NADPH Cancer Research Results

NADPH, Nicotinamide adenine dinucleotide phosphate: Click to Expand ⟱
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NADPH (Nicotinamide adenine dinucleotide phosphate) is a crucial molecule in cellular metabolism, playing a key role in various biological processes, including energy production, antioxidant defenses, and biosynthesis.
NADPH is essential for the proper functioning of the pentose phosphate pathway, which generates NADPH and ribose-5-phosphate. Cancer cells may exploit this pathway to support their high energy demands.
Many types of cancer, including breast, lung, and colon cancer, exhibit increased NADPH levels compared to normal tissues. This increase is often associated with enhanced glucose-6-phosphate dehydrogenase (G6PD) activity, a key enzyme in the pentose phosphate pathway that generates NADPH.
Scientific Papers found: Click to Expand⟱
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
964- SIL,    Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCP↓, Hif1a↓, NADPH↓, angioG↓, FASN↓, ACC↓,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, NA, NA
*COX2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE↓,
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, NA, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,

Showing Research Papers: 51 to 60 of 60
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 60

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 2,   GSH⇅, 1,   HO-1↑, 1,   MDA↑, 1,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 2,   SOD↑, 1,   Thiols↓, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   NADPH↓, 4,   NADPH↑, 1,   PKM2↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   iNOS↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   PI3K↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 2,   NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

Half-Life↝, 1,  

Functional Outcomes ⓘ

toxicity↝, 2,  
Total Targets: 41

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GCLC↑, 1,   GSH↑, 1,   GSTA1↑, 2,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 3,   ROS↑, 1,   Trx↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

G6PD↑, 1,   GlucoseCon↑, 1,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 4,   SIRT1↑, 1,   SIRT2↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   iNOS↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

Migration ⓘ

APP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL5↓, 1,   IL6↓, 1,   Inflam↓, 4,   NF-kB↓, 2,   TNF-α↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   Risk↓, 1,  
Total Targets: 47

Scientific Paper Hit Count for: NADPH, Nicotinamide adenine dinucleotide phosphate
4 Hydrogen Gas
3 Curcumin
3 Honokiol
3 Parthenolide
3 Quercetin
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Capsaicin
2 Chrysin
2 Radiotherapy/Radiation
2 Selenite (Sodium)
2 Thymoquinone
1 1,8-Cineole
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Boswellia (frankincense)
1 brusatol
1 Brucea javanica
1 Caffeic acid
1 Metformin
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Chlorogenic acid
1 Choline
1 Coenzyme Q10
1 Crocetin
1 Chemotherapy
1 diet FMD Fasting Mimicking Diet
1 Gambogic Acid
1 Germacranolide
1 Huperzine A/Huperzia serrata
1 Methylene blue
1 Pterostilbene
1 Resveratrol
1 Rosmarinic acid
1 salinomycin
1 Selenium
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:624  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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