AIF Cancer Research Results

AIF, Apoptosis-Inducing Factor: Click to Expand ⟱
Source:
Type:
AIF is a mitochondrial oxidoreductase that contributes to cell death programmes and participates in the assembly of the respiratory chain.
Nuclear translocation of AIF occurs during cell death and has been associated with human disorders. Expression Levels:
AIF is often found to be overexpressed in several types of cancers, including breast, lung, and colorectal cancers.
The expression of AIF can vary significantly between different tumor types and even among patients with the same type of cancer.
Survival Rates:
High levels of AIF expression have been associated with poor prognosis in certain cancers, indicating a potential role in tumor aggressiveness and metastasis.
Conversely, low AIF expression may correlate with better survival outcomes in some contexts.
Overexpression: In many cancers, AIF is overexpressed, which is often associated with poor prognosis, increased tumor aggressiveness, and resistance to therapy.
Scientific Papers found: Click to Expand⟱
4942- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
chemoPv↑, TumCG↓, TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
5158- PLB,    Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
- in-vitro, Cerv, ME-180
TumCG↓, ROS↑, Apoptosis↑, MMP↓, DNAdam↑, Cyt‑c↑, AIF↑, Casp3↑, Casp9↑, eff↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp/ABCB1↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP/DDIT3↑,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP/DDIT3↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
1480- SFN,    Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells
- in-vitro, CRC, HCT116
tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
5084- SSE,  GEM,    The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
- in-vitro, PC, PANC1 - vitro+vivo, PC, Panc02
tumCV↓, ChemoSen↑, TumCG↓, OS↑, MMP↓, AIF↑, GSH↓, Trx↓, ROS↑, AntiTum↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, Var, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
635- VitC,  VitK3,    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
- in-vitro, Var, NA
RNR↓, GSH↓, Trx1↓, GPx↓, lipid-P↑, AIF↑, ROS↑,

Showing Research Papers: 51 to 63 of 63
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 63

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 1,   GPx↓, 2,   GSH↓, 7,   GSH/GSSG↓, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   i-H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 1,   HO-2↓, 1,   lipid-P↑, 5,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 1,   ROS↓, 4,   ROS↑, 42,   ROS⇅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   SOD↓, 1,   SOD2↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↓, 1,   TrxR↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 7,   compIV↓, 1,   mtDam↑, 3,   OXPHOS↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   AMPK↑, 1,   ATP↓, 6,   ECAR↝, 1,   GlucoseCon↓, 5,   Glycolysis↓, 7,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HK2↓, 4,   lactateProd↓, 5,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 1,   RNR↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 56,   AIF↝, 1,   APAF1↑, 2,   Apoptosis↑, 28,   mt-Apoptosis↑, 1,   ASC↓, 1,   Bak↑, 1,   BAX↑, 26,   Bax:Bcl2↑, 2,   Bcl-2↓, 22,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↑, 6,   p‑BID↓, 1,   BIM↑, 2,   Casp↑, 10,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 27,   cl‑Casp3↑, 1,   CASP4↑, 1,   Casp6↑, 1,   Casp7↑, 3,   Casp8↑, 13,   cl‑Casp8↑, 1,   Casp9↑, 22,   cl‑Casp9↑, 2,   proCasp9↓, 1,   Cyt‑c↑, 40,   Diablo↑, 5,   DR5↑, 5,   Endon↑, 4,   Fas↑, 2,   FasL↑, 2,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 2,   iNOS↓, 2,   Mcl-1↓, 5,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 3,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 3,   p‑p38↑, 1,   PUMA↑, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 7,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 4,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   Akt↑, 1,   p‑Akt↓, 7,   EGFR↓, 3,   EGFR↑, 1,   ERK↓, 5,   p‑ERK↓, 3,   p‑ERK↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IKKα↓, 1,   JAK↓, 2,   JNK↓, 3,   JNK↑, 5,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 3,   p‑MAPK↑, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   mTORC2↓, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 2,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT3↓, 9,   p‑STAT3↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF4↑, 1,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 3,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXM1↓, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 4,   HMTs↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↑, 2,   SOX9↓, 1,   TCF-4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 8,   p‑eIF2α↑, 1,   ER Stress↑, 9,   GRP78/BiP?, 1,   GRP78/BiP↑, 7,   GRP94↑, 2,   HSF1↓, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autoF↓, 1,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↑, 1,   lysoMP↑, 1,   lysosome↝, 1,   MitoP↑, 1,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 18,   hTERT/TERT↓, 1,   P53↓, 1,   P53↑, 11,   p‑P53↑, 2,   PARP↑, 2,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 10,   PARP1↑, 1,   PCNA↓, 3,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 2,   TOP2↓, 2,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 3,   p‑CDK4↓, 1,   CDK6↓, 5,   CDK8↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 10,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 6,   GADD45A↑, 1,   mitA↑, 1,   P21↓, 1,   P21↑, 13,   p27/CDKN1B↑, 4,   p‑RB1↓, 2,   TumCCA↑, 26,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 2,   CD133↓, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 5,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 2,   NOTCH1↓, 1,   STAT1↓, 1,   TumCG↓, 10,   TumCG↑, 1,   TumCP↓, 14,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 12,   Ca+2↝, 2,   Cal1↑, 2,   cal2↓, 1,   cal2↑, 1,   Cdc42↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 6,   FAK↓, 3,   p‑FAK↓, 1,   ITGB1↓, 1,   LAMs↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP2↓, 10,   MMP7↓, 1,   MMP9↓, 11,   MMPs↓, 1,   N-cadherin↓, 1,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 2,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumMeta↓, 7,   Twist↓, 4,   Tyro3↓, 1,   uPA↓, 2,   Vim↓, 1,   Vim↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   Endoglin↑, 3,   HIF-1↓, 1,   Hif1a↓, 5,   NO↑, 1,   VEGF↓, 9,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT1↓, 2,   MMP↓, 37,   MPT↑, 2,   NHE1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 7,   DR4↑, 3,   ICAM-1↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 2,   Inflam↓, 2,   Inflam↝, 1,   NF-kB↓, 15,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 10,   BioAv↝, 1,   ChemoSen↑, 17,   CYP1A1↓, 2,   Dose↑, 1,   Dose↝, 4,   Dose∅, 2,   eff↓, 11,   eff↑, 7,   eff↝, 3,   GSTA1↑, 1,   GSTZ1↝, 1,   Half-Life↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   RadioS↑, 6,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 18,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   p‑BRCA1↑, 1,   CEA↓, 1,   EGFR↓, 3,   EGFR↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   LDH↑, 1,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 5,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 3,   hepatoP↑, 1,   hepatoP∅, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   OS↑, 1,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 4,   toxicity↑, 3,   TumNum↓, 1,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 382

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   ARE↑, 1,   Catalase↑, 6,   GPx↑, 6,   GSH↑, 5,   GSH/GSSG↑, 1,   GSR↓, 1,   GSTs↑, 3,   H2O2↓, 2,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 2,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 2,   MDA↓, 5,   MPO↓, 2,   MPO↑, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↑, 6,   RNS↓, 1,   ROS↓, 6,   ROS↑, 2,   ROS⇅, 1,   mt-ROS?, 1,   SOD↑, 8,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mtDam↓, 2,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 2,   ATP↑, 2,   glucose↓, 1,   GSK‐3β↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   AIF↑, 1,   Apoptosis↓, 3,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   cl‑Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   iNOS↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑JNK↓, 1,   PI3K↓, 1,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↓, 1,   other↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 1,   P53↑, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   MMP3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   NO↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   MMP↓, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD40↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 3,   COX2/PTGS2↑, 1,   IL10↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   Imm↑, 1,   INF-γ↓, 1,   Inflam↓, 9,   IP-10/CXCL-10↓, 1,   pol-M2 MC↑, 1,   NF-kB?, 1,   NF-kB↓, 1,   PGE2↓, 2,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 2,   eff↑, 5,   Half-Life↓, 1,   Half-Life↝, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BP↓, 1,   IL6↓, 3,   LDH↓, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 3,   AntiCan↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 5,   chemoP↑, 3,   cognitive↑, 3,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 7,   Obesity↓, 2,   radioP↑, 1,   Stroke↓, 1,   toxicity↓, 2,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  
Total Targets: 146

Scientific Paper Hit Count for: AIF, Apoptosis-Inducing Factor
5 Phenethyl isothiocyanate
4 Betulinic acid
4 Quercetin
3 Allyl isothiocyanate
3 Curcumin
2 3-bromopyruvate
2 Allicin (mainly Garlic)
2 Boswellia (frankincense)
2 Fisetin
2 Gossypol/AT-101
2 isoquercitrin
2 Magnolol
2 Marjoram (Origanum majorana)
2 Sulforaphane (mainly Broccoli)
1 Auranofin
1 Apigenin (mainly Parsley)
1 Metformin
1 Artemisinin
1 2-DeoxyGlucose
1 Berberine
1 Benzyl isothiocyanate
1 Capsaicin
1 methylseleninic acid
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetate
1 Ellagic acid
1 Emodin
1 Eugenol
1 Formononetin
1 Gambogic Acid
1 Graviola
1 Hyperoside
1 iodine
1 Kaempferol
1 Licochalcone A
1 Luteolin
1 Methyl Jasmonate
1 Moringa oleifera
1 Plumbagin
1 salinomycin
1 Shikonin
1 Selenite (Sodium)
1 Gemcitabine (Gemzar)
1 Thymoquinone
1 Thymol-Thymus vulgaris
1 Vitamin C (Ascorbic Acid)
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:520  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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