mtDam Cancer Research Results

mtDam, mitochondrial damage: Click to Expand ⟱
Source:
Type:
Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.
Scientific Papers found: Click to Expand⟱
6126- CHr,    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
- in-vitro, Melanoma, NA
tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,
6624- Cic,    Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *TNF-α↓, *IL1β↓, *MDA↓, *Catalase↑, *GSH↑, *NRF2↑, *mtDam↓, *Inflam↓, *Apoptosis↓, *ROS↓, *cognitive↑, *Aβ↓, *BDNF∅, *APP↓, *BACE/β-secretase↓,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, Var, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, Synergy↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
404- CUR,    Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1/ATG6↑, LC3s↑, p62↓, Ferroptosis↑,
481- CUR,  CHr,  Api,    Flavonoid-induced glutathione depletion: Potential implications for cancer treatment
- in-vitro, Liver, A549 - in-vitro, Pca, PC3 - in-vitro, AML, HL-60
GSH↓, mtDam↑, MMP↓, Cyt‑c↑,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,
6416- CUR,  QC,  FA,  RES,  EGCG  Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders
- Review, AD, NA
*DRP1/DNM1L↓, *FIS1↓, *MFN2↑, *OPA1↑, *DRP1/DNM1L↓, *FIS1↓, *OPA1↑, *MFN1↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *MFN1↑, *MFN2↑, *memory↑, *mtDam↓, *DRP1/DNM1L↓, *FIS1↓,
6408- CUR,    Protective Effects of a Natural Product, Curcumin, against Amyloid β Induced Mitochondrial and Synaptic Toxicities in Alzheimer'S Disease
- in-vitro, AD, SH-SY5Y
*mtDam↓, *eff↓, *eff↑, *FIS1↓, *lipid-P↓, *ATP↑,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
6249- Cyc,    Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
HH↓, OCR↓, TumCP↓, Apoptosis↑, ROS↑, MMP↑, mtDam↑,
7439- CYN,    Cynaropicrin Induces Reactive Oxygen Species-Dependent Paraptosis-Like Cell Death in Human Liver Cancer Cells
- in-vitro, Liver, Hep3B
tumCV↓, mtDam↑, ER Stress↑, i-Ca+2↑, ROS↑, Alix/AIP‑1↓, eff↓,
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6689- DFC,    Diclofenac-Induced Apoptosis in the Neuroblastoma Cell Line SH-SY5Y: Possible Involvement of the Mitochondrial Superoxide Dismutase
- in-vitro, neuroblastoma, SH-SY5Y
Apoptosis↑, mtDam↑, ROS↑, SOD2↓, MMP↓, Cyt‑c↑, Dose↝, BBB↑,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, Synergy↑, Synergy↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
6719- DHCA,    Anticancer potential of dihydrocaffeic acid: a chlorogenic acid metabolite
- in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116 - in-vitro, Nor, HDFa
*antiOx↑, *cardioP↑, *neuroP↑, selectivity↑, selectivity↓, TumCCA↑, ROS↑, mtDam↑,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
6290- DL,    Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells
- in-vitro, AML, K562 - in-vitro, AML, HL-60
BAX↑, Cyt‑c↑, Casp9↑, cl‑Casp3↑, mtDam↑, Apoptosis↑,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
3241- EGCG,    Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, ChemoSen↑,
643- EGCG,    New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
- Analysis, Var, NA
H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2/KDR/Flk1↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,
668- EGCG,    The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
- Review, BC, MCF7 - Review, BC, MDA-MB-231
HER2/EBBR2↓, EGFR↓, mtDam↑, ROS↑, PI3K/Akt↓, P53↑, P21↑, Casp3↑, Casp9↑, BAX↑, PTEN↑, Bcl-2↓, hTERT/TERT↓, STAT3↓, TumCCA↑, Hif1a↓,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
5527- EP,    Nanosecond pulsed electric field (nsPEF) application effects on human cells: intracellular membrane disruption and apoptosis induction
- in-vivo, Var, NA
*Dose↓, Apoptosis↑, DNAdam↑, mtDam↑,
5495- EP,    Irreversible electroporation in focal therapy for prostate cancer: current status and future directions
- Review, Pca, NA
Ca+2↑, ATP↓, mtDam↑, ROS↑, CellMemb↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6427- FEO,    Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma
- vitro+vivo, HCC, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCG↓, survivin↓, mtDam↑, Casp3↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6983- Form,    Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation
- vitro+vivo, Nor, HUVECs - vitro+vivo, Diabetic, NA
*BloodF↑, *Ferroptosis↓, *eff↓, *mtDam↓, *xCT/SLC7A11↑, *GPx4↑, *Wound Healing↑, *CD31/PECAM-1↑, *mt-ROS↓,
6973- Form,    Formononetin enhances the chemosensitivity of triple negative breast cancer via BTB domain and CNC homolog 1-mediated mitophagy pathways
- Human, BC, NA
TumMeta↓, OS↑, TumCP↓, mtDam↑, Apoptosis↑, BACH1↑, eff↓, ChemoSen↑,
8596- FSO,    Treatment with flaxseed oil induces apoptosis in cultured malignant cells
- in-vitro, BC, MCF7 - in-vitro, Melanoma, B16-BL6
TumCG↓, selectivity↑, Apoptosis↑, DNAdam↑, Casp↑, mtDam↑, cl‑PARP↑, MMP↓,
7007- Fuc,    The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
- Review, Var, NA
TumCCA↑, Apoptosis↑, NK cell↑, chemoP↑, TumCG↓, *Inflam↓, *antiOx↑, *AntiThr↑, *AntiViral↑, angioG↓, ChemoSen↑, ROS↑, GSH↓, mtDam↓, MMP↓, DNMT3B↓, TumCG↓, Dose↝, Dose↝, QoL∅, fatigue∅, Dose↝,
7043- GA,    Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase
- in-vitro, Lung, Calu-1 - in-vitro, Lung, A549
TumCG↓, MMP↓, ROS↑, GSH↓, eff↑, eff↓, eff↑, mtDam↑, Ca+2↑,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7315- Gos,    Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- vitro+vivo, CRC, HT29 - in-vitro, CRC, COLO205
TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,
854- Gra,  AgNPs,    Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy
- vitro+vivo, AML, THP1 - in-vitro, AML, AMJ13 - vitro+vivo, lymphoma, HBL
TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,

Showing Research Papers: 51 to 100 of 201
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 201

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   ARE↓, 1,   Catalase↓, 2,   Catalase↑, 2,   Fenton↑, 3,   GPx↓, 4,   GPx↑, 1,   GPx4↓, 5,   GSH↓, 17,   GSH↑, 1,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSSG↑, 1,   H2O2↑, 4,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↑, 4,   Iron↑, 7,   i-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 11,   MDA↓, 1,   MDA↑, 4,   i-MDA↑, 1,   NADPH/NADP+↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 2,   Prx↓, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 6,   ROS↑, 128,   ROS⇅, 1,   ROS∅, 1,   mt-ROS↑, 7,   SOD↓, 5,   SOD↑, 1,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   SFXN2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 6,   compI↓, 4,   compII↓, 2,   compIV↓, 1,   compV↓, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   HTRA2/Omi/PARK13↑, 1,   MFN2↓, 1,   mitResp↓, 4,   mtDam?, 1,   mtDam↓, 3,   mtDam↑, 160,   OCR↓, 5,   OXPHOS↓, 1,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PINK1↑, 4,   SDH↓, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   ALAT↓, 3,   AMP↑, 1,   AMPK↑, 7,   ATP↓, 23,   DHODH↓, 2,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 13,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 2,   HK2↓, 12,   lactateProd↓, 5,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PFKP↓, 2,   PKM2↓, 3,   PKM2↑, 2,   Pyruv↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 86,   mt-Apoptosis↑, 2,   BAD↑, 3,   Bak↑, 2,   BAX↓, 3,   BAX↑, 27,   Bax:Bcl2↑, 8,   Bcl-2↓, 26,   Bcl-xL↓, 7,   BID↑, 2,   cl‑BID↑, 2,   BIM↑, 1,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 1,   Casp↑, 14,   Casp1↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   cl‑Casp12↝, 1,   Casp3↓, 1,   Casp3↑, 44,   cl‑Casp3↑, 12,   proCasp3↓, 1,   Casp6↑, 1,   Casp7↑, 4,   Casp8↑, 8,   cl‑Casp8↑, 1,   Casp9↑, 28,   cl‑Casp9↑, 4,   CellShr↑, 1,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 33,   mt-Cyt‑c↓, 1,   Diablo↑, 2,   DR5↑, 5,   FADD↑, 2,   Fas↓, 1,   Fas↑, 6,   FasL↑, 1,   Ferroptosis↑, 9,   GranB/GZMB↝, 1,   GSDME-N↑, 1,   IAP1↓, 2,   ICD↑, 2,   iNOS↓, 2,   iNOS↑, 1,   Mcl-1↓, 3,   MDM2↓, 3,   MLKL↑, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 3,   NOXA↑, 2,   p38↓, 1,   p38↑, 1,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 5,   TNFR 1↑, 1,   TumCD↑, 13,   XIAP↓, 2,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 28,   Akt↑, 1,   p‑Akt↓, 8,   AKT1↓, 1,   Akt2↓, 1,   CaMKII ↓, 1,   CK2↓, 1,   p‑cMET↑, 1,   EGFR↓, 5,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 1,   p‑ERK↑, 2,   FGFR1↓, 2,   FGFR2↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   Hippo↝, 1,   IGFR↓, 1,   JAK↓, 2,   JAK2↓, 2,   JNK↑, 2,   p‑JNK↑, 2,   MAPK↓, 5,   MAPK↑, 5,   mTOR↓, 15,   p‑mTOR↓, 5,   P70S6K↓, 1,   PDGFR-BB↑, 1,   PI3K↓, 18,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 6,   p‑PTEN↓, 1,   RAS↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 2,   STAT↓, 1,   STAT3↓, 15,   STAT3↑, 1,   p‑STAT3↓, 2,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 5,   p‑ATF4↝, 1,   cJun↓, 1,   cMyc↓, 4,   DNMT3B↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↓, 1,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO4↓, 1,   HDAC↓, 3,   HDAC8↓, 1,   miR-34a↑, 2,   MTA2↓, 1,   Myc↓, 1,   OCT4↓, 4,   other↝, 9,   PAX2↓, 1,   SOX2↓, 3,   SOX4↓, 2,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 27,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 9,   p‑CHOP/DDIT3↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↝, 1,   ER Stress↑, 28,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP90↓, 2,   IRE1↑, 1,   PERK↑, 3,   p‑PERK↝, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 2,   ATG7↑, 2,   autolysosome↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3A↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 5,   LC3s↑, 2,   MitoP↓, 1,   MitoP↑, 4,   p62↓, 3,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 4,   RUBCN↓, 1,   TumAuto↓, 2,   TumAuto↑, 24,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   DNAdam↑, 20,   hTERT/TERT↓, 4,   P53↑, 18,   P53↝, 1,   p‑P53↑, 3,   PARP↓, 2,   PARP↑, 3,   cl‑PARP↑, 15,   PCNA↓, 2,   Telomerase↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TP53↓, 1,   γH2AX↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK2↓, 7,   CDK4↓, 11,   CDK6↓, 4,   CDKN1C/p57↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 13,   cycE/CCNE↓, 3,   GADD45A↑, 1,   Ki-67↓, 5,   P21↓, 2,   P21↑, 12,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   TumCCA↑, 52,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 3,   CD133↓, 1,   CD24↓, 1,   cFos↓, 1,   CSCs↓, 8,   CSCs↑, 1,   Diff↑, 1,   EIF4E↓, 2,   FGF↓, 1,   Gli1↓, 1,   HH↓, 2,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 5,   NOTCH1↓, 1,   PTCH1↓, 1,   Shh↓, 1,   STAT1↓, 2,   TumCG↓, 30,   TumCG↑, 1,   TumCP↓, 43,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 2,   AP-1↓, 2,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 17,   Ca+2↝, 1,   i-Ca+2↑, 2,   cal2↑, 1,   COL1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 11,   EMT↓, 16,   EMT↝, 1,   FAK↓, 2,   p‑FAK↑, 1,   Fibronectin↓, 1,   MMP-10↓, 1,   MMP2↓, 8,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 2,   N-cadherin↓, 7,   PAK1↓, 1,   PDGF↓, 1,   Slug↓, 2,   Smad1↓, 1,   Snail↓, 5,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TSC1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 16,   TumCMig↓, 20,   TumMeta↓, 10,   TumPF↓, 1,   Twist↓, 2,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 8,   Zeb1↓, 4,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   Hif1a↓, 8,   Hif1a↑, 1,   Hypoxia↓, 1,   NO↓, 1,   NO↑, 3,   VCAM-1↓, 2,   VEGF↓, 13,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CellMemb↓, 1,   CellMemb↑, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 53,   MMP↑, 2,   MMP↝, 1,   MPT↓, 1,   MPT↑, 8,   TRPV1↑, 2,   TRPV2↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 2,   cGAS–STING↑, 2,   COX2/PTGS2↓, 11,   CXCR4↓, 1,   DR4↑, 2,   Eos↑, 1,   HCAR2↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IL1↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL4↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 9,   Imm↝, 2,   Inflam↓, 6,   IRAK1↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 21,   NF-kB↑, 2,   NK cell↑, 2,   NLRP3↓, 2,   p65↓, 2,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 2,   PSA↓, 2,   TCF↓, 2,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 3,   TNF-α↓, 5,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 1,   AR↑, 1,   PPARγ↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 1,   AKR1B10↓, 1,   BioAv↓, 8,   BioAv↑, 5,   BioAv↝, 3,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 35,   Dose?, 2,   Dose↑, 1,   Dose↝, 25,   Dose∅, 4,   eff↓, 28,   eff↑, 32,   eff↝, 2,   eff∅, 1,   Half-Life↝, 3,   MDR1↓, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 2,   RadioS↑, 6,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 39,   Synergy?, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AR↓, 1,   AR↑, 1,   AST↓, 3,   EGFR↓, 5,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 9,   LDH↓, 8,   LDH↑, 2,   LDH↝, 1,   Myc↓, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   TP53↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 9,   cachexia↓, 1,   CardioT↑, 1,   chemoP↑, 7,   chemoPv↑, 4,   ChemoSideEff↓, 1,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 6,   QoL∅, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity↑, 3,   toxicity↝, 4,   TumVol↓, 3,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 553

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 20,   ARE↑, 2,   Catalase↑, 13,   GPx↑, 7,   GPx4↑, 3,   GSH↑, 11,   GSH/GSSG↑, 1,   GSS↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 15,   Iron↓, 1,   i-Iron↓, 2,   Keap1↓, 2,   lipid-P↓, 14,   MDA↓, 12,   MPO↓, 3,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 31,   Prx↓, 1,   ROS↓, 47,   ROS↑, 1,   ROS⇅, 2,   ROS↝, 1,   mt-ROS↓, 2,   SOD↑, 18,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 2,   Trx↑, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 5,   DRP1/DNM1L↑, 1,   FIS1↓, 6,   MFN1↓, 1,   MFN1↑, 2,   MFN2↓, 1,   MFN2↑, 4,   mtDam↓, 37,   mtDam↑, 1,   OCR↓, 1,   OPA1↓, 1,   OPA1↑, 2,   PGC-1α↑, 3,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 2,   ALAT↓, 3,   AMPK↑, 7,   ATP↑, 3,   ATP∅, 1,   CRM↑, 2,   glucose↓, 1,   GSK‐3β↓, 4,   LDHA↓, 1,   LDHA↑, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↑, 2,   PKM2↓, 1,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 13,   ASC↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 5,   Casp↓, 1,   cl‑Casp1↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 3,   Casp9↓, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 5,   GSDMD↓, 1,   iNOS↓, 3,   p38↓, 1,   p38↑, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   Akt↝, 1,   CaMKII ↓, 1,   CREB↑, 1,   p‑CREB↑, 1,   JNK↓, 3,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↝, 1,   mTOR↑, 1,   PI3K↑, 1,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   p‑cJun↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 3,   HSP70/HSPA5↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   IGF-1↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2↓, 4,   Ca+2↝, 1,   MMP9↓, 1,   MMPs↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CD31/PECAM-1↑, 1,   p‑eNOS↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 2,   GastroP↑, 1,   MMP↓, 2,   MMP↑, 4,   TJ↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD40↓, 1,   COX2/PTGS2↓, 6,   ICAM-1↓, 1,   IL10↓, 2,   IL10↑, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 7,   IL6↓, 7,   Inflam↓, 30,   IP-10/CXCL-10↓, 1,   NeuroI↓, 4,   NF-kB↓, 11,   NK cell↑, 1,   NLRP3↓, 5,   p65↓, 1,   PGE2↓, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR4↓, 1,   TNF-α↓, 12,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 3,   AChE∅, 1,   BDNF↑, 6,   BDNF∅, 1,   ChAT↑, 1,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 3,   Aβ↓, 8,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   IDE↑, 1,   PSEN1/PS1↓, 1,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   ER(estro)↓, 1,   PPARα↝, 1,   PPARγ↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 5,   BioAv↝, 5,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↓, 1,   Dose↝, 5,   eff↓, 2,   eff↑, 9,   Half-Life↝, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 2,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   BP∅, 1,   BUN↓, 1,   creat↓, 3,   IL6↓, 7,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiArt↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 4,   AntiTum↑, 1,   cardioP↑, 12,   chemoP↑, 2,   cognitive↑, 17,   hepatoP↑, 11,   Learn↑, 4,   memory↑, 15,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 24,   NP/CIPN↓, 1,   Obesity↓, 2,   OS↑, 1,   RenoP↑, 3,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 5,   Stroke↝, 1,   toxicity↓, 15,   toxicity↑, 1,   toxicity↝, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 1,   AntiP↑, 4,   AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 2,  
Total Targets: 241

Scientific Paper Hit Count for: mtDam, mitochondrial damage
14 Silver-NanoParticles
8 Ivermectin
6 Curcumin
6 Licochalcone A
5 Honokiol
5 Isobavachalcone
5 Luteolin
5 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Resveratrol
4 EGCG (Epigallocatechin Gallate)
4 Lycopene
4 Selenite (Sodium)
3 3-bromopyruvate
3 Berberine
3 Betulinic acid
3 Capsaicin
3 Centella asiatica / Gotu kola → asiaticoside
3 Quercetin
3 Dandelion Root
3 Kaempferol
3 SonoDynamic Therapy UltraSound
3 Magnolol
3 Magnetic Fields
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorogenic acid
2 chitosan
2 Chrysin
2 Copper and Cu NanoParticles
2 Ferulic acid
2 Diclofenac
2 Indole-3-carbinol
2 D-limonene
2 Electrical Pulses
2 Formononetin
2 Gallic acid
2 Gossypol/AT-101
2 Hydrogen Gas
2 doxorubicin
2 Hyperthermia
2 HydroxyTyrosol
2 Isoliquiritigenin
2 isoorientin
2 isoquercitrin
2 Linalool
2 Mangiferin
2 Melatonin
2 Phycocyanin
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Astragalus
1 Glucose
1 entinostat
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Radiotherapy/Radiation
1 Beta-Caryophyllene
1 bempedoic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Carvacrol
1 Cannabidiol
1 Celastrol
1 chaetocin
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Cyclopamine
1 Cynaropicrin
1 Docosahexaenoic Acid
1 Dihydrocaffeic Acid
1 Diindolylmethane
1 Docetaxel
1 Disulfiram
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Flaxseed Oil
1 Fucoidan
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hibiscus sabdariffa
1 Hyperoside
1 Inulin Prebiotic
1 Isorhamnetin
1 Lapatinib
1 Cisplatin
1 Methylene blue
1 Matrine
1 Methyl Jasmonate
1 Magnetic Field Rotating
1 Morin
1 Mushroom Maitake
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Nimbolide
1 Pachymic acid
1 Phenylbutyrate
1 Piperlongumine
1 Plumbagin
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Selenium
1 Ursolic acid
1 Urolithin
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:614  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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