IL10 Cancer Research Results

IL10, Interleukin-10: Click to Expand ⟱
Source:
Type:
IL-10 is a multifaceted immune-suppressive cytokine and possesses immune-regulatory and angiogenic functions.
It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions.
The role of IL-10 in tumor pathogenesis is currently highly controversial, with some findings showing that IL-10 promotes tumor development and angiogenesis, while others supporting that it inhibits tumor growth and metastasis.

IL-10 is often expressed in various cancers, including breast cancer, colorectal cancer, melanoma, and lymphoma. Its expression can vary significantly depending on the tumor type and the immune context.
Elevated levels of IL-10 are frequently associated with the presence of tumor-infiltrating immune cells, particularly Tregs and M2 macrophages.
Scientific Papers found: Click to Expand⟱
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, NA, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
4220- PI,    Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
- in-vivo, AD, NA - in-vivo, MS, NA
*memory↑, *iNOS↓, *NRF2↑, *HO-1↑, *TAC↑, *TNF-α↓, *IL1β↓, *NF-kB↓, *IL10↑, *FOXP3↑, *BDNF↑, other↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓,
5624- ProBio,  Bif,    A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer
- Trial, Testi, NA
Dose↝, TNF-α↓, IL6↓, IL10↓, IL12↓, IL22↓, toxicity↓,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
916- QC,    Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
- Review, Ovarian, NA
COX2↓, CRP↓, ER Stress↑, Apoptosis↑, GRP78/BiP↑, CHOP↑, p‑STAT3↓, PI3K↓, Akt↓, mTOR↓, cMyc↓, cycD1/CCND1↓, cFLIP↓, IL6↓, IL10↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3025- RosA,    Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
- in-vivo, IBD, NA
*GutMicro↑, *ROCK1↓, *Rho↓, *CaMKII ↓, *Zeb1↓, *ZO-1↓, *E-cadherin↓, *IL1β↓, *IL6↓, *TNF-α↓, *GRP78/BiP↓, *PERK↓, *IRE1↓, *ATF6↓, *CHOP↓, *Casp12↓, *Casp9↓, *BAX↓, *Casp3↓, *Cyt‑c↓, *RIP1↓, *MLKL↓, *IL10↑, *Bcl-2↑, *ER Stress↓,
3660- SFN,    Sulforaphane - role in aging and neurodegeneration
- Review, AD, NA
*antiOx↑, *Inflam↓, *NRF2↑, *NF-kB↓, *HDAC↓, *DNMTs↓, *neuroP↑, *AntiAge↑, *DNMT1↓, *DNMT3A↓, *memory↑, *HO-1↑, *ROS↓, *NO↓, *GSH↑, *NF-kB↓, *TNF-α↓, *IL10↑,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31↓, Hif1a↓, VEGFR2↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2213- SK,    Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,
3409- TQ,    Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
- in-vivo, Nor, NA
*MDA↓, *TGF-β↓, *CRP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *Casp3↓, *GSH↑, *NRF2↑, *IL10↑, *neuroP↑, *ROS↓, *Apoptosis↓, *Inflam↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3557- TQ,    Thymoquinone protects against lipopolysaccharides-induced neurodegeneration and Alzheimer-like model in mice.
- in-vivo, AD, NA
*Inflam↓, *antiOx↑, *cognitive↑, *TNF-α↓, *IL1β↓, *AChE↓, *IL10↑, *ChAT↑, *Aβ↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,

Showing Research Papers: 51 to 73 of 73
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 73

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 2,   H2O2↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 4,   ROS↑, 5,   ROS⇅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   FGFR1↓, 1,   MEK↓, 1,   MMP↓, 4,   OCR↓, 1,   Raf↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 7,   ECAR↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDH↑, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 2,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↑, 5,   Bak↑, 1,   BAX↓, 1,   BAX↑, 3,   Bcl-2↓, 3,   Bcl-xL↓, 1,   BID↓, 1,   BIM↓, 1,   Casp↑, 1,   Casp3↓, 2,   Casp3↑, 4,   Casp8↑, 1,   Casp9↑, 3,   cFLIP↓, 3,   Cyt‑c↑, 5,   Diablo↑, 1,   DR5↑, 2,   Fas↑, 1,   FasL↑, 1,   iNOS↓, 2,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 2,   MAPK↝, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   p27↑, 1,   p38↑, 2,   survivin↓, 3,   TRAIL↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↑, 1,   miR-21↑, 1,   other↑, 1,   pRB↓, 1,   p‑pRB↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   eIF2α↓, 1,   ER Stress↑, 2,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   LC3B-II↑, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

CYP1B1↑, 1,   DNMT1↓, 1,   DNMTs↓, 1,   p16↑, 1,   P53↑, 6,   PARP↓, 1,   cl‑PARP↑, 1,   PARP1↑, 1,   PCNA↓, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 4,   E2Fs↓, 1,   P21↑, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   CSCs↓, 1,   EMT↓, 4,   ERK↓, 3,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 1,   FGF↓, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   IGFBP3↑, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   NOTCH↓, 2,   P70S6K↓, 1,   PI3K↓, 8,   PTEN↑, 2,   RAS↓, 2,   Shh↓, 1,   STAT3↓, 5,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↓, 1,   AP-1↓, 1,   CD31↓, 1,   CLDN2↓, 1,   CXCL12↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   ITGA5↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 5,   MMP9:TIMP1↓, 1,   MMPs↓, 5,   N-cadherin↓, 2,   PDGF↓, 1,   PKCδ↓, 2,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 2,   TSP-1↑, 2,   TumCP↓, 1,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 4,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 2,   Hif1a↓, 4,   NO↓, 1,   VEGF↓, 8,   VEGFR2↓, 4,  

Barriers & Transport ⓘ

GLUT1↓, 2,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 7,   CRP↓, 2,   CXCL1↓, 1,   CXCR4↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 8,   IL12↓, 2,   IL1β↓, 1,   IL2↑, 2,   IL22↓, 1,   IL6↓, 7,   Inflam↓, 1,   JAK2↓, 1,   MDSCs↓, 1,   NF-kB↓, 3,   p65↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 3,   Dose↝, 2,   eff↑, 10,   Half-Life↑, 1,   RadioS↑, 1,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 2,   EGFR↓, 2,   HER2/EBBR2↓, 1,   IL6↓, 7,   Ki-67↓, 1,   KRAS↓, 1,   LDH↑, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 219

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Catalase↑, 6,   GPx↓, 1,   GPx↑, 2,   GSH↑, 9,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 5,   lipid-P↓, 2,   MDA↓, 5,   MPO↓, 1,   Nrf1↑, 1,   NRF2↑, 7,   Prx↑, 1,   ROS↓, 7,   SOD↑, 7,   TAC↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3,   cMyc↓, 1,   LDH↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   MLKL↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,  

Protein Folding & ER Stress ⓘ

ATF6↓, 1,   CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   IRE1↓, 1,   PERK↓, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   HDAC↓, 1,   mTOR↑, 1,   STAT3↓, 1,  

Migration ⓘ

AP-1↓, 2,   ARG↑, 1,   E-cadherin↓, 1,   MMP9↓, 3,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TumCI↓, 1,   TumCP↓, 1,   Zeb1↓, 1,   ZO-1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   LOX1↓, 1,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 5,   CRP↓, 2,   FOXP3↑, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL10↓, 4,   IL10↑, 11,   IL12↓, 1,   IL17↓, 2,   IL1β↓, 11,   IL2↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 2,   IL6↓, 6,   IL6↑, 1,   IL8↓, 3,   Inflam↓, 11,   MCP1↓, 1,   MyD88↓, 1,   NF-kB↓, 11,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 14,   TRIF↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BDNF↑, 2,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   eff↓, 1,   Half-Life↓, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   AST↓, 3,   BP↓, 1,   CRP↓, 2,   GutMicro↑, 1,   IL6↓, 6,   IL6↑, 1,   LDH↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 2,   cognitive↑, 3,   hepatoP↑, 5,   memory↑, 4,   neuroP↑, 6,   Pain↓, 1,   RenoP↑, 3,  

Infection & Microbiome ⓘ

IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 128

Scientific Paper Hit Count for: IL10, Interleukin-10
7 Magnetic Fields
6 Propolis -bee glue
5 Berberine
5 Lycopene
5 Quercetin
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Butyrate
3 chitosan
2 Betulinic acid
2 Bifidobacterium
2 Boron
2 Curcumin
2 Hydrogen Gas
2 Magnetic Field Rotating
2 Piperine
2 Shikonin
1 Silver-NanoParticles
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Aspirin -acetylsalicylic acid
1 Aloe anthraquinones
1 Baicalein
1 Baicalin
1 Radiotherapy/Radiation
1 Selenium
1 Bruteridin(bergamot juice)
1 Docetaxel
1 Chrysin
1 Citric Acid
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Honokiol
1 Luteolin
1 immunotherapy
1 Magnolol
1 Naringin
1 probiotics
1 Resveratrol
1 Rosmarinic acid
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:562  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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