Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Scientific Papers found: Click to Expand⟱

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

-

Review,

Var,

NA

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

566-

ART/DHA,

2DG,

Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

PC9

GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,

1079-

ART/DHA,

Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

-

in-vitro,

GC,

BGC-823

 20 mg/L

 20 mg/L @ 60hr

-

in-vitro,

GC,

HGC27

-

in-vitro,

GC,

MGC803

TumCP↓, Apoptosis↑, COX2/PTGS2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,

4278-

ART/DHA,

Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway

-

in-vivo,

Var,

NA

Rats

*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,

5133-

ART/DHA,

Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

U251

AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP/DDIT3↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,

2576-

ART/DHA,

AL,

The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

-

in-vitro,

OS,

MG63

-

in-vivo,

NA,

NA

0 mg/kg per
day, i.p.), allicin (5 mg/kg per day, i.p.)

mice

Synergy↑, tumCV↓, Casp3↑, Casp9↑, Apoptosis↑, TumCG↓,

3160-

Ash,

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

-

Review,

Var,

NA

TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,

1369-

Ash,

Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis

-

in-vitro,

Melanoma,

U266

9 μM

tumCV↓, Apoptosis↑, BAX↑, Cyt‑c↑, Bcl-2↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, ROS↑, eff↓,

1371-

Ash,

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine

-

in-vitro,

AML,

HL-60

ROS↑, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, eff↓,

1364-

Ash,

Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress

-

in-vitro,

Bladder,

J82

cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, MMP↓, DNAdam↑, eff↓,

5362-

AV,

Anti-cancer effects of aloe-emodin: a systematic review

-

Review,

Var,

NA

AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,

5365-

AV,

Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications

-

Review,

Nor,

NA

-

Review,

IBD,

NA

-

Review,

Diabetic,

NA

*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,

5502-

Ba,

An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

-

Review,

Var,

NA

*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,

5250-

Ba,

Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment

-

Review,

Var,

NA

Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, Synergy↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,

5251-

Ba,

The Fascinating Effects of Baicalein on Cancer: A Review

-

Review,

Var,

NA

AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,

1533-

Ba,

Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation

-

in-vitro,

BrCC,

MCF7

85μM for 24 h

-

in-vitro,

Nor,

MCF10

557uM

tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,

1532-

Ba,

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

-

Review,

Var,

NA

ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27/CDKN1B↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,

1526-

Ba,

Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells

-

in-vitro,

AML,

HL-60

25uM

Apoptosis↑, cl‑PARP↑, DNAdam↑, cl‑BID↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9?, H2O2↑, ROS↑,

1525-

Ba,

almon,

Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway

-

in-vitro,

Lung,

H1975

-

in-vivo,

Lung,

NA

mice

Synergy↑, TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp9↑, p‑PI3K↓, p‑Akt↓, ROS↑, eff↓,

1524-

Ba,

Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells

-

in-vitro,

Lung,

A549

25–125 uM, 24hr

100uM

DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,

1521-

Ba,

Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells

-

in-vitro,

Bladder,

5637

0,50,150,250 uM

TumCG↓, Apoptosis↑, IAP1↓, IAP2/BIRC3↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,

2474-

Ba,

Anticancer properties of baicalein: a review

-

Review,

Var,

NA

-

in-vitro,

Nor,

BV2

ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,

2476-

Ba,

Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells

-

in-vitro,

Lung,

A549

0-125uM

TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,

2477-

Ba,

Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells

-

in-vitro,

CRC,

T24/HTB-9

TumCG↓, TumCCA↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, p‑Akt↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, 12LOX↓,

2606-

Ba,

Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma

-

Review,

HCC,

NA

ChemoSen↑, TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, MMPs↓, MAPK↓, TGF-β↓, ZFX↓, p‑MEK↓, ERK↓, MMP2↓, MMP9↓, uPA↓, TIMP1↓, TIMP2↓, NF-kB↓, p65↓, p‑IKKα↓, Fas↑, Casp2↑, Casp3↑, Casp8↑, Casp9↑, Bcl-xL↓, BAX↑, ER Stress↑, Ca+2↑, JNK↑, P53↑, ROS↑, H2O2↑, cMyc↓, CD24↓, 12LOX↓,

2600-

Ba,

Baicalein Induces Apoptosis and Autophagy via Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Cells

-

in-vitro,

HCC,

SMMC-7721 cell

19.89uM 48h

-

in-vitro,

HCC,

Bel-7402

ER Stress↑, Bcl-2↓, Ca+2↑, JNK↑, CHOP/DDIT3↑, Casp9↑, Casp3↑, PARP↑, Apoptosis↑, UPR↑,

2618-

Ba,

Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer

-

in-vitro,

Lung,

H1299

12.5, 25, and 50 μM

-

in-vivo,

Lung,

A549

10, 20, and 40 μM

TumCG↓, TumCP↓, Apoptosis↑, GLUT1↓, GLS↓, mTOR↓, *toxicity∅, cl‑Casp9↓, cl‑Casp3↓, GSH↓, GlutMet↓,

2617-

Ba,

Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review

-

Review,

Var,

NA

Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,

2627-

Ba,

Cisplatin,

Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways

-

in-vivo,

Var,

NA

RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,

2296-

Ba,

The most recent progress of baicalein in its anti-neoplastic effects and mechanisms

-

Review,

Var,

NA

CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,

5539-

BBM,

Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway

-

vitro+vivo,

CRC,

SW480

tumCV↓, TumCCA↑, MMP↓, P53↑, Casp3↑, Casp9↑, BAX↑, PARP↑, Bcl-2↓, TumVol↑,

5547-

BBM,

Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway

-

in-vitro,

CRC,

HT29

tumCV↓, selectivity↑, Casp3↑, Casp9↑, Bax:Bcl2↑, ATG5↑, Beclin-1/ATG6↑, TumCP↓, MEK↓, ERK↓,

5553-

BBM,

A review on berbamine–a potential anticancer drug

-

Review,

Var,

NA

P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,

1398-

BBR,

Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage

-

in-vitro,

Kidney,

NA

TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,

1393-

BBR,

EPI,

Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest

-

in-vitro,

Bladder,

T24/HTB-9

ChemoSen↑, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, P53↑, P21↑, Bcl-2↓, ROS↑,

1402-

BBR,

Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction

-

in-vitro,

GBM,

T98G

tumCV↓, ROS↑, Ca+2↑, ER Stress↑, eff↓, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, cl‑PARP↑,

1404-

BBR,

Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation

-

in-vitro,

Pca,

PC3

Apoptosis↑, *Apoptosis∅, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, eff↓, Cyt‑c↑,

2691-

BBR,

Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells

-

in-vitro,

Oral,

KB

tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,

2678-

BBR,

Berberine as a Potential Agent for the Treatment of Colorectal Cancer

-

Review,

CRC,

NA

*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,

2674-

BBR,

Berberine: A novel therapeutic strategy for cancer

-

Review,

Var,

NA

-

Review,

IBD,

NA

Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,

2686-

BBR,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

-

Review,

Nor,

NA

Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,

5178-

BBR,

Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

PC3

TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,

5639-

BCA,

Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition

-

in-vitro,

BC,

NA

TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,

6501-

BCP,

β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study

-

in-vitro,

Oral,

KB

TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,

6509-

BCP,

βcaryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells

-

in-vitro,

Lung,

A549

tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,

5592-

BetA,

Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells

-

in-vitro,

Liver,

HepG2

10 to 15 mg/mL

-

in-vitro,

Cerv,

HeLa

Casp3↑, Casp9↑, cl‑PARP↑, Apoptosis↑, Cyt‑c↑, MMP↓,

5591-

BetA,

Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment

-

Review,

BC,

NA

IC50 values ranging from 1 to 13.0 μg mL−1

BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

-

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

-

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

-

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

2718-

BetA,

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis

-

in-vitro,

AML,

U937

TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,

2717-

BetA,

Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma

-

in-vitro,

Melanoma,

U266

10-40uM

-

in-vivo,

Melanoma,

NA

Nude Mouse Xenograft Model

-

in-vitro,

Melanoma,

RPMI-8226

Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,

Showing Research Papers: 51 to 100 of 550
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 550

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↑, 2, NA⇅, 1, NA?, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 2, antiOx↑, 7, antiOx⇅, 1, ARE↓, 1, Catalase↓, 14, Catalase↑, 7, Copper↑, 1, Fenton↑, 2, frataxin↑, 1, GCLC↑, 1, GCLM↓, 1, GCLM↑, 1, GPx↓, 5, GPx↑, 3, GPx4↓, 5, GSH↓, 40, GSH↑, 9, GSH/GSSG↓, 4, GSR↑, 3, GSS↑, 1, GSSG↓, 1, GSSG↑, 1, GSTs↓, 1, GSTs↑, 2, H2O2↓, 1, H2O2↑, 8, i-H2O2↑, 1, HO-1↓, 7, HO-1↑, 13, HO-1↝, 1, HO-2↓, 1, Iron↑, 1, Keap1↓, 1, lipid-P↓, 8, lipid-P↑, 13, lipid-P↝, 1, MDA↓, 5, MDA↑, 5, MPO↓, 2, NADPH/NADP+↓, 1, NOX4↑, 1, NQO1↓, 1, NQO1↑, 2, Nrf1↑, 1, NRF2↓, 16, NRF2↑, 23, p‑NRF2↓, 1, p‑NRF2↑, 1, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, ROS?, 3, ROS↓, 26, ROS↑, 263, ROS⇅, 10, ROS↝, 2, ROS∅, 1, i-ROS↓, 1, i-ROS↑, 5, mt-ROS↑, 7, SAM-e↝, 1, SOD?, 1, SOD↓, 15, SOD↑, 8, SOD2↓, 3, SOD2↑, 2, TBARS↑, 2, Thiols↓, 1, Trx↓, 1, Trx1↑, 1, ox-Trx1↑, 1, TrxR↓, 6, TrxR1↓, 3, xCT/SLC7A11↓, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2, FTL↑, 1, IronCh↑, 3, NCOA4↑, 1, STEAP3↑, 1, Tf↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2, BCR↓, 1, CDC2↓, 8, CDC25↓, 15, CDC25↑, 1, p‑CDC25↑, 1, compI↓, 2, compIII↓, 1, compV↓, 1, EGF↓, 4, ETC↓, 2, ETC↝, 1, Insulin↓, 2, MCU↓, 1, MFN2↓, 1, MFN2↑, 1, mitResp↓, 2, MKK7↓, 1, mtDam↑, 31, OCR↓, 3, OXPHOS↓, 1, mt-OXPHOS↓, 1, PDH↓, 1, PINK1↑, 2, SDH↓, 1, SIRT3↓, 2, SIRT3↑, 3,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6, 5LO↓, 2, p‑ACC↑, 1, ACLY↓, 2, ACSL4↑, 1, ACSL5↑, 2, ALAT↓, 2, ALAT↑, 1, ALAT↝, 1, ALDOA↓, 1, AMP↑, 1, AMPK↓, 1, AMPK↑, 19, AMPK↝, 1, p‑AMPK↑, 2, p‑AMT/GCST/T-protein↑, 1, ATP↓, 14, ATP↝, 1, CAIX/CA9↑, 1, citrate↓, 1, CPT1A↓, 1, ECAR↝, 1, ENO1↓, 2, FASN↓, 2, FASN↑, 2, FBPase↑, 1, GLS↓, 1, glucoNG↑, 1, glucose↓, 1, GlucoseCon↓, 12, GlutMet↓, 1, Glycolysis↓, 24, GSK‐3β↓, 10, GSK‐3β↑, 6, p‑GSK‐3β↓, 5, p‑GSK‐3β↑, 1, Histones↑, 1, HK1↓, 1, HK2↓, 11, lactateProd↓, 10, lactateProd↑, 1, LDHA↓, 6, LDL↓, 1, NAD↝, 1, NADPH↓, 2, NADPH↑, 2, O-Glc↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 6, PFK↓, 1, PFK1↓, 2, PFK2?, 1, PFK2↓, 2, PFKP↓, 1, PGK1↓, 1, PKM2↓, 4, PKM2∅, 1, PLA2↓, 1, polyA↓, 1, PPP↓, 2, Pyruv↓, 1, p‑S6↓, 1, SAT1↑, 1, SIRT1↓, 5, SIRT1↑, 2, SREBP1/SREBF1↓, 2, SREBP2↓, 1, TCA?, 1, TCA↓, 3, TCA↑, 1, TS↓, 3, Warburg↓, 3, β-oxidation↓, 1,

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1, AIF↑, 20, APAF1↑, 18, Apoptosis↓, 9, Apoptosis↑, 286, mt-Apoptosis↑, 4, ASK1↑, 2, BAD?, 1, BAD↓, 4, BAD↑, 20, p‑BAD↓, 1, Bak↓, 1, Bak↑, 16, BAX?, 1, BAX↓, 2, BAX↑, 228, BAX⇅, 1, BAX↝, 1, Bax:Bcl2↓, 1, Bax:Bcl2↑, 54, Bcl-2↓, 227, Bcl-2↑, 6, Bcl-2↝, 1, Bcl-2∅, 1, cl‑Bcl-2↓, 1, Bcl-xL↓, 54, Bcl-xL↑, 2, BID↓, 2, BID↑, 17, p‑BID↓, 1, cl‑BID↑, 3, BIM↑, 5, BNIP3↑, 2, BNIP3↝, 1, BOK↑, 2, Casp↑, 13, Casp↝, 1, Casp10↓, 1, Casp10↑, 3, Casp12?, 1, Casp12↑, 9, Casp12↝, 1, cl‑Casp12↑, 1, Casp2↑, 5, Casp3?, 1, Casp3↓, 7, Casp3↑, 371, Casp3↝, 1, Casp3∅, 1, cl‑Casp3↓, 1, cl‑Casp3↑, 62, cl‑Casp3⇅, 1, proCasp3↓, 3, proCasp3↑, 4, pro‑Casp3↑, 1, CASP4↑, 1, Casp6↓, 1, Casp6↑, 4, Casp7?, 1, Casp7↑, 41, cl‑Casp7↑, 7, Casp8↓, 3, Casp8↑, 122, Casp8↝, 1, Casp8∅, 2, cl‑Casp8↑, 16, proCasp8↓, 2, proCasp8↑, 2, pro‑Casp8↑, 1, Casp9?, 2, Casp9↓, 4, Casp9↑, 432, Casp9↝, 1, Casp9∅, 1, p‑Casp9↑, 2, cl‑Casp9↓, 2, cl‑Casp9↑, 66, proCasp9↓, 4, proCasp9↑, 5, pro‑Casp9↑, 1, CellShr↑, 1, cFLIP↓, 11, Cyt‑c↓, 3, Cyt‑c↑, 184, Cyt‑c↝, 1, Cyt‑c?, 1, Diablo↑, 10, DR5↑, 37, FADD↑, 14, Fas↓, 2, Fas↑, 32, FasL↓, 1, FasL↑, 22, Ferroptosis↑, 5, cl‑GSDME↑, 1, HEY1↓, 1, IAP1↓, 15, IAP2/BIRC3↓, 5, cl‑IAP2/BIRC3↑, 1, ICD↑, 2, iNOS↓, 15, Mcl-1↓, 40, Mcl-1↑, 1, p‑Mcl-1↓, 1, MDM2↓, 11, MDM2↑, 2, MLKL↑, 1, p‑MLKL↓, 1, MOMP↓, 1, MOMP↑, 8, NAIP↓, 2, Necroptosis↑, 3, necrosis↑, 2, NOXA↑, 7, p38↓, 6, p38↑, 30, p‑p38↓, 4, p‑p38↑, 6, PUMA↑, 6, PUMA↝, 1, Pyro↑, 1, RIP3↑, 3, p‑RIP3↑, 1, survivin↓, 66, survivin↝, 1, TNFR 1↑, 2, TRAIL↑, 8, TRAILR↑, 2, TumCD↓, 1, TumCD↑, 22, XIAP↓, 35, XIAP↑, 1, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1, Akt?, 1, Akt↓, 121, Akt↑, 8, p‑Akt↓, 43, AKT1↓, 6, Akt2↓, 2, AMPKα↑, 1, BRAF↝, 1, CaMKII ↓, 2, CK2↓, 4, cMET↓, 3, p‑cMET↑, 1, CREB2↓, 1, cSrc↓, 3, EF-1α↓, 1, EGFR↓, 31, EGFR↑, 1, p‑EGFR↓, 3, ERK↓, 44, ERK↑, 11, p‑ERK↓, 17, p‑ERK↑, 3, p‑ERK⇅, 1, e-ERK↑, 1, FGFR1↓, 3, FGFR2↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 14, Hippo↑, 1, HRAS↓, 2, IGF-1R↓, 8, IKKα↓, 5, IKKα↑, 1, p‑IKKα↓, 1, IκB↑, 1, p‑IκB↓, 3, JAK↓, 3, JAK1↓, 4, JAK1↑, 1, JAK2↓, 9, p‑JAK2↓, 2, JNK↓, 6, JNK↑, 33, p‑JNK↓, 5, p‑JNK↑, 4, cl‑JNK↑, 1, LIMK1↓, 1, MAP2K1/MEK1↓, 1, MAPK↓, 33, MAPK↑, 22, MAPK↝, 2, p‑MAPK↓, 1, p‑MAPK↑, 1, MEK↓, 6, p‑MEK↓, 3, p‑MEK↑, 1, MKK4↓, 1, mTOR↓, 59, mTOR↑, 1, mTOR↝, 2, p‑mTOR↓, 15, mTORC2↓, 3, NRAS↓, 1, p70S6↓, 2, p70S6↑, 1, P70S6K↓, 3, p‑P70S6K↓, 2, P90RSK↓, 1, PDGFR-BB↓, 1, PDGFRA↓, 1, PI3K↓, 87, PI3K↑, 2, p‑PI3K↓, 8, PI3K/Akt↓, 6, PI3K/Akt↝, 1, PI3k/Akt/mTOR↝, 1, PIAS-3↑, 1, PIK3CA↓, 1, PKA↓, 2, PKCδ↓, 8, p‑PKCδ↓, 1, cl‑PKCδ↑, 1, PTEN↓, 1, PTEN↑, 30, PTEN↝, 1, Raf↓, 8, c-Raf↓, 1, RAS↓, 8, RAS↑, 1, RIP1↑, 1, S6K↓, 1, p‑S6K↓, 1, SHP1↓, 1, SHP1↑, 3, Sp1/3/4↓, 5, Src↓, 3, c-Src↓, 1, STAT↓, 2, STAT3↓, 53, STAT3↑, 2, p‑STAT3↓, 15, p‑STAT3↑, 2, STAT5↓, 2, STAT6↓, 1, TK1↓, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2, ATF4↑, 12, ATF4↝, 1, ATFs↑, 1, ChrMod↝, 1, cJun↓, 5, cJun↑, 4, p‑cJun↑, 2, cMyc↓, 33, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 7, DNMT3A↓, 2, DNMTs↓, 5, EZH2↓, 2, FOXM1↓, 1, FOXO↑, 2, FOXO1↑, 4, FOXO3↓, 3, FOXO3↑, 6, FOXO4↑, 1, GATA3↑, 1, H3↑, 2, ac‑H3↑, 1, H4↑, 2, ac‑H4↑, 1, HATs↓, 5, HATs↑, 1, HDAC↓, 15, HDAC1↓, 4, HDAC10↑, 1, HDAC2↓, 2, HDAC3↓, 4, HDAC8↓, 2, HES1↓, 1, miR-106b↓, 1, miR-133a-3p↑, 1, miR-155↓, 3, miR-17↓, 1, miR-195↑, 1, miR-21↓, 6, miR-21↑, 1, miR-221↓, 1, miR-25-5p↓, 1, miR-25-5p↑, 1, miR-27a-3p↑, 1, miR-339-5p↝, 1, miR-34a↓, 2, miR-34a↑, 2, Myc↓, 5, MYCN↓, 1, n-MYC↓, 1, OCT4↓, 9, OCT4↑, 1, other↓, 4, other↑, 6, other↝, 10, PhotoS↑, 2, SALL4↓, 1, SETBP1↓, 1, sonoS↑, 1, SOX2↓, 7, SOX4↓, 1, SOX4↑, 2, SUV39H↓, 2, TCF-4↓, 2, TET3↑, 1, tumCV?, 1, tumCV↓, 98,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3, cl‑ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 28, cl‑CHOP/DDIT3↑, 1, CUL1↝, 1, CUL5↝, 1, eIF2α↓, 1, eIF2α↑, 9, p‑eIF2α↓, 1, p‑eIF2α↑, 2, ER Stress↓, 2, ER Stress↑, 52, GRP78/BiP?, 1, GRP78/BiP↓, 2, GRP78/BiP↑, 19, GRP94↑, 2, HSF1↓, 1, HSP27↓, 7, HSP27↝, 1, HSP70/HSPA5↓, 4, HSP70/HSPA5↑, 1, HSP70/HSPA5↝, 1, HSP72↓, 1, HSP90↓, 11, HSP90↑, 1, HSPs↓, 1, IRE1↑, 6, PDI↑, 1, PERK↑, 10, p‑PERK↑, 1, SERPINH1/HSP47↓, 1, UPR↑, 7, XBP-1↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1, ATG5↑, 9, ATG5↝, 1, ATG7↑, 2, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 20, Beclin-1/ATG6↝, 1, CTSB↓, 2, CTSD↓, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 4, LC3A↑, 3, LC3B↑, 2, LC3B-II↑, 5, LC3I↑, 1, LC3II↓, 1, LC3II↑, 7, LC3s↑, 2, MitoP↑, 2, p62↓, 5, p62↑, 3, PARK2↑, 2, SESN2↑, 1, TumAuto↑, 42,

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1, ATM↑, 3, p‑ATM↑, 2, ATR↑, 1, p‑BRCA1↑, 1, DFF45↓, 2, DFF45↑, 2, DNA-PK↑, 2, DNAdam↓, 2, DNAdam↑, 81, DNArepair↓, 2, DNArepair↑, 1, ERCC1↓, 1, ERCC4/XPF↓, 1, hTERT/TERT↓, 14, Ku70/XRCC6↓, 1, MGMT↓, 2, p16↑, 3, P53?, 1, P53↓, 3, P53↑, 122, P53∅, 1, p‑P53↓, 1, p‑P53↑, 5, p53 Wildtype↓, 1, PARP↓, 4, PARP↑, 40, PARP↝, 1, p‑PARP↑, 1, cl‑PARP↓, 3, cl‑PARP↑, 128, cl‑PARP∅, 1, PARP1↑, 2, cl‑PARP1↑, 3, PCNA↓, 28, RAD51↓, 1, SIRT6↑, 1, Telomerase↓, 15, TOP1↓, 2, TOP2↓, 4, TP53↑, 1, UHRF1↓, 1, γH2AX↑, 11, γH2AX↝, 1, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 16, CDK1↑, 4, p‑CDK1↑, 1, CDK2↓, 38, CDK2↑, 3, p‑CDK2↓, 1, CDK4↓, 46, CDK4↑, 3, p‑CDK4↓, 1, CDK6↓, 19, CDK6↑, 2, CDK8↓, 1, CHK1↓, 2, CHK1↑, 1, p‑CHK1↑, 1, Chk2↓, 2, Chk2↑, 1, ChrCon↑, 2, Cyc↓, 2, cycA1/CCNA1↓, 13, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 34, CycB/CCNB1↑, 3, cycD1/CCND1↓, 81, cycD1/CCND1↑, 3, p‑cycD1/CCND1↓, 1, CycD3↓, 4, cycE/CCNE↓, 25, cycE/CCNE↑, 1, cycE1↓, 1, E2Fs↓, 3, Ki-67↓, 16, mitA↑, 1, p19↑, 1, P21?, 1, P21↓, 4, P21↑, 82, p27/CDKN1B↓, 1, p27/CDKN1B↑, 33, pRB↑, 1, p‑pRB↓, 2, RB1↑, 1, p‑RB1↓, 4, Securin↓, 1, TumCCA?, 1, TumCCA↓, 10, TumCCA↑, 193, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, ALDH↓, 3, ALDH1A1↓, 2, BMP7/OP1↓, 1, BMPs↑, 1, CD133↓, 7, CD24↓, 2, CD34↓, 1, CEBPA↑, 1, cFos↓, 5, cMYB↓, 1, CSCs↓, 28, Diff↓, 1, Diff↑, 3, FGF↓, 4, Gli↓, 1, Gli1↓, 4, HH↓, 3, IGF-1↓, 8, IGF-2↓, 1, IGFBP3↑, 3, JAG1↓, 1, Jun↓, 1, p‑Jun↑, 1, Ki-67↓, 16, Let-7↑, 3, mTORC1↓, 5, p‑mTORC1↓, 1, Nanog↓, 7, Nanog↑, 1, Nestin↓, 3, NICD↓, 1, NOTCH↓, 11, NOTCH1↓, 10, NOTCH1↑, 1, NOTCH3↓, 2, OGFr↑, 2, PTCH1↓, 1, SCF↓, 1, Shh↓, 5, Smo↓, 3, STAT1↓, 1, TAZ↓, 1, TumCG?, 2, TumCG↓, 72, TumCG↑, 3, TumCP↓, 131, TumCP↑, 3, tyrosinase↓, 1, URGCP/URG4↓, 1, Wnt?, 1, Wnt↓, 26, Wnt/(β-catenin)↓, 6, ZFX↓, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg?, 1, AntiAg↓, 1, AntiAg↑, 1, AP-1↓, 11, AP-1↑, 1, BACH1↓, 1, Ca+2↓, 6, Ca+2↑, 45, Ca+2↝, 4, i-Ca+2↑, 4, mt-Ca+2↑, 1, CAFs/TAFs↓, 1, cal2↑, 4, CCN2/CTGF↓, 1, Cdc42↑, 1, COL1↓, 2, COL3A1↓, 1, DLC1↑, 3, E-cadherin↓, 8, E-cadherin↑, 40, EM↑, 1, EMT↓, 51, EMT↑, 2, EMT↝, 1, EpCAM↓, 1, FAK↓, 16, p‑FAK↓, 2, Fibronectin↓, 1, FOSB↑, 1, GLI2↓, 1, IQGAP3↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB3↓, 1, ITGB4↓, 1, KRAS↓, 1, LAMs↓, 1, LEF1↓, 1, MALAT1↓, 1, MMP1↓, 5, MMP13↓, 3, MMP2↓, 78, MMP3↓, 5, MMP7↓, 9, MMP9↓, 90, MMP9↑, 1, MMPs↓, 27, MUC4↓, 1, N-cadherin↓, 29, p‑p44↓, 1, PDGF↓, 4, proline↓, 1, Rac1↓, 1, Rho↓, 2, ROCK1↓, 2, Slug?, 1, Slug↓, 11, Smad1↓, 1, SMAD2↓, 1, p‑SMAD2↓, 1, SMAD3↓, 3, SMAD3↑, 1, p‑SMAD3↓, 1, SMAD4↓, 1, p‑SMAD4↓, 2, Snail?, 1, Snail↓, 25, TET1↓, 1, TET1↑, 4, TGF-β↓, 16, TGF-β↑, 3, TIMP1↓, 2, TIMP1↑, 8, TIMP2↓, 3, TIMP2↑, 11, TIMP3↑, 1, TRIB3↑, 1, TSP-1↑, 3, TumCA↓, 2, TumCA↑, 1, TumCI↓, 71, TumCI↑, 1, TumCMig↓, 55, TumMeta↓, 47, TumMeta↑, 4, TumPF↓, 2, Twist↓, 17, uPA↓, 21, uPAR↓, 1, Vim↓, 31, Zeb1↓, 11, ZEB2↓, 3, α-tubulin↑, 1, β-catenin/ZEB1↓, 35, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 74, angioG↑, 1, CD31/PECAM-1↓, 3, Endoglin↑, 2, HIF-1↓, 4, Hif1a↓, 48, Hif1a↑, 1, NO↓, 3, NO↑, 2, VCAM-1↓, 3, VEGF↓, 82, VEGF↑, 1, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 16,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, BBB∅, 2, CLDN2↓, 1, CLDN2↑, 1, CX43/GJA1↓, 1, EPR↑, 3, GLUT1↓, 13, GLUT1↑, 1, GLUT2↓, 1, GLUT3↑, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 193, MMP↑, 1, MPT↑, 8, NHE1↓, 1, TRPM7↓, 1, TRPV1↑, 1, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD4+↓, 1, CD4+↑, 2, CD44↓, 12, CD8+↑, 1, cDC2↓, 2, p‑cDC2↑, 1, COX1↓, 1, COX2/PTGS2↓, 71, CXCL1↓, 2, CXCL12↓, 1, CXCR2↓, 1, CXCR4↓, 13, CXCR4↑, 1, DR4↑, 8, DR4∅, 1, FOXP3↓, 1, FOXP3↑, 1, HLA-I/II↑, 1, HMGB1↓, 2, ICAM-1↓, 4, IFN-γ↓, 3, IFN-γ↑, 2, Igs↓, 1, IL1↓, 4, IL10↓, 3, IL12↓, 2, IL12↑, 1, IL17↓, 1, IL1β↓, 14, IL2↓, 2, IL2↑, 2, IL4↓, 1, IL6↓, 33, IL8↓, 6, Imm↑, 9, Imm↝, 2, Inflam↓, 29, pol-M1↑, 1, MCP1/CCL2↓, 4, MCT1↓, 1, NAF1↓, 1, NF-kB↓, 121, NF-kB↑, 4, p‑NF-kB↓, 2, p‑NF-kB↑, 2, NK cell↑, 3, NLRP3↑, 1, p50↓, 2, p65↓, 7, PD-1↓, 1, PD-L1↓, 3, PGE2↓, 19, PSA↓, 7, RAGE↓, 2, SOCS-3↓, 1, T-Cell↑, 2, T-Cell↝, 1, Th1 response↑, 2, Th17↑, 1, TLR4↓, 3, TNF-α↓, 30, TNF-α↑, 5, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2, TRADD↑, 1, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, AR↓, 11, ER-α36↓, 1, ER(estro)↓, 1, PPARα↓, 1, cl‑PPARα↓, 1, PPARγ↓, 2, PPARγ↑, 2, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, AKR1B10↓, 1, BioAv↓, 30, BioAv↑, 32, BioAv↝, 5, BioEnh↑, 4, ChemoSen?, 2, ChemoSen↓, 3, ChemoSen↑, 112, ChemoSen↝, 1, CompStab↑, 3, CompStab↝, 2, CYP1A1↓, 2, CYP1A1↑, 1, CYP1B1↑, 1, CYP3A4↓, 2, DDS↑, 1, Dose?, 5, Dose↓, 4, Dose↑, 9, Dose⇅, 1, Dose↝, 43, Dose∅, 7, eff↓, 77, eff↑, 68, eff↝, 8, eff∅, 1, GSTA1↓, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 10, MDR1↓, 4, MRP1/ABCC1↓, 2, MRP1/ABCC1↝, 1, P-gp/ABCB1↓, 13, P450↓, 4, RadioS↑, 37, selectivity?, 1, selectivity↓, 2, selectivity↑, 88, Synergy?, 1, Synergy↑, 76, TET2↓, 1, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 2, ALAT↑, 1, ALAT↝, 1, ALP↝, 1, AR↓, 11, AST↓, 2, AST↑, 1, AST↝, 1, BRAF↝, 1, p‑BRCA1↑, 1, CEA↓, 1, CRP↓, 1, E6↓, 1, E7↓, 1, EGFR↓, 31, EGFR↑, 1, p‑EGFR↓, 3, EZH2↓, 2, FOXM1↓, 1, HER2/EBBR2↓, 14, hTERT/TERT↓, 14, IL6↓, 33, KRAS↓, 1, LDH↓, 5, LDH↑, 5, LDH↝, 2, Myc↓, 5, PD-L1↓, 3, PSA↓, 7, RAGE↓, 2, TG/TAG↓, 1, TP53↑, 1, TRIB3↑, 1, Tumccf↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 44, antiD↑, 1, antiNeop↑, 1, AntiTum↑, 23, cachexia↓, 2, cardioP↑, 5, CardioT↑, 1, chemoP↑, 24, chemoPv↑, 18, chemoPv⇅, 1, ChemoSideEff↓, 5, cognitive?, 1, hepatoP↓, 1, hepatoP↑, 7, neuroP↑, 2, NP/CIPN↓, 1, OS↑, 8, Pain↓, 2, PFS↓, 1, Pin1↓, 2, QoL↑, 4, QoL∅, 1, radioP↑, 6, RenoP↑, 9, Risk↓, 9, Strength↑, 1, toxicity↓, 11, toxicity↑, 4, toxicity↝, 4, toxicity∅, 1, TumVol↓, 24, TumVol↑, 1, TumW↓, 13, Weight↑, 2, Weight∅, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, Bacteria↓, 2, GutMicro↑, 2, GutMicro↝, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2, Ingr↝, 7,
Total Targets: 1025

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5, antiOx↑, 78, ARE↑, 1, Catalase↓, 1, Catalase↑, 38, Fenton↓, 1, GPx↑, 30, GSH↑, 38, GSR↓, 1, GSR↑, 4, GSTs↓, 2, GSTs↑, 10, H2O2↓, 2, HDL↑, 2, HO-1↓, 2, HO-1↑, 15, Keap1↓, 2, Keap1↑, 1, Keap1↝, 1, lipid-P↓, 29, MDA↓, 28, MPO↓, 3, NADH↓, 1, NOX↓, 1, NOX4↓, 1, NQO1↑, 2, NRF2↓, 1, NRF2↑, 35, Prx↑, 1, RNS↓, 4, ROS↓, 95, ROS↑, 3, ROS∅, 1, mt-ROS?, 1, SOD↓, 2, SOD↑, 46, SOD1↑, 1, SOD2↑, 1, TAC↑, 3, TBARS↓, 3, Trx↑, 1, uricA↓, 1, VitC↑, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2, IronCh↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1, FIS1↓, 1, Insulin↑, 1, MFN2↑, 1, mitResp↑, 1, mtDam↓, 2, PGC-1α↑, 2, PGC-1α↝, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 1, adiP↑, 1, ALAT↓, 12, AMPK↓, 1, AMPK↑, 5, ATP↓, 2, ATP↑, 7, cAMP↑, 2, DGAT1↓, 1, FASN↓, 1, glucose↓, 3, glucose↝, 1, GlucoseCon↑, 1, GSK‐3β↓, 5, H2S↑, 2, HMG-CoA↓, 1, LDHA↑, 1, LDL↓, 3, lipidLev↓, 3, NAD↓, 1, NAD↑, 1, NADPH↓, 3, NADPH↑, 2, PLA2↓, 1, SIRT1↑, 7,

Cell Death(tgid=5) ⓘ

AIF↓, 2, APAF1↓, 2, Apoptosis↓, 15, Apoptosis↑, 1, Apoptosis∅, 1, ASK1↓, 1, BAX↓, 18, Bax:Bcl2↓, 1, Bax:Bcl2↑, 3, Bax:Bcl2↝, 1, Bcl-2↓, 3, Bcl-2↑, 12, Bcl-xL↑, 1, Casp↓, 1, Casp12↓, 1, Casp3?, 1, Casp3↓, 35, Casp3↑, 3, Casp3∅, 1, cl‑Casp3↓, 3, cl‑Casp3↑, 1, Casp6↓, 1, Casp8↓, 3, Casp8↑, 1, cl‑Casp8↑, 1, Casp9↓, 29, Casp9↑, 4, Casp9∅, 1, cl‑Casp9↓, 4, cl‑Casp9↑, 1, Cyt‑c↓, 11, Cyt‑c∅, 1, Fas↓, 2, Fas↑, 2, FasL↓, 1, GSDMD↓, 1, iNOS↓, 17, iNOS↑, 1, MLKL↓, 1, necrosis↓, 1, p38↓, 2, p‑p38↓, 1, Pyro↓, 1, TUNEL↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5, Akt↑, 6, p‑Akt↓, 1, p‑Akt↑, 1, Akt2↓, 1, CaMKII ↓, 1, CREB↑, 2, ERK↓, 5, ERK↑, 3, p‑ERK↑, 1, HGF/c-Met↑, 1, IKKα↓, 1, IKKα↑, 1, IκB?, 1, JAK↓, 1, JAK2↑, 1, JNK↓, 5, p‑JNK↓, 2, MAPK↓, 8, mTOR↓, 1, mTOR↑, 4, p‑mTOR↓, 1, PDGFR-BB↓, 1, PDGFRB↓, 1, PI3K↓, 5, PI3K↑, 5, PKCδ↓, 1, PKCδ↑, 1, RIP1↓, 1, STAT↓, 1, STAT3↓, 2, STAT3↑, 3, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF4↓, 1, cJun↓, 1, p‑cMyc↑, 1, HDAC↓, 2, HDAC2↓, 1, HDAC3↓, 1, HOTAIR↑, 1, other↓, 2, other↑, 5, other↝, 5, RUNX2↑, 1, tumCV↓, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1, CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 1, ER Stress↓, 2, GRP78/BiP↓, 2, GRP78/BiP↑, 2, GRP94↑, 1, HSP27↑, 1, HSP70/HSPA5↑, 1, HSPs↓, 1, HSPs↑, 1, IRE1↓, 1, PERK↓, 1, UPR↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4, Beclin-1/ATG6↑, 2, LC3II↓, 1, LC3II↑, 2, p62↓, 1, p62↑, 2, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5, p16↓, 1, P53↓, 5, P53↑, 2, PARP∅, 1, cl‑PARP↓, 1, cl‑PARP↑, 2, PARP1↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, GADD34↓, 1, Ki-67↓, 1, P21↓, 3, P21↑, 2, TumCCA↑, 3,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Diff↝, 1, Ki-67↓, 1, neuroG↑, 1, TumCP↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 3, AP-1↓, 1, Ca+2↓, 1, Ca+2↑, 1, COL1↓, 2, COL1↑, 1, E-cadherin↓, 1, E-cadherin↑, 1, EMT↓, 1, MLC2/MYL9↝, 1, MMP13↓, 2, MMP9↓, 1, p‑Rac1↓, 1, Rho↓, 1, ROCK1↓, 1, p‑SMAD2↓, 1, p‑SMAD3↑, 1, p‑T-cadherin↓, 1, TGF-β↓, 1, TregCell↑, 1, TumCI↓, 1, TumCMig↓, 1, Vim↓, 1, Zeb1↓, 1, α-SMA↓, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, angioG↑, 1, eNOS↑, 1, Hif1a↓, 4, Hif1a↑, 1, NO↓, 11, NO↑, 1, VCAM-1↓, 2, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 12, GastroP↑, 3, GLUT2↑, 1, GLUT4↑, 1, IBI↑, 1, MMP↓, 3, MMP↑, 10, OCLN↝, 1, TJ↑, 1, TRPA1↑, 1, TRPC1↓, 1, ZO-1↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1, CD19↑, 1, CD25+↑, 1, CD4+↑, 3, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 26, COX2/PTGS2↑, 1, CXCR4↓, 1, FOXP3↑, 1, HMGB1↓, 1, IFN-γ↓, 2, IL1↓, 1, IL10↓, 6, IL10↑, 4, IL17↓, 2, IL18↓, 2, IL1β↓, 25, IL2↓, 3, IL33↓, 1, IL4↓, 2, IL4↑, 1, IL5↓, 1, IL6↓, 34, IL6↑, 1, IL8↓, 4, Imm↓, 1, Imm↑, 5, INF-γ↓, 2, Inflam↓, 90, Inflam↑, 1, LPS↓, 1, M2 MC↑, 1, pol-M2 MC↑, 1, MCP1/CCL2↓, 2, MyD88↓, 1, NeuroI↓, 2, NF-kB↓, 32, p‑NF-kB↓, 1, NK cell↑, 1, NLRP3↓, 3, PGE2↓, 14, RANTES↓, 1, TLR4↓, 6, TNF-α↓, 45, Treg lymp↝, 1, TRIF↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 3, Ach↑, 1, AChE↓, 12, BChE↓, 4, BDNF↓, 1, BDNF↑, 9, ChAT↑, 2, DA↑, 1, MAOA↓, 2, NGF↑, 2, PSD95↑, 1, SNAP25↑, 1, TPH1↓, 1, TrkB↑, 2,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, Aβ↓, 13, Aβ42↓, 3, BACE/β-secretase↓, 6, IDE↑, 1, tau↓, 3, p‑tau↓, 2, XO↝, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1, PPARα↑, 1, PPARα↝, 1, PPARγ↓, 1, PPARγ↑, 5,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 28, BioAv↑, 28, BioAv⇅, 1, BioAv↝, 12, BioEnh↑, 2, CYP2D6↓, 1, CYP2E1↓, 2, Dose↓, 1, Dose↑, 1, Dose⇅, 1, Dose↝, 8, eff↓, 2, eff↑, 6, eff↝, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 2, Half-Life↝, 9, P-gp/ABCB1↓, 2, P450↓, 2, P450↝, 1, selectivity↑, 1, Synergy↑, 7,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12, ALB↝, 1, ALP↓, 5, AST↓, 11, BG↓, 1, BloodF↑, 2, BP↓, 5, BUN?, 1, BUN↓, 2, CEA↓, 1, creat↓, 8, CRP↓, 3, hs-CRP↓, 1, IL6↓, 34, IL6↑, 1, LDH↓, 6, NOS2↓, 1, SpO2↑, 1, Urea↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2, AntiAge↑, 1, antiAll↑, 13, AntiArt↑, 4, AntiCan↑, 15, antiCG↑, 1, AntiDiabetic↑, 20, antiNeop↑, 1, antiPs↑, 3, AntiTum↓, 2, AntiTum↑, 4, cardioP?, 1, cardioP↑, 33, chemoP↑, 7, chemoPv↑, 1, cognitive↑, 16, diuretic↑, 3, hepatoP↑, 29, Learn↑, 1, memory↑, 12, motorD↑, 4, Mucositis↓, 2, neuroP↓, 1, neuroP↑, 53, Obesity↓, 4, OS↑, 1, Pain↓, 2, radioP↑, 3, RenoP↑, 8, Stroke↓, 4, toxicity?, 1, toxicity↓, 36, toxicity↑, 4, toxicity↝, 6, toxicity∅, 8, Weight↑, 1, Wound Healing↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13, AntiFungal↓, 1, AntiFungal↑, 3, AntiP↑, 2, AntiViral↑, 8, Bacteria↓, 15, Diar↓, 2, GutMicro↑, 10, Inf↓, 1, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,
Total Targets: 428

Scientific Paper Hit Count for: Casp9, Caspase-9

21 Quercetin
18 Silver-NanoParticles
18 Baicalein
17 Luteolin
16 Curcumin
16 Thymoquinone
15 Emodin
14 Fisetin
13 Kaempferol
12 Sulforaphane (mainly Broccoli)
11 Apigenin (mainly Parsley)
11 Magnolol
9 Allicin (mainly Garlic)
9 Berberine
9 Betulinic acid
9 Chrysin
9 Morin
8 Honokiol
8 Silymarin (Milk Thistle) silibinin
7 Cisplatin
7 Artemisinin
7 Alpha-Lipoic-Acid
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
6 Citric Acid
6 D-limonene
6 Eugenol
6 Garcinol
6 Graviola
5 Ginkgetin
5 Ivermectin
5 Matrine
5 Phenethyl isothiocyanate
5 Shikonin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Ashwagandha(Withaferin A)
4 Bromelain
4 Boron
4 Capsaicin
4 Carvacrol
4 chaetocin
4 Photodynamic Therapy
4 Radiotherapy/Radiation
4 Formononetin
4 Fucoidan
4 Juglone
4 Licochalcone A
4 Lycopene
4 Magnetic Fields
4 Plumbagin
4 Resveratrol
3 5-fluorouracil
3 Berbamine
3 Boswellia (frankincense)
3 α-Bisabolol / Chamomile oil
3 Carnosic acid
3 Chlorogenic acid
3 Dandelion Root
3 Evodiamine
3 Ferulic acid
3 Gallic acid
3 Geraniol
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Hyperoside
3 Isoliquiritigenin
3 isoorientin
3 Vitexin
3 Licorice
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Propolis -bee glue
3 Piperlongumine
3 Selenium NanoParticles
3 Aflavin-3,3′-digallate
2 Astragalus
2 Andrographis
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Beta-Caryophyllene
2 Brucea javanica
2 Bullatacin
2 Thymol-Thymus vulgaris
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Carvone
2 Polyphenols
2 Deguelin
2 Docetaxel
2 Echinacea
2 Electrical Pulses
2 Paclitaxel/Taxol
2 Hydrogen Gas
2 Chemotherapy
2 Hibiscus sabdariffa
2 Rutin
2 Isobavachalcone
2 phytic acid, Inositol hexakisphosphate
2 isoquercitrin
2 lambertianic acid
2 low dose naltrexone
2 Linalool
2 methylseleninic acid
2 Mangiferin
2 doxorubicin
2 Mistletoe/Viscum album Extracts
2 Nimbolide
2 Oleuropein
2 Phycocyanin
2 Rosmarinic acid
2 salinomycin
2 Selenium
2 chitosan
2 Selenite (Sodium)
2 Ursolic acid
1 1,8-Cineole
1 entinostat
1 Camptothecin
1 Resiquimod
1 Gemcitabine (Gemzar)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Fennel Oil/Foeniculum vulgare
1 Metformin
1 2-DeoxyGlucose
1 almonertinib
1 epirubicin
1 Biochanin A
1 Bufalin/Huachansu
1 brusatol
1 borneol
1 Caffeic acid
1 Sorafenib (brand name Nexavar)
1 Celecoxib
1 Chlorophyllin
1 Cinnamon
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Cynaropicrin
1 Diclofenac
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Geldanamycin
1 Radicicol/monorden
1 Flaxseed/Linseed
1 olaparib/LYNPARZA
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Baicalin
1 Indole-3-carbinol
1 Isovitexin
1 L-Theanine
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Magnetic Field Rotating
1 Melatonin
1 Moringa oleifera
1 Methylsulfonylmethane
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 sericin
1 Propyl gallate
1 topotecan
1 Piperine
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 polyethylene glycol
1 Auranofin
1 Spirulina(Arthrospira/Limnospira)
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Vitamin K2
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:45  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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