TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱

Source:

Type:

Tumor Cell Death

Scientific Papers found: Click to Expand⟱

5746-

CA,

Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

LNCaP

tumCV↓, ROS↑, TumCCA↑, Apoptosis↑, p‑MAPK↓, ERK↓, JNK↓, p38↓, IL6↓, JAK1↓, p‑STAT3↓, cycD1/CCND1↓, CDK1↓, BAX↑, Casp3↑, Bcl-2↓, TumCD↑,

5923-

CA,

RosA,

Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study

-

Review,

Var,

NA

TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,

5849-

CAP,

The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review

-

Review,

Var,

NA

TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP/DDIT3↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,

5944-

Cela,

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

-

in-vitro,

AML,

U937

TumCP↓, TumCCA↑, TumCD↑, HSP90↓, HSP70/HSPA5↑, cycD1/CCND1↓, CDK4↓, CDK6↓, ATPase↓,

6645-

Cen,

Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review

-

Review,

Var,

NA

TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, Synergy↑, *toxicity↓,

7183-

CHA,

The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells

-

in-vitro,

AML,

HL-60

-

in-vitro,

AML,

KG-1

-

in-vitro,

lymphoma,

U937

TumCD↓, SUV39H↓, CD11b↑, Diff↑, H3K9↓, Synergy↑,

7165-

CHA,

The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase

-

in-vitro,

Cerv,

HeLa

ROS↑, TumCD↑, TrxR1↓, other↝, GSR↓, Trx↓, eff↓,

5991-

Chit,

Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies

-

Review,

BC,

NA

*other↝, *BioAv↓, eff↑, toxicity↓, eff↑, TumCD↑, Half-Life↑, selectivity↑, EPR↑, ROS↑, Apoptosis↑, eff↑,

6075-

CHL,

docx,

The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro

-

vitro+vivo,

BC,

4T1

TumCMig↓, ChemoSen↑, TumMeta↓, TumCCA↑, Trx↓, ROS↓, TumCD↑, GSTP1/GSTπ↓,

6131-

CHr,

Bor,

Z,

Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells

-

in-vitro,

Lung,

A549

*BioAv↑, ROS↑, TumCD↑, TumCCA↑, MMP2↓, TumMeta↓, TumCI↓, GSH↓, eff↑,

6139-

CHr,

Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials

-

Review,

Var,

NA

RadioS↑, PhotoS↑, ROS↑, DNAdam↑, TumCCA↑, TumCD↑, selectivity↑, *ROS↓, *Inflam↓, *DNAdam↓, *antiOx↑, *lipid-P↓, *BioAv↑, Synergy↑, GSH↓, Catalase↓, ALAT↓, Ca+2↓, MDA↑,

2791-

CHr,

Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction

-

in-vitro,

Ovarian,

OV90

TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,

4761-

CoQ10,

Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer

-

in-vitro,

PC,

NA

-

in-vivo,

PC,

NA

MIA PaCa-2 xenograft mouse model

*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,

4769-

CoQ10,

CoQ10 Is Key for Cellular Energy and Cancer Support

-

Review,

Var,

NA

Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,

9272-

CRAN,

Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents

-

Review,

Var,

NA

A review of cranberry research targeting cancer revealed positive effects of cranberries or cranberry derived constituents against 17 different cancer

TumCD↑, Apoptosis↑, necrosis↑, TumAuto↑, TumCP↓, ROS↝, tumCV↓, lipid-P↓, TNF-α↓, IL6↓, ROS↓, TumCCA↑, ROS↑, H2O2↑, PI3K↓, Akt↓, mTOR↓, Ingr↝,

6524-

CRV,

d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells

-

in-vitro,

GC,

AGS

ROS↑, MMP↝, JAK↓, STAT3↓, TumCD↑,

7411-

CS,

Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

CRC,

HCT116

AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,

1596-

Cu,

CDT,

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

-

Review,

Var,

NA

TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,

474-

CUR,

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

-

in-vitro,

PC,

PANC1

6, 10 and 12 µM, 24 h

-

in-vitro,

PC,

MIA PaCa-2

TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,

6214-

CUR,

Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve

-

Review,

CardioV,

NA

TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, Synergy↑, PhotoS↑, eff↑, ROS↑, GSH↓,

6218-

CUR,

Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications

-

Review,

Var,

NA

NF-kB↓, TrxR↓, ROS↑, TumMeta↓, TumCD↑, RadioS↑, BioAv↝, BioAv↑,

6672-

Deg,

Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice

-

vitro+vivo,

CRC,

COLO205

-

in-vitro,

CRC,

HCT116

Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,

6696-

DFC,

MET,

Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

-

in-vitro,

GBM,

GBM

compI↓, Glycolysis↓, OCR↓, Glycolysis↑, lactateProd↓, eff↑, TumCP↓, TumCMig↓, TumCD∅,

6665-

DFE,

Cytotoxic Effect of Phoenix dactylifera (Iraqi Date) Leaves and Fruits Extracts against Breast Cancers Cell Lines

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

CAL51

-

in-vitro,

BC,

MCF7

TumCD↑, eff↓, selectivity↑, AntiCan↑, TumCP↓, MMP↓, cl‑Casp3↑, cl‑PARP↑,

6668-

DFE,

AgNPs,

Saponin-Derived Silver Nanoparticles from Phoenix dactylifera (Ajwa Dates) Exhibit Broad-Spectrum Bioactivities Combating Bacterial Infections

-

in-vitro,

Lung,

A549

*AntiBio↑, antiOx↑, TumCD↑, ROS↑, DNAdam↑, *Catalase↑, *GPx↑, *SOD↑, *ROS↓,

4456-

DFE,

Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells

-

in-vitro,

Pca,

PC3

TumCD↑, MMP↓, mt-ROS↑, Apoptosis↑, TumCCA↑,

1847-

dietFMD,

VitC,

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

-

in-vitro,

PC,

PANC1

vitamin C (≥0.3 mM)

TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,

1863-

dietFMD,

Chemo,

Effect of fasting on cancer: A narrative review of scientific evidence

-

Review,

Var,

NA

Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,

6345-

DRE,

Human clinical trials on for cancer killing dandelion extract

-

Review,

AML,

NA

TumCD↑,

6318-

DRE,

Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways

-

vitro+vivo,

CRC,

HCT116

mouse xenograft model of colon cancer

-

NA,

Nor,

NCM460

TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,

6354-

DRE,

Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture

-

Review,

AML,

NA

ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,

6367-

DRE,

Antioxidant and antimicrobial activities of Dandelion root extract (Taraxacum officinale) and its cytotoxic effect on MDA-MB-231 breast cancer cells

-

in-vitro,

BC,

MDA-MB-231

0.5, 1.0, 2.5 and 5 mg/mL

TumCD↑, *antiOx↑, *ROS↓, tumCV↓, Apoptosis↑, ROS↑, TumCCA↑, MOMP↑, ROS↑,

6364-

DRE,

Dandelion Root Extract Sensitizes Leukemia Cells to VP-16 Induced Cell Death

-

in-vitro,

CLL,

NA

TumCP↓, MMP↓, ROS↑, TumCD↑, ChemoSen↑, chemoP↑, QoL↑,

6744-

DSF,

Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

T47D

TumCD↑, ChemoSen↑, BAX↑, Apoptosis↑, CSCs↓, ROS↑, eff↝, JNK↑, p38↑, NF-kB↓,

4915-

DSF,

Cu,

Disulfiram: A novel repurposed drug for cancer therapy

-

Review,

Var,

NA

ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, Synergy↑, selectivity↑, Proteasome?,

5008-

DSF,

Cu,

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

-

in-vitro,

HCC,

NA

selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,

5009-

DSF,

Cu,

Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines

-

vitro+vivo,

lymphoma,

NA

 (1μM) of Cu2+,

0.435±0.109μM and 0.085±0.015μM DS

AntiTum↑, ROS↑, JNK↑, NRF2↓, eff↓, TumCD↑,

5006-

DSF,

Cu,

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

-

vitro+vivo,

lymphoma,

NA

TumCD↑, TumCP↑, Apoptosis↑, NRF2↓, ROS↑, p‑JNK↑, p65↓, eff↓, NF-kB↓,

6608-

Ech,

CBC,

The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway

-

in-vitro,

Lung,

A549

tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Casp3↑, TumCD↑,

3208-

EGCG,

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α

-

in-vitro,

Colon,

HT29

-

in-vitro,

Nor,

3T3

TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,

5931-

EGCG,

BTZ,

EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism

-

in-vitro,

Pca,

PC3

TumAuto↑, CHOP/DDIT3↓, TumCD↓, eff↓,

5223-

EMD,

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

-

in-vitro,

CRC,

DLD1

-

in-vitro,

Nor,

CCD841

tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,

6834-

EMD,

Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9

-

in-vitro,

Cerv,

HeLa

50 AM

AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, TumCD↑, DNAdam↑,

5256-

EP,

Pulsed electric fields: a sharp sword in the battle against cancers

-

Review,

Var,

NA

BioAv↑, TumCD↑, MMP↓, Apoptosis↑, TumCCA↑, Imm↑, RadioS↑, ChemoSen↑,

5489-

EP,

Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation

-

in-vitro,

Colon,

NA

We measured electroporation and cell killing thresholds for 150 ns–1 ms PEF, uni- and bipolar, delivered in 10- to 300-pulse trains at up to 1 MHz rates.

eff↑, TumCD↑, MusCon↓, Temp↓, eff↑, eff↓, eff↑, eff∅, other↑,

5491-

EP,

Nano-pulse stimulation™ therapy (NPS™) is superior to cryoablation in clearing murine melanoma tumors

-

in-vivo,

Melanoma,

B16-F10

murine melanoma tumors, Mice: Female C57BL/6J mice, 6-8 weeks old

TumCD↑, eff↑, MusCon↓, CellMemb↑, ER Stress↑, other↝,

5493-

EP,

Schottky nanodiodes array enabled triboelectric nanosecond pulse generator for ultralow-cost tumor therapy

-

Review,

Var,

NA

other↝, other↝, Ca+2↑, TumCD↑, Imm↑, TumCG↓, other↓,

5494-

EP,

An Overview of Subnanosecond Pulsed Electric Field Biological Effects: Toward Contactless Technologies for Cancer Treatment

-

Review,

Var,

NA

other↝, ROS↑, Temp∅, CellMemb↑, Ca+2↑, Apoptosis↑, TumCD↑, MMP↓, necrosis↑, TumVol↓, Remission↑,

5519-

EP,

Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions

-

Review,

Var,

NA

MMP↓, Ca+2↑, Synergy↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,

6794-

EPA,

EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction

-

in-vitro,

BC,

NA

-

vitro+vivo,

PC,

MIA PaCa-2

ROS↑, Casp8↑, Apoptosis↑, ROS↑, TumCG↓, TumCD↑, eff↑,

Showing Research Papers: 51 to 100 of 232
Prev Page 2 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 232

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5, Catalase↓, 3, Catalase↑, 2, Fenton↑, 2, GPx↓, 1, GPx↑, 1, GPx4↓, 2, GPx4↑, 1, GSH↓, 16, GSH↑, 1, GSH⇅, 1, GSH/GSSG↓, 2, GSR↓, 1, GSR↑, 1, H2O2↑, 11, i-H2O2↑, 1, mt-H2O2↑, 1, HO-1↓, 3, HO-1↑, 1, Iron↑, 4, Keap1↓, 1, lipid-P↓, 1, lipid-P↑, 9, MDA↑, 4, NOX2↑, 1, NQO1↑, 1, NRF2↓, 5, NRF2↑, 2, ROS↓, 8, ROS↑, 102, ROS⇅, 3, ROS↝, 1, ROS∅, 1, i-ROS↑, 2, mt-ROS↑, 7, SOD↓, 1, SOD↑, 1, SOD1↓, 1, SOD2↓, 1, SOD2↑, 1, Thiols↓, 1, Trx↓, 3, TrxR↓, 1, TrxR1?, 1, TrxR1↓, 2, xCT/SLC7A11↓, 4,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2, CDC25↓, 3, compI↓, 3, compIII↓, 1, ETC↓, 4, ETC↝, 1, Insulin↓, 1, mitResp↓, 4, mtDam↓, 1, mtDam↑, 12, OCR↓, 4, OXPHOS↓, 1, OXPHOS↑, 1, PDH↓, 2, PINK1↑, 1, SDH↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ACC↓, 1, ACC↑, 1, ACLY↓, 1, ALAT↓, 1, AMPK↑, 4, p‑AMPK↑, 1, ATP↓, 9, ATP↑, 1, FASN↓, 2, GLS↓, 1, GlucoseCon↓, 4, Glycolysis↓, 7, Glycolysis↑, 1, GSK‐3β↑, 1, HK2?, 1, HK2↓, 4, lactateProd↓, 3, LDHA↓, 3, MCT4↓, 1, NAD↓, 2, NADPH↓, 2, NADPH↑, 1, PDK1 / PDPK1↓, 2, PFK↓, 1, PKM2↓, 2, p‑PKM2↓, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 2, Warburg↓, 2,

Cell Death(tgid=5) ⓘ

AIF↑, 3, APAF1↑, 1, Apoptosis↓, 5, Apoptosis↑, 78, mt-Apoptosis↑, 1, autoS↑, 1, BAD↑, 2, Bak↑, 1, BAX?, 1, BAX↓, 1, BAX↑, 26, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↓, 31, Bcl-xL↓, 5, BID↑, 2, BIM↑, 1, BNIP3?, 1, Casp↑, 8, Casp1↑, 1, Casp12↑, 1, Casp3↑, 40, cl‑Casp3↑, 12, proCasp3↓, 1, proCasp3↑, 1, pro‑Casp3↑, 1, Casp6↑, 1, Casp7↑, 6, cl‑Casp7↑, 1, Casp8↑, 7, Casp9↓, 1, Casp9↑, 19, cl‑Casp9↑, 6, pro‑Casp9↑, 1, cFLIP↓, 2, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 27, Endon↑, 1, Fas↑, 3, FasL↑, 1, Ferroptosis↑, 6, HEY1↓, 1, IAP1↓, 1, ICD↑, 1, iNOS↓, 1, Mcl-1↓, 6, MDM2↓, 1, MOMP↓, 1, MOMP↑, 5, Necroptosis↑, 2, necrosis↑, 5, p38↓, 1, p38↑, 7, p‑p38↑, 2, Paraptosis↑, 2, survivin↓, 1, TumCD?, 1, TumCD↓, 11, TumCD↑, 215, TumCD∅, 4, XIAP↓, 1, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 23, Akt↑, 1, p‑Akt↓, 6, p‑Akt↑, 2, AKT1↓, 1, CK2↓, 1, EGFR↓, 2, p‑EGFR↓, 1, ERK↓, 7, ERK↑, 1, p‑ERK↑, 2, HER2/EBBR2↓, 1, Hippo↓, 1, IKKα↓, 1, p‑IKKα↓, 1, p‑IκB↓, 1, JAK↓, 1, JAK1↓, 1, JAK2↓, 1, JNK↓, 4, JNK↑, 5, p‑JNK↑, 2, MAPK↓, 3, MAPK↑, 2, p‑MAPK↓, 1, Mst1↑, 1, mTOR↓, 9, mTOR↑, 1, p‑mTOR↓, 3, mTORC2↓, 1, p‑p70S6↑, 1, P70S6K↓, 2, PDGFR-BB↓, 1, PI3K↓, 14, PI3K↑, 2, PKCδ↓, 1, PTEN↑, 1, STAT↓, 1, STAT3↓, 9, STAT3↑, 1, p‑STAT3↓, 3, STAT5↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↑, 3, ChrMod↑, 2, cMyc↓, 3, FOXM1↓, 1, FOXO1↓, 1, FOXO3↑, 1, FOXO4↑, 1, H3↑, 1, H3K4↓, 1, H3K9↓, 1, HDAC↓, 2, OCT4↓, 2, other?, 1, other↓, 2, other↑, 4, other↝, 10, PhotoS↑, 3, sonoS↑, 1, SOX2↓, 1, SOX4↓, 1, SUV39H↓, 1, TFE3↑, 1, tumCV↓, 19, tumCV↑, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 5, eIF2α↑, 1, p‑eIF2α↑, 1, ER Stress↑, 16, GRP78/BiP↓, 1, GRP78/BiP↑, 4, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↑, 2, HSP90↓, 5, IRE1↑, 1, p‑IRE1↑, 1, PERK↑, 1, p‑PERK↑, 1, Proteasome?, 1, UPR↑, 2, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2, ATG5↑, 3, Beclin-1/ATG6↑, 3, CTSB↓, 1, CTSD↓, 1, LAMP2↑, 1, LC3B-II↑, 2, LC3II↑, 1, MitoP↑, 2, p62↑, 1, p‑p62↑, 1, PARK2↑, 1, TumAuto↓, 1, TumAuto↑, 18,

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 2, DNAdam↑, 31, hTERT/TERT↓, 1, p16↑, 2, P53↓, 1, P53↑, 23, PARP↓, 3, PARP↑, 4, cl‑PARP↑, 17, PCNA↓, 3, γH2AX↑, 5, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5, CDK2↓, 8, CDK4↓, 7, CDK6↓, 2, CDKN2C/p18↑, 1, cellSen↑, 1, CHK1↓, 1, Chk2↓, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 9, cycD1/CCND1↓, 11, cycE/CCNE↓, 3, E2Fs↓, 2, Ki-67↓, 2, mitA↓, 1, mitA↑, 1, P21↓, 2, P21↑, 10, p27/CDKN1B↓, 1, p27/CDKN1B↑, 3, p‑RB1↓, 1, TumCCA↓, 2, TumCCA↑, 69,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4, CD133↓, 2, cFos↑, 1, CSCs↓, 13, CSCs↑, 1, CSCs↝, 1, Diff↓, 1, Diff↑, 2, IGF-1↓, 2, IGF-2↑, 1, Ki-67↓, 2, mTORC1↓, 1, NOTCH↓, 1, NOTCH↑, 1, NOTCH1↓, 2, TumCG?, 1, TumCG↓, 29, TumCP?, 1, TumCP↓, 37, TumCP↑, 2, TumCP∅, 1, Wnt↓, 4,

Migration(tgid=13) ⓘ

AP-1↓, 1, ATPase↓, 1, BACH1↓, 1, Ca+2↓, 1, Ca+2↑, 13, i-Ca+2↑, 1, CD11b↑, 1, i-Chl↑, 1, Cofilin↓, 1, DLC1↑, 1, E-cadherin↓, 1, E-cadherin↑, 4, EMT↓, 7, EpCAM↓, 2, FAK↓, 1, Fibronectin↓, 1, hnRNPA1↓, 1, LAMs↓, 1, LIMK2↓, 1, MMP1↓, 1, MMP15↓, 1, MMP2↓, 9, MMP9↓, 8, MMPs↓, 5, N-cadherin↓, 4, PAK1↑, 1, ROCK1↓, 1, Slug?, 1, Slug↓, 4, Snail?, 1, Snail↓, 6, TGF-β↓, 1, TIMP1↑, 1, TIMP2↓, 1, TIMP2↑, 1, TumCA↓, 1, TumCI↓, 12, TumCMig↓, 16, TumMeta↓, 18, Twist↓, 1, TXNIP↑, 1, uPA↓, 1, Vim↓, 3, Zeb1↓, 2, α-SMA↓, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 5, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16, angioG↑, 1, HIF-1↓, 1, Hif1a↓, 4, NO↑, 2, VEGF↓, 7,

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1, CellMemb↑, 4, CLDN1↓, 1, EPR↑, 2, GLUT1↓, 3, GLUT3↓, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 44, MMP↝, 1, MPT↑, 2, SVCT-2↝, 1, TRPM7↑, 1, TRPV1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, CD44↓, 3, CD8+↑, 2, COX2/PTGS2↓, 7, COX2/PTGS2↑, 1, DCells↑, 1, DR4↑, 1, FOXP3↑, 1, HMGB1↓, 1, ICAM-1↓, 1, IL1β↓, 1, IL2↓, 1, IL6↓, 6, IL8↓, 3, Imm↑, 10, Imm↝, 1, Inflam↓, 6, M2 MC↓, 1, NF-kB↓, 21, NF-kB↑, 3, p‑NF-kB↓, 1, p65↓, 2, PD-1↓, 1, PD-L1↓, 1, PGE2↓, 1, TCF↝, 1, TNF-α↓, 3, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1, Temp↓, 1, Temp∅, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1, ER-α36↓, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 7, BioAv↝, 5, ChemoSen↑, 35, CompStab↑, 2, CYP3A4↓, 1, Dose?, 3, Dose↓, 2, Dose↑, 1, Dose↝, 30, Dose∅, 1, eff↓, 39, eff↑, 42, eff↝, 4, eff∅, 1, GSTP1/GSTπ↓, 1, Half-Life↓, 1, Half-Life↑, 1, Half-Life↝, 1, P-gp/ABCB1↓, 1, P-gp/ABCB1∅, 1, RadioS↑, 14, selectivity↓, 1, selectivity↑, 53, Synergy↑, 27,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AR↑, 1, BG↓, 1, BloodF↑, 1, E6↓, 2, E7↓, 1, EGFR↓, 2, p‑EGFR↓, 1, Ferritin↓, 1, FOXM1↓, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, IL6↓, 6, LDH?, 1, LDH↓, 3, LDH↑, 2, PD-L1↓, 1, Polyps↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13, AntiCan⇅, 1, antiNeop↑, 1, AntiTum↑, 8, Appetite↑, 1, BowelM↑, 1, breath↑, 1, cardioP↑, 2, chemoP↑, 8, chemoPv↑, 4, ChemoSideEff↓, 2, hepatoP↑, 4, MusCon↓, 2, NP/CIPN↓, 1, OS↑, 8, OS⇅, 1, Pain↓, 2, PFS↑, 1, QoL↑, 2, radioP↑, 1, Remission↑, 1, RenoP↑, 1, Risk↓, 3, Sleep↑, 1, Strength↑, 2, toxicity↓, 7, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, TumVol↓, 13, TumW↓, 2, Weight↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1, Bacteria↓, 2, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 498

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 13, Catalase↑, 5, GPx↑, 3, GPx1↑, 1, GSH↑, 1, GSTs↑, 3, HDL↑, 1, HO-1↓, 1, HO-1↑, 1, hyperG↝, 1, Keap1↝, 1, lipid-P↓, 2, MDA↓, 2, NRF2↑, 3, Prx↑, 1, RNS↓, 2, ROS↓, 12, ROS↑, 1, ROS∅, 2, mt-ROS?, 1, SOD↓, 1, SOD↑, 2, SOD1↑, 2, SOD2↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↝, 1, Insulin↑, 1, mitResp↑, 1, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2, AMPK↑, 1, ATP↑, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, LDL↓, 1, lipidLev↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

AIF↓, 1, BAX↓, 1, Casp1↓, 1, Casp3?, 1, Casp3↓, 2, cl‑Casp3↓, 1, cl‑Casp8↓, 1, Cyt‑c↓, 1, iNOS↓, 1, TumCD↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 1, mTOR↓, 1, PI3K↓, 1, RIP1↓, 1, STAT3↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2, RUNX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3II↑, 1, p62↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, P53↓, 1, PARP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1, BMP2↑, 1, neuroG↑, 1, TumCG∅, 1,

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1, VCAM-1↓, 2,

Barriers & Transport(tgid=15) ⓘ

MMP↑, 2, MMP∅, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2, COX2/PTGS2↑, 1, IL18↓, 1, IL1β↓, 2, IL6↓, 4, Inflam↓, 10, pol-M2 MC↑, 1, NF-kB↓, 3, PGE2↓, 1, PSA∅, 1, TNF-α↓, 4,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 1, AChE↓, 1, BDNF↑, 2, MAOA↓, 1, NGF↑, 2, β-Endo↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 1, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3, BioAv↑, 10, BioAv↝, 2, CompStab↝, 1, CYP2E1↓, 1, Dose↝, 1, Half-Life∅, 1, selectivity↑, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 2, BMD↑, 1, BP↓, 2, HOMA↓, 1, hs-CRP↓, 1, IL6↓, 4, PSA∅, 1, TC↓, 1, TG/TAG↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5, antiAll↑, 2, AntiCan↑, 4, antiCG↑, 1, AntiDiabetic↑, 5, antiPs↑, 1, AntiTum↓, 1, AntiTum↑, 2, cardioP↑, 1, chemoP↑, 1, cognitive↑, 3, hepatoP↑, 2, memory↑, 1, neuroP↑, 5, Obesity↓, 2, OS↑, 1, radioP↑, 1, RenoP↑, 1, Stroke↓, 2, toxicity↓, 15, toxicity↑, 2, toxicity↝, 5, toxicity∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, AntiP↑, 2, AntiViral↑, 2, Bacteria↓, 4, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1, Ingr↝, 2,
Total Targets: 143

Scientific Paper Hit Count for: TumCD, Tumor Cell Death

23 Silver-NanoParticles
12 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
9 Magnetic Field Rotating
6 Electrical Pulses
6 Phenethyl isothiocyanate
6 Selenite (Sodium)
5 Curcumin
5 Copper and Cu NanoParticles
5 Dandelion Root
5 Disulfiram
5 Ivermectin
4 Radiotherapy/Radiation
4 Chemotherapy
4 Photodynamic Therapy
4 Metformin
4 Eugenol
4 Quercetin
4 VitK3,menadione
3 Rosmarinic acid
3 Hyperthermia
3 Astaxanthin
3 Melatonin
3 Chrysin
3 Date Fruit Extract
3 Eurycomanone
3 Fisetin
3 salinomycin
2 3-bromopyruvate
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 α-Bisabolol / Chamomile oil
2 Caffeic acid
2 chaetocin
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Fenbendazole
2 Ginkgetin
2 Gossypol/AT-101
2 Honokiol
2 Isobavachalcone
2 phytic acid, Inositol hexakisphosphate
2 isoorientin
2 Sulforaphane (mainly Broccoli)
2 Kaempferol
2 lambertianic acid
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Methylene blue
2 Matrine
2 mebendazole
2 Magnesium
2 Methylglyoxal
2 Phenylbutyrate
2 Selenium
1 1,8-Cineole
1 2-DeoxyGlucose
1 Auranofin
1 Gold NanoParticles
1 Allyl isothiocyanate
1 Anethole/trans-Anethole
1 Anti-oxidants
1 Aloe anthraquinones
1 Baicalein
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Bullatacin
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Chlorophyllin
1 Docetaxel
1 Zinc
1 Cranberry
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Deguelin
1 Diclofenac
1 Echinacea
1 Cannabichromene
1 Bortezomib
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Galloflavin
1 Ginkgo biloba
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Indole-3-carbinol
1 Inositol
1 iodine
1 Paclitaxel/Taxol
1 Isothiocyanates
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Linalool
1 Luteolin
1 SonoDynamic Therapy UltraSound
1 Magnolol
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 Caffeine
1 methotrexate
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Nimbolide
1 Propyl gallate
1 Phycocyanin
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Perilla
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Thymoquinone
1 Urolithin
1 Vitexin
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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