CD44 Cancer Research Results

CD44, CD44: Click to Expand ⟱
Source:
Type:
CD44 represents a common biomarker of cancer stem cells, and promotes epithelial-mesenchymal transition. CD44 is a well-known marker of CSCs and plays important roles in tumor initiation and development.
Scientific Papers found: Click to Expand⟱
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,
4956- PEITC,    Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells
- vitro+vivo, Lung, A549
GSH↓, ROS↑, mtDam↑, mitResp↓, MMP↓, CSCs↓, OCT4↓, ABC↓, SOX2↓, CD133↓, CD44↓, ALDH↓, Nanog↓, TumCG↓,
4957- PEITC,    Phenethyl Isothiocyanate (PEITC) from Cruciferous Vegetables Targets Human Cancer Stem-Like Cells
- vitro+vivo, Cerv, HeLa
CSCs↓, ALDH↓, CD44↓, CD24↓, cl‑PARP↑, DR4↑, DR5↑,
4960- PEITC,    Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells
- in-vivo, Cerv, HeLa
CD44↓, CD24↓, CSCs↓, cl‑PARP↑, DR4↑, DR5↑, TumCP↓,
1236- PTS,    Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumMeta↓, EMT↓, E-cadherin↑, Zeb1↓, Snail↓, β-catenin/ZEB1↓, CD44↓, MMPs↓, CSCs↓,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
- Review, Var, NA
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
4690- PTS,  immuno,    Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies
- Review, Var, NA
eff↑, Half-Life↑, TumCG↓, TumMeta↓, angioG↓, CSCs↓, Apoptosis↑, Synergy↑, CD44↓, CD24↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
59- QC,    Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)
- in-vitro, BC, MDA-MB-231
ALDH1A1↓, CXCR4↓, MUC1↓, EpCAM↓, CSCs↓, TumCP↓, TumCI↓, CD44↓, CD24↓, Apoptosis↑, TumCCA↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
61- QC,    Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, ARPE-19
p‑PI3K↓, p‑Akt↓, p‑ERK↓, NF-kB↓, p38↓, ABCG2↓, CD44↓, CD133↓, CSCs↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
3081- RES,    Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?
- Review, CRC, NA
NF-kB↓, FAK↓, Ki-67↓, MMP9↓, CSCs↓, CD44↓, CD133↓, ALDH1A1↓, EMT↓, ChemoSen↑, Hif1a↓, ITGB1↓, Inflam↓,
4657- RES,    Resveratrol, cancer and cancer stem cells: A review on past to future
- Review, Var, NA
CSCs↓, CD133↓, Shh↓, Twist↓, Snail↓, MMP2↓, MMP9↓, Smad1↓, CD44↓, ALDH1A1↓, OCT4↓, Nanog↓, STAT3↓, survivin↓, cycD1/CCND1↓, COX2/PTGS2↓, cMyc↓,
4667- RES,  CUR,  SFN,    Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models
- Review, Var, NA
CSCs↓, ChemoSen↑, RadioS↑, ALDH↓, CD44↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, HH↓, NF-kB↓,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
- in-vitro, Var, NA
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP/DDIT3↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
5036- SAS,    Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
xCT/SLC7A11↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, Synergy↑, TumCG↓,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,

Showing Research Papers: 51 to 76 of 76
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 76

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Fenton↑, 1,   GPx4↓, 2,   GSH↓, 5,   GSH↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 3,   Iron↓, 1,   Iron↑, 2,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 5,   ROS?, 1,   ROS↓, 4,   ROS↑, 22,   SOD↓, 1,   SOD↑, 2,   mt-SOD↑, 1,   Thiols↓, 1,   xCT/SLC7A11↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   compI↓, 1,   ETC↝, 1,   mitResp↓, 2,   mtDam↑, 3,   OCR↓, 2,   OXPHOS↓, 1,   PDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↓, 3,   ECAR↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 3,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   NAD↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PKM2↑, 1,   SIRT1↓, 5,   SIRT2↓, 1,   SREBP1/SREBF1↓, 3,   TCA↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↑, 21,   Apoptosis∅, 1,   BAD↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 6,   Bcl-2↓, 12,   BIM↑, 1,   Casp↑, 3,   Casp12?, 1,   Casp3↓, 1,   Casp3↑, 13,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 3,   Casp8∅, 1,   Casp9↑, 11,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 11,   Diablo↑, 1,   DR5↑, 5,   Fas↑, 5,   Ferroptosis↑, 3,   HEY1↓, 1,   IAP1↓, 1,   ICD↑, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MOMP↑, 1,   p38↓, 3,   p38↑, 2,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 8,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 3,   XIAP↓, 5,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   p‑Akt↓, 5,   AKT1↓, 1,   cMET↓, 1,   EGFR↓, 5,   ERK↓, 4,   ERK↑, 2,   p‑ERK↓, 3,   HER2/EBBR2↓, 4,   IKKα↓, 1,   JNK↓, 2,   JNK↑, 2,   MAPK↓, 4,   MAPK↑, 2,   mTOR↓, 12,   p‑mTOR↓, 2,   p70S6↓, 1,   PI3K↓, 9,   p‑PI3K↓, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PTEN↑, 2,   RET↓, 1,   STAT3↓, 8,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 10,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO3↝, 1,   HATs↑, 1,   HDAC↓, 5,   miR-133a-3p↑, 1,   miR-140↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-22↑, 1,   miR-29b↓, 1,   miR-34a↑, 1,   miR-485↑, 1,   Myc↓, 1,   OCT4↓, 18,   other↓, 1,   other↝, 1,   SOX2↓, 13,   SOX4↓, 2,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↓, 1,   ER Stress↑, 4,   ERStress↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 8,   DNAdam⇅, 1,   hTERT/TERT↓, 2,   P53↑, 10,   PARP↑, 1,   cl‑PARP↑, 8,   PCNA↓, 2,   Telomerase↓, 4,   TOP2↓, 1,   TP53↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 1,   CDK4↓, 4,   CDK6↓, 1,   CHK1↑, 2,   Chk2↑, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 8,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   cycE/CCNE↝, 1,   E2Fs↓, 2,   Ki-67↓, 2,   mitA↑, 1,   p19↑, 1,   P21↓, 2,   P21↑, 11,   p27/CDKN1B↑, 3,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 24,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 10,   ALDH1A1↓, 10,   BMI1↓, 1,   CD133↓, 22,   CD24↓, 12,   CD34↓, 1,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 58,   CSCs↑, 1,   CSCsMark↓, 2,   Diff↑, 1,   Gli1↓, 3,   HH↓, 5,   HMGCR↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 2,   LGR5↓, 1,   Nanog↓, 19,   Nestin↓, 1,   NOTCH↓, 6,   NOTCH1↓, 6,   NOTCH3↓, 1,   PTCH1↓, 1,   Shh↓, 3,   Smo↓, 2,   TumCG↓, 19,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 18,   TumCP↑, 2,   Wnt↓, 16,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 6,   E-cadherin↓, 1,   E-cadherin↑, 10,   EMT↓, 19,   EpCAM↓, 4,   FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MMP1↓, 2,   MMP2↓, 15,   proMMP2↓, 1,   MMP7↓, 1,   MMP9↓, 16,   MMPs↓, 4,   MUC1↓, 1,   N-cadherin↓, 8,   PAK1↓, 1,   PDGF↓, 1,   RECK↑, 1,   Slug↓, 5,   Smad1↓, 1,   Snail↓, 10,   TET1↓, 1,   TGF-β↓, 1,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 2,   TumCI↓, 16,   TumCMig↓, 12,   TumMeta↓, 12,   Twist↓, 5,   uPA↓, 3,   Vim↓, 10,   Zeb1↓, 3,   α-SMA↓, 1,   β-catenin/ZEB1↓, 20,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 15,   Endoglin↓, 1,   HIF-1↓, 1,   Hif1a↓, 7,   VCAM-1↓, 1,   VEGF↓, 16,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   EPR↑, 1,   EPR↝, 1,   MMP↓, 17,   MPT↑, 2,   NHE1↓, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 74,   CD44↑, 1,   CD44↝, 1,   COX2/PTGS2↓, 7,   CXCR4↓, 5,   DR4↑, 3,   HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 1,   IL4↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 18,   NK cell↑, 1,   p50↓, 1,   p65↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 1,   TCF↓, 2,   TNF-α↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 3,   BioAv↓, 6,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 21,   ChemoSen⇅, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 10,   eff↓, 6,   eff↑, 7,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,   MDR1↓, 4,   MDR1↑, 1,   P-gp/ABCB1↓, 4,   P450↓, 2,   RadioS↑, 7,   selectivity↑, 10,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 5,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 2,   IL6↓, 4,   LDH↑, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 1,   TP53↑, 1,   Tumccf↓, 1,   Tumccf↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiNeop↑, 3,   AntiTum↑, 3,   cardioP↑, 2,   chemoP↑, 2,   ChemoSideEff↓, 1,   FTO↑, 1,   hepatoP↑, 2,   OS↑, 1,   QoL↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 5,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,   GutMicro↝, 1,  
Total Targets: 378

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 3,   GPx↑, 2,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 2,   GSTs↑, 2,   HDL↑, 1,   HO-1↓, 1,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 3,   ROS↓, 4,   SOD↑, 2,   SOD1↑, 2,   xCT/SLC7A11↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↝, 1,   HMG-CoA↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Casp9↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑ERK↑, 1,   HGF/c-Met↑, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HDAC↓, 1,   HDAC3↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Migration(tgid=13) ⓘ

TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 7,   NF-kB↓, 1,   TLR4↓, 2,   TNF-α↓, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 6,   BioAv↝, 2,   CompStab↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 4,   Pain↓, 2,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 3,   Diar↓, 1,   GutMicro↑, 1,  
Total Targets: 70

Scientific Paper Hit Count for: CD44, CD44
8 EGCG (Epigallocatechin Gallate)
7 Sulforaphane (mainly Broccoli)
6 Curcumin
6 Resveratrol
4 Quercetin
3 Eugenol
3 Phenethyl isothiocyanate
3 Pterostilbene
3 salinomycin
2 Ashwagandha(Withaferin A)
2 Bromelain
2 Fisetin
2 Genistein (soy isoflavone)
2 HydroxyTyrosol
2 iodine
2 Ivermectin
2 Magnetic Fields
2 Patchouli Oil (Pogostemon cablin)
1 Astragalus
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Atorvastatin
1 Berberine
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 Carvacrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Cucurbitacin
1 Electrical Pulses
1 Honokiol
1 Extracorporeal Shock Wave Therapy
1 Isothiocyanates
1 Isovitexin
1 Kaempferol
1 low dose naltrexone
1 Radiotherapy/Radiation
1 Mistletoe/Viscum album Extracts
1 Phenylbutyrate
1 immunotherapy
1 isoflavones
1 Sulfasalazine
1 Silymarin (Milk Thistle) silibinin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:48  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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