ALAT Cancer Research Results

ALAT, ALT, alanine aminotransferase: Click to Expand ⟱
Source:
Type: enzyme
(or ALT) -Used to be called serum glutamic-pyruvic transaminase (SGPT)
Most common in the liver.
An enzyme your body needs to break down proteins into energy.
It plays a crucial role in amino acid metabolism and is often measured in blood tests to assess liver function.
The catabolism of alanine by alanine aminotransferase 2 (ALT2) to pyruvate, was critical for the survival of non-small cell lung carcinoma (NSCLC) cells during glucose starvation. After knockdown of ALT2, cells were significantly more sensitive to glucose withdrawal compared to wildtype cells, which were rescued when supplemented with pyruvate.
Alanine aminotransferase (ALT) expression is highly elevated in the serum of patients with hepatocellular carcinoma.
A common example of dietary cancer therapy is the ketogenic diet, providing a fat-rich, low carbohydrate diet. The rationale is to reduce circulating glucose levels and induce ketosis.
Used as a clinical biomarker for Liver function.


Scientific Papers found: Click to Expand⟱
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↓,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, Synergy↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
6561- GSL,    Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiCan↑, *BioAv↝, *Dose↝, *toxicity↓, *Catalase↑, *NADPH↑, *GSR↑, *ALAT∅, *AST∅,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
2525- H2,    Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
- in-vivo, Var, NA
OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,
2524- H2,    Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
- Trial, Var, NA
hepatoP↑, *ALAT↓, *AST↓, Dose↝, Dose↝,
1415- HCA,    Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status
- in-vivo, Nor, NA
*OS↑, *toxicity↓, *AST∅, *ALAT∅, *Strength↑, *memory∅, *other↑, *other↑, *other↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
4238- HNK,    Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
- Review, AD, NA - NA, Park, NA
*BDNF↑, *hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *SIRT3↑, *Aβ↓, *Apoptosis↓, *ROS↓, *MMP↑, *Ca+2↓, *Casp3↓, *Ach↑, *PPARγ↑, *PGC-1α↑, *motorD↑, *TNF-α↓, *IL1β↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7803- IBC,    Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response
- in-vivo, Nor, NA - in-vitro, NA, HepG2
*hepatoP↓, *ALAT↑, *AST↑, *ROS↑, *MDA↑, *Catalase↓, *GSH↓, *GPx↓, *i-Iron↑,
7636- Ins,    Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models
- Review, Nor, NA
*glucose↝, *lipid-P↓, *ROS↓, *BioAv↑, *hepatoP↑, *Inflam↓, *MMP↑, *ATP↑, *GutMicro↑, *Dose↝, *Half-Life↝, *BioAv↑, *Synergy↑, *hepatoP↑, *SOD↑, *Catalase↑, *Casp3↓, *ALAT↓, *AST↓, *AMPK↑, *SREBP1/SREBF1↑, NA↑,
7814- ISQ,    Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
- in-vivo, Nor, NA
*ROS↓, *AntiCan↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *HSP90↓, *AST↓, *ALAT↓, *antiAll↑,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
8086- KAE,    Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety
- Review, Nor, NA
*hepatoP↑, *BioAv↝, *CYP2E1↓, *antiOx↑, *AST↓, *ALAT↓, *ROS↓, *lipid-P↓, *SIRT1↑, *GSH↑, *SOD↑, *p‑SMAD2↓, *p‑SMAD3↓, *COL1↓, *other↝,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8242- LCA,    Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A
- in-vivo, LiverDam, NA
*ALAT↓, *AST↓, *Inflam↓, *ROS↓, *TLR4↓, *MAPK↓, *NF-kB↓, *TXNIP↓, *NLRP3↓, *NRF2↑, *p62↑, *hepatoP↑, *autophagy↑,
8256- LCA,    Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice
- in-vivo, Colon, CT26
TumVol?, TumCP↓, *RenoP↑, *creat↓, BUN↓, hepatoP↑, *ALAT↓, *AST↓, *NO↓, *lipid-P↓, *GSH↑, chemoP↑, Dose↝,
8129- LF,    Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy
- Trial, CRC, NA
Dose↝, toxicity↓, INF-γ↝, other↑, *ROS↓, Imm↑, WBC↑, Neut↑, T-Cell↑, *antiOx↑, *GSH↑, *chemoP↑, *RenoP↑, *hepatoP↑, BUN↓, creat↓, ALAT↓, AST↓, RBC↑, PC↑, Mucositis↓, *AntiBio↑, *AntiViral↑, *AntiFungal↑, *Inflam↓,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8550- Matr,    Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway
- vitro+vivo, Liver, HUH7
other↝, Wnt↓, β-catenin/ZEB1↓, EMT↓, TumCMig↓, TumCI↓, Inflam↓, hepatoP↑, AST?, ALB↑, ALAT↓, ALP↓, GGT/CD224↓, TBIL↓, DBIL↓, IBIL↓,
8548- Matr,    The DHCR7 is the key target of lipotoxic liver injury caused by matrine through abnormal activation of the cholesterol synthesis pathway
- in-vitro, LiverDam, NA
*insect↑, *hepatoP↓, *ALAT↑, *AST↑, *CYP51/14LDM↑, *DHCR7↑, *toxicity↝,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
200- MFrot,  MF,    Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice
- in-vivo, BC, MDA-MB-231 - in-vivo, BC, MCF7
ALAT↓, TumVol↓, TumCCA↑, TumCG↓, TumMeta↓, Imm↑, P53↑, ALAT↓, AST↓,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3842- MO,    Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *hepatoP↑, *lipid-P↓, *ALAT↓, *AST↓, *ALP↓, *creat↓, *RenoP↑, NF-kB↓, ChemoSen↑, *memory?,
8904- MOR,    A 13-week subchronic toxicity study of dietary administered morin in F344 rats
- in-vivo, Nor, NA
*Dose?, *ALAT↓, *ALP↓, *creat↑, *Urea↑, *toxicity↝,
8887- MOR,    Morin hydrate ameliorates Di-2-ethylhexyl phthalate (DEHP) induced hepatotoxicity in a mouse model via TNF-α and NF-κβ signaling
- in-vivo, Nor, NA
*Dose↝, *hepatoP↑, *ALAT↓, *AST↓, *Bil↓, *ROS↓, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *TNF-α↓, *NF-kB↓,
8781- MSM,    Methylsulfonylmethane for treatment of low back pain: A safety analysis of a randomized, controlled trial
- Trial, Nor, NA
*WBC∅, *PC∅, *Bil∅, *AST∅, *ALAT∅, *creat∅, *BP∅,
8766- MSM,    Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
TumCG↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, TumVol↓, AST↓, ALAT↓,
8802- MT/VAE,    Pharmakokinetics of Mistletoe Lectins after Intravenous Application of a Mistletoe Product in Healthy Subjects
- Trial, Nor, NA
*Dose↝, *hepatoP↑, *Half-Life↝, *ALAT↑, *AST↑, toxicity↝, Dose↝,
8433- OM,    Toxicological Assessment of Origanum majorana L.: Evaluation of Its Cytotoxicity, Genotoxicity, and Acute Oral Toxicity
- in-vivo, Nor, NA
*toxicity↓, *hepatoP↑, *cardioP↑, *ALAT↓, *Astr↓, *LDH↓,

Showing Research Papers: 51 to 100 of 141
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 141

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Bil↝, 1,   Catalase↓, 6,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 8,   GSH↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 3,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NRF2↓, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 24,   ROS⇅, 1,   SOD↓, 4,   TAC↓, 1,   TrxR1↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compII↓, 1,   ETC↓, 1,   mtDam↑, 4,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 25,   ALAT↑, 2,   ALAT↝, 1,   ALAT∅, 1,   ATP↓, 4,   FASN↓, 1,   glucose↓, 1,   Glycolysis↓, 4,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HK2↓, 2,   lactateProd↓, 1,   LDL↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 2,   SCD1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 18,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 12,   Bax:Bcl2↑, 3,   Bcl-2↓, 15,   Bcl-xL↓, 2,   BID↑, 1,   BNIP3↑, 1,   Casp↑, 3,   Casp12↑, 2,   Casp3↑, 18,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 9,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 11,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 12,   DR5↑, 2,   FADD↑, 2,   Fas↑, 5,   IAP2/BIRC3↓, 1,   iNOS↓, 2,   Mcl-1↓, 3,   MDM2↓, 1,   MOMP↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 3,   PUMA↑, 1,   survivin↓, 2,   TRAIL↑, 1,   TumCD↑, 3,   XIAP↓, 5,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 17,   p‑Akt↓, 4,   CK2↓, 1,   p‑cMET↑, 1,   EGFR↓, 3,   ERK↓, 9,   p‑ERK↑, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HRAS↓, 1,   IGF-1R↓, 1,   JAK2↓, 2,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 4,   mTOR↓, 7,   P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 11,   p‑PI3K↓, 1,   PKA↓, 1,   PTEN↑, 2,   p‑PTEN↓, 1,   RAS↑, 1,   STAT3↓, 10,   p‑STAT3↓, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   cMyc↓, 6,   EZH2↓, 1,   FOXO3↓, 1,   HDAC↓, 3,   miR-124-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↑, 1,   other↝, 2,   PhotoS↑, 1,   SOX2↓, 1,   tumCV?, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 2,   HSP70/HSPA5↑, 1,   IRE1↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 3,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   DNAdam↑, 7,   hTERT/TERT↓, 1,   P53↓, 1,   P53↑, 12,   PARP↑, 3,   cl‑PARP↑, 5,   PCNA↓, 6,   TOP1↓, 1,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 3,   CDK4↓, 8,   CDK4↑, 1,   CDK6↓, 3,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 9,   CycD3↓, 1,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 4,   mitA↑, 1,   P21↑, 9,   p27/CDKN1B↑, 1,   pRB↓, 1,   TumCCA↑, 21,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CSCs↓, 2,   FGF↓, 1,   Gli↓, 1,   HH↓, 1,   Ki-67↓, 4,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   Shh↓, 2,   TumCG↓, 12,   TumCP↓, 15,   tyrosinase↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   i-Ca+2↑, 2,   E-cadherin↓, 3,   E-cadherin↑, 3,   EMT↓, 8,   F-actin↓, 1,   p‑FAK↓, 1,   p‑FAK↑, 1,   Fibronectin↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 11,   MMP2↑, 1,   MMP9↓, 13,   MMPs↓, 5,   MTA1↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   Slug?, 1,   Slug↓, 2,   Smad1↑, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 8,   TumCMig↓, 11,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 3,   Vim↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   Hif1a↓, 6,   VEGF↓, 20,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   MMP↓, 11,   MMP↑, 2,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 14,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 2,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   INF-γ↝, 1,   Inflam↓, 6,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 16,   NF-kB↑, 1,   NK cell↑, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   T-Cell↑, 1,   TLR4↓, 2,   TNF-α↓, 7,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 7,   BioAv↝, 1,   ChemoSen↑, 16,   Dose?, 1,   Dose↑, 1,   Dose↝, 11,   Dose∅, 1,   eff↓, 1,   eff↑, 8,   eff↝, 1,   eff∅, 2,   P-gp/ABCB1↓, 3,   RadioS↑, 4,   selectivity↓, 1,   selectivity↑, 9,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 25,   ALAT↑, 2,   ALAT↝, 1,   ALAT∅, 1,   ALB↑, 2,   ALP↓, 8,   ALP↑, 1,   ALP↝, 1,   AR↓, 1,   AST?, 1,   AST↓, 18,   AST↑, 2,   AST↝, 1,   AST∅, 1,   Bil↝, 1,   BUN↓, 2,   creat↓, 4,   DBIL↓, 1,   EGFR↓, 3,   EZH2↓, 1,   hTERT/TERT↓, 1,   IBIL↓, 1,   IL6↓, 8,   KRAS↓, 1,   LDH↓, 2,   PC↑, 1,   PD-L1↓, 1,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 8,   AntiTum↑, 2,   cardioP↑, 3,   chemoP↑, 10,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 12,   Mucositis↓, 1,   neuroP↑, 2,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 4,   PFS↓, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   TumVol?, 1,   TumVol↓, 4,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 375

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 44,   ARE↑, 1,   Bil↓, 5,   Bil∅, 1,   Catalase↓, 1,   Catalase↑, 36,   GPx↓, 3,   GPx↑, 26,   GSH↓, 2,   GSH↑, 50,   GSH/GSSG↑, 3,   GSR↑, 7,   GSSG↓, 3,   GSTs↑, 7,   H2O2↓, 1,   HDL↓, 1,   HDL↑, 2,   HDL∅, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 16,   i-Iron↑, 1,   Keap1↓, 4,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 36,   MDA↓, 42,   MDA↑, 1,   MPO↓, 7,   NQO1↑, 7,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 32,   ROS↓, 74,   ROS↑, 1,   mt-ROS?, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 51,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 1,   Thiols↑, 1,   TOS↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↓, 1,   Insulin↑, 1,   mtDam↓, 2,   OCR↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACC↑, 1,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 103,   ALAT↑, 4,   ALAT∅, 5,   AMPK↓, 1,   AMPK↑, 12,   p‑AMPK↑, 2,   ATP↓, 1,   ATP↑, 4,   cAMP↑, 1,   CPT1A↑, 1,   CRM↑, 2,   CYP51/14LDM↑, 1,   DGAT1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   H2S↑, 1,   HK2↓, 1,   lactateProd↓, 1,   LDL↓, 8,   lipidLev↓, 2,   NAD↓, 1,   NADPH↓, 1,   NADPH↑, 3,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↑, 9,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 8,   ASC↓, 2,   BAX↓, 6,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 5,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 12,   cl‑Casp3↓, 3,   proCasp3↓, 2,   Casp8↓, 1,   Casp9↓, 4,   Cyt‑c↓, 5,   Fas↓, 2,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 12,   necrosis↓, 2,   p38↓, 2,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↑, 1,   ERK↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↓, 3,   mTOR↑, 2,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 4,   PI3K↑, 2,   PP2A↑, 1,   STAT3↑, 1,   p‑STAT3↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 3,   p‑cJun↓, 1,   OCT4↓, 1,   other↑, 5,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 4,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 5,   GRP78/BiP↓, 2,   HSP27↑, 1,   HSP90↓, 1,   HSPs↓, 1,   NQO2↑, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   NOTCH1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   BACH1↓, 1,   Ca+2↓, 2,   Cartilage↑, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   LRP1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 1,   MMP9↑, 1,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 6,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TXNIP↓, 2,   Vim↓, 1,   α-SMA↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   eNOS↓, 1,   Hif1a↓, 1,   NO↓, 9,   VCAM-1↓, 2,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 3,   GastroP↑, 2,   GLUT4↑, 1,   IBI↑, 2,   MMP↑, 6,   OATPs↓, 1,   TRPM7↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 9,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 4,   IL10↑, 5,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 18,   IL2↓, 3,   IL22↓, 1,   IL4↓, 4,   IL5↓, 1,   IL6↓, 31,   IL8↓, 4,   Imm↓, 1,   Imm↑, 8,   Inflam?, 1,   Inflam↓, 61,   Inflam↑, 1,   LPS↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB↓, 33,   NLRP3↓, 10,   p65↓, 1,   PGE2↓, 10,   RAGE↓, 1,   TLR4↓, 8,   TNF-α↓, 42,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 2,   AChE↓, 5,   BDNF↓, 1,   BDNF↑, 4,   DHCR7↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 3,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 5,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   GR↑, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 14,   BioAv↝, 11,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2E1↓, 3,   Dose?, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 23,   eff↑, 9,   eff↝, 1,   GSTA1↑, 3,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 6,   P-gp/ABCB1↓, 3,   P450↓, 1,   P450↑, 1,   P450↝, 1,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 103,   ALAT↑, 4,   ALAT∅, 5,   ALB↑, 2,   ALP↓, 22,   AST↓, 99,   AST↑, 4,   AST∅, 5,   BG↓, 1,   Bil↓, 5,   Bil∅, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 5,   BP∅, 1,   BUN↓, 4,   CEA↓, 1,   creat↓, 10,   creat↑, 1,   creat∅, 1,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 31,   LDH↓, 14,   LDH↑, 1,   PC∅, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 3,   Urea↓, 4,   Urea↑, 1,   WBC∅, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 2,   antiAll↑, 11,   AntiArt↑, 5,   AntiCan↑, 12,   antiD↓, 1,   AntiDiabetic↑, 13,   antiM↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   antiPy↑, 1,   AntiTum↑, 1,   cardioP↑, 28,   chemoP↑, 4,   cognitive↑, 13,   hepatoP↓, 3,   hepatoP↑, 86,   memory?, 1,   memory↑, 10,   memory∅, 1,   motorD↑, 3,   neuroP?, 1,   neuroP↑, 27,   Obesity↓, 8,   OS↑, 1,   Pain↓, 3,   radioP↑, 1,   RenoP↓, 1,   RenoP↑, 20,   RenoP↝, 1,   Sleep↑, 1,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 4,   toxicity↓, 17,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 3,   Weight↓, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 4,   Bacteria↓, 10,   GutMicro↑, 11,   insect↑, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 7,  
Total Targets: 398

Scientific Paper Hit Count for: ALAT, ALT, alanine aminotransferase
6 Selenium NanoParticles
6 Silymarin (Milk Thistle) silibinin
6 Thymoquinone
5 Carvacrol
4 Silver-NanoParticles
4 Centella asiatica / Gotu kola → asiaticoside
4 Emodin
4 Hydrogen Gas
4 Matrine
3 Curcumin
3 Baicalein
3 Chemotherapy
3 Dandelion Root
3 Ferulic acid
3 Kaempferol
3 Licochalcone A
3 Shikonin
2 Resveratrol
2 Boron
2 Selenium
2 Caffeic acid
2 Chrysin
2 Honokiol
2 Hyperoside
2 isoquercitrin
2 Luteolin
2 Lycopene
2 Moringa oleifera
2 Morin
2 Methylsulfonylmethane
2 Marjoram (Origanum majorana)
2 Propolis -bee glue
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
1 1,8-Cineole
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Ashwagandha(Withaferin A)
1 Berberine
1 Betulinic acid
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Carnosic acid
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Camu camu
1 Celastrol
1 Crocetin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 diet Fermented Foods
1 diet Short Term Fasting
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Eugenol
1 Formononetin
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Gamma-aminobutyric acid
1 Gossypol/AT-101
1 Germacranolide sesquiterpene lactone
1 HydroxyCitric Acid
1 Isobavachalcone
1 Inositol
1 Lactoferrin/Talactoferrin
1 Linalool
1 Metformin
1 Magnetic Field Rotating
1 Magnetic Fields
1 Mistletoe/Viscum album Extracts
1 Patchouli Oil (Pogostemon cablin)
1 Phycocyanin
1 Piperine
1 Polyphenols
1 Quercetin
1 Rutin
1 Salvia officinalis
1 chitosan
1 polyethylene glycol
1 Date Fruit Extract
1 Cisplatin
1 Ursolic acid
1 Vitamin B5,Pantothenic Acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:554  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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