TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱

Source:

Type:

Tumor Cell Death

Scientific Papers found: Click to Expand⟱

1847-

dietFMD,

VitC,

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

in-vitro,

PC,

PANC1

vitamin C (≥0.3 mM)

TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,

4915-

DSF,

Cu,

Disulfiram: A novel repurposed drug for cancer therapy

Review,

Var,

ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, eff↑, selectivity↑, Proteasome?,

5008-

DSF,

Cu,

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

in-vitro,

HCC,

selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,

5009-

DSF,

Cu,

Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines

vitro+vivo,

lymphoma,

 (1μM) of Cu2+,

0.435±0.109μM and 0.085±0.015μM DS

AntiTum↑, ROS↑, JNK↑, NRF2↓, eff↓, TumCD↑,

5006-

DSF,

Cu,

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

vitro+vivo,

lymphoma,

TumCD↑, TumCP↑, Apoptosis↑, NRF2↓, ROS↑, p‑JNK↑, p65↓, eff↓, NF-kB↓,

3208-

EGCG,

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α

in-vitro,

Colon,

HT29

in-vitro,

Nor,

3T3

TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,

5223-

EMD,

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

in-vitro,

CRC,

DLD1

in-vitro,

Nor,

CCD841

tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,

5256-

EP,

Pulsed electric fields: a sharp sword in the battle against cancers

Review,

Var,

BioAv↑, TumCD↑, MMP↓, Apoptosis↑, TumCCA↑, Imm↑, RadioS↑, ChemoSen↑,

5489-

EP,

Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation

in-vitro,

Colon,

We measured electroporation and cell killing thresholds for 150 ns–1 ms PEF, uni- and bipolar, delivered in 10- to 300-pulse trains at up to 1 MHz rates.

eff↑, TumCD↑, MusCon↓, Temp↓, eff↑, eff↓, eff↑, eff∅, other↑,

5491-

EP,

Nano-pulse stimulation™ therapy (NPS™) is superior to cryoablation in clearing murine melanoma tumors

in-vivo,

Melanoma,

B16-F10

murine melanoma tumors, Mice: Female C57BL/6J mice, 6-8 weeks old

TumCD↑, eff↑, MusCon↓, CellMemb↑, ER Stress↑, other↝,

5493-

EP,

Schottky nanodiodes array enabled triboelectric nanosecond pulse generator for ultralow-cost tumor therapy

Review,

Var,

other↝, other↝, Ca+2↑, TumCD↑, Imm↑, TumCG↓, other↓,

5494-

EP,

An Overview of Subnanosecond Pulsed Electric Field Biological Effects: Toward Contactless Technologies for Cancer Treatment

Review,

Var,

other↝, ROS↑, Temp∅, CellMemb↑, Ca+2↑, Apoptosis↑, TumCD↑, MMP↓, necrosis↑, TumVol↓, Remission↑,

5519-

EP,

Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions

Review,

Var,

MMP↓, Ca+2↑, eff↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,

2497-

Fenb,

In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells

in-vitro,

GBM,

Dose?, selectivity↑, TumCD↑, α-tubulin↓,

2849-

FIS,

Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells

in-vitro,

Melanoma,

U266

40 μg/ml

TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,

2518-

H2,

Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity

in-vitro,

BC,

4T1

CaCO3 nanoparticles-coated magnesium system (Mg-CaCO3) is developed.

in-vitro,

Nor,

3T3

TumCD↑, CD4+↑, ROS↓,

2073-

HNK,

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

in-vitro,

OS,

U2OS

21.5 μM

in-vivo,

NA,

40 mg/kg

TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,

869-

Lae,

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review

TumCD↑,

2923-

LT,

Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells

in-vitro,

NA,

Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,

2546-

M-Blu,

SDT,

The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro

in-vitro,

sarcoma,

S180

1,10,100uM  0.24 W/cm(2) for 30 seconds

TumCD↑,

1785-

MEL,

Antitumoral melatonin-loaded nanostructured lipid carriers

in-vitro,

Var,

selectivity↑, TumCD↑,

995-

MEL,

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma

vitro+vivo,

GBM,

1.5 and 3.0 mM

five glioma tumor initiating cell lines (GBM1A [15], QNS120, GBM612, GBM965, and QNS108

LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,

2235-

MF,

Increase of intracellular Ca2+ concentration in Listeria monocytogenes under pulsed magnetic field

in-vitro,

Inf,

~7mT, us duration, repeat every second

Ca+2↑, TumCD↑,

528-

MF,

Caff,

Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells

in-vitro,

GBM,

U373MG

3mT, 50Hz

Ca+2↑, TumCP∅, TumCD∅, eff↑,

533-

MF,

Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization

in-vitro,

BC,

MDA-MB-231

1mT, 50Hz for 4 h

in-vitro,

Nor,

MCF10

TumCD↑, necrosis↑, mt-ROS↑, other↑, *STAT3↓, STAT3↑,

523-

MF,

MTX,

Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage

in-vitro,

AML,

THP1

10uM(MTX), 0.1 and 0.6 μT

in-vitro,

NA,

PC12

pheocrmomocytoma (PC12) Pheochromocytoma is a type of tumor

in-vivo,

Cerv,

HeLa

H2O2↑, TumCD↑, CellMemb↑, eff↑,

3492-

MFrot,

Chemo,

MF,

Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells

eff↑, TumCD↑,

3493-

MFrot,

MF,

Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes

in-vivo,

GBM,

20 ± 2 mT and a rotating frequency of 20 Hz

TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,

3494-

MFrot,

MF,

Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance

in-vitro,

Var,

eff↑, TumCD↑,

2258-

MFrot,

MF,

EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE

in-vitro,

GBM,

GBM

in-vitro,

Nor,

SVGp12

TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,

186-

MFrot,

MF,

Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields

in-vitro,

GBM,

GBM

 new device that generates oscillating magnetic fields (OMF) by rapid rotation of strong permanent magnets in specially designed patterns of frequency and timing

in-vitro,

Lung,

mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,

184-

MFrot,

MF,

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

in-vitro,

GBM,

GBM

 80mT pulsed

ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,

198-

MFrot,

MF,

Biological effects of rotating magnetic field: A review from 1969 to 2021

Review,

Var,

AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,

595-

MFrot,

VitC,

MF,

The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

in-vitro,

PC,

MIA PaCa-2

4mT, 1000rpm

51% reduction

reduces IC50 value of cells treated with Vit C and magnetic field

in-vitro,

CRC,

SW-620

23% reduction

in-vitro,

NA,

HT1080

37% reduction

in-vitro,

Pca,

PC3

40% reduction

in-vitro,

OS,

U2OS

46% reduction

in-vitro,

BC,

MCF-7

33% reduction

in-vitro,

Nor,

CCD-18Co

-7% reduction

health normal colon cells *****

TumCD↑, eff↑, *TumCG∅,

4970-

Nimb,

Insights into Nimbolide molecular crosstalk and its anticancer properties

Review,

Var,

chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,

2078-

PB,

Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response

in-vitro,

CRC,

HCT116

0-20mM

p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,

2039-

PB,

TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment

in-vitro,

Lung,

A549

in-vitro,

Nor,

HEK293

TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,

4948-

PEITC,

Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo

vitro+vivo,

Oral,

CAL27

vitro+vivo,

Oral,

FaDu

vitro+vivo,

Oral,

SCC4

vitro+vivo,

Oral,

SCC9

TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,

4953-

PEITC,

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

in-vitro,

CLL,

 4-8 µM

ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,

4954-

PEITC,

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

vitro+vivo,

Ovarian,

SKOV3

 5 μM

ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,

4955-

PEITC,

Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1299

TumCG↓, α-tubulin↓, TumCD↑, TumCCA↑, Apoptosis↑,

4943-

PEITC,

Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation

in-vitro,

Ovarian,

OVCAR-3

23.2 microM

TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,

1765-

PG,

Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion

in-vitro,

Lung,

A549

800 uM at 24 h

in-vitro,

Lung,

Calu-6

TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,

2943-

PL,

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

in-vitro,

CRC,

HCT116

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF-7

TrxR1?, TumCD↑, ROS↑, GSH↓, eff↑,

3381-

QC,

Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase

in-vitro,

Cerv,

HeLa

SREBP1↓, TumCP↓, TumCD↑, AMPK↑, SREBP1↓, FASN↓, ACC↓,

3378-

QC,

CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia

in-vitro,

AML,

CK2↓, PI3K↓, TumCD↑, Akt↓, Mcl-1↓, PTEN↑,

73-

QC,

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90

in-vitro,

Pca,

LNCaP

5, 10, 25, 50, 100 uM

 Normal prostate epithelial cells

in-vitro,

Pca,

DU145

in-vitro,

Pca,

PC3

HSP90↓, Casp3↑, Casp9↑, TumCG↓, TumCD↑, selectivity↑, toxicity↓,

93-

QC,

Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells

in-vitro,

Pca,

PC3

 30 nM: 25, 50, 75, 100 uM

hnRNPA1↓, Casp3↑, Casp7↑, TumCD↑, IAP1↓,

884-

RES,

PTS,

Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

pterostilbene displayed a 1.97-fold lower IC50 when compared to resveratrol (42.3 µM vs. 83.5 µM

TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,

3017-

RosA,

Per,

Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells

in-vitro,

Lung,

A549

TumCD∅, ROS↓, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2↓, SOD2↓, FOXO1↓, NF-kB↓, JNK↓, antiOx↑, tumCV∅,

Showing Research Papers: 51 to 100 of 124
Prev Page 2 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 124

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

CD8+↑, 1,
Total Targets: 191

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1, SIRT1↑, 1,

DNA Damage & Repair ⓘ

P53↓, 1,

Cell Cycle & Senescence ⓘ

P21↓, 1,

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1, STAT3↓, 1, TumCG∅, 1,

Migration ⓘ

β-Endo↑, 1,

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,

Synaptic & Neurotransmission ⓘ

5HT↓, 1,

Clinical Biomarkers ⓘ

BMD↑, 1,

Functional Outcomes ⓘ

AntiAge↑, 2, OS↑, 1, toxicity↓, 1, toxicity∅, 1,
Total Targets: 15

Scientific Paper Hit Count for: TumCD, Tumor Cell Death

22 Silver-NanoParticles
12 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
8 Magnetic Field Rotating
6 Electrical Pulses
6 Selenite (Sodium)
5 Copper and Cu NanoParticles
5 Phenethyl isothiocyanate
4 Chemotherapy
4 Disulfiram
4 Quercetin
4 VitK3,menadione
3 Astaxanthin
3 Melatonin
3 salinomycin
2 3-bromopyruvate
2 Rosmarinic acid
2 Apigenin (mainly Parsley)
2 Curcumin
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 Phenylbutyrate
1 2-DeoxyGlucose
1 Auranofin
1 Gold NanoParticles
1 Hyperthermia
1 Radiotherapy/Radiation
1 Anti-oxidants
1 Aloe anthraquinones
1 Baicalein
1 Photodynamic Therapy
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Boron
1 Caffeic acid
1 Metformin
1 Chrysin
1 chemodynamic therapy
1 Date Fruit Extract
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Fenbendazole
1 Fisetin
1 Hydrogen Gas
1 Honokiol
1 Laetrile B17 Amygdalin
1 Luteolin
1 Methylene blue
1 SonoDynamic Therapy UltraSound
1 Caffeine
1 methotrexate
1 Nimbolide
1 Propyl gallate
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Perilla
1 Selenium NanoParticles
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Selenium
1 Thymoquinone
1 Urolithin
1 Magnesium
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

TumCD Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Synaptic & Neurotransmission ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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