Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.
Scientific Papers found: Click to Expand⟱
6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Apoptosis↑, PI3K↓, Akt↓, TumCG↓, TumCCA↑, HSP60/HSPD1↓, Ki-67↓, ChemoSen↑,
1584- Citrate,    Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, i-Ca+2↓, TumCMig↓, CD133↓, pH↑, ChemoSen↑, Ki-67↓, eff↑,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27/CDKN1B↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
8846- DIM,  ORM,    Diindolylmethane Promotes Metabolic Crisis and Enhances the Efficacy of Centchroman in Breast Cancer: A 1H NMR-Based Approach
- vitro+vivo, BC, NA
AntiCan↑, EPR↑, Synergy↑, TumCG↓, Glycolysis↓, PKM2↓, GLUT1↓, Hif1a↓, eff↑, Glycine↓, Alanine↓, toxicity↓, Dose↝, TumW↓, Ki-67↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, Synergy↑, NRF2↑, HO-1↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
686- EGCG,    Prevention effect of EGCG in rat's lung cancer induced by benzopyrene
- in-vivo, Lung, NA
NF-kB↓, p50↓, Ki-67↓,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, Var, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
6428- FEO,  Eug,    Triggering of apoptosis and cell cycle arrest by fennel and clove oils in Caco-2 cells: the role of combination
- in-vitro, Colon, Caco-2
TumCCA↑, Apoptosis↑, Dose↝, TumCCA↑, Ki-67↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
6967- Form,  BTZ,    Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
- in-vivo, Melanoma, U266 - in-vivo, Melanoma, RPMI-8226
Synergy↑, NF-kB↓, PI3K↓, Akt↓, AP-1↓, COX2/PTGS2↓, MMP9↓, Casp3↑, cl‑PARP↑, Dose↝, Ki-67↓, VEGF↓,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
8300- FS,    Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
- Trial, Pca, NA
Dose↝, TumCP↓, Ki-67↓, *toxicity↓, Ingr↑, testos↓, DHT↓, Risk↓, Dose↝,
8304- FS,    Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer
- Trial, Pca, NA
NF-kB↓, VEGF↓, Ki-67↓, TumCP↓,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
8590- FS,    The Effect of Flaxseed in Breast Cancer: A Literature Review
- Review, BC, NA
*BioAv↑, *antiOx↑, *TC↓, *cardioP↑, *Ingr↑, *Ingr↑, chemoP↑, ChemoSen↑, TumVol↓, TumCG↓, Risk↓, Risk↓, Ki-67↓, OS↑, TumMeta↓,
7041- GA,    Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
- vitro+vivo, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, Nor, HK-2
selectivity↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumVol↓, TumW↓, Ki-67↓, MMP9↓, TumAuto↑, LC3B-II↓, Beclin-1/ATG6↓, p62↑,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31/PECAM-1↓,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
1190- GBE,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, Ki-67↑,
7136- GI,    [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2
- vitro+vivo, NSCLC, H1650
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, EGFR↓, STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, TumCG↓, Ki-67↓, eff↑, Dose↝,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
7326- GSE,    LEUCOSELECT PHYTOSOME MODULATES SERUM EICOSAPENTAENOIC ACID, DOCOSAHEXAENOIC ACID and PROSTAGLANDIN E3 IN A PHASE 1 LUNG CANCER CHEMOPREVENTION STUDY
- in-vitro, Lung, A549 - in-vitro, Lung, H520
antiNeop↑, Ki-67↓, other↑, PGE3↑,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
5049- HPT,    Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
- vitro+vivo, PC, Panc02 - vitro+vivo, PC, Bxpc-3
tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,
7637- Ins,    Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes
- vitro+vivo, BC, 4T1
TumVol↓, Dose↝, *toxicity↓, AMPK↓, Ki-67↓,
7728- IP6,    G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HT-29
AntiCan↑, TumCCA↑, Ki-67↓, PCNA↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
9183- ITCs,  PEITC,    Isothiocyanates: translating the power of plants to people
- Review, Var, NA
*BioAv↑, *Half-Life↝, *BioAv↝, Ki-67↓, HDAC3↓, HDAC↓, Inflam↓, Bacteria↓, PSA↓, *cognitive↑, 8-oxo-dG↓, Risk↓,
7997- itraC,    Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway
- vitro+vivo, SCC, NA
TumCP↓, TumCCA↑, Apoptosis↑, TumCI↓, TumCMig?, TumCG↓, Ki-67↓, HH?,
8001- itraC,    Repurposing itraconazole as an anticancer agent
- Review, Var, NA
*AntiFungal↑, AntiCan↑, P-gp/ABCB1↓, HH↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, angioG↓, LymphAG↓, ChemoSen↑, OS↑, Gli1↓, Ki-67↓, CSCs↓,
8009- itraC,    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
- vitro+vivo, Melanoma, SK-MEL-28 - vitro+vivo, Melanoma, A375
OS↑, TumCP↓, Ki-67↓, TumCP↓, Gli1↓, GLI2↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, AXIN1↑, GLI3↑, AXIN1↑, HH↓, PI3K↓, Akt↓, *toxicity↓,
7993- itraC,    Preclinical evaluation of itraconazole in docetaxel-resistant prostate cancer xenograft models
- in-vivo, Pca, NA
TumCG∅, TumMeta↓, Ki-67↓, Gli1↓, HH↓,
8034- IVM,  doxoR,    Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation
- in-vitro, Oral, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↓, BAX↑, Casp3↑, P53↑, Bcl-2↓, Ki-67↓, IL6↓, ROS↑, mtDam↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,

Showing Research Papers: 51 to 100 of 173
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 173

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 5,   Catalase↓, 2,   GPx↑, 2,   GPx4↓, 7,   GSH↓, 12,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Iron↑, 1,   Iron↝, 1,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 5,   MDA↑, 4,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 5,   NRF2↝, 1,   ox-PrxI↑, 1,   PYCR1↓, 1,   ROS↓, 7,   ROS↑, 56,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 2,   TAC↓, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   CDC25↝, 1,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   PDH↝, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ACSL4↑, 1,   Alanine↓, 1,   ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 4,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   ENO1↓, 1,   FABP4↑, 1,   FAO↑, 1,   FASN↓, 3,   FBI-1↓, 1,   glucose↓, 3,   GlucoseCon↓, 5,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 11,   Glycolysis↝, 1,   GPI↓, 1,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HK1↓, 1,   HK2↓, 7,   lactateProd↓, 7,   LDHA↓, 3,   PCK1↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 2,   PFK1↓, 1,   PGE3↑, 1,   PKM2↓, 7,   PPP↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TCA↑, 1,   TPI↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 55,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 38,   Bax:Bcl2↑, 9,   Bcl-2↓, 43,   Bcl-xL↓, 7,   BIM↑, 1,   Casp↑, 7,   proCasp↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 36,   cl‑Casp3↑, 19,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 4,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 14,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 16,   Diablo↑, 4,   DR5↑, 6,   FADD↑, 2,   Fas↑, 3,   Ferroptosis↑, 6,   GSDMD↑, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 8,   MDM2↓, 1,   MDM2↑, 2,   p‑MDM2↓, 1,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 19,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↑, 2,   TUNEL↑, 1,   XIAP↓, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 45,   Akt↑, 1,   p‑Akt↓, 7,   AMPKα↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑CREB↑, 1,   cSrc↓, 2,   EGFR↓, 13,   p‑EGFR↓, 1,   ERK↓, 10,   ERK↑, 3,   p‑ERK↓, 5,   p‑ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 1,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK1↓, 2,   JAK2↓, 7,   JNK↓, 1,   JNK↑, 8,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 9,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   mTOR↓, 24,   p‑mTOR↓, 2,   mTORC2↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 30,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PKCδ↓, 2,   PTEN↑, 8,   RAS↓, 1,   p‑RSK↑, 1,   SHP1↓, 1,   Sp1/3/4↓, 2,   STAT3↓, 25,   STAT3↑, 2,   p‑STAT3↓, 5,   STAT6↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   CBP↓, 1,   cJun↑, 2,   cMyc↓, 9,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   FOXO1↓, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac∅, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   miR-106b↓, 1,   miR-107↑, 1,   miR-126↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-21↓, 1,   miR-224↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   OCT4↓, 4,   other↑, 1,   other↝, 3,   SD↑, 1,   SOX2↓, 2,   SUV39H↓, 1,   tumCV↓, 19,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   LC3B↑, 1,   LC3B-II↓, 1,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 1,   p62↑, 3,   PARK2↑, 1,   TumAuto↑, 10,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATM↑, 2,   BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 12,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 2,   NKX3.1↓, 1,   P53↓, 2,   P53↑, 24,   p‑P53↑, 2,   PARP↑, 5,   cl‑PARP↑, 18,   PARP1↑, 1,   PCNA↓, 31,   PCNA↑, 1,   POLD1↓, 1,   TOP1↓, 1,   TOP2↓, 2,   TP53↑, 1,   XRCC1↓, 1,   γH2AX↑, 5,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 2,   CDK1↝, 1,   CDK2↓, 12,   CDK2↑, 1,   CDK4↓, 9,   CDK6↓, 6,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 28,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   GADD45A↓, 1,   Ki-67↓, 164,   Ki-67↑, 3,   MAD↓, 1,   P21↓, 3,   P21↑, 15,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 4,   RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 54,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 2,   AXIN1↑, 2,   BMPs↑, 1,   CD133↓, 5,   CD34↓, 2,   cFos↓, 1,   CSCs↓, 9,   CSCsMark↓, 1,   Diff↑, 1,   FGF↓, 1,   Gli1↓, 5,   HH?, 1,   HH↓, 6,   IGF-1↓, 2,   IGFBP3↓, 1,   Jun↓, 1,   Ki-67↓, 164,   Ki-67↑, 3,   MCM2↓, 1,   mTORC1↓, 2,   Nanog↓, 3,   NOTCH↓, 6,   NOTCH1↓, 2,   NOTCH1↑, 2,   OGFr↑, 1,   p300↓, 1,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 56,   TumCG↑, 2,   TumCG∅, 1,   TumCP?, 1,   TumCP↓, 66,   tyrosinase↓, 1,   Wnt↓, 7,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 5,   i-Ca+2↓, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 17,   EMT?, 1,   EMT↓, 22,   EpCAM↓, 1,   FAK↓, 7,   p‑FAK↓, 2,   Fibronectin↓, 2,   Furin↓, 1,   GLI2↓, 2,   GLI3↑, 1,   ITGA5↓, 1,   ITGB1↓, 2,   KRAS↓, 1,   L-sel↑, 1,   MALAT1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 30,   MMP9↑, 1,   MMPs↓, 5,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 11,   pax↓, 2,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   SMAD2↓, 2,   SMAD2↑, 1,   SMAD3↓, 2,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 2,   TIMP2↑, 2,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 33,   TumCMig?, 1,   TumCMig↓, 26,   TumCMig↑, 1,   TumMeta↓, 23,   TumMeta↑, 2,   TumPF↓, 2,   Twist↓, 4,   uPA↓, 4,   Vim?, 1,   Vim↓, 10,   Zeb1↓, 3,   ZEB2↓, 2,   β-catenin/ZEB1↓, 10,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23,   CD31/PECAM-1↓, 9,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 12,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   PGI2↓, 1,   VEGF↓, 27,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 6,   GLUT3↓, 1,   IBI↑, 1,   MMP↓, 20,   MMP↑, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   p‑cDC2↓, 1,   COX2/PTGS2↓, 20,   CXCL12↓, 1,   CXCR3↓, 1,   CXCR4↓, 4,   DR4↑, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↑, 1,   IL10↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↑, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 4,   Inflam↓, 13,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 36,   NF-kB↑, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 2,   PD-1↝, 1,   PD-L1↓, 5,   PGE2↓, 3,   PSA↓, 3,   Th1 response↑, 1,   TIM-3↑, 1,   TNF-α↓, 14,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 4,   COMT↓, 2,   DHT↓, 1,   ENL↑, 1,   ER-α36↓, 1,   FGF21↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 10,   BioAv↝, 4,   CBR1↓, 1,   ChemoSen↑, 39,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 31,   Dose∅, 1,   eff↓, 11,   eff↑, 20,   eff↝, 3,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 4,   Half-Life↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 1,   RadioS↑, 12,   selectivity↑, 15,   Synergy↑, 41,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 1,   ALP↓, 1,   AR↓, 4,   ascitic↓, 1,   AST↓, 1,   BG↓, 1,   BRCA1↓, 1,   CA125↓, 1,   CA19-9↓, 1,   CEA↓, 1,   CRP↓, 2,   EGFR↓, 13,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 10,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 1,   PD-L1↓, 5,   PSA↓, 3,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↓, 2,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 2,   chemoP?, 1,   chemoP↑, 6,   chemoPv↑, 6,   ChemoSideEff↓, 2,   hepatoP↑, 4,   K17↓, 1,   neuroP↑, 2,   OS↑, 9,   OS∅, 1,   PFS∅, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 9,   Strength↑, 1,   toxicity↓, 10,   toxicity↝, 2,   TumNum↓, 3,   TumVol↓, 23,   TumW↓, 12,   Weight↓, 1,   Weight∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 600

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 15,   Bil↓, 1,   Catalase↑, 9,   GPx↑, 9,   GSH↑, 11,   GSR↑, 2,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 5,   Keap1↓, 1,   lipid-P↓, 6,   MDA↓, 9,   NQO1↑, 2,   NRF2↑, 11,   ROS↓, 20,   SOD↑, 14,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 1,   ATP↓, 1,   ATP↑, 2,   FASN↓, 1,   glucose↓, 3,   GSK‐3β↓, 2,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   PFK↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   AKT1↓, 1,   Akt2↓, 1,   CREB↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   ERK↑, 1,   IKKα↓, 1,   MAPK↓, 1,   PI3K↑, 1,   PP2A↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 4,   Ki-67↑, 3,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 4,   Ki-67↑, 3,   Nestin↑, 1,   NOTCH1↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   Cartilage↑, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   ROCK1↓, 1,   TGF-β1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   CD31/PECAM-1↓, 1,   NO↓, 3,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,   MMP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   Eos↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 6,   IL22↓, 2,   IL6↓, 6,   Imm↓, 1,   INF-γ↑, 1,   Inflam↓, 18,   Inflam↑, 1,   NF-kB↓, 7,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   PGE2↓, 2,   PSA↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 11,  

Cellular Microenvironment(tgid=17) ⓘ

TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↓, 1,   BDNF↑, 4,   GABA↑, 2,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 1,   PSD95↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   Aβ42↓, 2,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

DHT↓, 1,   Estro↓, 1,   FGF21↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 7,   BioAv↝, 7,   Dose↑, 1,   Dose↝, 7,   Half-Life↓, 1,   Half-Life↝, 1,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 2,   AST↓, 5,   Bil↓, 1,   BP↝, 1,   CEA↓, 1,   CRP↓, 3,   EGFR↓, 1,   hs-CRP↓, 1,   IL6↓, 6,   LDH↓, 3,   PSA↓, 1,   TC↓, 2,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 1,   AntiArt↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 6,   AntiTum↑, 1,   cardioP↑, 14,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 5,   hepatoP↑, 8,   memory↑, 6,   neuroP↑, 16,   Obesity↓, 3,   OS↑, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 1,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity↓, 8,   toxicity↝, 5,   toxicity∅, 2,   Weight↓, 1,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 3,   Ingr↝, 4,  
Total Targets: 213

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
6 Benzyl isothiocyanate
5 Melatonin
5 EGCG (Epigallocatechin Gallate)
5 Quercetin
5 Flaxseed/Linseed
5 Magnolol
5 Thymoquinone
4 Berberine
4 itraconazole
4 Luteolin
4 Lycopene
4 Resveratrol
3 Capsaicin
3 Formononetin
3 Phenethyl isothiocyanate
3 doxorubicin
3 L-Theanine
3 SDG/lignans
3 Linalool
3 Sulforaphane (mainly Broccoli)
2 Açaí, Euterpe oleracea
2 Silver-NanoParticles
2 Cisplatin
2 Artemisinin
2 Baicalein
2 Boswellia (frankincense)
2 Carnosic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 chaetocin
2 Chrysin
2 Docetaxel
2 Eugenol
2 Ferulic acid
2 Fisetin
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Ivermectin
2 Kaempferol
2 Metformin
2 Piperlongumine
2 Gemcitabine (Gemzar)
1 Astragalus
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Aspirin
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Black Rice, Oryza sativa
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Cat’s Claw
1 Chlorogenic acid
1 Propolis -bee glue
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Ormeloxifene (Centchroman)
1 D-limonene
1 Ellagic acid
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Bortezomib
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Hyperthermia
1 Inositol
1 phytic acid, Inositol hexakisphosphate
1 isoorientin
1 Isothiocyanates
1 Juglone
1 Licochalcone A
1 low dose naltrexone
1 Curcumin
1 Radiotherapy/Radiation
1 Matrine
1 mebendazole
1 Sulindac
1 Modified Citrus Pectin
1 immunotherapy
1 Lemon Balm/Melissa officinalis
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
1 Phycocyanin
1 Piperine
1 Psoralidin
1 Pterostilbene
1 Rosmarinic acid
1 Sesamin
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Xylitol
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:425  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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