CHOP Cancer Research Results

CHOP, GADD153: Click to Expand ⟱
Source:
Type: Protein
GADD153 and CHOP (C/EBP-homologous protein) refer to the same protein. GADD153 stands for "Growth Arrest and DNA Damage-inducible protein 153," while CHOP stands for "C/EBP Homologous Protein."
DDIT3 (DNA Damage Inducible Transcript 3), also known as CHOP (C/EBP Homologous Protein), is a transcription factor that plays a significant role in the cellular response to stress, particularly in the context of the unfolded protein response (UPR) and apoptosis.

CHOP is an important component of the endoplasmic reticulum (ER) stress response. Research has shown that knockdown of CHOP not only enhances tunicamycin-induced autophagy, but also significantly attenuates ER stress-induced apoptosis in human colon cancer cells.
GADD153, also known as CHOP (C/EBP homologous protein), is a transcription factor that plays a significant role in cellular stress responses, particularly in the context of the endoplasmic reticulum (ER) stress response. It is part of the unfolded protein response (UPR), which is activated when there is an accumulation of misfolded proteins in the ER.
Scientific Papers found: Click to Expand⟱
3716- FA,    Ferulic Acid as a Protective Antioxidant of Human Intestinal Epithelial Cells
- in-vitro, IBD, NA - in-vivo, NA, NA
*antiOx↑, *Inflam↓, *ER Stress↓, *other↑, *angioG↑, *Hif1a↑, *VEGF↑, *NO↓, *SIRT1↑, *PERK↓, *ATF4↓, *CHOP↓, *GutMicro↑,
2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2855- FIS,    Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
- in-vitro, RCC, Caki-1
TumCCA↑, cl‑PARP↑, Apoptosis↑, Casp↑, P53↑, DR5↑, CHOP↑, ROS↑, ER Stress↑, ATF4↑, XBP-1↑, eff∅,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP↑, ROS↑, cMyc↓, cardioP↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
1968- GamB,    Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis
- in-vitro, Lung, A549
tumCV↓, ROS↑, GRP78/BiP↑, CHOP↑, ATF6↑, Casp12↑, p‑PERK↑, ER Stress↑,
815- GAR,    Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation
- vitro+vivo, Lung, A549
ALDH1A1↓, CHOP↑,
821- GAR,    Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
- in-vitro, Liver, Hep3B
ROS↑, CHOP↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,
4506- GLA,    A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells
- in-vitro, BC, BT474
Apoptosis↓, Ca+2↑, MMP↓, p‑eIF2α↑, CHOP↑, ER Stress↑, ROS↑,
839- Gra,    Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
- in-vitro, Liver, HepG2
tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, NA, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1↑, *p62↓, *mTOR↓,
1912- HCQ,  TMZ,    Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
- in-vivo, GBM, U87MG
LC3B-II↑, CHOP↑, cl‑PARP↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
601- HT,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, NA, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, JNK↑, TNF-α↓, PPP2R1A↑,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, NA, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP↝, p‑ATF4↝, cl‑Casp12↝,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3459- MF,    EFFECT OF PULSED ELECTROMAGNETIC FIELDS ON ENDOPLASMIC RETICULUM STRESS
- in-vitro, Cerv, HeLa
GRP78/BiP↑, GRP94↑, CHOP↑, ER Stress↓,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27↑,
150- NRF,  CUR,  docx,    Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells
- in-vitro, Pca, C4-2B
p‑Akt↓, p‑eIF2α↑, ER Stress↑, ATF4↑, CHOP↑, TRIB3↑, ChemoSen↑, Casp3↑, cl‑PARP↑, BID↑, XBP-1↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
2065- PB,  TMZ,    Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells
- in-vitro, GBM, NA
eff↑, ROS↑, MMP↓, ER Stress↑, CHOP↑, GRP78/BiP↑, pro‑Casp12↓, eff↝, Ca+2↝,
2076- PB,    Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
TumCP↓, TumAuto↑, Apoptosis↑, ER Stress↑, BID↑, CHOP↑, PDI↑, IRE1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, LC3B↑, Beclin-1↑, other↝, other↝,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
2041- PB,    The Effect of Glucose Concentration and Sodium Phenylbutyrate Treatment on Mitochondrial Bioenergetics and ER Stress in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*mitResp↓, *ER Stress↓, MMP↓, GlucoseCon↓, OCR↓, CHOP↑,
4951- PEITC,    ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis
- in-vitro, Ovarian, PA1 - in-vitro, Ovarian, SKOV3
ROS↑, TumCP↓, GSH↓, selectivity↑, UPR↑, CHOP↑, ER Stress↑, GRP78/BiP↑, PERK↑, ATF6↑, eff↓, TumCG↓, Apoptosis↑, toxicity↓,
1943- PL,    Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells
- in-vitro, GBM, NA - in-vivo, NA, NA
selectivity↑, ROS↑, selectivity↑, Prx4↓, *Prx4∅, ER Stress↑, CHOP↑, UPR↑,
1939- PL,    Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP↑, Dose↝,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
2954- PL,    The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
- Review, Var, NA
NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,
4693- PTS,    Pterostilbene in the treatment of inflammatory and oncological diseases
BioAv↑, *Inflam↓, *antiOx↑, AntiTum↑, BBB↑, Half-Life↝, *ROS↓, *NRF2↑, *NQO1↑, *HO-1↑, PTEN↑, miR-19b↓, TumCCA↑, ER Stress↑, PERK↑, ATF4↑, CHOP↑, Ca+2↝, EMT↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, ChemoSen↑, toxicity∅, toxicity↝,
3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, NA, HepG2
*Inflam↓, *UPR↓, *GRP58↓, *XBP-1↓, *ER Stress↓, *antiOx↑, TNF-α↓, p‑eIF2α↓, p‑IRE1↓, p‑JNK↓, CHOP↓,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
*BG↓, *ROS↓, *SOD↑, *MDA↓, *ER Stress↓, *iNOS↓, *CHOP↓, *GRP78/BiP↓, *antiOx↓, *Inflam↓, *JAK2↑, *STAT3?,
3362- QC,    The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action
- in-vitro, Cerv, HeLa
Apoptosis↑, cycD1/CCND1↓, Casp3↑, GRP78/BiP↑, CHOP↑, tumCV↓, IRE1↑, p‑PERK↑, c-ATF6↑, ER Stress↑,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP↑,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,
88- QC,  PacT,    Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production
- vitro+vivo, Pca, PC3
ROS↑, ER Stress↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCMig↓, GRP78/BiP↑, CHOP↑, TumCG↓,
916- QC,    Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
- Review, Ovarian, NA
COX2↓, CRP↓, ER Stress↑, Apoptosis↑, GRP78/BiP↑, CHOP↑, p‑STAT3↓, PI3K↓, Akt↓, mTOR↓, cMyc↓, cycD1/CCND1↓, cFLIP↓, IL6↓, IL10↓,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4↑, CHOP↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
3065- RES,    Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
- in-vitro, lymphoma, NA
UPR↑, IRE1↑, p‑eIF2α↑, PERK↑, ATF6↑, GRP78/BiP↑, GRP94↑, CHOP↑, GADD34↑, ATF4↑, XBP-1↑, Ca+2↑, ER Stress↑,

Showing Research Papers: 51 to 100 of 117
Prev Page 2 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 117

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   Catalase↓, 2,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GSH↓, 7,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   HO-1↓, 1,   HO-1↑, 4,   Keap1↝, 1,   MDA↓, 1,   MDA↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 6,   Prx4↓, 1,   Prx4↑, 1,   ROS↓, 3,   ROS↑, 25,   ROS⇅, 1,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TrxR↓, 2,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 4,   CDC2↓, 2,   CDC25↓, 3,   EGF↓, 2,   FGFR1↓, 1,   MEK↓, 1,   MMP↓, 14,   mtDam↑, 1,   OCR↓, 1,   Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   ALAT∅, 1,   AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 7,   FASN↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   HK2↓, 3,   lactateProd↓, 1,   LDH↑, 3,   PPARγ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 3,   Apoptosis↓, 2,   Apoptosis↑, 15,   ASK1↑, 1,   BAD↑, 2,   Bak↑, 2,   BAX↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 1,   Bcl-2↓, 12,   BID↑, 2,   BIM↑, 2,   Casp↑, 1,   Casp1↓, 1,   Casp12↑, 4,   cl‑Casp12↝, 1,   pro‑Casp12↓, 1,   Casp3↓, 1,   Casp3↑, 16,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 7,   cl‑Casp8↑, 2,   Casp9↑, 9,   cl‑Casp9↑, 3,   cFLIP↓, 2,   Cyt‑c↑, 10,   Cyt‑c↝, 1,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 7,   Endon↑, 1,   Fas↑, 3,   FasL↑, 2,   Ferroptosis↑, 1,   GADD34↑, 1,   HGF/c-Met↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 6,   MAPK↑, 3,   Mcl-1↓, 1,   Mcl-1↑, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   NOXA↑, 1,   p27↑, 3,   p38↓, 1,   p38↑, 2,   p‑p38↑, 3,   PPP2R1A↑, 1,   survivin↓, 5,   Telomerase↓, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

EF-1α↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   cJun↑, 1,   H3↓, 1,   H3↑, 1,   H4↓, 1,   H4↑, 1,   HATs↑, 1,   miR-21↓, 1,   miR-21↑, 1,   other?, 1,   other↝, 2,   p‑pRB↓, 1,   tumCV↓, 8,  

Protein Folding & ER Stress ⓘ

ATF6↑, 3,   cl‑ATF6↑, 1,   c-ATF6↑, 1,   ATFs↑, 1,   CHOP↓, 1,   CHOP↑, 41,   p‑CHOP↝, 1,   cl‑CHOP↑, 1,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 10,   p‑eIF2α↝, 1,   ER Stress↓, 2,   ER Stress↑, 29,   GRP78/BiP↓, 1,   GRP78/BiP↑, 18,   GRP94↑, 4,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   IRE1↑, 3,   p‑IRE1↓, 1,   PERK↑, 5,   p‑PERK↑, 4,   p‑PERK↝, 1,   UPR↑, 6,   XBP-1↑, 4,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3B-II↑, 2,   LC3II↑, 2,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DFF45↑, 1,   DNAdam↑, 4,   DNArepair↓, 1,   P53↑, 10,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 9,   PARP1↑, 1,   PCNA↓, 4,  

Cell Cycle & Senescence ⓘ

CDK1↓, 4,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 6,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 1,   P21?, 1,   P21↑, 8,   RB1↓, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 3,   CD34↓, 1,   CD44↓, 1,   cFos↓, 2,   cFos↑, 1,   cMET↓, 1,   p‑cMET↑, 1,   CSCs↓, 3,   EMT↓, 9,   EP4↑, 1,   ERK↓, 3,   ERK↑, 3,   p‑ERK↓, 1,   FGF↓, 1,   p‑FOXO3↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 4,   HDAC2↓, 1,   HDAC3↓, 1,   IGFBP3↑, 2,   mTOR↓, 11,   mTORC1↓, 2,   mTORC2↓, 1,   Nanog↓, 2,   Nestin↓, 2,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 2,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↓, 1,   PTEN↑, 3,   RAS↓, 2,   RAS↑, 1,   Shh↓, 3,   SOX2↓, 2,   p‑Src↓, 1,   STAT1↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,   STAT6↓, 1,   p‑STAT6↓, 1,   TCF↑, 1,   TOP2↓, 1,   TumCG↓, 8,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 7,   Ca+2↝, 2,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   FAK↓, 3,   Fibronectin↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MET↓, 1,   p‑MET↓, 1,   miR-19b↓, 1,   MMP2↓, 7,   MMP9↓, 6,   MMPs↓, 5,   N-cadherin↓, 4,   PDGF↓, 2,   PKA↓, 1,   PKCδ↓, 1,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 2,   Snail↓, 4,   SOX4↓, 1,   SOX4↑, 1,   TET1↓, 1,   TGF-β↓, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 7,   TumCMig↓, 5,   TumCP↓, 8,   TumMeta↓, 5,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 4,   uPAR↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 1,   ZO-1↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 7,   ATF4↝, 1,   p‑ATF4↝, 1,   EGFR↓, 6,   EGFR↑, 1,   Hif1a↓, 2,   PDI↑, 1,   VEGF↓, 8,   VEGFR2↓, 3,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 3,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   COX2↓, 6,   CRP↓, 2,   CXCR4↓, 2,   ICAM-1↓, 2,   IKKα↓, 3,   IKKα↑, 1,   IL10↓, 2,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 5,   IL8↓, 1,   Inflam↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 12,   NF-kB↑, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 2,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 3,   BioEnh↑, 1,   ChemoSen↑, 8,   Dose↑, 1,   Dose↝, 3,   eff↓, 3,   eff↑, 6,   eff↝, 2,   eff∅, 1,   Half-Life↓, 1,   Half-Life↝, 4,   MDR1↓, 1,   MRP1↓, 1,   RadioS↑, 5,   selectivity↑, 12,  

Clinical Biomarkers ⓘ

ALAT∅, 1,   AR↓, 2,   AST∅, 1,   BMPs↑, 1,   CEA↓, 1,   CRP↓, 2,   EGFR↓, 6,   EGFR↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 5,   Ki-67↓, 1,   LDH↑, 3,   NSE↓, 1,   PSA↓, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 2,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 376

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 8,   Catalase↑, 4,   GPx↑, 2,   GSH↑, 5,   GSTs↑, 1,   HO-1↑, 3,   lipid-P↓, 2,   MDA↓, 4,   NQO1↑, 2,   NRF2↑, 4,   Prx4∅, 1,   ROS↓, 9,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 6,  

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1,   MMP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 2,   NADPH↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 3,   SREBP1↓, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 2,   GRP58↓, 1,   iNOS↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↓, 1,   CHOP↓, 6,   ER Stress↓, 7,   GRP78/BiP↓, 4,   IRE1↓, 1,   PERK↓, 2,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

p16↓, 1,   P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   STAT3?, 1,  

Migration ⓘ

Ca+2↓, 1,   p‑Rac1↓, 1,   TXNIP↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   ATF4↓, 2,   Hif1a↑, 1,   NO↓, 1,   PDI↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IFN-γ↓, 1,   IKKα↑, 1,   IL10↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL6↓, 3,   Inflam↓, 12,   JAK2↑, 1,   NF-kB↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   BG↓, 1,   GutMicro↑, 2,   IL6↓, 3,  

Functional Outcomes ⓘ

cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 1,   motorD↑, 1,   neuroP↑, 5,   RenoP↑, 2,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 101

Scientific Paper Hit Count for: CHOP, GADD153
10 Quercetin
7 Curcumin
6 Silver-NanoParticles
6 Ashwagandha(Withaferin A)
5 Fisetin
5 Luteolin
5 Piperlongumine
5 Shikonin
4 Apigenin (mainly Parsley)
4 Baicalein
4 Resveratrol
4 Phenylbutyrate
3 Artemisinin
3 Berberine
3 Boron
3 EGCG (Epigallocatechin Gallate)
3 Honokiol
3 Rosmarinic acid
3 salinomycin
2 Vitamin C (Ascorbic Acid)
2 Betulinic acid
2 Garcinol
2 temozolomide
2 HydroxyTyrosol
1 Alpha-Lipoic-Acid
1 Andrographis
1 Melatonin
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 5-fluorouracil
1 Photodynamic Therapy
1 Biochanin A
1 Boswellia (frankincense)
1 Bortezomib
1 Carnosic acid
1 Crocetin
1 Copper and Cu NanoParticles
1 Ellagic acid
1 Electrical Pulses
1 Ferulic acid
1 Fenbendazole
1 Gambogic Acid
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Hydrogen Gas
1 hydroxychloroquine
1 Magnetic Fields
1 Naringin
1 nelfinavir/Viracept
1 Docetaxel
1 Oleuropein
1 Phenethyl isothiocyanate
1 Pterostilbene
1 Paclitaxel
1 Scoulerine
1 Selenium NanoParticles
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:490  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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