Casp7 Cancer Research Results

Casp7, Caspase-7: Click to Expand ⟱
Source:
Type:
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups: the initiator caspases (caspase-2, −8, −9 and −10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, −6, and −7) that carry out the demolition phase of apoptosis. Downregulation of caspase-3 is an effective apoptosis-evading mechanism frequently observed in cancer cells in association with acquired chemoresistance to apoptosis-inducing anticancer drugs. Indeed, re-expression of caspase-3 often restores sensitivity to apoptosis.
Caspase-7:
Role: Executioner caspase similar to caspase-3.
Cancers: Expression levels can vary; often studied in breast and prostate cancers.
Prognosis: Its prognostic value is less clear and may depend on the cancer type.
Scientific Papers found: Click to Expand⟱
850- Gra,    Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin
- in-vitro, PC, PC3 - in-vitro, Pca, DU145
ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
8025- IVM,    Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
- in-vitro, CRC, SW480 - in-vivo, CRC, HCT116
*AntiP↓, *Inflam↓, *AntiViral↑, AntiTum↑, TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, cl‑PARP↑, Bcl-2↓, mt-ROS↑, eff↓, Dose↝, TumCCA↑,
7965- JG,    Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8060- KAE,    Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,
8061- KAE,    Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, Risk↓, VEGF↓, TumCP↓, Dose↝, P53↑,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
- in-vitro, NSCLC, NA
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
1064- LT,  Cisplatin,    Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
- vitro+vivo, Lung, LNM35 - in-vitro, CRC, HT-29 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Casp3↑, Casp7↑, HDAC↓,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, Synergy↑,
8525- MAG,    Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells
- in-vitro, Thyroid, NA
Casp3↑, Casp7↑, PARP↑, Akt↓, p‑PTEN↓, p‑Akt↓,
8557- Matr,    Effects of matrine in combination with cisplatin on liver cancer
- in-vivo, Liver, HepG2
ChemoSen?, TumW↓, TumVol↓, survivin↓, XIAP↓, Casp3↑, Casp7↑, Casp9↑,
8649- MBZ,    Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01)
- in-vitro, GC, AGP01
TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, cMyc↓,
8786- mCHEMO,    Metronomic chemotherapy in cancer treatment: new wine in an old bottle
- Review, Var, NA
eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,
8753- MeSA,    Methylseleninic acid inhibits human glioma growth in vitro and in vivo by triggering ROS-dependent oxidative damage and apoptosis
- vitro+vivo, GBM, U251 - in-vitro, GBM, U87MG
Apoptosis↑, Casp7↑, Casp9↑, Casp3↑, ROS↑, TumCG↓,
3486- MF,    Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death
- in-vitro, BC, MCF-10AT
ChemoSen↑, tumCV↓, cl‑PARP↑, Casp7↑, Casp9↑, survivin↓, BAX↑, DNAdam↑, ROS↑, eff↓,
497- MF,    In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells
- vitro+vivo, BC, MCF7 - vitro+vivo, Lung, A549
TumCG↓, TumVol↓, Casp3↑, Casp7↑, Apoptosis↑, DNAdam↑, TumCCA↑, ChemoSen↑, EPR↑,
506- MF,  doxoR,    Pulsed Electromagnetic Field Stimulation Promotes Anti-cell Proliferative Activity in Doxorubicin-treated Mouse Osteosarcoma Cells
- in-vitro, OS, LM8
TumCP↓, p‑CHK1↓, Ca+2↑, Casp3↓, Casp7↓, p‑BAD↓, ChemoSen↑,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, ChemoSen↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
9154- MG, MIC-1,    Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
- in-vitro, BC, NA
Ingr↝, *TumCG↓, Cyt‑c↑, P53↑, cl‑Casp7↑, survivin↓, Bcl-2↓, Bcl-xL↓, MMP↓, ROS↑, PHB↑,
9087- MGF,    Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
- Review, Var, NA
TumCP↓, TumCI↓, angioG↓, *BioAv↓, *neuroP↑, *Inflam↓, *AntiCan↑, *ROS↓, *BioAv↑, *BioAv↝, *Half-Life↝, *BBB↓, CDK1↑, CycB/CCNB1↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, PI3K↓, Akt↓, mTOR↓, MMP↓, MOMP↑, Apoptosis↑, lipid-P↑, TCA↓, NRF2↑, NQO1↑, ROS↓, RadioS↑,
1762- MNPs,  Fe,    Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
- in-vitro, RCC, NA
Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,
8611- MO,    Antitumoral effects of Melissa officinalis on breast cancer in vitro and in vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Casp7↑, Ki-67↓, TumVol↓,
8610- MO,    Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species
- in-vitro, CRC, HT-29 - in-vitro, Colon, T84
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, CDKN2C/p18↑, P21↑, cl‑Casp3↑, cl‑Casp7↑, Apoptosis↑, ROS↑, eff↓,
8907- MO,    Phenolic Extraction of Moringa Oleifera Leaves Induces Caspase-Dependent and Caspase-Independent Apoptosis through the Generation of Reactive Oxygen Species and the Activation of Intrinsic Mitochondrial Pathway in Human Melanoma Cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCP↓, selectivity↑, ROS↑, MMP↓, BAX↑, Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, AIF↑,
8771- MSM,    Methylsulfonylmethane induces caspase-dependent apoptosis in acute myeloid leukemia cell lines
- in-vitro, lymphoma, U937 - in-vitro, AML, HL-60
tumCV↓, Casp3↑, Casp7↑, Apoptosis↑,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
8454- OM,    Aqueous Extract of Origanum majorana at Low Temperature (0°C) Promotes Mitochondrial Fusion and Contributes to Induced Apoptosis in Human Breast Cancer Cells
- in-vitro, BC, NA
Ingr?, selectivity↑, Casp7↑, AIF↑, HO-1↑, ROS↑, P53↑, Bcl-2↓,
8426- OM,    Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway
- in-vitro, CRC, HT-29 - in-vitro, Colon, Caco-2
TumCP↓, tumCV↓, mitA↑, DNAdam↑, Casp3↑, Casp7↑, survivin↓, TumAuto↑,
8429- OM,    Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo
- vitro+vivo, NSCLC, A549 - in-vitro, Lung, LNM35
tumCV↓, Casp3↑, Casp7↑, survivin↓, TumCG↓, TumCMig↓, TumCI↓, *toxicity↓,
2078- PB,    Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response
- in-vitro, CRC, HCT116
p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,
2039- PB,    TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
36- QC,    Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
P53↑, P21↑, BAX↑, Casp3↑, Casp7↑, TumCCA↑, ROS↑, TumCCA↑, Apoptosis↑,
93- QC,    Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells
- in-vitro, Pca, PC3
hnRNPA1↓, Casp3↑, Casp7↑, TumCD↑, IAP1↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
1388- Sco,    Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells
- in-vitro, CRC, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, eff↓,
1403- SDT,  BBR,    From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Lung, LLC1
eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,

Showing Research Papers: 51 to 100 of 116
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 116

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 2,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 12,   GSH↑, 2,   GSH/GSSG↓, 2,   GSR↓, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   mt-H2O2↑, 1,   HO-1↑, 4,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↑, 4,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 4,   OSI↑, 1,   Prx4↑, 1,   ROS↓, 4,   ROS↑, 44,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 4,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 1,   TrxR↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 4,   OCR↓, 2,   mt-OXPHOS↓, 1,   PHB↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACSL4↑, 1,   ALAT↝, 1,   AMP↑, 1,   AMPK↑, 3,   ATP↓, 4,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 5,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 3,   LDL↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 2,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 4,   Apoptosis↓, 3,   Apoptosis↑, 58,   BAD↓, 2,   BAD↑, 4,   p‑BAD↓, 1,   Bak↑, 3,   BAX↑, 36,   Bax:Bcl2↑, 7,   Bcl-2↓, 40,   Bcl-2↑, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 6,   BID↑, 4,   p‑BID↓, 1,   BIM↑, 2,   BOK↑, 1,   Casp↑, 6,   Casp↝, 1,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 87,   cl‑Casp3↑, 13,   Casp6↑, 1,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 98,   cl‑Casp7↑, 15,   Casp8↑, 13,   cl‑Casp8↑, 4,   Casp9?, 1,   Casp9↑, 42,   cl‑Casp9↑, 7,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   Diablo↑, 1,   DR5↑, 3,   FADD↑, 2,   Fas↑, 8,   FasL↑, 2,   Ferroptosis↑, 2,   IAP1↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 2,   Mcl-1↓, 5,   p‑Mcl-1↓, 1,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   NAIP↓, 1,   p38↓, 1,   p38↑, 8,   p‑p38↑, 1,   PUMA↑, 2,   RIP3↑, 1,   survivin↓, 21,   TRAIL↑, 2,   TumCD↓, 1,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 20,   p‑Akt↓, 8,   AKT1↓, 2,   CK2↓, 2,   cMET↓, 1,   p‑CREB↓, 1,   cSrc↓, 1,   EGFR↓, 9,   ERK↓, 12,   ERK↑, 2,   e-ERK↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IκB↓, 1,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 3,   p‑MAPK↓, 1,   MKK4↓, 1,   mTOR↓, 12,   p‑mTOR↓, 2,   PDGFRA↓, 1,   PI3K↓, 18,   PTEN↑, 5,   p‑PTEN↓, 1,   RAS↓, 2,   RIP1↑, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   c-Src↓, 1,   STAT3↓, 11,   p‑STAT3↓, 4,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF4↑, 4,   ATF4↝, 1,   cJun↓, 1,   cMyc↓, 13,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   p‑FOXO3↓, 1,   H3↓, 1,   HATs↓, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   miR-21↓, 1,   miR-339-5p↝, 1,   Myc↓, 2,   OCT4↓, 4,   other↑, 1,   other↝, 1,   SOX2↓, 1,   SOX4↑, 1,   tumCV↓, 24,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 9,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 10,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 3,   XBP-1↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↑, 24,   P53↓, 1,   P53↑, 26,   P53∅, 1,   PARP↑, 8,   PARP↝, 1,   cl‑PARP↑, 33,   PARP1↑, 1,   PCNA↓, 8,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 6,   p‑CDK2↓, 2,   CDK4↓, 11,   p‑CDK4↓, 1,   CDK6↓, 4,   CDKN2C/p18↑, 1,   p‑CHK1↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 7,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 22,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   cycE1↓, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 3,   P21↑, 14,   p27/CDKN1B↑, 4,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 41,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD133↓, 2,   cFos↓, 1,   CSCs↓, 6,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 3,   IGF-2↑, 1,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 4,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 3,   STAT1↓, 1,   TumCG↓, 20,   TumCP↓, 32,   TumCP↑, 2,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 6,   cal2↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 7,   EM↑, 1,   EMT↓, 15,   FAK↓, 3,   GLI2↓, 2,   hnRNPA1↓, 1,   ITGB4↓, 1,   LEF1↓, 2,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 10,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 14,   MMPs↓, 5,   N-cadherin↓, 6,   PAI-1/SERPINE1↑, 1,   PCBP1↓, 1,   Slug↓, 5,   Snail↓, 9,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TumCI↓, 16,   TumCMig↓, 10,   TumMeta↓, 17,   Twist↓, 6,   TXNIP↑, 2,   uPA↓, 3,   Vim↓, 6,   Zeb1↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 15,   angioG↑, 2,   CD31/PECAM-1↓, 2,   HIF-1↓, 1,   Hif1a↓, 11,   VCAM-1↓, 1,   VEGF↓, 21,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,   EPR↑, 1,   GLUT1↓, 2,   IBI↑, 1,   MMP?, 1,   MMP↓, 21,   MMP∅, 1,   MPT↑, 2,   OCLN↑, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 12,   CXCR4↓, 3,   DR4↑, 1,   ICAM-1↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL6↓, 5,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 5,   MCT1↓, 1,   NF-kB↓, 19,   p‑NF-kB↑, 1,   NK cell↑, 2,   p50↓, 1,   PGE2↓, 3,   PSA↓, 2,   SOCS-3↓, 1,   TCF↓, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 3,   ChemoSen?, 1,   ChemoSen↑, 24,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose↑, 2,   Dose↝, 12,   Dose∅, 2,   eff↓, 12,   eff↑, 13,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 6,   selectivity?, 1,   selectivity↑, 24,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↝, 1,   ALP↝, 1,   AR↓, 3,   AST↝, 1,   p‑BRCA1↑, 1,   EGFR↓, 9,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 5,   LDH↓, 1,   LDH↑, 1,   Myc↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 1,   chemoP↑, 6,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   OS↑, 1,   PFS↑, 1,   RenoP↑, 1,   Risk↓, 5,   toxicity↓, 2,   toxicity↝, 1,   TumNum↓, 1,   TumVol↓, 7,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 438

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 8,   GPx↑, 8,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 7,   MDA↓, 3,   NRF2↑, 2,   ROS↓, 13,   SOD↑, 8,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   HMG-CoA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp7↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   MAPK↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   GastroP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 5,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 3,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 19,   NF-kB↓, 3,   NK cell↑, 2,   PGE2↓, 2,   PSA∅, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 3,   Dose↝, 2,   GSTA1↑, 1,   Half-Life↝, 2,   P450↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BP↓, 1,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 3,   LDH↓, 1,   PSA∅, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 4,   AntiDiabetic↑, 6,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 6,   chemoPv↑, 1,   diuretic↑, 1,   hepatoP↑, 6,   neuroP↑, 11,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↓, 1,   AntiViral↑, 4,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 104

Scientific Paper Hit Count for: Casp7, Caspase-7
8 Thymoquinone
6 EGCG (Epigallocatechin Gallate)
6 Kaempferol
5 Quercetin
5 Sulforaphane (mainly Broccoli)
5 Magnetic Fields
4 Silver-NanoParticles
3 Cisplatin
3 Chrysin
3 Fucoidan
3 Marjoram (Origanum majorana)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 Cinnamon
2 doxorubicin
2 Echinacea
2 Fisetin
2 Graviola
2 Lemon Balm/Melissa officinalis
2 Phenylbutyrate
2 Piperlongumine
1 Auranofin
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Bromelain
1 borneol
1 Black turtle bean
1 Caffeic acid
1 Carvacrol
1 Cat’s Claw
1 Cucurbitacin
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 Docetaxel
1 Emodin
1 Eurycomanone
1 Eugenol
1 Fenbendazole
1 Flaxseed/Linseed
1 Ginger/6-Shogaol/Gingerol
1 Hibiscus sabdariffa
1 Honokiol
1 Inulin Prebiotic
1 Isoliquiritigenin
1 Ivermectin
1 Juglone
1 Lapachol
1 Licochalcone A
1 Licorice
1 Luteolin
1 Lycopene
1 Magnolol
1 Matrine
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 Mangiferin
1 magnetic nanoparticles
1 Iron
1 Moringa oleifera
1 Methylsulfonylmethane
1 Nimbolide
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 SonoDynamic Therapy UltraSound
1 Shikonin
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:43  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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