TLR4 Cancer Research Results

TLR4, Toll-like receptor 4: Click to Expand ⟱
Source:
Type:
Also called CD284 (cluster of differentiation 284)
A key activator of the innate immune response and plays a central role in the fight against bacterial infections.
Accumulating evidences demonstrated that the activation of TLR4 in tumor microenvironment can not only boost the anti-tumor immunity but also give rise to immune surveillance and tumor progression. "double-edged sword” role of TLR4 activation
Scientific Papers found: Click to Expand⟱
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,
2139- TQ,    Thymoquinone regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the TLR4 signaling pathway
- in-vivo, Nor, NA
*TLR4↓, *NF-kB↓, *Inflam↓, *Hif1a↑, *motorD↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3556- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *memory↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *NF-kB↓, *IRF3↓, TLR4↓, MyD88↓, TRIF↓,
3570- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *IRF3↓, *TLR4↓, *memory↑, *NF-kB↓, *MyD88↓, *TRIF↓, *BBB↑, *cognitive↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,

Showing Research Papers: 51 to 70 of 70
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 70

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↓, 1,   Catalase↓, 2,   GSH↓, 3,   GSH↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 1,   NRF2↓, 3,   NRF2↑, 2,   ROS↓, 4,   ROS↑, 19,   SOD↓, 2,   SOD↑, 1,   TAC↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 2,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALAT↓, 1,   AMPK↓, 1,   ATP↓, 2,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HK2↓, 5,   lactateProd↓, 2,   LDHA↓, 2,   LDL↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 3,   PKM2↓, 3,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 13,   ASC↑, 1,   BAD↑, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-xL↓, 3,   BNIP3↑, 1,   Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp3↓, 2,   Casp3↑, 11,   cl‑Casp3↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 5,   DR5↑, 1,   Fas↑, 2,   FasL↑, 1,   IAP1↓, 1,   iNOS↓, 3,   iNOS↑, 1,   Mcl-1↓, 2,   MDM2↓, 2,   MOMP↑, 1,   NOXA↑, 1,   p38↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 1,   TRAIL↑, 1,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 12,   Akt↑, 2,   p‑Akt↓, 2,   EGFR↓, 2,   ERK↓, 4,   ERK↑, 1,   p‑ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 2,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 2,   MARK4↓, 1,   MEK↓, 1,   mTOR↓, 9,   P70S6K↓, 2,   PI3K↓, 8,   Raf↓, 1,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 5,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   cMyc↓, 2,   DNMT3B↓, 1,   FOXM1↓, 1,   FOXO3↓, 1,   H3↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   miR-21↑, 1,   OCT4↓, 1,   other↝, 1,   SOX2↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   e-HSP70/HSPA5↓, 1,   PERK↑, 3,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↑, 3,   p62↓, 3,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 3,   hTERT/TERT↓, 4,   P53↑, 6,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 2,   cl‑PARP↑, 2,   PCNA↓, 2,   Telomerase↓, 2,   TOP1↓, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   p‑CDK1↓, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 3,   CDK6↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 5,   p27/CDKN1B↑, 2,   pRB↓, 1,   p‑pRB↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   CSCs↓, 3,   FGF↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↑, 1,   Shh↓, 1,   TumCG↓, 10,   TumCP↓, 12,   TumCP∅, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   CCN2/CTGF↓, 1,   E-cadherin↑, 5,   EMT↓, 6,   EMT↝, 1,   FAK↓, 3,   Fibronectin↓, 1,   GIT1↓, 1,   LRP1↓, 1,   MMP-10↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 3,   MTA1↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 10,   TumCMig↓, 10,   TumMeta↓, 5,   Twist↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim↓, 2,   Zeb1↓, 1,   α-SMA↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   angioG↑, 1,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   Hif1a↓, 4,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   CLDN2↓, 1,   CX43/GJA1↓, 1,   GLUT1↓, 1,   GLUT3↓, 1,   MMP↓, 8,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   GM-CSF↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 4,   IL1β↓, 5,   IL1β↑, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 8,   IL6↑, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 5,   IRAK4↓, 1,   IRF3↓, 1,   MDSCs↓, 1,   MyD88↓, 2,   MyD88↑, 1,   NF-kB↓, 20,   NF-kB↑, 1,   NLRP3↓, 2,   NLRP3↑, 1,   p65↓, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 3,   T-Cell↑, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 21,   TLR4↑, 2,   TLR4↝, 1,   TNF-α↓, 8,   TNF-α↑, 1,   TRIF↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   ChemoSen↓, 1,   ChemoSen↑, 9,   Dose↑, 1,   Dose↝, 2,   Dose∅, 3,   eff↓, 1,   eff↑, 12,   eff↝, 1,   eff∅, 1,   Half-Life↝, 2,   MDR1↓, 2,   P-gp/ABCB1↓, 1,   RadioS↑, 2,   selectivity↑, 4,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   CRP↓, 1,   EGFR↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 8,   IL6↑, 2,   LDH↓, 5,   LDH↑, 1,   PD-L1↓, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 5,   cardioP↑, 2,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   neuroP↑, 2,   OS↑, 2,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 1,   TumVol↓, 1,  
Total Targets: 322

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 25,   Bil↑, 1,   Catalase↑, 20,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 1,   GPx↑, 12,   GPx1↑, 1,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 21,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 19,   Keap1↓, 1,   lipid-P↓, 12,   mt-lipid-P↓, 1,   MDA↓, 27,   MPO↓, 4,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 4,   NRF2↑, 30,   Prx↑, 1,   ROS?, 1,   ROS↓, 39,   mt-ROS↓, 1,   SOD↑, 24,   SOD1↑, 2,   TAC↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 9,   AMPK↑, 6,   ATP↑, 1,   cAMP↑, 1,   CRM↑, 1,   glucose↓, 2,   glucose↝, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 3,   lipidLev↓, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   ASC↓, 1,   BAX↓, 5,   Bcl-2↑, 3,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 7,   Casp8↓, 1,   Casp9↓, 5,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 2,   iNOS↓, 14,   iNOS↑, 2,   necrosis↓, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↑, 1,   CREB↑, 1,   ERK↓, 3,   p‑ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   p‑IKKα↓, 1,   p‑IκB↓, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 3,   MAPK↓, 10,   MAPK↑, 1,   p‑MAPK?, 1,   mTOR↓, 2,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PTEN↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   cMyc↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↓, 1,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 3,   ARG1/2↑, 1,   BACH1↓, 1,   Ca+2↓, 3,   COL1↓, 2,   E-cadherin↑, 1,   EMT↓, 1,   MMP9↓, 5,   MMPs↓, 1,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 4,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 2,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 11,   VCAM-1↓, 4,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 5,   BBB↝, 1,   CLDN1↑, 1,   CLDN3↑, 1,   GastroP↑, 1,   GLUT2↑, 1,   IBI↑, 2,   MMP↑, 4,   OCLN↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 24,   CXCR4↓, 1,   HMGB1↓, 2,   ICAM-1↓, 5,   IFN-γ↓, 4,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 1,   IL10↑, 4,   IL12↓, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 31,   IL2↓, 2,   IL23↓, 2,   IL4↓, 1,   IL4↑, 2,   IL5↓, 1,   IL6↓, 23,   IL6↑, 1,   IL8↓, 5,   Imm↑, 1,   Inflam↓, 42,   Inflam↑, 1,   IRF3↓, 4,   LPS↓, 1,   MCP1/CCL2↓, 1,   MyD88↓, 9,   NF-kB↓, 42,   NLRP3↓, 13,   p65↓, 2,   p‑p65↓, 1,   PGE2↓, 8,   TLR2↓, 6,   TLR4↓, 45,   TLR4↑, 1,   TLR4∅, 1,   TNF-α↓, 30,   TRAF6↓, 1,   TRIF↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   BChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   MAOA↓, 1,   NGF↑, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 14,   BACE/β-secretase↓, 3,   tau↓, 2,   p‑tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   cortisol↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 11,   BioAv↝, 3,   BioEnh↑, 1,   CYP2E1↓, 1,   Dose↝, 2,   eff↑, 5,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   P450↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   AST↓, 11,   Bil↑, 1,   BP↓, 5,   BUN?, 1,   BUN↓, 2,   creat↓, 4,   CRP↓, 2,   IL6↓, 23,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 2,   AntiCan↑, 2,   antiD↓, 1,   AntiDiabetic↑, 5,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 14,   chemoP↑, 3,   cognitive↑, 13,   hepatoP↑, 16,   Learn↑, 1,   memory↑, 17,   motorD↑, 2,   neuroP?, 1,   neuroP↑, 27,   NP/CIPN↓, 1,   Obesity↓, 1,   RenoP↓, 1,   RenoP↑, 8,   Strength↑, 1,   Stroke↓, 4,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 6,   GutMicro↑, 10,   Sepsis↓, 4,  
Total Targets: 287

Scientific Paper Hit Count for: TLR4, Toll-like receptor 4
7 Propolis -bee glue
5 Thymoquinone
3 Curcumin
3 Hyperoside
2 Allicin (mainly Garlic)
2 Artemisinin
2 Beta-Caryophyllene
2 Carvacrol
2 Chlorogenic acid
2 Chrysin
2 Dandelion Root
2 Emodin
2 Hydrogen Gas
2 Licochalcone A
2 Morin
2 Quercetin
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 Apigenin (mainly Parsley)
1 Baicalein
1 α-Bisabolol / Chamomile oil
1 Cinnamon
1 Crocetin
1 Cucurbitacin
1 D-limonene
1 Ferulic acid
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Chemotherapy
1 Paclitaxel/Taxol
1 Kaempferol
1 Licorice
1 Linalool
1 Luteolin
1 Lycopene
1 Magnolol
1 Matrine
1 Magnetic Field Rotating
1 Magnetic Fields
1 Zeolite
1 Nimbolide
1 Resveratrol
1 Salvia miltiorrhiza
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:559  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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