GlucoseCon Cancer Research Results

GlucoseCon, Glucose Consumption: Click to Expand ⟱
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Glucose consumption is often elevated in cancer cells due to an increased reliance on glycolysis for energy production, even in the presence of oxygen. This phenomenon, known as the Warburg effect, is a metabolic shift that allows cancer cells to rapidly proliferate and survive in nutrient-poor environments.

The increased glucose consumption in cancer cells can be detected using positron emission tomography (PET) scans, which measure the uptake of a glucose analog labeled with a radioactive tracer.
Scientific Papers found: Click to Expand⟱
6688- DFC,    New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- in-vivo, lymphoma, U937
AntiCan↑, COX2/PTGS2↓, Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, lactateProd↓, TumCP↓, other∅, toxicity↝,
6693- DFC,    New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells
- vitro+vivo, Var, NA
Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, Glycolysis↓,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27/CDKN1B↑, Insulin↓, IGF-1↓,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1612- EA,    Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cell
- in-vitro, EC, NA
NHE1↓, i-pH↓, ROS↓, GlucoseCon↓, NHE1↓, Glycolysis↓,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
937- EGCG,    Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells
- in-vitro, Pca, MIA PaCa-2
lactateProd↓, Glycolysis↓, GlucoseCon↓, LDHA↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1/ATG6↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
2459- EGCG,    Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2‑mediated glycolysis
- in-vitro, Tong, Tca8113 - in-vitro, Tong, TSCCa
EGFR↓, Akt↓, ERK↓, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓,
6856- FBZ,    Fenbendazole Suppresses Growth and Induces Apoptosis of Actively Growing H4IIE Hepatocellular Carcinoma Cells via p21-Mediated Cell-Cycle Arrest
- in-vitro, Liver, H4IIE
TumCCA↑, P21↑, cycD1/CCND1↓, CycB/CCNB1↓, GlucoseCon∅, lactateProd∅, ROS∅, selectivity↑,
6853- FBZ,    Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp/ABCB1∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, Synergy↑, Dose↝, TumCG↓,
2494- FBZ,    Oral Fenbendazole for Cancer Therapy in Humans and Animals
- Review, Var, NA
Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, Synergy↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, Synergy↑,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
7298- GlaB,    Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, NA
Gli1↓, GlucoseCon↑, lactateProd↝, Warburg↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, Var, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1 / PDPK1↓, Apoptosis↑, LDHA↓,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, CompStab↑, BioAv↑, BioAv↑,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
7910- IVT,    Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1975
TumCG↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, ChemoSen↑,
8089- KAE,    Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, B16-F10
TumCMig↓, TumCI↓, TumMeta↓, ECAR↓, GlucoseCon↓, ATP↓, Pyruv↓, lactateProd↓, HK2↓, VDAC1↓, Akt↓, GSK‐3β↝, Glycolysis↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
2390- KAE,    Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis
- in-vitro, CRC, HCT8
eff↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, glucose↑,
8733- M-Blu,    Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Review, AD, NA - Review, Stroke, NA
*ETC↑, *ROS↓, *Inflam↓, *memfluid↑, *BloodF↑, *BBB↑, *OCR↑, *ATP↑, *BioAv↑, *Aβ↓, *compIV↑, *Stroke↓, *compI↑, *compII↑, *compIII↑, *GlucoseCon↑, *neuroG↑,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
8647- MBZ,    The Antihelminthic Drug, Mebendazole, Induces Apoptosis in Adult T-Cell Leukemia/Lymphoma Cancer Cells: In-Vitro Trial
- in-vitro, ALL, NA
tumCV↓, Apoptosis↑, GlucoseCon↓, GLUT1↓,
8816- MCP,    Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, 4T1
GlucoseCon↓, GLUT1↓, Gal-3↓, ROS↓, NRF2↓, Hif1a↓, angioG↓, pol-M2 MC↓, p‑STAT3↓, TumCG↓, TumW↓,
8725- MeJa,    Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
- vitro+vivo, HCC, HCCLM3 - in-vitro, Liver, Bel-7402 - in-vitro, Liver, Hep3B - in-vitro, HCC, SMMC-7721 cell
HK2↓, MMP↓, Cyt‑c↑, AIF↑, Glycolysis↓, ChemoSen↑, selectivity↑, lactateProd↓, GlucoseCon↓, Synergy↑, Synergy↑,
2456- MET,    Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
GlucoseCon↓, TumCG↓, HK2↓, p‑AMPK↑, TXNIP↓, *toxicity↓,
2457- MET,    Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- in-vitro, Lung, Calu-1
HK1↓, HK2↓, GlucoseCon↓, MMP↓, ATP↓,
214- MFrot,  MF,    Modification of bacterial cellulose through exposure to the rotating magnetic field
- in-vitro, Nor, NA
CellMemb↑, GlucoseCon↓,
8740- MGO,    Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation
- in-vitro, Liver, HepG2
GLO-I↓, HAGH/GLO2↓, RAGE↑, AGEs↑, Hypoxia↑, ROS↑, GlucoseCon↑, GLUT1↑, HK2↑, PFK1↑, LDH↑, lactateProd↑, Glycolysis↑, Hif1a↑, Warburg↑,
995- MLT,    Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
- vitro+vivo, GBM, NA
LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,
8863- MOR,    Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
- in-vitro, Colon, SW48
TumCP↓, Apoptosis↑, ROS↑, MMP↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, ATP↓, GlucoseCon↓, GLUT1↓, Warburg↓, Dose↝, Catalase↓, GSH↓, ADP:ATP↑, AMP↑,
968- OA,    Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MBT-2
Hif1a↓, SIRT3↑, SOD2↑, GlucoseCon↓, Glycolysis↓, TumCG↓,
991- OA,    Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
- in-vivo, NA, NA - in-vivo, Nor, NA
*Glycolysis↓, *GlucoseCon↓, *lactateProd↓, *ECAR↓, *HK2↓, *PFK↓, *PKM2↓, *LDHA↓,
1226- OLST,    Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation
- vitro+vivo, GC, NA
PGM1∅, FASN↓, Apoptosis↑, lipidLev↑, GlucoseCon↑, eff↑,
2452- PA,    Targeting Pyruvate Kinase M2 and Hexokinase II, Pachymic Acid Impairs Glucose Metabolism and Induces Mitochondrial Apoptosis
- in-vitro, BC, SkBr3
HK2↓, GlucoseCon↓, lactateProd↓, mtDam↑, ATP↓, ROS↑, PKM2↑,
2396- PACs,    PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
- in-vitro, HCC, HCCLM3 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2 - in-vitro, Nor, L02
TumCP↓, TumCCA↓, Apoptosis↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, HK2↓, PFK↓, OXPHOS↑, ChemoSen↑, HSP90↓, Hif1a↓,
2039- PB,    TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,
2041- PB,    The Effect of Glucose Concentration and Sodium Phenylbutyrate Treatment on Mitochondrial Bioenergetics and ER Stress in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*mitResp↓, *ER Stress↓, MMP↓, GlucoseCon↓, OCR↓, CHOP/DDIT3↑,
2421- PB,    Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
- in-vitro, HCC, HCCLM3 - in-vivo, NA, NA - in-vitro, HCC, Bel-7402 - in-vitro, HCC, SMMC-7721 cell - in-vitro, Nor, L02
Glycolysis↓, Apoptosis↑, TumCP↓, lactateProd↓, GlucoseCon↓, HK2↓, ChemoSen↑, *toxicity↓, cMyc↓, PFK1↓, LDHA↓, cMyc↓, ChemoSen↑,
2382- PBG,    Integration with Transcriptomic and Metabolomic Analyses Reveals the In Vitro Cytotoxic Mechanisms of Chinese Poplar Propolis by Triggering the Glucose Metabolism in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, HepG2
TumCP↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GLUT1↓, GLUT2↓, LDHA↓, HK2↓, PKM2↓, PFK↓, Dose↝,

Showing Research Papers: 51 to 100 of 149
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 149

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   Catalase↓, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 3,   GSH↓, 4,   GSH↑, 2,   GSH∅, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   HO-2↓, 1,   HO-2↑, 1,   Iron↑, 2,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NRF2↓, 4,   NRF2↑, 4,   ROS↓, 4,   ROS↑, 48,   ROS⇅, 3,   ROS↝, 1,   ROS∅, 2,   i-ROS↓, 1,   mt-ROS↑, 4,   SOD2↑, 1,   TKT↝, 1,   Trx1↓, 2,   TrxR↓, 2,   TrxR1↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   ETC↓, 2,   Insulin↓, 2,   KIF2C↓, 1,   mitResp↓, 1,   mtDam↑, 3,   OCR↓, 6,   OCR↑, 3,   OXPHOS↓, 3,   OXPHOS↑, 4,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↓, 2,   PDH↑, 3,   PDH∅, 1,   p‑PDH↓, 1,   SDH↑, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACSL1↓, 1,   ALDOB↑, 1,   AminoA↓, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 3,   ATP↓, 30,   ATP↑, 1,   ATP↝, 1,   ATP:AMP↓, 1,   CPT1A↓, 1,   ECAR↓, 9,   ECAR↝, 1,   ENO1↓, 1,   ENO3↑, 1,   FAO↓, 1,   FASN↓, 4,   FBP1↑, 1,   FDG↓, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↑, 1,   GlucoseCon↓, 111,   GlucoseCon↑, 8,   GlucoseCon↝, 1,   GlucoseCon∅, 2,   Glycolysis↓, 70,   Glycolysis↑, 2,   GPI↓, 1,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   HAGH/GLO2↓, 1,   HK1↓, 2,   HK2↓, 45,   HK2↑, 2,   HK3↑, 1,   lact/pyru↓, 1,   lactateProd↓, 81,   lactateProd↑, 4,   lactateProd↝, 1,   lactateProd∅, 2,   LAR↓, 1,   LDHA↓, 30,   LDHA↑, 1,   LDHA∅, 1,   lipidLev↑, 1,   MCT4↓, 2,   NAD↓, 1,   NADPH↓, 2,   PCK1↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 2,   PFK↓, 6,   PFK1↓, 9,   PFK1↑, 1,   PFK2↓, 1,   PFKP↓, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM1∅, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM1↑, 2,   PKM2↓, 41,   PKM2↑, 1,   PKM2∅, 2,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 1,   PYGL↓, 1,   Pyruv↓, 3,   Pyruv↑, 1,   R5P↝, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 1,   TPI↓, 1,   TS↓, 1,   Warburg↓, 15,   Warburg↑, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   Apoptosis↓, 1,   Apoptosis↑, 33,   m-Apoptosis↑, 1,   ASC↑, 1,   BAD↑, 2,   Bak↑, 1,   BAX↑, 8,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 8,   Bcl-xL↓, 3,   BID↑, 1,   p‑BID↓, 1,   BNIP3↑, 1,   Casp↑, 1,   Casp∅, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 20,   cl‑Casp3↑, 3,   Casp7↑, 3,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 11,   cl‑Casp9↑, 2,   Cyt‑c↑, 8,   Cyt‑c↝, 1,   Diablo↑, 1,   DR5↑, 2,   Endon↑, 1,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 3,   GSDMC↑, 1,   GSDME-N↑, 1,   iNOS↓, 1,   Mcl-1↓, 3,   p‑Mcl-1↓, 1,   MDM2↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 2,   PUMA↑, 1,   Pyro↑, 2,   survivin↓, 3,   TumCD↑, 4,   XIAP↓, 1,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 23,   Akt↑, 3,   p‑Akt↓, 6,   p‑Akt↑, 1,   AKT1↓, 1,   CaMKII ↓, 1,   EGFR↓, 8,   ERK↓, 5,   p‑ERK↓, 1,   IGF-1R↓, 1,   JAK↓, 2,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   p‑JNK↑, 1,   MARK4↓, 1,   mTOR↓, 19,   p‑mTOR↓, 2,   p‑P70S6K↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K↓, 13,   PI3K↑, 2,   p‑PI3K↓, 1,   PKA↓, 3,   PKCδ↓, 2,   PTEN↑, 5,   Raf↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 8,   p‑STAT3↓, 8,   p‑STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↓, 1,   cMyc↓, 15,   DNMTs↓, 1,   FOXM1↓, 1,   H3↓, 1,   H3K9↓, 1,   HDAC↓, 3,   HDAC2↓, 2,   HMTs↓, 2,   miR-155↓, 1,   miR-339-5p↑, 1,   miR-34a↑, 2,   Myc↓, 3,   OCT4↓, 1,   other↓, 2,   other↝, 3,   other∅, 1,   SUV39H↓, 1,   TBX15↑, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 3,   eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↝, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   Beclin-1/ATG6↝, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↑, 1,   LC3s↓, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 2,   p‑BRCA1↑, 1,   DNAdam↓, 1,   DNAdam↑, 7,   mt-DNAdam↑, 1,   hTERT/TERT↓, 2,   P53↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   PCNA↓, 1,   SIRT6↑, 2,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 4,   p‑CDK4↓, 1,   CDK6↓, 3,   CDK8↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 6,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 2,   Ki-67↓, 5,   P21↑, 7,   p27/CDKN1B↑, 2,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 20,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 1,   CD133↑, 1,   CD24↓, 1,   cFos↓, 1,   CSCs?, 1,   CSCs↓, 5,   Gli1↓, 2,   GTPBP4↓, 1,   HH↓, 2,   IGF-1↓, 1,   IGF-2↑, 1,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↑, 1,   PTCH1↓, 1,   Shh↓, 1,   TumCG↓, 33,   TumCG↑, 1,   TumCP↓, 37,   Wnt↓, 2,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 4,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   Cav1↑, 1,   E-cadherin↑, 5,   EMT↓, 10,   FAK↓, 1,   p‑FAK↓, 2,   Furin↓, 1,   GIT1↓, 1,   MMP2↓, 6,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 5,   MUC4↓, 1,   N-cadherin↓, 2,   Slug↓, 3,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 1,   talin↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 1,   TumCI↓, 13,   TumCMig↓, 11,   TumMeta↓, 13,   TumPF↓, 1,   Twist↓, 4,   TXNIP↓, 1,   TXNIP↑, 1,   uPA↓, 1,   Zeb1↓, 2,   ZEB2↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   EGR4↓, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 26,   Hif1a↑, 3,   Hypoxia↑, 1,   LOX1↓, 1,   NO↓, 1,   NO↑, 2,   VEGF↓, 11,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   GLUT1↓, 38,   GLUT1↑, 3,   GLUT1∅, 1,   GLUT2↓, 3,   GLUT3↓, 3,   GLUT3∅, 1,   GLUT4↓, 4,   MMP↓, 19,   NHE1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 6,   COX2/PTGS2↑, 1,   Gal-3↓, 1,   HCAR1↓, 2,   HMGB1↓, 1,   ICAM-1↓, 1,   Igs↑, 1,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 5,   IL6↑, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   M2 MC↓, 1,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 5,   NF-kB↓, 13,   p‑NF-kB↓, 1,   NK cell↑, 2,   NLRP3↓, 1,   p‑p65↓, 1,   PD-L1↓, 1,   RAGE↑, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 3,   i-pH↓, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 8,   BioAv↝, 1,   BioEnh?, 1,   ChemoSen↓, 1,   ChemoSen↑, 27,   CompStab↑, 1,   CYP1A1↓, 1,   Dose?, 1,   Dose↝, 9,   Dose∅, 3,   eff↓, 13,   eff↑, 15,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 2,   P-gp/ABCB1↑, 1,   P-gp/ABCB1∅, 1,   RadioS↑, 7,   selectivity?, 1,   selectivity↑, 18,   Synergy↑, 19,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   p‑BRCA1↑, 1,   EGFR↓, 8,   Ferritin↓, 1,   FOXM1↓, 1,   hTERT/TERT↓, 2,   IL6↓, 5,   IL6↑, 1,   LDH↓, 4,   LDH↑, 2,   LDH∅, 1,   Myc↓, 3,   PD-L1↓, 1,   RAGE↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   cachexia↓, 1,   chemoP↑, 2,   hepatoP↓, 1,   neuroP↑, 1,   OS↑, 2,   Strength↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 4,   TumW↓, 4,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 487

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   mt-antiOx↑, 1,   Catalase↑, 6,   Copper↓, 1,   GPx↑, 5,   GPx4↑, 1,   GSH↑, 15,   GSR↑, 2,   GSTs↑, 3,   H2O2∅, 1,   HO-1↑, 8,   Iron↓, 1,   lipid-P↓, 6,   MDA↓, 3,   MPO↓, 1,   NQO1↑, 3,   NRF2↑, 9,   Prx↑, 1,   ROS↓, 26,   ROS↑, 2,   mt-ROS↓, 1,   SOD↑, 6,   TAC↑, 1,   Trx↓, 1,   Trx↑, 1,   VitC↑, 2,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   compIV↑, 1,   DRP1/DNM1L↓, 1,   ETC↑, 1,   MFN2↑, 1,   mitResp↓, 1,   OCR↑, 2,   PDH↑, 1,   PGC-1α↑, 1,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   Acetyl-CoA↑, 2,   ALAT↓, 1,   AMPK↑, 4,   AMPK⇅, 1,   ATP↑, 7,   ECAR↓, 2,   FAO↑, 1,   G6PD↑, 1,   glucose↓, 1,   GlucoseCon↓, 4,   GlucoseCon↑, 23,   Glycolysis↓, 3,   Glycolysis↑, 4,   Glycolysis↝, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   HK2↓, 4,   HK2↑, 1,   lactateProd↓, 3,   LDHA↓, 2,   lipidLev↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PFK2↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PKM2↑, 1,   PPP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 1,   Akt↑, 2,   ERK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   PFKFB2↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PKCδ↑, 1,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↑, 1,   FOXO3↑, 1,   other↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   MMP9↓, 1,   TXNIP↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   Hif1a↑, 2,   VCAM-1↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   GLUT2↑, 1,   GLUT3↑, 4,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CXCL1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL6↓, 5,   IL8↓, 1,   Inflam↓, 18,   NF-kB↓, 5,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 5,   AChE↓, 4,   ChAT↑, 5,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 10,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   FGF21↑, 1,   PPARα↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 4,   BioAv↝, 5,   Dose↝, 3,   eff↑, 2,   eff↝, 1,   Half-Life↓, 1,   Half-Life∅, 1,   P450↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↝, 1,   CRP↓, 1,   Hcy/homoC↓, 1,   IL6↓, 5,   IRes↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   AntiCan↑, 3,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 7,   chemoP↑, 1,   cognitive↑, 13,   hepatoP↑, 6,   memory↑, 9,   motorD↓, 1,   motorD↑, 1,   neuroP↑, 19,   Obesity↓, 2,   OS↑, 1,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 6,   toxicity↑, 1,   toxicity∅, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 4,  
Total Targets: 188

Scientific Paper Hit Count for: GlucoseCon, Glucose Consumption
14 Alpha-Lipoic-Acid
11 Shikonin
7 Quercetin
6 Resveratrol
5 Curcumin
5 Kaempferol
5 Rosmarinic acid
4 Artemisinin
4 Betulinic acid
4 EGCG (Epigallocatechin Gallate)
3 2-DeoxyGlucose
3 Baicalein
3 Chrysin
3 Dichloroacetate
3 Fenbendazole
3 Methylene blue
3 Phenylbutyrate
3 Vitamin B1/Thiamine
2 Berberine
2 chaetocin
2 Citric Acid
2 Diclofenac
2 diet Methionine-Restricted Diet
2 Ellagic acid
2 Graviola
2 Honokiol
2 Isovitexin
2 Metformin
2 Oroxylin-A
2 Propolis -bee glue
2 Pterostilbene
2 Sulforaphane (mainly Broccoli)
2 Vitamin K2
1 Radiotherapy/Radiation
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 tamoxifen
1 Baicalin
1 Capsaicin
1 Cichoric acid / Chicoric acid
1 salinomycin
1 Deguelin
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Galloflavin
1 Glabrescione B
1 Isoliquiritigenin
1 Ivermectin
1 mebendazole
1 Modified Citrus Pectin
1 Methyl Jasmonate
1 Magnetic Field Rotating
1 Magnetic Fields
1 Methylglyoxal
1 Melatonin
1 Morin
1 Orlistat
1 Pachymic acid
1 Proanthocyanidins
1 Phosphatidylserine
1 Silymarin (Milk Thistle) silibinin
1 Cisplatin
1 Thymoquinone
1 triptolide
1 Vitamin B2,Riboflavin
1 Vitamin C (Ascorbic Acid)
1 Vitexin
1 Whole Body Vibration
1 Worenine
1 β‐Elemene
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:623  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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