HO-1 Cancer Research Results

HO-1, HMOX1: Click to Expand ⟱
Source:
Type:
(Also known as Hsp32 and HMOX1)
HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene.
HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer.
-widely regarded as having antioxidant and cytoprotective effects
-The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage

Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by:
  Reducing oxidative stress and inflammation
  Promoting angiogenesis (the formation of new blood vessels)
  Inhibiting apoptosis (programmed cell death)
  Enhancing cell migration and invasion
When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions.

A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1.

-Curcumin   Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects.
-Resveratrol  Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties.
-Quercetin   Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses.
-EGCG     Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties.
-Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes.
-Luteolin    Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models.
-Apigenin   Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities.
Scientific Papers found: Click to Expand⟱
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
5864- CA,    Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- vitro+vivo, Stroke, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,
5871- CA,    Carnosic Acid Attenuates an Early Increase in ROS Levels during Adipocyte Differentiation by Suppressing Translation of Nox4 and Inducing Translation of Antioxidant Enzymes
- in-vitro, Nor, NA
*ROS↓, *NF-kB↓, *Nrf1↑, *HO-1↑, *GSTs↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
4264- CA,    HO-1_Pathway">Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp↓, ChemoSen↑,
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
5766- CAPE,    A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model
- in-vivo, Nor, NA
*MDA↓, *NF-kB↓, *p65↓, *TNF-α↓, *cl‑Casp3↓, *GSR↑, *GSH↑, *NRF2↑, *HO-1↑, *Bax:Bcl2↓, *antiOx↑, *Inflam↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,
5900- CAR,  TV,    Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2↓, MMP2↑, MMP9↓, BioAv↑,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
6638- Cen,    Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice
- in-vivo, AD, NA
*memory↑, *Aβ↓, *NRF2↑, *toxicity↓, *neuroP↑, *ROS↓, *mtDam↓, *cognitive↑, NQO1↑, HO-1↑,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6013- CGA,    Advances in Pharmacological Properties, Molecular Mechanisms, and Bioavailability Strategies of Chlorogenic Acid in Cardiovascular Diseases Therapy
- Review, CardioV, NA
*BioAv↝, *BioAv↝, *BP↓, *ROS↓, *NADPH↓, *AntiAg↑, *TXA2↓, *antiOx↑, *cardioP↑, *Inflam↓, *SOD↑, *Catalase↑, *Ferroptosis↓, *NF-kB↓, *JNK↓, *NRF2↑, *HO-1↑, *toxicity↓, *BioAv↓, *BioAv↑, *BioAv↑, eff↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2↓, TNF-α↓, IL1β↓, IL6↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2591- CHr,  doxoR,    Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway
- in-vitro, HCC, Bel-7402
NRF2↓, ChemoSen↑, HO-1↓,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6632- Cic,    Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain
- vitro+vivo, Nor, NA
*antiOx↑, *Obesity↓, *NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *ATP↑, *COX2↓, *iNOS↓, *neuroP↑,
6144- Cin,    The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells
- in-vitro, Colon, HCT116
Nrf1↑, HO-1↑, chemoPv↑,
6315- Cro,    Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
- in-vivo, NA, NA
*cardioP↑, *Inflam↓, *antiOx↑, *ROS↓, *AntiCan↑, *memory↑, *NF-kB↓, *TLR1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *DNAdam↓, PTEN↓, MMP↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6299- Cro,    Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,
6297- Cro,    Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
- in-vitro, Nor, RAW264.7
*NO↓, *iNOS↓, *Inflam↓, *MEK↓, JNK↓, NF-kB↓, NRF2↑, HO-1↑, hepatoP↑, neuroP↑,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, NA, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6225- CUR,    Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance
- Review, Var, NA
ox-Trx1↑, TrxR1↓, TrxR↓, ROS↑, GSH/GSSG↓, eff↓, Fenton↑, H2O2↑, *NRF2↑, *Keap1↓, *HO-1↑, *NQO1↑, ChemoSen↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6210- CUR,    Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis
Ferroptosis↑, *Ferroptosis↓, ROS↑, Fenton↑, *IronCh↑, GPx4↓, MDA↑, GSH↓, *NRF2↑, *HO-1↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2↑, *NF-kB↓, *ICAM-1↓, *MCP1↓, *HO-1↑, CXCc↓,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP↑,
1410- CUR,    Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway
- vitro+vivo, OS, MG63
tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT↓, ROS↑, MDA↑, GSH↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,

Showing Research Papers: 51 to 100 of 279
Prev Page 2 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 279

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Fenton↑, 4,   Ferroptosis↑, 2,   GPx4↓, 3,   GSH↓, 4,   GSH↑, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   HNE↑, 1,   HO-1↓, 4,   HO-1↑, 14,   Iron↑, 2,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 3,   NADH↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 4,   NRF2↑, 8,   OXPHOS↓, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 1,   ROS↑, 17,   mt-ROS↑, 1,   ox-Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   ETC↓, 1,   mitResp↓, 1,   MMP↓, 4,   MMP↑, 1,   mtDam↑, 3,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 2,   ATG7↑, 1,   cMyc↓, 2,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   HK2↓, 3,   lactateProd↓, 1,   lactateProd↑, 1,   LDH↓, 1,   LDHA↓, 2,   LDL↓, 1,   NADPH↓, 1,   PDK1↓, 2,   PKM2↓, 2,   PPARα↓, 1,   SCD1↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   Akt↑, 2,   p‑Akt↓, 1,   Apoptosis↑, 12,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 1,   Casp↑, 3,   Casp3↑, 5,   Casp9↑, 2,   Cyt‑c↑, 5,   Ferroptosis↑, 2,   hTERT/TERT↓, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 3,   MAPK↑, 2,   MAPK↝, 1,   Mcl-1↓, 2,   MCT1↓, 1,   survivin↓, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   SOX9?, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   EZH2↓, 1,   HATs↓, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP↑, 2,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3II↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNMT1↓, 1,   DNMTs↓, 3,   p16↑, 1,   P53↑, 6,   p‑P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   PCNA↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK4↓, 2,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↑, 4,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD133↑, 1,   CD44↓, 1,   cFos↓, 1,   CIP2A↓, 1,   CSCs↓, 4,   EMT↓, 3,   EMT↝, 1,   ERK↓, 4,   p‑ERK↑, 1,   FOXO↑, 1,   FOXO1↓, 1,   Gli↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HH↓, 1,   mTOR↓, 7,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   OCT4↓, 2,   PI3K↓, 6,   PI3K↝, 1,   PTEN↓, 1,   PTEN↑, 1,   SOX2↓, 2,   Src↓, 1,   STAT↓, 1,   STAT3↓, 5,   STAT3↑, 1,   TOP1↓, 1,   TumCG↓, 5,   Wnt↓, 5,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AP-1↓, 1,   AP-1↑, 1,   Ca+2↑, 2,   CLDN1↓, 1,   CXCL12↓, 1,   E-cadherin↑, 2,   FAK↑, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   LAMs↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↑, 1,   MMP9↓, 8,   MMPs↓, 2,   N-cadherin↓, 1,   PKCδ↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 1,   TumCI↓, 7,   TumCMig↓, 2,   TumCP↓, 8,   TumMeta↓, 4,   Twist↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 4,   VEGF↓, 8,   VEGFR2↓, 2,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2↓, 6,   COX2↑, 1,   CXCc↓, 1,   CXCR4↓, 2,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 3,   JAK↓, 1,   JAK2↓, 2,   M1↓, 1,   MCP1↓, 1,   NF-kB?, 1,   NF-kB↓, 11,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 2,   TLR4↓, 2,   TNF-α↓, 5,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 1,   ChemoSen↑, 12,   eff↓, 1,   eff↑, 9,   Half-Life↝, 1,   RadioS↑, 1,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 1,   AST↓, 1,   EGFR↓, 2,   EZH2↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 8,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   cardioP↑, 3,   CardioT↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↓, 1,   hepatoP↑, 2,   neuroP↑, 3,   OS↑, 1,   radioP↑, 3,   RenoP↑, 1,   toxicity↑, 1,   toxicity↝, 1,  
Total Targets: 271

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   ARE↑, 2,   Catalase↑, 14,   Ferroptosis↓, 2,   GPx↑, 10,   GSH↑, 16,   GSR↑, 3,   GSS↑, 1,   GSTs↑, 4,   HDL↑, 1,   HO-1↓, 2,   HO-1↑, 33,   Keap1↓, 3,   lipid-P↓, 8,   lipid-P↑, 1,   MDA↓, 14,   NOX4↓, 1,   NQO1↑, 8,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 34,   ROS↓, 33,   ROS↑, 1,   SOD↑, 19,   SOD1↑, 2,   TAC↑, 2,   TBARS↓, 1,   Trx↑, 1,   Trx1↑, 1,   UCPs↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   MEK↓, 1,   mtDam↓, 2,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 4,   AMPK↑, 2,   cytoP450↓, 1,   GAPDH↑, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 1,   GLUT2↑, 2,   HMG-CoA↓, 1,   LDH↓, 2,   LDH↑, 1,   LDHA↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PFK↓, 1,   PKM2↓, 1,   PPARα↝, 1,   PPARγ↑, 2,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 4,   BAX↓, 2,   Bax:Bcl2↓, 1,   Bcl-2↑, 3,   Casp↓, 1,   Casp3↓, 5,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   Fas↓, 1,   Ferroptosis↓, 2,   HGF/c-Met↑, 1,   iNOS↓, 9,   JNK↓, 3,   MAPK↓, 3,   TRPV1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↓, 1,   CHOP↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   p‑ERK↑, 1,   GSK‐3β↓, 2,   HDAC↓, 1,   miR-34a↓, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   p300↓, 1,   PI3K↑, 2,   SOX2↑, 1,   STAT↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ki-67↑, 1,   Na+↑, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 4,   NO↑, 1,   TXA2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT3↑, 1,   GLUT4↑, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 13,   COX2↑, 1,   CRP↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 8,   IL6↓, 9,   Imm↑, 2,   Inflam↓, 23,   MCP1↓, 1,   NF-kB↓, 16,   NF-kB↑, 2,   p65↓, 1,   PGE2↓, 3,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 16,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 5,   BDNF↑, 3,   MAOA↓, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   MAOB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 8,   BioAv↝, 5,   ChemoSen↑, 1,   Dose↝, 2,   eff↑, 6,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 5,   BMD↑, 1,   BP↓, 2,   CRP↓, 2,   GutMicro↑, 3,   IL6↓, 9,   Ki-67↑, 1,   LDH↓, 2,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 10,   chemoP↑, 1,   cognitive↓, 1,   cognitive↑, 6,   hepatoP↑, 9,   memory↑, 8,   neuroP↑, 18,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity↝, 2,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 183

Scientific Paper Hit Count for: HO-1, HMOX1
17 Curcumin
15 Sulforaphane (mainly Broccoli)
15 Thymoquinone
13 Resveratrol
11 Luteolin
10 Quercetin
9 Chemotherapy
9 Silymarin (Milk Thistle) silibinin
9 Shikonin
8 Ashwagandha(Withaferin A)
7 Hydrogen Gas
6 Baicalein
6 Chlorogenic acid
6 Chrysin
6 Fisetin
6 Honokiol
6 Lycopene
5 Alpha-Lipoic-Acid
5 diet FMD Fasting Mimicking Diet
5 EGCG (Epigallocatechin Gallate)
5 Ferulic acid
5 Propolis -bee glue
4 doxorubicin
4 Berberine
4 Beta-Caryophyllene
4 Betulinic acid
4 Carnosic acid
4 Crocetin
4 Vitamin C (Ascorbic Acid)
4 Piperlongumine
4 Pterostilbene
4 Rosmarinic acid
3 Cisplatin
3 Artemisinin
3 Radiotherapy/Radiation
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Capsaicin
3 Celastrol
2 Silver-NanoParticles
2 Selenite (Sodium)
2 Allicin (mainly Garlic)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Cinnamon
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Emodin
2 Geraniol
2 Vitamin K2
1 1,8-Cineole
1 5-Aminolevulinic acid
1 chemodynamic therapy
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 xanthohumol
1 Brucea javanica
1 brusatol
1 Bromelain
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 methotrexate
1 Cucurbitacin
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Dipyridamole
1 Dandelion Root
1 Disulfiram
1 Eugenol
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 HydroxyCitric Acid
1 Juglone
1 Melatonin
1 Metformin
1 Magnetic Fields
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Oleuropein
1 Propyl gallate
1 Piperine
1 salinomycin
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Sesame seeds and Oil
1 Spermidine
1 erastin
1 Taurine
1 5-fluorouracil
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:597  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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