TLR4 Cancer Research Results

TLR4, Toll-like receptor 4: Click to Expand ⟱
Source:
Type:
Also called CD284 (cluster of differentiation 284)
A key activator of the innate immune response and plays a central role in the fight against bacterial infections.
Accumulating evidences demonstrated that the activation of TLR4 in tumor microenvironment can not only boost the anti-tumor immunity but also give rise to immune surveillance and tumor progression. "double-edged sword” role of TLR4 activation
Scientific Papers found: Click to Expand⟱
3556- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *memory↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *NF-kB↓, *IRF3↓, TLR4↓, MyD88↓, TRIF↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3570- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *IRF3↓, *TLR4↓, *memory↑, *NF-kB↓, *MyD88↓, *TRIF↓, *BBB↑, *cognitive↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,

Showing Research Papers: 51 to 55 of 55
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 55

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,  

Immune & Inflammatory Signaling ⓘ

MyD88↓, 1,   NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 1,   TRIF↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   lipid-P↓, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 2,   ROS↓, 2,   SOD↑, 1,   TAC↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   LDH↓, 1,  

Cell Death ⓘ

BAX↓, 1,   Casp3↓, 1,   iNOS↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Migration ⓘ

MMP9↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↑, 1,   COX2↓, 2,   CRP↓, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 5,   IL6↓, 2,   Inflam↓, 5,   MyD88↓, 3,   NF-kB↓, 5,   TLR2↓, 4,   TLR4↓, 4,   TNF-α↓, 4,   TRIF↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 4,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   GutMicro↑, 1,   IL6↓, 2,   LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 2,   cognitive↑, 3,   hepatoP↑, 1,   memory↑, 3,   neuroP↑, 1,   RenoP↑, 2,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   IRF3↓, 4,  
Total Targets: 67

Scientific Paper Hit Count for: TLR4, Toll-like receptor 4
7 Propolis -bee glue
5 Thymoquinone
3 Curcumin
2 Allicin (mainly Garlic)
2 Artemisinin
2 Beta-Caryophyllene
2 Carvacrol
2 Chlorogenic acid
2 Chrysin
2 Dandelion Root
2 Quercetin
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 Apigenin (mainly Parsley)
1 Baicalein
1 α-Bisabolol / Chamomile oil
1 Cinnamon
1 Crocetin
1 Cucurbitacin
1 D-limonene
1 Emodin
1 Ferulic acid
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Luteolin
1 Lycopene
1 Magnolol
1 Magnetic Field Rotating
1 Magnetic Fields
1 Nimbolide
1 Resveratrol
1 Salvia miltiorrhiza
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:559  State#:%  Dir#:%
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