EPR Cancer Research Results

EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱
Source:
Type:
Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.
Scientific Papers found: Click to Expand⟱
6491- Nimb,    Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells
- Review, PC, NA
eff↑, uPA↓, uPAR↓, p‑EGFR↓, VEGFR1↓, NF-kB↓, IKKα↓, MMP2↓, MMP9↓, TIMP2↑, TumCP↓, IGFR↓, Akt↓, ERK↓, TumCCA↓, BAX↑, BAD↑, FasL⇅, Cyt‑c↑, EPR↑,
992- PL,    Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1
- in-vivo, BC, NA
EPR↓, Glycolysis↓, GAPDH↓, GSTP1/GSTπ↝, FBPase↑,
4472- SeNPs,    Therapeutic potential of selenium nanoparticles
- Review, Var, NA
*ROS↓, *BioAv↑, *antiOx↑, toxicity↓, eff↑, *other↝, EPR↑, selectivity↑, eff↑, RadioS↑, eff↑, *Bacteria↓,

Showing Research Papers: 51 to 53 of 53
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 53

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 3,   GPx4↓, 1,   GSH↓, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 3,   ROS↑, 26,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↝, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Alanine↓, 1,   ATP↓, 1,   FBPase↑, 1,   GAPDH↓, 1,   Glycine↓, 1,   Glycolysis↓, 2,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 15,   mt-Apoptosis↑, 1,   BAD↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Casp↑, 4,   Casp1↓, 1,   Casp3↑, 6,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 4,   Cyt‑c↑, 5,   Fas↑, 1,   FasL⇅, 1,   Ferroptosis↑, 1,   MOMP↑, 1,   p‑p38↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   p‑EGFR↓, 2,   ERK↓, 1,   p‑ERK↓, 1,   IGFR↓, 1,   IKKα↓, 1,   MAPK↓, 1,   MAPK↑, 2,   PI3K↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXM1↓, 1,   other↑, 3,   other↝, 7,   SOX2↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 4,   HSP70/HSPA5↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 11,   DNArepair↓, 3,   P53↑, 2,   P53↝, 1,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   Ki-67↓, 2,   P21↑, 2,   p27/CDKN1B↑, 1,   TumCCA↓, 1,   TumCCA↑, 12,   TumCCA⇅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs↓, 1,   CSCsMark↓, 1,   Diff↑, 1,   Ki-67↓, 2,   NOTCH↓, 1,   TumCG↓, 9,   TumCP↓, 8,   TumCP↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   EMT↓, 1,   p‑FAK↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MMP9↑, 1,   MMPs↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumMeta↓, 8,   TumMeta↑, 1,   uPA↓, 1,   uPAR↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   Hif1a↓, 1,   Hif1a↑, 1,   Hypoxia↓, 2,   VEGF↓, 5,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   EPR↓, 2,   EPR↑, 45,   EPR↝, 2,   GLUT1↓, 1,   MMP↓, 3,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD44↓, 2,   HMGB1↓, 1,   IL1↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↑, 1,   Imm↑, 3,   Inflam↓, 1,   NF-kB↓, 3,   NK cell↑, 1,   NLRP3↑, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 10,   BioEnh↑, 3,   ChemoSen↑, 22,   CompStab↑, 1,   DDS↑, 3,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 13,   Dose∅, 1,   eff↓, 2,   eff↑, 40,   eff↝, 1,   GSTP1/GSTπ↝, 1,   Half-Life↓, 1,   Half-Life↑, 4,   Half-Life∅, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   RadioS↑, 6,   selectivity↑, 10,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 2,   p‑EGFR↓, 2,   FOXM1↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   antiNeop↑, 1,   AntiTum↑, 4,   chemoP↑, 2,   LC↑, 2,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 5,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 1,   GutMicro↝, 1,  
Total Targets: 176

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 3,   other↝, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   EPR↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Imm↑, 2,   Inflam↓, 4,   NF-kB↓, 1,   NLRP3↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioEnh↑, 1,   CompStab↑, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   Bone Healing↑, 1,   cardioP↑, 1,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 5,  
Total Targets: 45

Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect
11 Silver-NanoParticles
9 chitosan
5 doxorubicin
4 borneol
3 Ascorbyl Palmitate
3 Gold NanoParticles
3 Hyperthermia
3 Linalool
2 chemodynamic therapy
2 Gemcitabine (Gemzar)
2 Curcumin
2 Selenium NanoParticles
2 Electrical Pulses
2 Radiotherapy/Radiation
2 Magnetic Fields
2 Magnetic Field Rotating
2 Morin
1 Photodynamic Therapy
1 EMF
1 Artemisinin
1 Paclitaxel/Taxol
1 Berbamine
1 Beta-Caryophyllene
1 Capsaicin
1 urea
1 Folic Acid, Vit B9
1 Cucurbitacin
1 Diindolylmethane
1 Ormeloxifene (Centchroman)
1 EGCG (Epigallocatechin Gallate)
1 Geraniol
1 5-fluorouracil
1 iodine
1 Extracorporeal Shock Wave Therapy
1 mebendazole
1 Nimbolide
1 Piperlongumine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:612  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page