lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
Source:
Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
Scientific Papers found: Click to Expand⟱
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
5638- BCA,    Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway
- in-vitro, Oral, NA
tumCV↓, ROS↑, MMP↓, TumCMig↓, TAC↓, lipid-P↓, NF-kB↓, Apoptosis↑,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, eff↑,
5561- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease
- Review, AD, NA
*ROS↓, *cognitive↑, *BBB↑, *lipid-P↓, *eff↑,
5563- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease
- Review, AD, NA
*BBB↑, *lipid-P↓, *eff↑, *cognitive↑,
5481- BM,    Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies
- in-vitro, HCC, HepG2
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, lipid-P↓,
5473- BM,    Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *toxicity∅, *AChE↓, *ROS↓, *antiOx↑, *lipid-P↓, *cognitive↑, *memory↑, *Dose↝, *BioAv↓, *TumCCA↑, *BBB↝,
3698- BM,    Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
- in-vivo, AD, NA
*lipid-P↓, *ROS↓, *neuroP↑,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1↑, IL2↓, IL4↓, IFN-γ↓, COX2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
4272- Bor,    Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain
*NRF2↑, *ROS↓, *antiOx↑, *lipid-P↑, *Inflam↓, *DNAdam↓, *BDNF↑, *neuroP↑, *GSH↑,
760- Bor,    Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease
- in-vivo, AD, NA
*memory↑, *ROS↓, *GSH↑, *Aβ↓, *Inflam↓, *MMP↑, *lipid-P↓, *Ca+2↓, *cognitive↑, *TOS↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
1447- Bos,    Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vivo, BC, 4T1 - in-vitro, Nor, MCF10
tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,
5713- Brut,    Standardized bergamot polyphenolic fraction – a comprehensive dietary supplement with pleiotropic properties compared to other selected natural lipid-lowering substances available on the market
- Review, Nor, NA
*eff↑, *lipid-P↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6554- BSB,  doxoR,    α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress–Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats
- in-vivo, Nor, NA
*cardioP↑, *chemoP↑, *antiOx↑, *ROS↓, *toxicity↓, *DNAdam↓, *lipid-P↓, *ER Stress↓,
6560- BSB,  doxoR,    Α-Bisabolol, a Component of German Chamomile Tea Attenuates NLRP3 Inflammasome Mediated Pyroptosis, NF-ΚB/MAPK Signaling Activation and Apoptosis by Invoking NRF2 Mediated Antioxidant Defense Systems in Doxorubicin-Induced Liver Injury in Rats
- in-vivo, Nor, NA
*lipid-P↓, *antiOx↑, *Apoptosis↓, *Inflam↓,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp↓, ChemoSen↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5758- CAPE,  PBG,    Caffeic acid phenethyl ester and therapeutic potentials
- Review, Var, NA
*antiOx↑, *Inflam↓, ChemoSen↑, chemoP↑, COX1↓, COX2↓, selectivity↑, NF-kB↓, RadioS↑, *ROS↓, *lipid-P↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2↓, *Dose↝,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3873- Carno,    Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
- in-vivo, AD, NA
*ROS↓, *IronCh↑, *Aβ↓, *AntiAge↑, *lipid-P↓, *cognitive↑, *memory∅,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,
6139- CHr,    Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials
- Review, Var, NA
RadioS↑, PhotoS↑, ROS↑, DNAdam↑, TumCCA↑, TumCD↑, selectivity↑, *ROS↓, *Inflam↓, *DNAdam↓, *antiOx↑, *lipid-P↓, *BioAv↑, eff↑, GSH↓, Catalase↓, ALAT↓, Ca+2↓, MDA↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2↓, *NF-kB↓, *ROS↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,

Showing Research Papers: 51 to 100 of 310
Prev Page 2 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 310

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

4-HNE↑, 1,   antiOx↑, 1,   Catalase↓, 2,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 1,   HO-1↓, 1,   HO-1↑, 1,   i-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 4,   lipid-P↑, 5,   MDA↓, 3,   MDA↑, 3,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 18,   SOD↑, 1,   TAC↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

mt-ATP↓, 1,   MMP↓, 6,   MPT↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   ALAT↓, 1,   AMPK↑, 1,   cMyc↓, 1,   glucose↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 1,   PDK1↓, 1,   PDK3↑, 1,   PPARα↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 9,   Bak↓, 1,   BAX↑, 5,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 2,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 7,   Casp7↑, 2,   Casp8↑, 4,   Casp9↑, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 4,   DR4↑, 1,   DR5↑, 1,   FADD↑, 2,   Fas↑, 2,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 3,   Mcl-1↓, 1,   p38↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,   PhotoS↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3I↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 4,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 3,   Cyc↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 2,   P21↓, 1,   P21↑, 3,   p‑RB1↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   EMT↓, 1,   ERK↓, 3,   p‑ERK↓, 1,   FGF↓, 1,   GSK‐3β↓, 1,   Let-7↑, 1,   mTOR↓, 4,   NOTCH1↑, 1,   PI3K↓, 4,   STAT3↓, 2,   TOP1↓, 3,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

AXL↓, 1,   Ca+2↓, 1,   CEA↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   p‑FAK↓, 1,   Ki-67↓, 3,   miR-200b↑, 1,   MMP1↓, 1,   MMP2↓, 5,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TET1↑, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 5,   uPA↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 7,   ATF4↑, 1,   EGFR↓, 1,   EGFR↑, 1,   EPR↑, 1,   Hif1a↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 9,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 9,   CXCR4↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL2↑, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 8,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 2,   TLR4↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 1,   ChemoSen↑, 11,   DDS↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↑, 14,   eff↝, 1,   Half-Life↓, 2,   Half-Life↑, 1,   RadioS↑, 6,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

AFP↓, 2,   ALAT↓, 1,   AR↓, 2,   ascitic↓, 1,   AST↓, 1,   CEA↓, 1,   creat↓, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 2,   IL6↓, 1,   Ki-67↓, 3,   PD-L1↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 8,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 3,   hepatoP↑, 2,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   Weight↑, 1,  
Total Targets: 220

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 2,   CB2 / CNR2↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 22,   Catalase↓, 1,   Catalase↑, 15,   Ferroptosis↓, 1,   GPx↓, 2,   GPx↑, 10,   GPx4↑, 1,   GSH↑, 14,   GSR↑, 6,   GSTs↑, 1,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 6,   Keap1↑, 1,   lipid-P↓, 38,   lipid-P↑, 2,   MDA↓, 11,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 10,   ROS↓, 30,   ROS↑, 1,   SOD↑, 20,   TAC↑, 3,   TBARS↓, 1,   TOS↓, 2,   UCPs↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 2,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 5,   AMPK↑, 1,   LDH↓, 3,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 5,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 4,   Casp9↓, 1,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 4,   MAPK↓, 1,   MAPK↑, 1,   TRPV1↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 4,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   GSK‐3β↑, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↓, 1,   TRPM7↓, 1,  

Migration ⓘ

5LO↓, 4,   AntiAg↑, 2,   APP↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↑, 1,   MMP13↓, 1,   Na+↑, 1,   PKCδ↑, 1,   TGF-β↑, 1,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 4,   BBB↝, 1,   GastroP↑, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 8,   IL1β↓, 7,   IL6↓, 5,   IL6↑, 1,   Imm↑, 3,   Inflam↓, 25,   Inflam↑, 2,   JAK2↓, 1,   NF-kB↓, 10,   PGE2↓, 1,   TLR4↓, 2,   TNF-α↓, 10,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 10,   BChE↓, 3,   BDNF↓, 1,   BDNF↑, 3,   ChAT↑, 1,   GABA↝, 1,   MAOA↓, 1,   tau↓, 1,   p‑tau↓, 3,  

Protein Aggregation ⓘ

Aβ↓, 6,   BACE↓, 3,   MAOB↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1,   GR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 5,   BioAv⇅, 1,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↑, 7,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 5,   ALP↓, 5,   AST↓, 5,   BMD↑, 1,   BP↓, 2,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 5,   IL6↑, 1,   LDH↓, 3,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 9,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 10,   hepatoP↑, 6,   memory↑, 11,   memory∅, 1,   motorD↑, 1,   neuroP↑, 16,   NP/CIPN↓, 1,   Obesity↓, 3,   OS↑, 1,   Pain↓, 3,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 8,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   Bacteria↓, 4,   CD8+↑, 1,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 161

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
17 Curcumin
14 Thymoquinone
13 Quercetin
12 Silymarin (Milk Thistle) silibinin
10 Silver-NanoParticles
10 Alpha-Lipoic-Acid
10 Resveratrol
9 Eugenol
7 Artemisinin
7 Chrysin
7 Rosmarinic acid
7 Urolithin
6 Ashwagandha(Withaferin A)
6 Berberine
6 Carvacrol
6 Crocetin
6 Copper and Cu NanoParticles
6 Lycopene
6 Shikonin
5 Luteolin
5 Cinnamon
5 Ferulic acid
5 Piperlongumine
5 Selenium NanoParticles
5 Selenite (Sodium)
4 Vitamin C (Ascorbic Acid)
4 Bacopa monnieri
4 Boron
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Chemotherapy
3 Allicin (mainly Garlic)
3 Beta-Caryophyllene
3 α-Bisabolol / Chamomile oil
3 chitosan
3 Coenzyme Q10
3 Selenium
3 Dandelion Root
3 EGCG (Epigallocatechin Gallate)
3 erastin
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Juglone
3 Moringa oleifera
3 Phenethyl isothiocyanate
3 Pterostilbene
3 salinomycin
2 1,8-Cineole
2 alpha Linolenic acid
2 Astaxanthin
2 Baicalein
2 Biochanin A
2 beta-carotene(VitA)
2 doxorubicin
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carnosine
2 Citric Acid
2 Vitamin E
2 Disulfiram
2 Fisetin
2 Graviola
2 Hydrogen Gas
2 Nimbolide
2 Piperine
2 Rutin
2 Radiotherapy/Radiation
1 Astragalus
1 Glucose
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 Aloe anthraquinones
1 Betulinic acid
1 Bromelain
1 Bruteridin(bergamot juice)
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 immunotherapy
1 Carica papaya leaf extract
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 D-limonene
1 Cisplatin
1 Hydroxycinnamic-acid
1 Honokiol
1 HydroxyTyrosol
1 Linalool
1 Melatonin
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phosphatidylserine
1 Sulfasalazine
1 Sulforaphane (mainly Broccoli)
1 Shankhpushpi
1 Spermidine
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Vitamin B5,Pantothenic Acid
1 VitK3,menadione
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:453  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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