p27/CDKN1B Cancer Research Results

p27/CDKN1B, p27kip1: Click to Expand ⟱
Source:
Type:
The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

CDKN1B - Cyclin-Dependent Kinase Inhibitor 1B / p27

Abbreviation: CDKN1B, p27, p27Kip1

Type: Cyclin-dependent kinase inhibitor / cell-cycle regulator

Function: CDKN1B/p27 inhibits cyclin-CDK complexes, particularly cyclin E-CDK2 and cyclin A-CDK2, thereby restricting G1/S cell-cycle progression. It also regulates differentiation, transcription, cytoskeletal organization, cell migration, and cellular responses to growth-factor signaling.

Cancer: ↕ Context-dependent, but predominantly tumor-suppressive. Reduced nuclear p27 expression or functional loss can promote uncontrolled proliferation, tumor progression, and treatment resistance. However, cytoplasmic p27 can acquire CDK-independent pro-oncogenic functions that promote cell motility, invasion, and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
7507- FA,    Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Dose↝, ATR↑, ATM↑, P21↑, p27/CDKN1B↑, E2F4↑, RB1↑, TP53↑, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, TumCP↓, Casp1↑, Casp2↑, Casp8↑, Fas↑, TRADD↑, Bcl-2↓, XIAP↓, TumCCA↑,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27/CDKN1B↑, ERK↓, MAPK↓,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7593- I3C,    Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells
- Review, Pca, NA
Risk↓, TumCG↓, TumCCA↑, P21↑, p27/CDKN1B↑, CDK6↓, cl‑RB1↓, cl‑PARP↑, BAX↑, Bcl-2↓,
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
7726- IP6,    Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation
- in-vitro, BC, MCF7
AntiCan↑, PKCδ↑, ERK↓, Akt↓, p27/CDKN1B↑, p‑pRB↓,
7642- IP6,    Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, Apoptosis↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, AKT1↓, S6K↓, mTOR↓,
7645- IP6,  Ins,    Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview
- in-vitro, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, Diff↑, p27/CDKN1B↓, pRB↓, PI3K↓, RAS↓, ERK↓, Akt↓, NF-kB↓, Inflam↓, AntiTum↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,
8317- LIN,    Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
- in-vitro, Liver, HepG2
TumCP↓, TumCCA↑, CDK4↓, cycA1/CCNA1↓, P21↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, cl‑PARP↑, DNAdam↑, RAS↓, Akt↓, mTOR↓, ROS↑, MAPK↑,
6480- LIN,    Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs
- in-vitro, lymphoma, U937 - in-vitro, Var, HeLa
TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
8407- Lyco,    Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
- in-vitro, Pca, LNCaP
CholSyn↓, HMGCR↓, RAS↓, NF-kB↓, ROS↓, p‑Jun↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, p‑Akt↓, P21↑, p27/CDKN1B↑, P53↑, Bax:Bcl2↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
8641- MBZ,  ONC201,    The therapeutic potential of repurposed mebendazole, alone and in synergistic combination with ONC201, in the treatment of diffuse midline glioma
- in-vitro, GBM, NA
TumCCA↑, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Synergy↑, ChemoSen↑,
8742- MeSA,    Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells
- in-vitro, Pca, DU145
TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, p27/CDKN1B↑, P21↑, Apoptosis↑, Akt↓, ERK↓,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8774- MSM,    Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells
- in-vitro, Oral, YD-38
P21↑, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, Cyt‑c↑, TumCCA↑,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27/CDKN1B↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,

Showing Research Papers: 51 to 100 of 123
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 123

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 2,   antiOx⇅, 1,   ARE↑, 2,   Catalase↓, 2,   Catalase↑, 3,   Copper↑, 1,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 4,   GSTs↑, 1,   HO-1↓, 5,   HO-1↑, 2,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↑, 7,   ROS↓, 12,   ROS↑, 55,   ROS⇅, 4,   i-ROS↑, 1,   SOD↓, 3,   SOD↑, 3,   SOD2↓, 2,   TAC?, 1,   TAC↓, 1,   Trx↑, 1,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 3,   CDC25↓, 7,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 1,   ETC↓, 2,   Insulin↓, 2,   mitResp↓, 1,   mtDam↑, 3,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   PDH↑, 2,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   ACC↑, 1,   ALDOA↓, 1,   AMP↓, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 3,   GlucoseCon↓, 1,   Glycolysis↓, 6,   GSK‐3β↓, 7,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   Histones↑, 1,   HK2↓, 4,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDHA↓, 4,   LDL↓, 2,   MCT4↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 3,   PFK↓, 2,   PKM2↓, 3,   polyA↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TS↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 58,   mt-Apoptosis↑, 2,   BAD↓, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 39,   BAX⇅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 42,   Bcl-2↑, 1,   Bcl-xL↓, 15,   BID↓, 1,   BID↑, 3,   BIM↑, 3,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 12,   Casp1↑, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 45,   cl‑Casp3↑, 8,   Casp7↑, 4,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 1,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 25,   Diablo↑, 4,   DR5↓, 1,   DR5↑, 7,   FADD↑, 2,   Fas↑, 7,   FasL↑, 1,   Ferroptosis↑, 2,   iNOS↓, 2,   Mcl-1?, 1,   Mcl-1↓, 8,   MDM2↓, 5,   MDM2↑, 1,   NAIP↓, 1,   necrosis↑, 1,   oncosis↑, 1,   p38↓, 1,   p38↑, 6,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 2,   survivin↓, 21,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↑, 4,   XIAP↓, 11,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 53,   Akt↑, 1,   p‑Akt↓, 8,   AKT1↓, 1,   AMPKα↑, 1,   CK2↓, 1,   cMET↓, 2,   EGFR↓, 15,   ERK↓, 23,   p‑ERK↓, 4,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 3,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 1,   JAK2↓, 4,   JNK↓, 3,   JNK↑, 9,   p‑JNK↑, 1,   MAPK↓, 13,   MAPK↑, 4,   MEK↓, 1,   mTOR↓, 27,   p‑mTOR↓, 2,   p70S6↓, 1,   P70S6K↓, 3,   PI3K↓, 35,   p‑PI3K↓, 2,   PI3K/Akt↓, 2,   PKCδ↓, 3,   PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 3,   RAS↓, 8,   S6K↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 3,   STAT3↓, 22,   STAT3↑, 1,   p‑STAT3↓, 2,   STAT5↓, 2,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 2,   cJun↓, 2,   cJun↑, 1,   cMyc↓, 14,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 3,   FOXM1↓, 4,   FOXO↑, 3,   FOXO1↓, 1,   FOXO3↓, 3,   FOXO3↑, 3,   H3↓, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 7,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   IRF1↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   MTA2↓, 2,   Myc↓, 2,   n-MYC↓, 1,   OCT4↓, 3,   other↑, 1,   other↝, 4,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 2,   TCF-4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   IRE1↑, 3,   PERK↑, 2,   Proteasome↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 1,   CTSB↓, 1,   LC3A↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   ATR↑, 1,   p‑ATR↑, 1,   BRCA1↑, 3,   BRCA2↑, 1,   DNAdam↑, 21,   DNArepair↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 5,   P53↓, 2,   P53↑, 38,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 4,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 24,   PARP1↑, 1,   PCNA↓, 10,   RAD51↓, 1,   Telomerase↓, 5,   TOP1↓, 2,   TOP2↓, 4,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 37,   CDK2↑, 2,   CDK4↓, 41,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 13,   CDK6↑, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 9,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 62,   cycD1/CCND1↑, 1,   CycD3↓, 4,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   E2F4↑, 1,   E2Fs↓, 4,   Ki-67↓, 4,   P21↓, 7,   P21↑, 88,   p27/CDKN1B↓, 11,   p27/CDKN1B↑, 111,   cl‑p27/CDKN1B↓, 1,   pRB↓, 3,   pRB↑, 2,   p‑pRB↓, 4,   RB1↑, 2,   cl‑RB1↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 84,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   BMPs↑, 1,   CD133↓, 3,   cFos↓, 2,   CSCs↓, 9,   Diff↓, 1,   Diff↑, 4,   EP4/PTGER4↑, 1,   Gli↓, 1,   Gli1↓, 3,   HMGCR↓, 2,   IGF-1↓, 5,   IGFBP3↑, 1,   p‑Jun↓, 1,   Ki-67↓, 4,   Let-7↓, 1,   Let-7↑, 1,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 8,   NOTCH⇅, 1,   NOTCH1↓, 4,   NOTCH2↓, 1,   NOTCH2↑, 1,   PTCH1↓, 2,   Smo↓, 2,   TumCG↓, 20,   TumCG↑, 1,   TumCP↓, 40,   TumCP↑, 1,   Wnt?, 1,   Wnt↓, 12,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AP-1↓, 5,   CA↓, 1,   Ca+2↑, 7,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   Cdc42↑, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 13,   EMT↓, 15,   FAK↓, 6,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↑, 1,   LRP1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 2,   MMP7↓, 4,   MMP9↓, 23,   MMP9↑, 1,   MMPs↓, 9,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 5,   NCAM↑, 1,   PDGF↓, 4,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 6,   TGF-β↓, 2,   TIMP2↓, 1,   TIMP2↑, 3,   Trop2↓, 1,   TumCI↓, 12,   TumCMig↓, 15,   TumMeta↓, 14,   TumMeta↑, 2,   Twist↓, 8,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 9,   Zeb1↓, 7,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 10,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 18,   LOX1↓, 2,   NO↓, 2,   NO↑, 3,   VEGF↓, 30,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 30,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 1,   CD44↓, 3,   COX2/PTGS2↓, 19,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR4↓, 3,   DR4↑, 3,   FOXP3↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 5,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 10,   IL7↓, 1,   IL8↓, 6,   IL8↑, 1,   Imm↑, 2,   Inflam↓, 10,   IRAK1↓, 2,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 50,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 7,   PSA∅, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 11,   TNF-α↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AhR↑, 2,   AhR↓, 1,   AR↓, 10,   ER-α36↓, 1,   ER(estro)↓, 1,   GR↑, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 8,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 3,   ChemoSen↑, 34,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   Dose∅, 1,   eff↓, 7,   eff↑, 16,   eff↝, 3,   GSTA1↑, 1,   Half-Life↓, 5,   Half-Life↝, 4,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 3,   RadioS↑, 15,   selectivity↑, 24,   selectivity↝, 1,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 10,   BRCA1↑, 3,   E6↓, 1,   E7↓, 1,   EGFR↓, 15,   EZH2↓, 3,   FOXM1↓, 4,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 10,   Maspin↑, 1,   Myc↓, 2,   PD-L1↓, 3,   PSA↓, 7,   PSA∅, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 4,   ChemoSideEff↓, 2,   FTO↑, 1,   hepatoP↑, 4,   neuroP↑, 2,   NKG2D↑, 1,   OS↑, 2,   QoL↑, 2,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 5,   TumW↓, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 581

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 6,   GPx↑, 3,   GSH↑, 8,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 2,   Iron∅, 1,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 4,   RNS↓, 1,   ROS↓, 15,   SOD↓, 1,   SOD↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↑, 2,   CRM↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   glyC↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,   ERK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   MMP13↓, 1,   PAI-1/SERPINE1↓, 1,   Rho↓, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 2,   Inflam↓, 12,   NF-kB↓, 2,   NLRP3↓, 1,   PGE2↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 1,   BioAv↝, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   eff↑, 1,   GSTA1↑, 2,   Half-Life↓, 1,   Half-Life↝, 2,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   BUN↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 2,   antiD↓, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↓, 1,   cardioP↑, 6,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 3,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 1,   RenoP↑, 1,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 1,   Sepsis↓, 1,  
Total Targets: 116

Scientific Paper Hit Count for: p27/CDKN1B, p27kip1
6 Thymoquinone
6 phytic acid, Inositol hexakisphosphate
6 Resveratrol
5 Diindolylmethane
5 Lycopene
4 Berberine
4 Indole-3-carbinol
4 Fisetin
3 Alpha-Lipoic-Acid
3 Curcumin
3 EGCG (Epigallocatechin Gallate)
3 Gallic acid
3 Sulforaphane (mainly Broccoli)
3 Propolis -bee glue
2 Silver-NanoParticles
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalein
2 Cucurbitacin
2 diet Methionine-Restricted Diet
2 Eugenol
2 HydroxyTyrosol
2 Inositol
2 Phenethyl isothiocyanate
2 lambertianic acid
2 Linalool
2 Luteolin
2 Silymarin (Milk Thistle) silibinin
1 3-bromopyruvate
1 5-fluorouracil
1 Coenzyme Q10
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Berbamine
1 Biochanin A
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Cisplatin
1 Caffeic acid
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Deguelin
1 Emodin
1 Ferulic acid
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperoside
1 Isoliquiritigenin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Licochalcone A
1 Magnolol
1 mebendazole
1 Dordaviprone; Modeyso
1 methylseleninic acid
1 Metformin
1 Melatonin
1 Methylsulfonylmethane
1 Naringin
1 Oleuropein
1 Propyl gallate
1 Plumbagin
1 Quercetin
1 Rosmarinic acid
1 salinomycin
1 Turmerones
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:468  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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