23)

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 8,   chemoP↑, 2,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 2,   neuroP↑, 9,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24)

Bacteria↓, 3,  
Total Targets: 116

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
5 EGCG (Epigallocatechin Gallate)
5 Quercetin
5 Thymoquinone
4 Berberine
4 Resveratrol
3 Capsaicin
3 Formononetin
3 Sulforaphane (mainly Broccoli)
2 Silver-NanoParticles
2 Melatonin
2 Cisplatin
2 Artemisinin
2 Baicalein
2 Boswellia (frankincense)
2 Carnosic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 chaetocin
2 Chrysin
2 Docetaxel
2 Eugenol
2 Ferulic acid
2 Fisetin
2 Garcinol
2 Hydrogen Gas
2 Lycopene
2 Magnolol
2 Phenethyl isothiocyanate
2 Piperlongumine
2 Gemcitabine (Gemzar)
1 Astragalus
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Aspirin
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Carvacrol
1 Cat’s Claw
1 Chlorogenic acid
1 Propolis -bee glue
1 Cinnamon
1 Citric Acid
1 Crocetin
1 diet Methionine-Restricted Diet
1 D-limonene
1 Ellagic acid
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Bortezomib
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Hyperthermia
1 Juglone
1 Linalool
1 Metformin
1 immunotherapy
1 Mushroom Chaga
1 Piperine
1 Psoralidin
1 Pterostilbene
1 Rosmarinic acid
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:425  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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