OCT4 Cancer Research Results

OCT4, Octamer-binding transcription factor 4: Click to Expand ⟱
Source:
Type:
POU5F1 is a gene that encodes a transcription factor also known as Oct4.
OCT4 (Octamer-binding transcription factor 4) is a transcription factor that plays a crucial role in maintaining the pluripotency and self-renewal of embryonic stem cells. It is part of the core regulatory network that governs stem cell identity and is essential for the early stages of development.
OCT4 is often expressed in cancer stem cells, which are a subpopulation of cells within tumors that possess the ability to self-renew and drive tumorigenesis. The presence of OCT4 in these cells is associated with increased tumor aggressiveness and resistance to conventional therapies.
Scientific Papers found: Click to Expand⟱
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
5103- SK,    Attenuation of PI3K-Akt-mTOR Pathway to Reduce Cancer Stemness on Chemoresistant Lung Cancer Cells by Shikonin and Synergy with BEZ235 Inhibitor
- in-vitro, NSCLC, A549
CSCs↓, TumCP↓, Nanog↓, OCT4↓, p‑Akt↓, P70S6K↓, PI3K↓, mTOR↓, Synergy↑,
2365- VitD3,    Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1975 - in-vivo, NA, NA
Glycolysis↓, Warburg↓, GLUT1↓, LDHA↓, HK2↓, PKM2↓, OCT4↓, SOX2↓, Nanog↓, PI3K↓, Akt↓, mTOR↓,

Showing Research Papers: 51 to 54 of 54
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 54

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 4,   H2O2↑, 1,   HO-1↑, 2,   hyperG↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 3,   p‑NRF2↓, 1,   ROS↑, 20,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,   Thiols↓, 1,   TrxR↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compV↓, 1,   MFN2↓, 1,   mitResp↓, 1,   mtDam↑, 4,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   ATP↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 3,   p‑GSK‐3β↑, 1,   Histones↑, 1,   HK2↓, 3,   LDHA↓, 2,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   PKM2↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   Apoptosis↑, 15,   Apoptosis∅, 1,   ASK1↑, 2,   BAD↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 2,   Bcl-2↓, 16,   BID↑, 1,   p‑BID↓, 1,   BIM↑, 2,   Casp↑, 3,   Casp3↑, 15,   cl‑Casp3↑, 2,   Casp7↑, 4,   Casp8↑, 2,   Casp9↑, 7,   cl‑Casp9↑, 2,   Cyt‑c↑, 6,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↑, 2,   HEY1↓, 1,   IAP1↓, 1,   iNOS↓, 1,   Mcl-1↓, 1,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 1,   p38↓, 2,   p38↑, 2,   Pyro↑, 1,   survivin↓, 11,   survivin↝, 1,   TumCD↑, 2,   XIAP↓, 7,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 3,   p‑Akt↓, 3,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 1,   EF-1α↓, 1,   EGFR↓, 3,   ERK↓, 3,   ERK↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   Hippo↑, 1,   IKKα↓, 2,   JAK1↓, 1,   JAK2↓, 5,   JNK↓, 1,   JNK↑, 4,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 8,   mTOR↑, 2,   p‑mTOR↓, 1,   P70S6K↓, 1,   PDGFRA↓, 2,   PI3K↓, 11,   PI3K↑, 2,   PKA↓, 1,   PTEN↑, 2,   c-Raf↓, 1,   Sp1/3/4↓, 3,   STAT3↓, 14,   p‑STAT3↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↑, 1,   cMyc↓, 10,   DNMT1↓, 2,   DNMT3A↓, 1,   EZH2↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 3,   KLF2↓, 1,   KLF5↓, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   OCT4↓, 52,   OCT4↑, 1,   SOX2↓, 25,   SOX4↓, 3,   SOX4↑, 1,   SOX9?, 1,   tumCV↓, 6,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   cl‑CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DNAdam↑, 7,   ERCC1↓, 1,   hTERT/TERT↓, 1,   p16↑, 1,   P53↑, 9,   PARP↑, 1,   cl‑PARP↑, 5,   PCNA↓, 6,   SIRT6↓, 1,   Telomerase↓, 1,   TOP2↓, 2,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 3,   CDK4↓, 4,   CDK4↑, 2,   p‑CDK4↓, 1,   CDK6↓, 1,   CDK6↑, 2,   CHK1↑, 1,   Chk2↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 8,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↓, 2,   Ki-67↓, 3,   P21?, 1,   P21↑, 8,   p27/CDKN1B↑, 2,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 6,   ALDH1A1↓, 10,   BMI1↓, 1,   CD133↓, 16,   CD24↓, 1,   CD34↓, 1,   cFos↓, 1,   CLOCK↓, 1,   CSCs↓, 38,   CSCs↑, 1,   CSCsMark↓, 1,   Gli↓, 2,   Gli1↓, 5,   HH↓, 3,   Ki-67↓, 3,   mTORC1↓, 1,   Nanog↓, 37,   Nanog↑, 1,   Nestin↓, 1,   NOTCH↓, 3,   NOTCH1↓, 6,   NOTCH3↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 6,   Smo↓, 5,   TAZ↓, 1,   p‑TAZ↑, 1,   TumCG↓, 12,   TumCG↑, 1,   TumCP↓, 10,   TumCP↑, 1,   Wnt↓, 6,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 3,   E-cadherin↓, 2,   E-cadherin↑, 10,   EMT↓, 19,   EpCAM↓, 4,   FAK↓, 1,   Fibronectin↓, 2,   GLI2↓, 4,   LAMs↓, 1,   MMP1↓, 1,   MMP2↓, 14,   MMP9↓, 16,   MMPs↓, 5,   N-cadherin↓, 10,   RECK↑, 1,   Slug↓, 5,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 10,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 2,   TIMP2↑, 2,   TumCI↓, 12,   TumCMig↓, 11,   TumMeta↓, 9,   Twist↓, 2,   uPA↓, 1,   Vim↓, 13,   Zeb1↓, 5,   α-SMA↓, 1,   β-catenin/ZEB1↓, 8,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   Hif1a↓, 4,   VEGF↓, 9,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   MMP↓, 11,   MPT↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 16,   CD44↑, 1,   COX2/PTGS2↓, 6,   CXCL12↓, 1,   DR4↑, 1,   IL1β↓, 2,   IL6↓, 6,   IL8↓, 3,   Imm↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 10,   p65↓, 2,   PGE2↓, 1,   TCF↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 3,   BioAv↑, 3,   ChemoSen↑, 18,   CYP1A1↓, 1,   Dose↝, 4,   Dose∅, 1,   eff?, 1,   eff↓, 1,   eff↑, 12,   eff∅, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 4,   P450↓, 1,   RadioS↑, 2,   selectivity?, 1,   selectivity↑, 2,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   EGFR↓, 3,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 6,   LDH↓, 1,   LDH↑, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP?, 1,   chemoP↑, 1,   OS↑, 1,   toxicity↓, 2,   TumVol↓, 5,   TumW↓, 1,  
Total Targets: 344

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 3,   GPx↑, 2,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 3,   GSTs↑, 2,   HDL↑, 1,   HO-1↓, 1,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 3,   NRF2?, 1,   NRF2↑, 2,   ROS↓, 9,   SOD↑, 3,   SOD1↑, 2,   xCT/SLC7A11↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   glucose↝, 1,   HMG-CoA↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Casp9↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑ERK↑, 1,   HGF/c-Met↑, 1,   JAK2↑, 1,   MAPK↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HDAC↓, 1,   HDAC3↓, 1,   OCT4↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT2↑, 1,   OATPs↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   HMGB1↓, 1,   IFN-γ↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL4↓, 1,   IL6↓, 4,   IL8↓, 1,   Inflam↓, 9,   NF-kB↓, 3,   PGE2↓, 1,   TLR4↓, 2,   TNF-α↓, 6,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   BioAv↝, 3,   CompStab↑, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 1,   AntiArt↑, 2,   AntiCan↑, 3,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 5,   memory↑, 1,   neuroP↑, 5,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 1,  
Total Targets: 87

Scientific Paper Hit Count for: OCT4, Octamer-binding transcription factor 4
5 EGCG (Epigallocatechin Gallate)
4 Curcumin
4 Sulforaphane (mainly Broccoli)
4 Resveratrol
3 Eugenol
2 Artemisinin
2 Chlorogenic acid
2 Kaempferol
2 Pterostilbene
1 Silver-NanoParticles
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Baicalein
1 Berbamine
1 Berberine
1 Radiotherapy/Radiation
1 Betulinic acid
1 Bufalin/Huachansu
1 Centella asiatica / Gotu kola → asiaticoside
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Genistein (soy isoflavone)
1 Emodin
1 Evodiamine
1 Gallic acid
1 Garcinol
1 Honokiol
1 Matrine
1 Melatonin
1 Morin
1 Methylsulfonylmethane
1 Oleuropein
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Plumbagin
1 Quercetin
1 salinomycin
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:508  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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