SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱
Source:
Type:
SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.
Scientific Papers found: Click to Expand⟱
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2/PTGS2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7878- isoO,  Cisplatin,    Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,
8086- KAE,    Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety
- Review, Nor, NA
*hepatoP↑, *BioAv↝, *CYP2E1↓, *antiOx↑, *AST↓, *ALAT↓, *ROS↓, *lipid-P↓, *SIRT1↑, *GSH↑, *SOD↑, *p‑SMAD2↓, *p‑SMAD3↓, *COL1↓, *other↝,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
9067- L-THE,    l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways
- in-vivo, AD, NA
*AGEs↓, *Aβ42↓, *Ach↑, *AChE↓, *NF-kB↓, *SIRT1↑, *Inflam↓, *RAGE↓, *SOD2↑, *Catalase↑, *ROS↓, *PGC-1α↓, *BAX↓, *cl‑Casp3↓, *Bcl-2↑, *BDNF↑,
8157- lamb,    Pinus koraiensis leaf extract and lambertianic acid attenuate fatigue and improve endurance capacity via PI3K-mediated regulation of oxidative stress and mitochondrial biogenesis
- in-vivo, Nor, NA
*fatigue↓, *ROS↓, *NF-kB↓, *IL6↓, *SOD↑, *PI3K↑, *NRF2↑, *HO-1↑, *SIRT1↑, *PGC-1α↑, *Nrf1↑, *Strength↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
2589- LT,  Chemo,    Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway
- in-vitro, BC, MDA-MB-231
NRF2↓, HO-1↓, ChemoSen↑, CSCs↓, SIRT1↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, Var, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
6419- MLT,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
6418- MLT,  RES,    Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1α pathway activation
- in-vivo, AD, NA
*neuroP↑, *DRP1/DNM1L↓, *FIS1↓, *ROS↓, *MMP↑, *SIRT1↑, *PGC-1α↑, *Synergy↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
2938- NAD,    NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
- in-vivo, BC, NA
TumMeta↓, SIRT1↑,
2932- NAD,    Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
- in-vitro, Nor, NA
*SIRT1↑, *HO-1↑, *neuroP↑, *Apoptosis↓, *Inflam↓, *ROS↓, *antiOx↑, *toxicity↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
2936- NAD,    The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
- Review, Nor, NA
*ROS↓, *DNAdam↓, *neuroP↑, *Inflam↓, *BioAv↑, *SIRT1↑, BioAv↝,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
2963- PL,    Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease
- in-vitro, AD, HEK293
*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,
3919- PTS,    Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *SIRT1∅, *PPARα↑, *SOD2↑, *JNK↓, *p‑tau↓,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, Var, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *Synergy↑, *ROS↓, *cognitive↑, *Synergy↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3534- QC,  Lyco,    Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells
- in-vitro, Nor, HUVECs
*ROS↓, *NOX4↓, *Inflam↓, *NF-kB↓, *p65↓, *SIRT1↑, *cardioP↑, *IL6↓, *COX2/PTGS2↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
2339- QC,    Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *Sepsis↓, *PKM2↓, *SIRT1↓,
2338- QC,    Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
- Review, Nor, NA
*SIRT1↑, *NLRP3↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *PKM2↓, *HO-1↑, *ROS↓, *NO↓, *MDA↓, *antiOx↑, *COX2/PTGS2↓, *HMGB1↓, *iNOS↓, *NF-kB↓,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
1506- RES,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, Var, NA
DNMTs↓, BRCA1↑, HDAC↓, SIRT1↑, p300↓, survivin↓, HDAC1↓, HDAC3↓, HDAC8↓,
1282- RES,    Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1
- vitro+vivo, Var, NA
T-Cell↓, SIRT1↑, CD4+↓,
3614- RES,    Resveratrol--a boon for treating Alzheimer's disease?
- Review, AD, NA
*SIRT1↑, *neuroP↑,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2/PTGS2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
3613- RES,    Resveratrol for Alzheimer's disease
- Review, AD, NA
*SIRT1↑, *BioAv↝, *toxicity↓, *ROS↓, *antiOx↑, *Aβ↓, *MMP9↓, *TNF-α↓,
3798- RES,    Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- in-vivo, Nor, NA
*SIRT1↑, *BDNF↑, *PSD95↑, *memory↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
2331- RES,    Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1
- in-vivo, Nor, NA
*LDHA↑, *PKM2↑, *SIRT1↑, *Glycolysis↝,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,

Showing Research Papers: 51 to 100 of 140
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 140

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↓, 4,   Catalase↑, 1,   ENOX2↓, 1,   GPx↓, 2,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 5,   GSH↑, 1,   GSH∅, 1,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 5,   HO-1↑, 3,   HO-2↓, 1,   HO-2↑, 1,   lipid-P↑, 3,   MDA↑, 2,   NADH↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 4,   Prx↓, 1,   ROS↓, 6,   ROS↑, 35,   ROS⇅, 1,   SOD↓, 4,   SOD↑, 3,   SOD2↓, 2,   SOD2↑, 1,   TKT↝, 1,   Trx↓, 1,   TrxR↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   ETC↝, 1,   Insulin↓, 1,   mtDam↑, 2,   OCR↓, 2,   OXPHOS↓, 1,   OXPHOS↑, 2,   PDH↑, 1,   PDH↝, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 12,   p‑AMPK↑, 1,   ATP↓, 4,   ATP↑, 1,   CRM↑, 1,   ECAR↝, 1,   G6PD↓, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycolysis↓, 4,   Glycolysis↝, 1,   HK2↓, 2,   lactateProd↓, 1,   lactateProd∅, 1,   LDHA↓, 1,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1?, 2,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 1,   R5P↝, 1,   RARβ↑, 1,   SIRT1↓, 23,   SIRT1↑, 32,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↑, 21,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 12,   Bax:Bcl2↑, 4,   Bcl-2↓, 14,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↓, 1,   BIM↑, 2,   Casp↑, 6,   Casp1↓, 1,   Casp3↑, 19,   cl‑Casp3↑, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 1,   Casp8↑, 5,   Casp9↑, 11,   cFLIP↓, 2,   Cyt‑c↑, 12,   Diablo↑, 2,   DR5↑, 3,   Endon↑, 1,   FADD↑, 1,   Fas↓, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 3,   iNOS↓, 2,   Mcl-1↓, 2,   MDM2↓, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↑, 4,   p‑p38↑, 1,   Paraptosis↑, 1,   PUMA↑, 2,   RIP3↑, 1,   survivin↓, 9,   TumCD↑, 2,   XIAP↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 19,   Akt↑, 1,   p‑Akt↓, 5,   CIP2A↓, 1,   CK2↓, 1,   cSrc↓, 1,   EGFR↓, 8,   EGFR↑, 1,   ERK↓, 7,   p‑ERK↓, 3,   FOXD3↑, 1,   HGF/c-Met↓, 1,   IKKα↓, 1,   p‑IκB↑, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   mTOR↓, 14,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 18,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 2,   PTEN↓, 2,   PTEN↑, 8,   Raf↓, 1,   RAS↓, 1,   RIP1↑, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT3↓, 14,   p‑STAT3↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   cMyc↓, 6,   cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 3,   DNMTs↓, 2,   EZH2↓, 3,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↑, 3,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 6,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 3,   HMTs↑, 1,   miR-133a-3p↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-22↑, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   Myc↓, 2,   other↓, 1,   other↝, 1,   SOX2↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP72↓, 1,   HSP90↓, 3,   NQO2↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LAMP2↑, 1,   LC3II↑, 3,   p62↓, 1,   p62↑, 1,   TumAuto↑, 9,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 2,   DNAdam↓, 2,   DNAdam↑, 9,   hTERT/TERT↓, 2,   P53↓, 1,   P53↑, 16,   ac‑P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 9,   PCNA↓, 3,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 2,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 2,   CDK2↑, 3,   CDK4↓, 4,   CDK4↑, 2,   CDK6↓, 4,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↓, 1,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 5,   Ki-67↓, 6,   MAD↓, 1,   P21↑, 10,   p27/CDKN1B↑, 3,   p‑RB1↓, 2,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 2,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 5,   Diff↑, 1,   EP2↓, 1,   Gli1↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 6,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 1,   TumCG↓, 16,   TumCP↓, 19,   TumCP⇅, 1,   Wnt↓, 8,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

ASAP2↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 1,   Cdc42↓, 1,   CDH1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 8,   EMT↓, 14,   FAK↓, 3,   p‑FAK↓, 2,   Fibronectin↓, 1,   ITGB1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP13↓, 1,   MMP2↓, 13,   proMMP2↓, 1,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 17,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 5,   p‑pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 2,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 5,   talin↓, 1,   TGF-β↓, 5,   TGF-β↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 11,   TumCMig↓, 8,   TumMeta↓, 15,   TumMeta↑, 1,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim?, 1,   Vim↓, 8,   Vim↑, 1,   Zeb1↓, 4,   β-catenin/ZEB1↓, 11,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   ECM/TCF↓, 1,   EGR1↑, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 12,   LOX1↓, 1,   VEGF↓, 18,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP↓, 17,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CXCR4↓, 3,   DR4↑, 2,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL1β↓, 3,   IL2↑, 2,   IL4↑, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 3,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 28,   p‑NF-kB↓, 1,   NLRP3↓, 4,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 3,   PSA↓, 1,   T-Cell↓, 1,   TCF↓, 1,   Th1 response↑, 1,   TNF-α↓, 5,   TNF-α↑, 1,   Treg lymp↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 2,   ER(estro)↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 6,   BioAv↝, 3,   ChemoSen↑, 19,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↓, 2,   Dose↑, 1,   Dose↝, 12,   Dose∅, 3,   eff↓, 7,   eff↑, 9,   eff↝, 2,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 11,   selectivity↑, 7,   Synergy↑, 12,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BG↓, 1,   BRCA1↑, 2,   CA125↓, 1,   CEA↓, 2,   CRP↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 8,   EGFR↑, 1,   EZH2↓, 3,   Ferritin↓, 1,   hTERT/TERT↓, 2,   IL6↓, 8,   LDH↓, 2,   Maspin↑, 1,   Myc↓, 2,   NSE↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 10,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 4,   ChemoSideEff↓, 2,   hepatoP↑, 3,   memory↑, 1,   Obesity↓, 1,   OS↑, 3,   OS∅, 1,   PFS∅, 1,   QoL↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  
Total Targets: 494

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 43,   Catalase↑, 20,   GPx↑, 18,   GPx1↑, 1,   GSH↑, 22,   GSR↑, 4,   GSTs↑, 4,   H2O2↓, 2,   HDL∅, 1,   HO-1↑, 27,   HO-1⇅, 1,   Keap1↓, 2,   lipid-P↓, 22,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 19,   MPO↓, 4,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 2,   NRF2↓, 1,   NRF2↑, 33,   ROS↓, 66,   ROS↑, 1,   mt-ROS↓, 1,   SOD↑, 29,   SOD1↑, 1,   SOD2↑, 4,   TAC↑, 3,   TBARS↓, 1,   Thiols↑, 1,   Trx↑, 1,   UCPs↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 3,   ETC↑, 1,   FIS1↓, 1,   Insulin↓, 2,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 4,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 11,   SIRT3↑, 5,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   Acetyl-CoA↓, 2,   ALAT↓, 9,   AMPK↑, 26,   p‑AMPK↑, 1,   ATP↑, 3,   Buty↑, 1,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 1,   FAO↑, 2,   G6PD↑, 1,   glucose↓, 2,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   lipoGen↓, 1,   NAD↑, 2,   NADH:NAD↑, 1,   NADPH↓, 4,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PDKs↑, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 2,   PKM2↑, 2,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↓, 4,   SIRT1↑, 84,   SIRT1↝, 1,   SIRT1∅, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAX↓, 5,   Bcl-2↑, 4,   Bcl-2↝, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 6,   cl‑Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   iNOS↓, 9,   necrosis↓, 1,   p38↓, 1,   p‑p38↓, 1,   Pyro?, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 1,   Hippo↑, 1,   JAK2↓, 1,   JNK↓, 3,   MAPK↓, 4,   mTOR↓, 6,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 3,   PKA↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 2,   cMyc↑, 1,   FOXO↑, 3,   FOXO1↑, 2,   FOXO3↑, 5,   miR-155↓, 1,   miR-34a↓, 1,   other↓, 1,   other↑, 4,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   ER Stress↓, 6,   GRP78/BiP↓, 4,   HSP27↑, 1,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   IRE1↓, 1,   PDI↓, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   CTSZ↓, 1,   MitoP↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 4,   DNArepair↑, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↑, 1,   CLOCK↝, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 2,   Cartilage↑, 1,   COL1↓, 3,   Fibrosis↓, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   Na+↑, 1,   PDGF↓, 1,   p‑SMAD2↓, 2,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TXNIP↓, 2,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 5,   eNOS↑, 2,   Hif1a↑, 4,   NO↓, 12,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 7,   BBB↝, 1,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 6,   Na+↑, 1,   NHE3↑, 1,   TJ↑, 1,   TRPV1↑, 3,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 13,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 16,   IL2↓, 4,   IL23↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 22,   IL8↓, 2,   INF-γ↓, 1,   Inflam↓, 58,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   NeuroI↓, 2,   NF-kB↓, 26,   NF-kB↑, 1,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 2,   PGE2↓, 6,   RAGE↓, 2,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 27,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 4,   AChE↓, 6,   ADAM10↑, 3,   BDNF↓, 1,   BDNF↑, 14,   ChAT↑, 2,   MAOA↝, 1,   NGF↑, 1,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 17,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 1,   p‑tau↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 3,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 18,   BioAv↝, 8,   BioEnh↑, 2,   CompStab↝, 1,   CYP2E1↓, 3,   Dose?, 2,   Dose↑, 1,   Dose↝, 10,   eff↓, 2,   eff↑, 11,   Half-Life↓, 4,   Half-Life↝, 3,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 1,   AST↓, 8,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 2,   hs-CRP↓, 1,   IL6↓, 22,   IRes↑, 1,   RAGE↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 9,   antiAll↑, 1,   AntiCan↑, 4,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 23,   chemoP↑, 1,   cognitive↑, 21,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↑, 15,   Learn↑, 1,   memory↑, 17,   motorD↑, 3,   neuroP↑, 41,   Obesity↓, 5,   OS↑, 5,   radioP↑, 1,   RenoP↓, 1,   RenoP↑, 7,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 3,   Stroke↓, 2,   toxicity↓, 7,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 1,   GutMicro↑, 12,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 331

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein
36 Resveratrol
9 Capsaicin
7 Quercetin
6 Hydrogen Gas
6 Urolithin
5 Curcumin
5 EGCG (Epigallocatechin Gallate)
5 nicotinamide adenine dinucleotide
4 Gambogic Acid
4 Luteolin
4 Melatonin
4 Thymoquinone
3 Calorie Restriction Mimetics
3 Kaempferol
3 Shikonin
2 Silver-NanoParticles
2 Alpha-Lipoic-Acid
2 Crocetin
2 diet FMD Fasting Mimicking Diet
2 Chemotherapy
2 Ellagic acid
2 Electrical Pulses
2 Lycopene
2 Silymarin (Milk Thistle) silibinin
1 Astragalus
1 Magnetic Fields
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Artemisinin
1 Baicalein
1 Baicalin
1 Berberine
1 Beta-Caryophyllene
1 Carnosic acid
1 Carvacrol
1 Citicoline, CDP-Choline
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 HydroxyCitric Acid
1 Garcinol
1 Ferulic acid
1 Flaxseed/Linseed
1 Fucoidan
1 Honokiol
1 Hyperoside
1 Isoliquiritigenin
1 Butein
1 Scopoletin
1 isoorientin
1 Cisplatin
1 L-Theanine
1 lambertianic acid
1 Licochalcone A
1 Metformin
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Pterostilbene
1 Radiotherapy/Radiation
1 Rosmarinic acid
1 Sesame seeds and Oil
1 Salvia miltiorrhiza
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:634  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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