NADPH Cancer Research Results

NADPH, Nicotinamide adenine dinucleotide phosphate: Click to Expand ⟱
Source:
Type:
NADPH (Nicotinamide adenine dinucleotide phosphate) is a crucial molecule in cellular metabolism, playing a key role in various biological processes, including energy production, antioxidant defenses, and biosynthesis.
NADPH is essential for the proper functioning of the pentose phosphate pathway, which generates NADPH and ribose-5-phosphate. Cancer cells may exploit this pathway to support their high energy demands.
Many types of cancer, including breast, lung, and colon cancer, exhibit increased NADPH levels compared to normal tissues. This increase is often associated with enhanced glucose-6-phosphate dehydrogenase (G6PD) activity, a key enzyme in the pentose phosphate pathway that generates NADPH.
Scientific Papers found: Click to Expand⟱
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, NA, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,

Showing Research Papers: 51 to 52 of 52
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 52

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

G6PD↑, 1,   NAD↑, 1,   NADPH↑, 2,   SIRT1↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL2↓, 1,   IL5↓, 1,   IL6↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 2,  
Total Targets: 18

Scientific Paper Hit Count for: NADPH, Nicotinamide adenine dinucleotide phosphate
4 Hydrogen Gas
3 Curcumin
3 Honokiol
3 Parthenolide
3 Quercetin
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Chrysin
2 Radiotherapy/Radiation
2 Selenite (Sodium)
2 Thymoquinone
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Boswellia (frankincense)
1 brusatol
1 Brucea javanica
1 Caffeic acid
1 Metformin
1 Capsaicin
1 Chemotherapy
1 diet FMD Fasting Mimicking Diet
1 Gambogic Acid
1 Huperzine A/Huperzia serrata
1 Methylene blue
1 Pterostilbene
1 Resveratrol
1 Rosmarinic acid
1 salinomycin
1 Selenium
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:624  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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