IFN-γ Cancer Research Results

IFN-γ, Interferon-γ: Click to Expand ⟱
Source:
Type:
Plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer.
Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell apoptosis, and/or stimulate the activity of M1 proinflammatory macrophages to overcome tumor progression.
However, the current understanding of the roles of IFN-γ in the tumor microenvironment (TME) may be misleading in terms of its clinical application.

IFN-γ is often expressed in the tumor microenvironment, particularly in response to immune cell infiltration. Its expression can be influenced by the presence of tumor-infiltrating lymphocytes (TILs) and other immune cells.
High levels of IFN-γ are typically associated with a Th1 immune response, which is generally considered beneficial for anti-tumor immunity.

Tumor Suppression:
In many cases, IFN-γ has tumor-suppressive effects, as it can inhibit tumor cell proliferation and induce apoptosis in certain cancer types.
Scientific Papers found: Click to Expand⟱
9303- MushMait,    A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects
- Trial, BC, NA
Dose↝, *toxicity↓, Imm⇅, other↝, Dose↝, CD4+↑, IL2↑, IL10↑, TNF-α↑, IFN-γ↑, Imm↝,
5602- NaHCO3,  immuno,    Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
- in-vivo, BC, 4T1
Synergy↑, TumCG↓, OS↑, e-pH↑, IFN-γ↑, IL2↑, IL12↑, Dose↝, PD-L1↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
9054- PatchO,    Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
- in-vivo, Col, NA
*TNF-α↓, *IFN-γ↓, *IL1β↓, *IL6↓, *IL17↓, *iNOS↓, *COX2/PTGS2↓, *TJ↑, *ZO-1↑, *CLDN1↑, *OCLN↑, *MUC1↑, *MUC2↑, *Inflam↓, *IBI↑,
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
1164- PI,    Inhibition of T cell activation by the phytochemical piperine
- in-vitro, Nor, NA
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, Var, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
4499- Se,    Selenium and Selenoproteins in Gut Inflammation—A Review
- Review, IBD, NA
*Inflam↓, *IL2↓, *TNF-α↓, *IFN-γ↓, *PPARγ↓,
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1/CCL2↓, CXCL9↓, MIP-1β↓, IFN-γ↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
1049- SK,    Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2
- in-vivo, Var, NA
TNF-α↓, IL6↓, IFN-γ↓, IL1β↓, PD-L1↓, p‑PKM2↓,
3042- SK,    The protective effects of Shikonin on lipopolysaccharide/D -galactosamine-induced acute liver injury via inhibiting MAPK and NF-kB and activating Nrf2/HO-1 signaling pathways
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *IFN-γ↓, *ALAT↓, *AST↓, *MPO↓, *ROS↓, *JNK↓, *ERK↓, *p38↓, *NF-kB↓, *p‑IKKα↓, *SOD↑, *GSH↑, *HO-1↑, *NRF2↑, *hepatoP↑,
1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,
9040- SP,    Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial
- Trial, Covid, NA
*Dose↝, *OS↑, *IL6↓, *TNF-α↓, *IL10↓, *IP-10/CXCL-10↓, *MIP‑1α/CCL3?, *IFN-γ↑, *toxicity↓,
7936- TQ,    Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial
- Trial, Asthma, NA
*Dose↝, *FEV1↑, *PEF↑, *IgE↓, *IFN-γ↑, *eff↑, *IL4∅, *IL10∅, *IL17∅, *antiAll↑,
7938- TQ,    The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma
- in-vivo, Asthma, NA
*Dose↝, *Eos↓, *IFN-γ↑, *Inflam↓, *IL4↓, *antiOx↑, *NO↓, *COX2/PTGS2↓, *5LO↓, *antiAll↑,
7939- TQ,    Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysis
- Review, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *IL17↓, *IgE↓, *IFN-γ∅, *antiOx↑, *Inflam↓, *antiAll↑,
7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, *Th2↓, *IgE↓, *IgG1↓, *Inflam↓, *AirwayM↓, *IL4↓, *IL5↓, *IL13↓, *IFN-γ↑, *antiAll↑,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1/CCL2↓, *CXCc↓, *ROS↓, *antiAll↑,
3563- TQ,    Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *IFN-γ↑, *neuroP↑, *Inflam↓, *cognitive↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,

Showing Research Papers: 51 to 82 of 82
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 82

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 4,   GSH↑, 1,   HO-1↓, 2,   HO-1↑, 1,   lipid-P↓, 3,   lipid-P↑, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 3,   ROS?, 1,   ROS↓, 1,   ROS↑, 14,   ROS⇅, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   ATP↓, 1,   i-ATP↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   NADPH↓, 1,   p‑PKM2↓, 1,   SCD1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 2,   Apoptosis↑, 14,   BAX↑, 8,   BAX⇅, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Bcl-xL↓, 1,   BIM↓, 1,   Casp↑, 4,   Casp10↑, 1,   Casp12?, 1,   Casp3↓, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 6,   DR5↑, 2,   Fas?, 1,   Fas↑, 2,   GranA↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICD↑, 1,   iNOS↓, 6,   MDM2↓, 1,   Necroptosis↑, 1,   necrosis↑, 2,   p38↓, 1,   Perforin↓, 1,   Pyro↑, 1,   sFasL↑, 1,   survivin↓, 4,   TNFR 1↑, 1,   TRAILR↑, 1,   XIAP↓, 4,   YAP/TEAD↓, 2,   p‑YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   EGFR↓, 3,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   JAK3↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 2,   MEK↓, 1,   MOB1↓, 1,   mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 7,   PI3K/Akt↓, 1,   PI3K/Akt↑, 1,   PKCδ↓, 1,   Raf↓, 1,   RAS↓, 1,   RCC1↓, 1,   Sp1/3/4↓, 2,   STAT3↓, 6,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   cMyc↓, 3,   p‑cMyc↑, 1,   DNMTs↓, 1,   EZH2↓, 1,   HATs↑, 1,   HDAC↓, 3,   HDAC1↓, 1,   miR-124-3p↓, 1,   miR-34a↓, 1,   other↓, 2,   other↑, 1,   other↝, 3,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

i-CRT↓, 1,   ER Stress↑, 3,   HSP27↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 4,   hTERT/TERT↓, 2,   P53↑, 8,   cl‑PARP↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 4,   Telomerase↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 4,   CDK4↑, 1,   CDK6↓, 2,   CDK6↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   Ki-67↓, 3,   P21↑, 7,   p27/CDKN1B↑, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   TumCCA↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cMYB↓, 1,   CSCs↓, 2,   IGF-1↓, 1,   Ki-67↓, 3,   NICD↓, 1,   NOTCH1↓, 5,   TAZ↓, 1,   TumCG↓, 8,   TumCP↓, 12,   TumCP∅, 1,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AP-1↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↓, 2,   COL3A1↓, 1,   decorin↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   EMT↓, 9,   Galectin-9↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 9,   MMP7↓, 1,   MMP9↓, 6,   MMPs↓, 4,   N-cadherin↓, 1,   NFAT↑, 1,   PDGF↓, 1,   PGF↓, 1,   Slug↓, 2,   Snail↓, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 6,   TumMeta↓, 4,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 2,   Vim↓, 3,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 9,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   GLUT1↓, 1,   MMP↓, 6,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↓, 1,   CD25+↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 2,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 9,   COX2/PTGS2↓, 8,   CXCL12↓, 1,   CXCL9↓, 2,   CXCR4↓, 2,   DCells↑, 3,   FOXP3↓, 1,   FoxP3+↓, 1,   GNLY↓, 1,   HCAR2↑, 1,   i-HMGB1↓, 1,   IFN-γ↓, 20,   IFN-γ↑, 19,   IL1↓, 1,   IL1↑, 2,   IL10↓, 3,   IL10↑, 3,   IL12↑, 4,   IL13↓, 1,   IL15↑, 1,   IL17↑, 1,   IL1β↓, 9,   IL2↓, 4,   IL2↑, 6,   IL4↓, 4,   IL4↑, 2,   IL5↓, 1,   IL6↓, 11,   IL6↑, 2,   IL8↓, 3,   Imm↑, 7,   Imm⇅, 1,   Imm↝, 1,   Inflam↓, 9,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP-1β↓, 1,   NF-kB↓, 10,   NF-kB↑, 3,   p‑NF-kB↑, 1,   NK cell↑, 6,   NLRP3↓, 1,   PD-1↓, 1,   PD-1↑, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PD-L2↓, 1,   PGE2↓, 2,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 1,   T-Cell↑, 3,   Th1 response?, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 14,   TNF-α↑, 3,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER-α36↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 12,   CYP1A1↓, 1,   DDS↑, 1,   Dose↝, 11,   eff↓, 1,   eff↑, 10,   eff↝, 1,   MDR1↓, 3,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 3,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BG↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 3,   EZH2↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 11,   IL6↑, 2,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 4,   Pain↓, 1,   PFS↑, 1,   QoL↑, 2,   radioP↑, 2,   Risk↓, 2,   toxicity↓, 2,   TumVol↓, 4,   TumW↓, 3,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 344

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 23,   Catalase↑, 8,   GPx↓, 1,   GPx↑, 8,   GSH↑, 12,   GSR↑, 2,   GSTs↑, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↑, 10,   Keap1↓, 1,   lipid-P↓, 13,   MDA↓, 8,   MPO↓, 5,   NQO1↑, 1,   NRF2↑, 14,   ROS?, 1,   ROS↓, 20,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 3,   TBARS↓, 1,   Thiols↑, 1,   Trx↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 1,   ATP↓, 1,   ATP↑, 2,   GSK‐3β↓, 2,   LDL↓, 5,   NAD↓, 1,   SCFAs↑, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 8,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↓, 1,   p‑ERK↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 1,   PI3K↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 3,   HDAC↓, 2,   OCT4↓, 1,   other↓, 1,   other↑, 1,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSPs↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   RAD51↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   AP-1↑, 1,   MMP-10↝, 1,   MMP9↓, 2,   MUC1↑, 2,   TGF-β↓, 1,   TGF-β↑, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   Hif1a↓, 1,   NO↓, 7,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   CLDN1↑, 2,   CLDN3↑, 1,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 4,   MMP↑, 2,   MUC2↑, 1,   OATPs↓, 1,   OCLN↑, 3,   TJ↑, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD25+↓, 1,   CD4+↑, 3,   CD69↓, 1,   COX2/PTGS2↓, 11,   CTLA-4↓, 1,   CXCc↓, 2,   Eos↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 27,   IFN-γ↑, 14,   IFN-γ↝, 1,   IFN-γ∅, 1,   IgE↓, 3,   IgG1↓, 1,   IL1↓, 1,   IL10↓, 4,   IL10↑, 7,   IL10∅, 1,   IL12↓, 2,   IL13↓, 2,   IL13↑, 1,   IL17↓, 9,   IL17↑, 1,   IL17∅, 1,   IL18↓, 1,   IL1β↓, 14,   IL2↓, 6,   IL2↑, 1,   IL23↓, 1,   IL4↓, 8,   IL4↑, 1,   IL4↝, 1,   IL4∅, 1,   IL5↓, 3,   IL5↝, 1,   IL6↓, 22,   IL6↑, 1,   IL8↓, 4,   Imm↓, 1,   Imm↑, 4,   Inflam↓, 30,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   LTA/TNF-β↑, 1,   MCP1/CCL2↓, 4,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 17,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 3,   PGE2↓, 8,   RANTES↓, 1,   Th2↓, 1,   TLR2↓, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 24,   TNF-α↑, 5,   TNF-α↝, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↓, 1,   BDNF↑, 1,   BrainVol↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 2,   Aβ↓, 5,   BACE/β-secretase↓, 2,   tau↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 13,   BioAv↝, 2,   Dose↝, 8,   eff↑, 4,   Half-Life↓, 1,   Half-Life↑, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10,   AST↓, 9,   BP↓, 1,   BP↝, 1,   creat↓, 1,   CRP↓, 3,   FEV1↑, 1,   IL6↓, 22,   IL6↑, 1,   IRes↓, 1,   NLR↓, 1,   PEF↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 5,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↑, 13,   memory↑, 4,   neuroP↑, 10,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↑, 4,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 8,   toxicity↝, 3,   Weight↝, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 8,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 255

Scientific Paper Hit Count for: IFN-γ, Interferon-γ
7 Thymoquinone
6 Silymarin (Milk Thistle) silibinin
4 immunotherapy
3 Quercetin
2 Açaí, Euterpe oleracea
2 5-fluorouracil
2 Astaxanthin
2 chitosan
2 Curcumin
2 Chlorella (Chlorella vulgaris)
2 Spirulina(Arthrospira/Limnospira)
2 Docosahexaenoic Acid
2 Emodin
2 Hydrogen Gas
2 Luteolin
2 Lycopene
2 Magnetic Field Rotating
2 Magnetic Fields
2 Patchouli Oil (Pogostemon cablin)
2 Sulforaphane (mainly Broccoli)
2 Shikonin
1 Astragalus
1 alpha Linolenic acid
1 beta-glucans
1 Berberine
1 Betulinic acid
1 Bifidobacterium
1 Bromelain
1 Boron
1 Black turtle bean
1 Butyrate
1 Caffeine
1 Capsaicin
1 Carvacrol
1 Chrysin
1 Copper and Cu NanoParticles
1 Chemotherapy
1 diet Fermented Foods
1 diet FMD Fasting Mimicking Diet
1 Electrical Pulses
1 eicosapentaenoic acid
1 Flaxseed Oil
1 Cisplatin
1 Gallic acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginger/6-Shogaol/Gingerol
1 Honokiol
1 Rapamycin
1 Linalool
1 mebendazole
1 gefitinib, erlotinib
1 Mangiferin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 Nimbolide
1 Propolis -bee glue
1 Phycocyanin
1 Piperine
1 Selenium
1 Salvia miltiorrhiza
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:442  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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