HO-1 Cancer Research Results

HO-1, HMOX1: Click to Expand ⟱

Source:

Type:

(Also known as Hsp32 and HMOX1)
HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene.
HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer.
-widely regarded as having antioxidant and cytoprotective effects
-The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage

Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by:
Reducing oxidative stress and inflammation
Promoting angiogenesis (the formation of new blood vessels)
Inhibiting apoptosis (programmed cell death)
Enhancing cell migration and invasion
When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions.

A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1.

-Curcumin Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects.
-Resveratrol Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties.
-Quercetin Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses.
-EGCG Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties.
-Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes.
-Luteolin Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models.
-Apigenin Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities.

Scientific Papers found: Click to Expand⟱

2775-

Bos,

The journey of boswellic acids from synthesis to pharmacological activities

Review,

Var,

Review,

AD,

Review,

PSA,

ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,

2772-

Bos,

Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties

Review,

AD,

*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,

1425-

Bos,

Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway

in-vivo,

Nor,

*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,

7944-

BuckWS,

Extracts from Tartary Buckwheat Sprouts Restricts Oxidative Injury Induced by Hydrogen Peroxide in HepG2 by Upregulating the Redox System

in-vitro,

Nor,

HepG2

*ROS↓, *MMP↑, *TAC↑, *SOD↑, *Catalase↑, *GSTA1↑, *NRF2↑, *NQO1↑, *HO-1↑,

4263-

CA,

Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action

Review,

AD,

*neuroP↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,

4264-

CA,

HO-1_Pathway">Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway

in-vivo,

AD,

OVX mice

*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,

7516-

CA,

Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment

in-vivo,

AD,

50 mg/kg/day for two weeks

mice

*neuroP↑, *antiOx↑, *memory↑, *Learn↑, *cognitive↑, *ROS↓, *lipid-P↓, *NRF2↑, *HO-1↑, *Aβ↓, *BACE/β-secretase↓,

5864-

CA,

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

vitro+vivo,

Stroke,

PC12

Male C57BL/6 mice, aged 6–8 week

*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,

5871-

CA,

Carnosic Acid Attenuates an Early Increase in ROS Levels during Adipocyte Differentiation by Suppressing Translation of Nox4 and Inducing Translation of Antioxidant Enzymes

in-vitro,

Nor,

*ROS↓, *NF-kB↓, *Nrf1↑, *HO-1↑, *GSTs↑,

5859-

CAP,

Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?

Review,

Var,

*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,

5847-

CAP,

An updated review on molecular mechanisms underlying the anticancer effects of capsaicin

in-vitro,

Liver,

HepG2

HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,

2394-

CAP,

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

in-vitro,

Nor,

GES-1

(0, 2, and 8 μM)

*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,

5766-

CAPE,

A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model

in-vivo,

Nor,

rat

*MDA↓, *NF-kB↓, *p65↓, *TNF-α↓, *cl‑Casp3↓, *GSR↑, *GSH↑, *NRF2↑, *HO-1↑, *Bax:Bcl2↓, *antiOx↑, *Inflam↓,

5757-

CAPE,

Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application

Review,

Nor,

*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2/PTGS2↓, 5LO↓,

7520-

CAPE,

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway

in-vivo,

AD,

gainst the neurotoxicity of Aβ1-42 oligomers (AβO) in mice

*ROS↓, *NRF2↑, *HO-1↑, *Apoptosis↓, *Inflam↓, *Learn↑, *memory↑, *cognitive↑, *neuroP↑, *p‑GSK‐3β↓, GFAP↓,

5900-

CAR,

TV,

Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol

Review,

Nor,

*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,

6254-

CBC/D,

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

Review,

Var,

*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,

2392-

Cela,

The role of natural products targeting macrophage polarization in sepsis-induced lung injury

Review,

Sepsis,

TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,

5939-

Cela,

Chemo,

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

in-vitro,

Melanoma,

U266

in-vitro,

Melanoma,

RPMI-8226

TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,

5948-

Cela,

Recent Trends in anti-tumor mechanisms and molecular targets of celastrol

Review,

Var,

TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,

6638-

Cen,

Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice

in-vivo,

AD,

5xFAD mice

*memory↑, *Aβ↓, *NRF2↑, *toxicity↓, *neuroP↑, *ROS↓, *mtDam↓, *cognitive↑, NQO1↑, HO-1↑,

6650-

Cen,

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Review,

AD,

*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,

6018-

CGA,

Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems

Review,

Var,

Review,

RCC,

*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,

6017-

CGA,

Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment

Review,

Var,

AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,

6002-

CGA,

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Review,

Var,

Review,

Diabetic,

Review,

AD,

Review,

Park,

Review,

Stroke,

*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,

6013-

CGA,

Advances in Pharmacological Properties, Molecular Mechanisms, and Bioavailability Strategies of Chlorogenic Acid in Cardiovascular Diseases Therapy

Review,

CardioV,

*BioAv↝, *BioAv↝, *BP↓, *ROS↓, *NADPH↓, *AntiAg↑, *TXA2↓, *antiOx↑, *cardioP↑, *Inflam↓, *SOD↑, *Catalase↑, *Ferroptosis↓, *NF-kB↓, *JNK↓, *NRF2↑, *HO-1↑, *toxicity↓, *BioAv↓, *BioAv↑, *BioAv↑, Synergy↑,

6007-

CGA,

A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer

Review,

CRC,

antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,

6010-

CGA,

The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review

Review,

Nor,

*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,

7171-

CHA,

Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201

vitro+vivo,

GBM,

DIPG

 DIPG xenograft models

TumCG↓, TumCP↓, Apoptosis↓, OS↑, H3K9↓, SUV39H↓, Synergy↑, CSCs↓, SOX9↓, HGF/c-Met↓, FGF21↓, EGFR↓, PDGFR-BB↓, Wnt↓, MYCN↑, OLIG2↓, AURKB↓, HO-1↑, P21↑,

6128-

CHr,

Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential

Review,

Nor,

Review,

Var,

Review,

AD,

*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,

2590-

CHr,

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

in-vitro,

GBM,

T98G

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,

2591-

CHr,

doxoR,

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

in-vitro,

HCC,

Bel-7402

NRF2↓, ChemoSen↑, HO-1↓,

2807-

CHr,

Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats

in-vivo,

Nor,

Wistar rats

*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,

2785-

CHr,

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Review,

Var,

*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,

2794-

CHr,

An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

Review,

Park,

Review,

Stroke,

*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,

6623-

Cic,

MTX,

Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling

in-vivo,

Nor,

rats

*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,

6632-

Cic,

Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain

vitro+vivo,

Nor,

 effects of CA on lipopolysaccharide (LPS)-stimulated oxidative stress in BV-2 microglia and C57BL/6J mice

*antiOx↑, *Obesity↓, *NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *ATP↑, *COX2/PTGS2↓, *iNOS↓, *neuroP↑,

6144-

Cin,

The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells

in-vitro,

Colon,

HCT116

Nrf1↑, HO-1↑, chemoPv↑,

6315-

Cro,

Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress

in-vivo,

Nor,

Twenty male mice

*cardioP↑, *Inflam↓, *antiOx↑, *ROS↓, *AntiCan↑, *memory↑, *NF-kB↓, *TLR1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *DNAdam↓, PTEN↓, MMP↓,

6300-

Cro,

Interaction of saffron and its constituents with Nrf2 signaling pathway: A review

Review,

Nor,

Review,

Arthritis,

*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,

6299-

Cro,

Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats

in-vivo,

Nor,

Rats were pretreated with 25 or 50 mg/kg crocetin 6 h prior to treating with 5 mg/kg ATO to induce hepatic injury daily for 7 days.

*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,

6297-

Cro,

Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway

in-vitro,

Nor,

RAW264.7

*NO↓, *iNOS↓, *Inflam↓, *MEK↓, JNK↓, NF-kB↓, NRF2↑, HO-1↑, hepatoP↑, neuroP↑,

1571-

Cu,

Copper in cancer: From pathogenesis to therapy

Review,

Var,

*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1/ATG6↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,

6185-

Cuc,

Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics

Review,

Var,

Review,

Arthritis,

Review,

AD,

*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,

2688-

CUR,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Review,

Var,

Review,

AD,

*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, Synergy↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,

2819-

CUR,

Chemo,

Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury

Review,

Var,

*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2/PTGS2↑, *NF-kB↓, *ICAM-1↓, *MCP1/CCL2↓, *HO-1↑, CXCc↓,

2821-

CUR,

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Review,

Var,

*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,

3794-

CUR,

Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities

Review,

AD,

*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,

3795-

CUR,

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Review,

AD,

*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,

3576-

CUR,

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease

Review,

AD,

*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,

Showing Research Papers: 51 to 100 of 366
Prev Page 2 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 366

Pathway results for Effect on Cancer / Diseased Cells:

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,
Total Targets: 716

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

NA↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 119, ARE↓, 1, ARE↑, 8, Bil↑, 2, Catalase↑, 81, DUOX1↓, 1, Fenton↓, 3, GCLC↑, 5, GCLC↝, 1, GCLM↑, 4, GCLM↝, 1, GPx↓, 1, GPx↑, 54, GPx1↑, 1, GPx4↓, 2, GPx4↑, 6, GPx4∅, 1, GSH↓, 2, GSH↑, 90, GSH/GSSG↑, 1, GSR↓, 1, GSR↑, 9, GSS↑, 1, GSSG↓, 1, GSTs↓, 2, GSTs↑, 14, H2O2↓, 5, H2O2↑, 1, HDL↓, 1, HDL↑, 1, HNE↓, 2, HNE↑, 1, HO-1?, 2, HO-1↓, 9, HO-1↑, 237, HO-1⇅, 1, HO-1↝, 1, HO-1∅, 1, HO-2↓, 1, hyperG↝, 1, Iron↓, 3, Iron↝, 1, i-Iron↓, 1, Keap1↓, 12, Keap1↑, 1, Keap1↝, 2, lipid-P↓, 56, lipid-P↑, 3, mt-lipid-P↓, 1, MDA↓, 84, MDA↑, 1, MPO↓, 12, MPO↑, 1, NOX↓, 2, NOX1↓, 1, NOX2↓, 2, NOX4↓, 7, NQO1↑, 47, NQO1↝, 2, Nrf1↑, 3, NRF2↓, 7, NRF2↑, 216, NRF2∅, 1, p‑NRF2↑, 1, ONOO↓, 1, Prx↑, 4, RNS↓, 2, ROS?, 1, ROS↓, 201, ROS↑, 4, ROS⇅, 2, ROS∅, 1, mt-ROS?, 1, mt-ROS↓, 2, SOD↓, 2, SOD↑, 120, SOD1↑, 7, SOD2↑, 5, TAC↑, 13, TBARS↓, 4, Thiols↑, 1, TOS↓, 1, Trx↑, 3, Trx1↑, 6, TrxR↑, 2, TrxR1↑, 1, UCPs↑, 1, uricA↓, 1, VitC↑, 5, VitE↓, 1, VitE↑, 4, xCT/SLC7A11↓, 1, xCT/SLC7A11↑, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1, FTH1↓, 1, FTH1↑, 1, IronCh↑, 10, Mets↝, 1, NCOA4↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1, compII↑, 1, compIII↑, 1, DRP1/DNM1L↓, 1, Insulin↑, 1, MFN2↑, 1, mitResp↑, 1, mtDam↓, 9, mtDam↑, 1, NGB↑, 1, OCR↑, 1, PDH↑, 1, PGC-1α↓, 1, PGC-1α↑, 5, PGC-1α↝, 2, PINK1↓, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 3MST/MPST↑, 1, 5LO↓, 3, ACC↓, 1, ACSL4↓, 1, ACSL4∅, 1, ALAT↓, 18, AMPK↑, 17, p‑AMPK↑, 1, ATP↑, 10, Buty↑, 1, cAMP↑, 1, CBS↑, 1, CRM↑, 2, cytoP450↓, 1, FABP4↓, 1, FASN↓, 1, G6PD↑, 1, GAPDH↑, 1, glucose↓, 5, glucose↝, 1, GlucoseCon↑, 6, GlutMet↑, 1, Glycolysis↑, 3, GSK‐3β↓, 16, GSK‐3β↑, 3, p‑GSK‐3β↓, 1, p‑GSK‐3β↑, 4, H2S↑, 2, HK1↑, 1, HK2↑, 1, HMG-CoA↓, 1, LDHA↓, 1, LDL↓, 6, NAD↑, 1, NADH:NAD↑, 1, NADPH↓, 9, NADPH↑, 10, PDKs↓, 1, PFK↓, 1, PFK↑, 1, PKM2↓, 2, PKM2↑, 1, SCFAs↑, 1, SIRT1↓, 1, SIRT1↑, 25, SREBF2⇅, 1, SREBP1/SREBF1↓, 3,

Cell Death(tgid=5) ⓘ

AIF↓, 2, Apoptosis↓, 31, ASC?, 1, ASC↓, 1, ASK1↓, 1, BAX↓, 15, BAX↑, 2, Bax:Bcl2↓, 7, Bcl-2↓, 1, Bcl-2↑, 17, Bcl-xL↑, 1, BNIP3↓, 1, Casp↓, 2, Casp1↓, 4, proCasp1↓, 1, Casp12↓, 2, Casp3?, 1, Casp3↓, 27, Casp3↑, 1, Casp3∅, 1, cl‑Casp3↓, 5, cl‑Casp8↓, 1, cl‑Casp8↑, 1, Casp9↓, 7, Casp9↑, 1, Casp9∅, 1, Cyt‑c↓, 5, Cyt‑c∅, 3, Fas↓, 1, Ferroptosis↓, 12, Ferroptosis↑, 1, GranB/GZMB↓, 1, IAP1↓, 1, iNOS↓, 39, iNOS↑, 2, necrosis↓, 2, p38↓, 5, p‑p38↓, 3, Pyro?, 1, Pyro↓, 1, RIP1↓, 1, survivin↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6, Akt↑, 19, p‑Akt↓, 1, p‑Akt↑, 4, e-Akt↑, 1, AMPKα↑, 2, CREB↑, 4, p‑CREB↑, 2, ERK↓, 10, ERK↑, 9, p‑ERK↓, 2, p‑ERK↑, 3, e-ERK↑, 1, HGF/c-Met↑, 1, IKKα↓, 2, IKKα↑, 1, p‑IKKα↓, 1, IκB?, 1, IκB↓, 1, IκB↑, 2, JAK↓, 1, JAK2↓, 1, JAK2↑, 1, JNK↓, 8, p‑JNK↓, 5, p‑JNK↑, 1, LPAR1/EDG2↑, 1, MAPK?, 1, MAPK↓, 23, p‑MAPK?, 1, p‑MAPK↓, 2, MEK↓, 1, mTOR↓, 5, mTOR↑, 1, p‑mTOR↓, 2, PDGFR-BB↓, 1, PDGFRB↓, 1, PI3K↓, 3, PI3K↑, 14, p‑PI3K↑, 1, PKA↑, 2, PKCδ↓, 2, PKCδ↑, 1, PP2A↑, 2, PTEN↓, 1, STAT↓, 1, STAT3↓, 6, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF2↑, 1, ATF4↓, 3, ATF4↑, 1, cJun↓, 1, p‑cJun↓, 2, p‑cMyc↑, 1, DNMT1↓, 1, DNMT3A↓, 1, DNMTs↓, 1, FOXO↑, 1, FOXO3↑, 2, HDAC↓, 2, HDAC↑, 1, miR-34a↓, 1, other?, 1, other↓, 3, other↑, 6, other↝, 5, SOX2↑, 1, tumCV↓, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 8, CHOP/DDIT3↑, 1, p‑eIF2α↓, 1, ER Stress↓, 7, GRP78/BiP↓, 5, GRP78/BiP↑, 3, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 5, HSP70/HSPA5↝, 1, HSPs↑, 1, HSPs↝, 1, PERK↓, 1, UPR↑, 1, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↓, 1, autophagy↓, 1, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3B↓, 1, LC3II↓, 1, LC3II↑, 1, MitoP↑, 1, p62↓, 1, p62↑, 2, PARK2↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10, PARP↓, 1, PARP∅, 1, PARP1↓, 1, SIRT6↑, 1, Telomerase↓, 1, TOP1↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2, Ki-67↓, 1, Ki-67↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1, cFos↓, 1, Choline↑, 1, Diff↑, 1, Diff↝, 1, FGF↑, 1, HH↓, 1, IGF-1↓, 1, IGF-1↑, 1, Ki-67↓, 1, Ki-67↑, 1, Nestin↑, 1, neuroG↑, 3, NOTCH1↑, 1, p300↓, 1, TumCP↓, 2, Wnt↑, 1,

Migration(tgid=13) ⓘ

AntiAg↓, 2, AntiAg↑, 6, AP-1↓, 3, mt-ATPase↑, 1, Ca+2↓, 9, Ca+2↑, 1, i-Ca+2↓, 1, Cartilage↑, 1, COL1↓, 1, EMT↑, 1, Fibrosis↓, 1, heparanase↑, 1, LRP1↑, 1, MMP1↓, 1, MMP2↓, 2, MMP2↑, 2, MMP3↓, 1, MMP7↓, 1, MMP9↓, 8, MMP9↑, 1, MUC1↑, 1, Na+↑, 1, p‑Rac1↓, 1, Rho↓, 1, ROCK1↓, 1, TGF-β↓, 5, TGF-β↑, 2, TGF-β1↓, 2, TGF-β1↑, 1, TIMP1↓, 1, TumCI↓, 1, TumCMig↓, 1, TXNIP↓, 3, uPA↑, 1, α-SMA↓, 2, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2, angioG↑, 1, E-sel↓, 3, Endoglin↑, 1, eNOS↑, 1, p‑eNOS↑, 2, Hif1a↓, 2, Hif1a↑, 2, LOX1↓, 1, NO↓, 24, NO↑, 2, TXA2↓, 1, VCAM-1↓, 10, VEGF↓, 4, VEGF↑, 4,

Barriers & Transport(tgid=15) ⓘ

BBB?, 1, BBB↓, 1, BBB↑, 23, BBB↝, 1, GLUT2↑, 2, GLUT3↑, 4, GLUT4↑, 6, H+/K+-ATPase↓, 1, IBI↑, 4, memfluid↑, 1, MMP↓, 3, MMP↑, 15, Na+↑, 1, NHE3↑, 1, OCLN↑, 1, TJ↑, 1, TRPA1↑, 1, TRPC1↓, 1, TRPV1↑, 1, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1, CB2 / CNR2↑, 2, CD25+↑, 1, CD4+↑, 2, COX1↓, 2, COX2/PTGS2↓, 54, COX2/PTGS2↑, 2, CXCc↓, 1, FOXP3↑, 2, HMGB1↓, 5, ICAM-1↓, 10, IFN-γ↓, 8, IFN-γ↑, 1, IL1↓, 2, IL10↓, 7, IL10↑, 13, IL12↓, 3, IL17↓, 7, IL18↓, 4, IL1β↓, 75, IL2↓, 5, IL22↓, 1, IL23↓, 3, IL33↓, 2, IL4↓, 3, IL4↑, 5, IL6↓, 73, IL6↑, 3, IL8↓, 9, Imm↑, 4, Imm↝, 1, Inflam?, 2, Inflam↓, 145, Inflam↑, 2, LPS↓, 1, M2 MC↑, 1, pol-M2 MC↑, 1, MCP1/CCL2↓, 8, MCP1/CCL2↑, 1, MIP‑1α/CCL3↓, 1, MIP2↓, 2, MyD88↓, 2, NeuroI↓, 3, NF-kB↓, 97, NF-kB↑, 3, NLRP3↓, 29, NLRP3↑, 1, NOD1↓, 1, p65↓, 5, PGE2↓, 16, RAGE↓, 3, RANTES↓, 1, TLR1↓, 1, TLR2↓, 2, TLR3↓, 1, TLR4↓, 19, TLR4↑, 1, TLR4∅, 1, TNF-α↓, 98, TNF-α↑, 1, TRAF6↓, 1, Treg lymp↝, 1, TRIF↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 6, Ach↑, 4, AChE↓, 34, AChE∅, 1, BChE↓, 7, BChE∅, 1, BDNF↑, 30, BrainVol↑, 1, ChAT↑, 6, ChE↓, 1, GABA↑, 2, GDNF↑, 1, MAOA↓, 4, MAOB↓, 2, NGF↑, 5, PSD95↑, 4, SYP↑, 1, TPH1↓, 1, TrkB↑, 5,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, APP↓, 5, Aβ↓, 41, BACE/β-secretase↓, 15, tau↓, 11, p‑tau↓, 11, XO↓, 1, β-Amyloid↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, AKR1C3/17β-HSD5/PGF Synthase↑, 1, END↑, 1, ER(estro)↑, 1, FGF21↑, 1, GLP-1R↑, 1, GR↑, 2, NR1H4↑, 1, PPARα↑, 4, PPARα↝, 1, PPARγ↓, 2, PPARγ↑, 14, p‑PPARγ↓, 1, RAAS↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1, AKR1B10↝, 1, BioAv↓, 28, BioAv↑, 36, BioAv↝, 21, ChemoSen↑, 3, CompStab↑, 1, CYP2D6↓, 1, Dose?, 1, Dose↓, 1, Dose↑, 3, Dose↝, 21, eff↓, 2, eff↑, 22, eff↝, 1, GSTA1↓, 1, GSTA1↑, 4, Half-Life↓, 5, Half-Life↑, 3, Half-Life↝, 9, MRP↓, 1, P-gp/ABCB1↓, 1, P450↑, 2, selectivity↑, 2, Synergy↑, 16,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 18, ALB↑, 1, ALP↓, 3, AST↓, 19, BG↓, 1, Bil↑, 2, BloodF↑, 2, BMD↑, 2, BP↓, 6, BUN?, 1, BUN↓, 4, creat↓, 8, CRP↓, 5, Ferritin↑, 1, IL6↓, 73, IL6↑, 3, IRes↝, 1, LDH↓, 6, LDH↑, 3, NOS2↓, 4, RAGE↓, 3, SpO2↑, 1, TMAO↓, 1, Urea↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 9, antiAll↑, 10, AntiArt↑, 3, AntiCan↑, 11, antiCG↑, 2, AntiDiabetic↑, 12, antiPs↑, 2, AntiTum↑, 5, ANXi↓, 1, cardioP?, 2, cardioP↑, 45, CardioT↓, 2, chemoP↑, 13, chemoPv↑, 2, cognitive↓, 1, cognitive↑, 47, diuretic↑, 2, fatigue↓, 1, GFR↑, 1, hepatoP↓, 2, hepatoP↑, 45, Learn↑, 6, memory↑, 51, Mood↑, 1, motorD↓, 1, motorD↑, 5, neuroP↑, 115, NP/CIPN↓, 2, Obesity↓, 9, OS↑, 5, Pain↓, 4, QoL↑, 1, radioP↑, 7, RenoP↑, 25, Risk↓, 1, Risk↑, 1, Sleep↑, 1, Strength↑, 3, Stress↓, 1, Stroke↓, 11, toxicity↓, 18, toxicity↑, 2, toxicity↝, 4, toxicity∅, 3, Weight↓, 1, Weight↑, 1, Weight∅, 1, Wound Healing↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4, AntiFungal↑, 5, AntiViral↑, 7, Bacteria↓, 10, Diar↓, 3, GutMicro↑, 21, Sepsis↓, 7,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,
Total Targets: 619

Scientific Paper Hit Count for: HO-1, HMOX1

17 Curcumin
16 Luteolin
15 Resveratrol
15 Sulforaphane (mainly Broccoli)
15 Thymoquinone
11 Quercetin
9 Chemotherapy
9 Hydrogen Gas
9 Silymarin (Milk Thistle) silibinin
9 Shikonin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Ferulic acid
7 isoorientin
7 Lycopene
6 Cisplatin
6 Baicalein
6 Chlorogenic acid
6 Chrysin
6 Honokiol
6 Isoliquiritigenin
6 Morin
5 Alpha-Lipoic-Acid
5 diet FMD Fasting Mimicking Diet
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
5 Propolis -bee glue
4 doxorubicin
4 Berberine
4 Beta-Caryophyllene
4 Betulinic acid
4 Carnosic acid
4 Crocetin
4 Vitamin C (Ascorbic Acid)
4 Emodin
4 Piperlongumine
4 Pterostilbene
4 Rosmarinic acid
3 Artemisinin
3 Radiotherapy/Radiation
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Celastrol
3 isoquercitrin
3 Isovitexin
3 Kaempferol
3 Matrine
3 Vitexin
2 Silver-NanoParticles
2 Selenite (Sodium)
2 Allicin (mainly Garlic)
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Gallic acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Licochalcone A
2 SDG/lignans
2 Linalool
2 Melatonin
2 5-fluorouracil
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Vitamin K2
1 1,8-Cineole
1 5-Aminolevulinic acid
1 chemodynamic therapy
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 xanthohumol
1 Brucea javanica
1 brusatol
1 Bromelain
1 buckwheat sprouts
1 Caffeic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Cucurbitacin
1 Cynaropicrin
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 Dipyridamole
1 Dandelion Root
1 Disulfiram
1 Eugenol
1 Formononetin
1 Fucoidan
1 Ginkgo biloba
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 Juglone
1 Lactobacillus
1 lambertianic acid
1 Licorice
1 Lutein
1 Metformin
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Propyl gallate
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Piperine
1 Polyphenols
1 salinomycin
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Sesame seeds and Oil
1 Spermidine
1 erastin
1 Taurine
1 Urolithin
1 Vanillic Acid
1 Mung Bean Sprouts

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:597  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

HO-1 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

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