CHOP/DDIT3 Cancer Research Results

CHOP/DDIT3, GADD153: Click to Expand ⟱
Source:
Type: Protein
DDIT3, GADD153 and CHOP (C/EBP-homologous protein) refer to the same protein. GADD153 stands for "Growth Arrest and DNA Damage-inducible protein 153," while CHOP stands for "C/EBP Homologous Protein."
DDIT3 (DNA Damage Inducible Transcript 3), also known as CHOP (C/EBP Homologous Protein), is a transcription factor that plays a significant role in the cellular response to stress, particularly in the context of the unfolded protein response (UPR) and apoptosis.

CHOP is an important component of the endoplasmic reticulum (ER) stress response. Research has shown that knockdown of CHOP not only enhances tunicamycin-induced autophagy, but also significantly attenuates ER stress-induced apoptosis in human colon cancer cells.
GADD153, also known as CHOP (C/EBP homologous protein), is a transcription factor that plays a significant role in cellular stress responses, particularly in the context of the endoplasmic reticulum (ER) stress response. It is part of the unfolded protein response (UPR), which is activated when there is an accumulation of misfolded proteins in the ER.
Scientific Papers found: Click to Expand⟱
462- CUR,    Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
- in-vitro, Pca, PC3
Bcl-2↓, MMP↓, cl‑Casp3↑, BAX↑, BIM↑, p‑PARP↑, PUMA↑, p‑P53↑, ROS↑, p‑ERK↑, p‑eIF2α↑, CHOP/DDIT3↑, ATF4↑,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP/DDIT3↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,
143- CUR,    Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, ROS↑, LC3II↑, eff↓, tumCV↓,
118- CUR,    Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
ROS↑, Bcl-2↓, PARP↑, cDC2↓, CycB/CCNB1↓, MDM2↓, eff↓, eIF2α↑, ATF4↑, CHOP/DDIT3↑, ER Stress↑, TumCCA↑,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
8841- DIM,    3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
3203- EGCG,    (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress
- in-vitro, MM, NA
ROS↑, Ca+2↝, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, *GRP78/BiP↓, *UPR↓, UPR↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
3206- EGCG,    Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration
- Review, AMD, NA
*Ca+2↓, *ROS↓, *Apoptosis↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *PERK↓, *IRE1↓, *p‑PARP↓, *Casp3↓, *Casp12↓, *ER Stress↓, *UPR↓,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
5931- EGCG,  BTZ,    EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism
- in-vitro, Pca, PC3
TumAuto↑, CHOP/DDIT3↓, TumCD↓, eff↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP/DDIT3↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,
3716- FA,    Ferulic Acid as a Protective Antioxidant of Human Intestinal Epithelial Cells
- in-vitro, IBD, NA - in-vivo, NA, NA
*antiOx↑, *Inflam↓, *ER Stress↓, *other↑, *angioG↑, *Hif1a↑, *VEGF↑, *NO↓, *SIRT1↑, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *GutMicro↑,
2496- FBZ,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2855- FIS,    Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
- in-vitro, RCC, Caki-1
TumCCA↑, cl‑PARP↑, Apoptosis↑, Casp↑, P53↑, DR5↑, CHOP/DDIT3↑, ROS↑, ER Stress↑, ATF4↑, XBP-1↑, eff∅,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
1968- GamB,    Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis
- in-vitro, Lung, A549
tumCV↓, ROS↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, Casp12↑, p‑PERK↑, ER Stress↑,
7056- GamB,    Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy
- in-vitro, RCC, 786-O
ER Stress↑, TumAuto↑, ROS↑, PrxI↓, Apoptosis↑, BID↑, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
815- GAR,    Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation
- vitro+vivo, Lung, A549
ALDH1A1↓, CHOP/DDIT3↑,
821- GAR,    Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
- in-vitro, Liver, Hep3B
ROS↑, CHOP/DDIT3↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,
4506- GLA,    A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells
- in-vitro, BC, BT474
Apoptosis↓, Ca+2↑, MMP↓, p‑eIF2α↑, CHOP/DDIT3↑, ER Stress↑, ROS↑,
839- Gra,    Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
- in-vitro, Liver, HepG2
tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP/DDIT3↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1/ATG6↑, *p62↓, *mTOR↓,
1912- HCQ,  TMZ,    Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
- in-vivo, GBM, U87MG
LC3B-II↑, CHOP/DDIT3↑, cl‑PARP↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
601- HT,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, Colon, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, JNK↑, TNF-α↓, PPP2R1A↑,
7768- IBC,    Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells
- in-vitro, Pca, PC3
NA↑, TrxR1↓, ER Stress↑, TumCP↓, Apoptosis↑, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP/DDIT3↑, p‑eIF2α↑, eff↓, cl‑Casp3↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
8036- IVM,    Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway
- in-vitro, ESCC, KYSE-30
*AntiP↑, AntiTum↑, ER Stress↑, TumAuto↑, ATF4↑, CHOP/DDIT3↝, TumCG↓, PERK↑, ROS↑, *toxicity↓, Ca+2↑,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8098- KAE,    Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
- in-vitro, NSCLC, NA
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8219- LCA,    Licochalcone A Ameliorates Cognitive Dysfunction in an Alzheimer's Disease Model by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *Aβ↓, *ER Stress↓, *BioAv↑, *toxicity↓, *PERK↓, *eIF2α↓, *ATF4↓, *CHOP/DDIT3↓, *NRF2↑,
8210- LCA,    Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
- in-vitro, Bladder, T24/HTB-9
chemoPv↑, TumCP↓, ROS↑, Apoptosis↑, mtDam↑, Casp3↑, cl‑PARP↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, Casp12↑, mt-ROS↑, tumCV↓, GSH/GSSG↓, NA↓,

Showing Research Papers: 51 to 100 of 159
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 159

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   Copper↑, 1,   Fenton↑, 2,   GPx↓, 2,   GPx↑, 1,   GPx4↓, 5,   GSH↓, 13,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 3,   HO-1↓, 3,   HO-1↑, 13,   Iron↑, 5,   Keap1↝, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 3,   MPO↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 6,   NRF2↑, 14,   Prx↓, 1,   Prx4↓, 1,   Prx4↑, 1,   PrxI↓, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 85,   ROS⇅, 1,   mt-ROS↑, 3,   SOD↓, 3,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   ox-Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 3,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   FTL↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC2↑, 1,   CDC25↓, 6,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 10,   OCR↓, 2,   PDH↝, 1,   PGC-1α↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACC↑, 1,   ALAT∅, 1,   AMPK↓, 1,   AMPK↑, 5,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 5,   ENO1↓, 1,   FASN↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 15,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 7,   lactateProd↓, 3,   LDHA↓, 4,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   PKM2↑, 1,   SCD1↓, 1,   SIRT1↓, 2,   TCA↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 2,   Apoptosis↓, 3,   Apoptosis↑, 60,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 36,   Bax:Bcl2↑, 4,   Bcl-2↓, 37,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↑, 3,   cl‑BID↑, 1,   BIM↑, 5,   Casp↑, 6,   Casp1↓, 2,   Casp1↑, 1,   Casp12↑, 8,   cl‑Casp12↝, 1,   pro‑Casp12↓, 1,   Casp3↓, 1,   Casp3↑, 45,   cl‑Casp3↑, 13,   CASP4↑, 1,   Casp7↑, 6,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 13,   cl‑Casp8↑, 4,   Casp9↑, 27,   cl‑Casp9↑, 5,   cFLIP↓, 4,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 35,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 3,   DR5↑, 21,   Endon↑, 2,   Fas↑, 8,   FasL↑, 4,   Ferroptosis↑, 5,   GRP58↓, 1,   HEY1↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 1,   Mcl-1↓, 5,   Mcl-1↑, 1,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↓, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 7,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 3,   Pyro↑, 2,   survivin↓, 14,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 5,   XIAP↓, 12,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 29,   p‑Akt↓, 8,   AKT1↓, 1,   AMPKα↑, 1,   CIP2A↓, 1,   cMET↓, 2,   p‑cMET↑, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 8,   EGFR↑, 1,   ERK↓, 8,   ERK↑, 7,   p‑ERK↓, 2,   p‑ERK↑, 4,   FGFR1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↑, 1,   IKKα↓, 4,   IKKα↑, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↓, 2,   JNK↑, 13,   p‑JNK↓, 1,   p‑JNK↑, 3,   MAPK↓, 8,   MAPK↑, 8,   MEK↓, 1,   mTOR↓, 21,   p‑mTOR↓, 4,   mTORC2↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 21,   PI3K↑, 1,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 4,   PKCδ↑, 1,   PP2A↑, 1,   PPP2R1A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 6,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   RET↓, 1,   RIP1↓, 1,   p‑RSK↑, 1,   Sp1/3/4↓, 7,   p‑Src↓, 1,   STAT3↓, 19,   p‑STAT3↓, 2,   STAT6↓, 1,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 3,   ATF4↑, 30,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 2,   CBP↓, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 11,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   H4↓, 1,   H4↑, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 6,   HDAC2↓, 1,   HDAC3↓, 1,   HMTs↓, 1,   miR-124-3p↓, 1,   miR-19b↓, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-218↑, 1,   miR-34a↓, 1,   Myc↓, 3,   OCT4↓, 4,   other?, 1,   other↝, 3,   PAX2↓, 1,   PCAF↓, 1,   SOX2↓, 4,   SOX4↓, 2,   SOX4↑, 1,   SOX9↓, 1,   SUV39H↓, 1,   tumCV↓, 20,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 12,   cl‑ATF6↑, 2,   c-ATF6↑, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 125,   CHOP/DDIT3↝, 1,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   e-CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 12,   p‑eIF2α↓, 2,   p‑eIF2α↑, 17,   p‑eIF2α↝, 1,   ER Stress↓, 3,   ER Stress↑, 91,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 47,   GRP94↑, 8,   HSP27↑, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 4,   e-HSP70/HSPA5↑, 1,   HSP90↓, 7,   HSP90↑, 2,   e-HSP90↑, 2,   IRE1↓, 1,   IRE1↑, 12,   IRE1∅, 1,   p‑IRE1↓, 1,   p‑IRE1↑, 2,   NQO2↑, 1,   PDI↑, 3,   PERK↓, 1,   PERK↑, 24,   p‑PERK↑, 5,   p‑PERK↝, 1,   UPR↓, 1,   UPR↑, 20,   XBP-1↑, 12,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 6,   ATG7↑, 3,   Beclin-1/ATG6↑, 10,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B↑, 3,   LC3B-II↑, 3,   LC3II↑, 7,   LC3s↑, 2,   p62↓, 2,   p62↑, 3,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto↓, 1,   TumAuto↑, 22,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 14,   DNArepair↓, 1,   hTERT/TERT↓, 1,   P53↑, 26,   p‑P53↑, 2,   PARP↓, 2,   PARP↑, 7,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 27,   PARP1↑, 2,   PCNA↓, 9,   Telomerase↓, 1,   TOP2↓, 2,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   p‑CDK1↓, 1,   CDK2↓, 7,   CDK2↑, 2,   CDK4↓, 11,   CDK6↓, 4,   CDK6↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 16,   cycD1/CCND1↑, 2,   cycE/CCNE↓, 3,   GADD34↑, 3,   GADD45A↑, 1,   Ki-67↓, 6,   MAD↓, 1,   P21?, 1,   P21↓, 1,   P21↑, 21,   p27/CDKN1B↑, 5,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 45,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 2,   BMPs↑, 1,   CD133↓, 3,   CD24↓, 1,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 3,   cFos↑, 1,   CSCs↓, 16,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 1,   Gli1↓, 1,   IGF-1↓, 1,   IGFBP3↑, 2,   Ki-67↓, 6,   mTORC1↓, 2,   Nanog↓, 5,   Nestin↓, 2,   NOTCH↓, 4,   NOTCH1↓, 5,   NOTCH3↓, 2,   p300↓, 2,   PTCH1↓, 1,   Shh↓, 3,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 20,   TumCP↓, 30,   Wnt↓, 10,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 4,   AXL↓, 1,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 24,   Ca+2↝, 5,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↓, 1,   cal2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 7,   EMT↓, 18,   FAK↓, 5,   Fibronectin↓, 1,   GLI2↓, 1,   ITGB1↓, 1,   LIMK2↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP2↓, 17,   MMP3↓, 2,   MMP9↓, 19,   MMPs↓, 8,   N-cadherin↓, 9,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 2,   Slug↓, 5,   Snail↓, 11,   TET1↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TRIB3↑, 3,   TSC1↑, 1,   TSP-1↑, 1,   TumCI↓, 23,   TumCMig↓, 18,   TumMeta↓, 13,   TumMeta↑, 1,   Twist↓, 8,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 6,   uPAR↓, 1,   Vim↓, 12,   Vim↑, 1,   Zeb1↓, 2,   Zeb1↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 13,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   Endoglin↑, 1,   Hif1a↓, 14,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 23,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP↓, 40,   MMP↑, 1,   MPT↑, 1,   SLC12A5↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD44↓, 6,   CD47↓, 1,   CD8+↑, 2,   cDC2↓, 1,   COX2/PTGS2↓, 12,   CXCR4↓, 4,   DR4↑, 4,   FOXP3↑, 1,   HMGB1↓, 1,   e-HMGB1↑, 1,   ICAM-1↓, 3,   IL10↓, 3,   IL12↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 1,   Imm↝, 3,   Inflam↓, 5,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 26,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 2,   PSA↓, 3,   T-Cell↑, 1,   TCF↑, 1,   TLR4↓, 2,   TNF-α↓, 9,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   AR↑, 1,   ER-α36↓, 2,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 11,   BioAv↑, 10,   BioAv↝, 2,   BioEnh↑, 2,   ChemoSen↑, 27,   CYP1A1↓, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 8,   eff↓, 15,   eff↑, 23,   eff↝, 5,   eff∅, 1,   Half-Life↓, 3,   Half-Life↝, 5,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   RadioS↑, 7,   selectivity↑, 30,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 1,   AR↓, 6,   AR↑, 1,   AST∅, 1,   BG↓, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 8,   EGFR↑, 1,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 8,   LDH↓, 1,   LDH↑, 5,   Myc↓, 3,   NSE↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   PSA↓, 3,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   antiNeop↑, 2,   AntiTum↑, 5,   cachexia↓, 2,   cardioP↑, 2,   CardioT↑, 1,   chemoP↑, 7,   chemoPv↑, 3,   ChemoSideEff↓, 1,   hepatoP↓, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 3,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 4,   TumW↓, 3,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 635

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 22,   Catalase↑, 10,   GPx↑, 9,   GPx4↑, 1,   GSH↑, 9,   GSTs↑, 2,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 10,   hyperG↝, 1,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 6,   MDA↓, 11,   MPO↓, 2,   NQO1↑, 3,   NRF2↑, 18,   Prx↑, 1,   Prx4∅, 1,   RNS↓, 1,   ROS↓, 28,   ROS↑, 1,   ROS∅, 1,   mt-ROS↓, 1,   SOD↑, 16,   SOD1↑, 2,   SOD2↑, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↑, 1,   mitResp↓, 1,   mtDam↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   ATP↑, 1,   glucose↓, 2,   glucose↝, 2,   GSK‐3β↓, 2,   HMG-CoA↓, 1,   LDL↓, 2,   NAD↓, 1,   NADPH↓, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   BAX↓, 6,   Bcl-2↓, 1,   Bcl-2↑, 3,   Casp1↓, 1,   Casp12↓, 6,   Casp3?, 1,   Casp3↓, 7,   cl‑Casp3↓, 3,   cl‑Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   GRP58↓, 1,   iNOS↓, 8,   MLKL↓, 1,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↑, 1,   CaMKII ↓, 2,   CREB↑, 1,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 2,   mTOR↓, 2,   mTOR↑, 1,   PI3K↑, 1,   PROKR1↑, 1,   PROKR2↑, 1,   RIP1↓, 2,   STAT3?, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 7,   miR-34a↓, 1,   other↑, 2,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 3,   CHOP/DDIT3↓, 23,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   p‑eIF2α↓, 2,   cl‑eIF2α↑, 1,   ER Stress↓, 17,   GRP78/BiP↓, 16,   GRP78/BiP↑, 3,   GRP94↑, 1,   IRE1↓, 3,   PDI↓, 1,   PERK↓, 6,   p‑PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 4,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 1,   LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 2,   p‑PARP↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

Ca+2?, 1,   Ca+2↓, 3,   E-cadherin↓, 1,   EMT↑, 1,   MMP3↓, 1,   PROK2↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↑, 1,   TXNIP↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   E-sel↓, 1,   Endoglin↑, 1,   p‑eNOS↑, 1,   Hif1a↑, 1,   NO↓, 4,   NO↑, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   GLUT2↑, 1,   IBI↑, 1,   MMP↑, 3,   MUC5AC↓, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IFN-γ↓, 3,   IL10↓, 4,   IL10↑, 4,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 12,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL6↓, 12,   Imm↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 31,   LPS↓, 1,   NF-kB↓, 9,   NLRP3↓, 2,   PGE2↓, 3,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 3,   TNF-α↓, 16,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 1,   ChE↓, 1,   NGF↑, 2,   PSD95↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 5,   BACE/β-secretase↓, 3,   tau↓, 1,   p‑tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   END↑, 1,   PPARα↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   BioAv↝, 3,   CompStab↑, 1,   Dose↑, 1,   Dose↝, 5,   eff↓, 2,   eff↑, 2,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   BG↓, 2,   BMD↑, 1,   creat↓, 1,   IL6↓, 12,   LDH↓, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 5,   AntiArt↑, 2,   AntiCan↑, 2,   antiCG↑, 1,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↑, 2,   cardioP↑, 10,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 7,   hepatoP↓, 1,   hepatoP↑, 11,   Learn↑, 3,   memory↑, 8,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 22,   Obesity↓, 2,   RenoP↑, 5,   Stroke↓, 4,   toxicity↓, 8,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 2,   AntiViral↑, 2,   Bacteria↓, 3,   GutMicro↑, 7,   Sepsis↓, 2,  
Total Targets: 253

Scientific Paper Hit Count for: CHOP/DDIT3, GADD153
10 Quercetin
7 Curcumin
6 Silver-NanoParticles
6 Ashwagandha(Withaferin A)
6 Licochalcone A
5 EGCG (Epigallocatechin Gallate)
5 Fisetin
5 Luteolin
5 Piperlongumine
5 Shikonin
4 Apigenin (mainly Parsley)
4 Baicalein
4 Resveratrol
4 Garcinol
4 Kaempferol
4 Phenylbutyrate
3 Artemisinin
3 Berberine
3 Boron
3 Honokiol
3 Rosmarinic acid
3 salinomycin
2 Vitamin C (Ascorbic Acid)
2 Allyl isothiocyanate
2 Betulinic acid
2 Bortezomib
2 Crocetin
2 Gambogic Acid
2 Hydrogen Gas
2 temozolomide
2 HydroxyTyrosol
2 Matrine
1 Alpha-Lipoic-Acid
1 Andrographis
1 Melatonin
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 5-fluorouracil
1 Photodynamic Therapy
1 Biochanin A
1 Boswellia (frankincense)
1 Bullatacin
1 Carnosic acid
1 Capsaicin
1 Carvacrol
1 Cannabidiol
1 Celastrol
1 Chlorogenic acid
1 chaetocin
1 Copper and Cu NanoParticles
1 Diindolylmethane
1 Dandelion Root
1 Ellagic acid
1 Emodin
1 Electrical Pulses
1 Ferulic acid
1 Fenbendazole
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydroxychloroquine
1 Isobavachalcone
1 Isoliquiritigenin
1 Ivermectin
1 Isovitexin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Methyl Jasmonate
1 Magnetic Fields
1 Mangiferin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Naringin
1 nelfinavir/Viracept
1 Docetaxel
1 Oleuropein
1 Phenethyl isothiocyanate
1 Pterostilbene
1 Paclitaxel/Taxol
1 Scoulerine
1 Selenium NanoParticles
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Vitexin
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:490  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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