Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
Scientific Papers found: Click to Expand⟱
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,
724- Bor,    Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways?
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Apoptosis↑, Casp3↝, Casp8↝, Casp9↝,
1185- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA
BAX↑, NF-kB↓, cl‑PARP↑, Casp3↑, Casp8↑, *antiAll↑, *STAT6↓,
1424- Bos,    Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,
2024- Bos,    Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, Synergy↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, Synergy↑, MMP1↓, MMP2↓, Synergy↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑, *antiAll↑,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
8695- CAP,    Advances in cold atmospheric plasma therapy for cancer
- Review, Var, NA
Apoptosis↑, Pyro↑, Ferroptosis↑, necrosis↑, Bacteria↓, antiCG↓, ChemoSen↑, ROS↑, RNS↑, cl‑Casp3↑, BAX↑, PARP↑, Casp8↑, P53↑, Akt↓, Bcl-2↓, GSH↓, MDA↑, Iron↑, MAPK↓, MMP9↓, TumCG↓, selectivity↑, toxicity↝,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5959- CEL,    Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-κB as a possible target
- in-vitro, Cerv, HeLa
Apoptosis↑, Casp8↑, Casp9↑, cl‑BID↑, MMP↓, NF-kB↑, Dose⇅, chemoPv⇅, COX2/PTGS2↓,
7180- CHA,    Chaetocin: A review of its anticancer potentials and mechanisms
- Review, Var, NA
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumCMig↓, SUV39H↓, TrxR↓, Hif1a↓, HSP90↓, ox-Trx1↑, ROS↑, PI3K↓, Akt↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, DR5↑, CHOP/DDIT3↑, ATF3↑, angioG↓, VEGF↑, LDHA↓, ENO1↓,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
6069- CHL,  PDT,    Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
- in-vitro, Cerv, HeLa
eff↑, ROS↑, Casp8↓, Casp9↑, BAX↑, Cyt‑c↑, Bcl-2↓, AKT1↓,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, Synergy↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, ChemoSen↑, eff↑, eff↑, Synergy↑,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
7410- CS,    Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
- in-vitro, BC, MDA-MB-231
selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,
485- CUR,  PDT,    Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
- in-vitro, Melanoma, NA
NF-kB↓, Casp8↑, Casp9↑, p‑Akt↓, p‑ERK↓,
484- CUR,  PDT,    Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
- in-vitro, Melanoma, NA
Cyt‑c↑, Casp9↑, Casp8↑, NF-kB↓, EGFR↓,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,
159- CUR,    Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment
- in-vitro, Pca, DU145
ROS↑, p‑Jun↑, p‑p38↑, TumAuto↑, Casp8↑, Casp9↑, Akt↓, ERK↓, p38↓,
9105- CV,  AgNPs,    Apoptosis induction in colon cancer cells (SW480) by BiFe2O4@Ag nanocomposite synthesized from Chlorella vulgaris extract and evaluation the expression of CASP8, BAX and BCL2 genes
- in-vitro, Colon, SW480
selectivity↑, TumCCA↑, Casp8↑, BAX↑, Bcl-2↑, ROS↑,
7443- CYN,    Cynaropicrin, a sesquiterpene lactone, triggers apoptotic cell death in triple negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
6697- DFC,    Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS
- in-vitro, Liver, NA
Inflam↓, Casp3↑, Casp8↑, Casp9↑, MPT↑, mt-ROS↑,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3203- EGCG,    (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress
- in-vitro, MM, NA
ROS↑, Ca+2↝, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, *GRP78/BiP↓, *UPR↓, UPR↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
689- EGCG,    EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9
- vitro+vivo, Bladder, SW780
Casp8↑, Casp9↑, Casp3↑, BAX↑, PARP↑, TumVol↓, NF-kB↓, MMP9↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1/ATG6↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
6832- EMD,    Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
- in-vitro, Cerv, HeLa
Cyt‑c↑, APAF1↑, Fas↑, FasL↑, FADD↑, proCasp9↓, proCasp8↓, proCasp3↓, TumCP↓, Apoptosis↑, Casp9↑, Casp8↑, Casp3↑,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
1318- EMD,    Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species
- in-vitro, Nor, HL7702
*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,
6794- EPA,    EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction
- in-vitro, BC, NA - vitro+vivo, PC, MIA PaCa-2
ROS↑, Casp8↑, Apoptosis↑, ROS↑, TumCG↓, TumCD↑, eff↑,

Showing Research Papers: 51 to 100 of 235
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 235

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↓, 7,   Catalase↑, 1,   GCLM↓, 1,   GPx↓, 1,   GPx↑, 1,   GSH↓, 20,   GSH↑, 3,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 4,   i-H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 6,   HO-1↝, 1,   Iron↓, 1,   Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↑, 5,   MPO↓, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 4,   NRF2↑, 7,   p‑NRF2↑, 1,   RNS↑, 1,   ROS?, 3,   ROS↓, 8,   ROS↑, 106,   ROS⇅, 3,   ROS∅, 1,   i-ROS?, 1,   i-ROS↑, 2,   mt-ROS↑, 3,   SOD↓, 5,   SOD↑, 3,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 2,   TAC↓, 1,   TBARS↑, 1,   ox-Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 6,   CDC25↓, 13,   CDC25↑, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 1,   HSP60/HSPD1↑, 1,   mtDam↑, 9,   OCR↓, 1,   OXPHOS↓, 1,   PDH↓, 1,   PINK1↑, 1,   SDH↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 4,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 9,   AMPK↝, 1,   ATP↓, 4,   ATP↝, 1,   CAIX/CA9↓, 1,   citrate↓, 1,   CPT1A↓, 1,   ENO1↓, 1,   FABP4↓, 1,   FASN↓, 2,   FASN↑, 2,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 4,   Glycolysis↓, 6,   GSK‐3β↓, 5,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 3,   H2S↑, 1,   HK2↓, 5,   lactateProd↓, 5,   LDHA↓, 3,   LDL↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 2,   PFK1↓, 1,   PFK2?, 1,   PFK2↓, 1,   PKM2↓, 3,   PKM2∅, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   TCA↑, 1,   Warburg↓, 2,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 14,   APAF1↑, 6,   Apoptosis↓, 4,   Apoptosis↑, 116,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 11,   Bak↓, 1,   Bak↑, 4,   BAX↑, 86,   BAX⇅, 1,   BAX∅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 80,   Bcl-2↑, 4,   Bcl-2∅, 2,   Bcl-xL↓, 19,   Bcl-xL↑, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 9,   cl‑BID↑, 6,   BIM↑, 4,   BOK↑, 1,   Casp↑, 5,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 2,   Casp10∅, 1,   Casp12↑, 2,   Casp2↑, 4,   Casp3↓, 3,   Casp3↑, 146,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↑, 29,   proCasp3↓, 2,   proCasp3↑, 2,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 4,   Casp8↓, 5,   Casp8↑, 181,   Casp8↝, 1,   Casp8∅, 4,   cl‑Casp8↑, 30,   proCasp8↓, 2,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 2,   Casp9↑, 129,   Casp9↝, 1,   cl‑Casp9↑, 18,   proCasp9↓, 2,   proCasp9↑, 2,   cFLIP↓, 8,   Cyt‑c↑, 70,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 26,   DR5∅, 1,   FADD↑, 9,   FADD∅, 1,   Fas↓, 1,   Fas↑, 34,   FasL↓, 1,   FasL↑, 16,   Ferroptosis↑, 1,   IAP1↓, 7,   IAP2/BIRC3↓, 4,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 5,   Mcl-1↓, 18,   cl‑Mcl-1↑, 1,   MDM2↓, 5,   MDM2↑, 1,   p‑MDM2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 2,   p38↓, 2,   p38↑, 15,   p‑p38↓, 1,   p‑p38↑, 6,   PUMA↑, 3,   PUMA↝, 1,   Pyro↑, 2,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 31,   TNFR 1↑, 2,   TRAIL↑, 9,   TRAILR↑, 3,   TumCD↓, 1,   TumCD↑, 7,   XIAP↓, 23,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 56,   Akt↑, 3,   p‑Akt↓, 15,   AKT1↓, 2,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 2,   cMET↓, 3,   cSrc↓, 2,   EGFR↓, 16,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 23,   ERK↑, 6,   p‑ERK↓, 7,   p‑ERK↑, 1,   p‑ERK⇅, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 3,   IGF-1R↑, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 1,   p‑IκB↓, 1,   JAK1↓, 5,   p‑JAK1↓, 1,   JAK2↓, 7,   p‑JAK2↓, 4,   JNK↓, 2,   JNK↑, 14,   p‑JNK↓, 2,   p‑JNK↑, 2,   cl‑JNK↑, 1,   MAPK↓, 12,   MAPK↑, 8,   MEK↓, 2,   p‑MEK↓, 2,   mTOR↓, 28,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 6,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 40,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 5,   p‑PKCδ↓, 1,   cl‑PKCδ↑, 1,   PTEN↓, 2,   PTEN↑, 10,   Raf↓, 3,   RAS↓, 6,   RIP1↑, 1,   SHP1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 2,   STAT↓, 1,   STAT3↓, 21,   STAT3↑, 1,   p‑STAT3↓, 5,   STAT6↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 5,   ATFs↑, 1,   cJun↓, 2,   cJun↑, 3,   p‑cJun↑, 2,   cMyc↓, 11,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   H3↓, 2,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC1↓, 2,   HDAC3↓, 1,   HES1↓, 1,   miR-130a↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-21↓, 2,   Myc↓, 3,   MYCN↓, 1,   OCT4↓, 2,   other↓, 2,   other↑, 1,   other↝, 3,   PCAF↓, 1,   SOX2↓, 1,   SOX9↓, 1,   SUV39H↓, 1,   tumCV?, 1,   tumCV↓, 36,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 15,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 3,   UPR↑, 4,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG5↝, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 7,   Beclin-1/ATG6↝, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3B↑, 2,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 6,   p62↓, 2,   p62↑, 2,   PARK2↑, 1,   TumAuto↑, 17,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↑, 35,   DNArepair↓, 1,   hTERT/TERT↓, 5,   p16↑, 2,   P53↓, 1,   P53↑, 48,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 16,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 73,   cl‑PARP1↑, 2,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 6,   TOP1↓, 2,   TOP2↓, 4,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CDK1↓, 9,   CDK1↑, 4,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK2↓, 18,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 23,   CDK4↑, 2,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 8,   CDK6↑, 3,   CDK6∅, 1,   CDK8↓, 1,   CHK1↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 33,   cycD1/CCND1↑, 2,   cycD1/CCND1∅, 1,   CycD3↓, 1,   cycE/CCNE↓, 15,   cycE1↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 6,   mitA↑, 1,   p19↑, 1,   P21↑, 37,   p27/CDKN1B↑, 15,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↑, 91,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 9,   Diff↑, 2,   FGF↓, 1,   Gli1↓, 2,   HH↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   JAG1↓, 1,   p‑Jun↑, 1,   Ki-67↓, 6,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NICD↓, 1,   NOTCH↓, 4,   NOTCH1↓, 6,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 2,   Smo↓, 2,   STAT1↓, 1,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 43,   TumCG↑, 1,   TumCP↓, 60,   tyrosinase↓, 1,   Wnt↓, 12,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 5,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 14,   Ca+2↝, 4,   i-Ca+2↑, 3,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 9,   EM↑, 1,   EMT↓, 18,   EMT↑, 1,   FAK↓, 7,   p‑FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 35,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 41,   MMPs↓, 11,   MTA1↓, 1,   N-cadherin↓, 10,   PAK1↓, 1,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 8,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 15,   TET1↓, 1,   TGF-β↓, 7,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 7,   TIMP3↑, 1,   TSP-1↑, 1,   TumCI↓, 31,   TumCI↑, 1,   TumCMig↓, 25,   TumMeta↓, 16,   Twist↓, 6,   Tyro3↓, 1,   uPA↓, 11,   Vim↓, 7,   Vim↑, 1,   Zeb1↓, 2,   Zeb1↑, 1,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 16,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   HIF-1↓, 2,   Hif1a↓, 12,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 38,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   CLDN1↓, 1,   CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 4,   GLUT2↓, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 75,   MMP↑, 1,   MPT↑, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD8+↑, 1,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 6,   DR4↑, 7,   DR4∅, 2,   DR6↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL12↓, 2,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 12,   IL8↓, 5,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 12,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 55,   NF-kB↑, 6,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   p50↓, 2,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 2,   RAGE↓, 2,   T-Cell↝, 1,   TCF↑, 1,   TLR4↓, 2,   TNF-α↓, 14,   TNF-α↑, 5,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 7,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 13,   BioAv↑, 25,   BioAv↝, 2,   ChemoSen↓, 2,   ChemoSen↑, 41,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 13,   Dose∅, 3,   eff↓, 24,   eff↑, 30,   eff↝, 8,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 2,   P450↝, 1,   RadioS↑, 15,   selectivity↓, 1,   selectivity↑, 51,   Synergy↑, 20,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 4,   ALP↓, 2,   AR↓, 7,   ascitic↓, 1,   AST↓, 4,   CEA↓, 2,   EGFR↓, 16,   EGFR↑, 2,   p‑EGFR↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 12,   LDH↑, 1,   Myc↓, 3,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 2,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 1,   AntiTum↑, 4,   cachexia↓, 2,   cardioP↑, 2,   chemoP↑, 8,   chemoPv↑, 8,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   OS↑, 4,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 2,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 7,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 3,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 750

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 34,   Catalase↑, 17,   GPx↑, 13,   GSH↑, 15,   GSR↑, 2,   GSTs↑, 10,   H2O2↓, 1,   HDL↑, 2,   HO-1↑, 5,   hyperG↝, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 9,   MDA↓, 13,   MPO↓, 3,   NADH↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 11,   RNS↓, 3,   ROS↓, 32,   ROS↑, 3,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 20,   SOD1↑, 1,   TBARS↓, 2,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ALAT↓, 8,   AMPK↑, 2,   ATP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 3,   lipidLev↓, 1,   SIRT1↑, 4,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   ASC↓, 1,   BAD↓, 1,   BAX↓, 8,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 2,   Bcl-2↑, 3,   Casp1↓, 3,   Casp3↓, 10,   Casp3↑, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↓, 5,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 3,   Casp9↓, 4,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Fas↑, 2,   iNOS↓, 8,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 2,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↓, 1,   RIP1↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   cJun↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 1,   other↑, 2,   other↝, 1,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 1,   GRP78/BiP↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 2,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 3,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Ki-67↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   MMP13↓, 1,   MMP3↓, 1,   PAI-1/SERPINE1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5,   NO↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 2,   BBB↝, 1,   CLDN1↓, 1,   GastroP↑, 4,   IBI↑, 1,   MMP↓, 2,   MMP↑, 3,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 12,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 2,   IL13↑, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL6↓, 12,   IL6↑, 1,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 33,   IP-10/CXCL-10↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 3,   TNF-α↓, 16,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BChE↓, 2,   BDNF↑, 2,   NGF↑, 2,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARα↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 9,   BioAv↝, 5,   BioEnh↑, 1,   CYP2E1↓, 2,   Dose↝, 6,   eff↓, 1,   eff↑, 8,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 5,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 2,   AST↓, 9,   BP↓, 3,   BUN↓, 1,   CEA↓, 1,   creat↓, 3,   CRP↓, 1,   IL6↓, 12,   IL6↑, 1,   LDH↓, 4,   NOS2↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 6,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 7,   antiNeop↑, 1,   AntiTum↑, 3,   cardioP↑, 16,   chemoP↑, 5,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 16,   memory↑, 2,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 17,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 4,   Stroke↓, 3,   toxicity↓, 16,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 4,   Sepsis↓, 1,  
Total Targets: 257

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
11 Apigenin (mainly Parsley)
10 Fisetin
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Thymoquinone
6 Baicalein
6 Boswellia (frankincense)
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
5 Silver-NanoParticles
5 Magnolol
4 Phenethyl isothiocyanate
4 Curcumin
4 Emodin
4 Gambogic Acid
4 Morin
4 Luteolin
3 Allyl isothiocyanate
3 Artemisinin
3 Berberine
3 Betulinic acid
3 Benzyl isothiocyanate
3 Photodynamic Therapy
3 Citric Acid
3 Ferulic acid
3 Gallic acid
3 Garcinol
3 Hibiscus sabdariffa
3 Hyperoside
3 Kaempferol
3 Licorice
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Propyl gallate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Brucea javanica
2 Bromelain
2 Boron
2 Carvacrol
2 Thymol-Thymus vulgaris
2 chaetocin
2 Chrysin
2 Fucoidan
2 Ginkgetin
2 Graviola
2 Propolis -bee glue
2 Honokiol
2 Rutin
2 isoquercitrin
2 Juglone
2 Licochalcone A
2 Magnetic Fields
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Patchouli Oil (Pogostemon cablin)
2 Shikonin
2 Aflavin-3,3′-digallate
2 Ursolic acid
1 Resiquimod
1 Metformin
1 Cisplatin
1 2-DeoxyGlucose
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Trastuzumab
1 Berbamine
1 α-Bisabolol / Chamomile oil
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 Celecoxib
1 chitosan
1 Chlorophyllin
1 Crocetin
1 Carvone
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Diclofenac
1 Ellagic acid
1 eicosapentaenoic acid
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Isorhamnetin
1 L-Theanine
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Radiotherapy/Radiation
1 Lutein
1 Matrine
1 Methyl Jasmonate
1 Chemotherapy
1 Mangiferin
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Auranofin
1 Docetaxel
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:44  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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