GPx4 Cancer Research Results

GPx4, Glutathione Peroxidase 4: Click to Expand ⟱
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GPX4 (Glutathione Peroxidase 4) is a selenoprotein that plays a crucial role in the regulation of ferroptosis, a form of programmed cell death characterized by the iron-dependent accumulation of lipid reactive oxygen species (ROS).
GPX4 has been found to be upregulated in several tumor types, promoting cancer cell survival and resistance to therapy. For instance, GPX4 overexpression has been observed in renal cell carcinoma, pancreatic ductal adenocarcinoma, and triple-negative breast cancer, among others. -GPX4 is known as a lipid peroxidation inhibitor protein, and its antioxidant effect is closely related to ferrous iron
-GPX4 is a confirmed key regulator of ferroptosis.(downregulation of xCT and GPX4, confirming induces ferroptosis
Scientific Papers found: Click to Expand⟱
7562- HYP,  doxoR,    Hyperoside Inhibits Doxorubicin-Induced Ferroptosis in Cardiomyocytes via the Nrf2/GPX4 Pathway
- in-vivo, Nor, NA
*ROS↓, *Ferroptosis↓, *Apoptosis↓, *cardioP↑, *MDA↓, *SOD↑, *GPx↑, *i-Iron↓, *4-HNE↓, *GSH↑, *Ferritin↑, *ACSL4↓, *NRF2↑, *GPx4↑,
7545- HYP,    Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2
- in-vitro, CML, K562
xCT/SLC7A11↓, GPx4↓, Ferroptosis↑, ROS↑, lipid-P↑, mtDam↑, NRF2↓,
7766- ISL,    Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice
- in-vivo, Stroke, NA
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
7777- ISL,    Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
- vitro+vivo, Gall, SGC996
TumCP↓, Ferroptosis↑, HO-1↑, GPx4↓, i-Iron↑, ROS↑, lipid-P↑, GSH/GSSG↓, TumCG↓, NRF2↑,
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,
9230- ITCs,  AITC,  BITC,  PEITC,  SFN  Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death
- Review, Var, NA
Ferroptosis↑, Ingr↝, GSH↓, ROS↑, lipid-P↑, MDA↑, GPx4↓, Iron↑, xCT/SLC7A11↓,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
1924- JG,    Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8260- LCA,    Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↑, xCT/SLC7A11↓, Ferroptosis↑, GPx4↑, ROS↑, TumCP↓, TumCD↑, Iron↑,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8370- LT,    Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer
- vitro+vivo, Colon, NA
TumCP↓, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, Ferroptosis↑, pol-M1↑, CD8+↑, Imm↑,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8389- LT,    Luteolin-Manganese Nanozyme Induces Apoptosis and Ferroptosis for Enhanced Cancer Therapy
- in-vitro, Var, NA
ROS↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Ferroptosis↑, NRF2↓, GPx4↓, IronCh↑,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
8535- Matr,    Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel
- in-vitro, Cerv, NA
TumCG↓, *toxicity↓, Ferroptosis↑, GPx4↓, lipid-P↑, Iron↓, ROS↑, Piezo1↑,
8529- Matr,    Matrine targets β-catenin and blocks the formation of β-catenin/TCF7L2 complex to promote ferroptosis and inhibit metastasis in triple-negative breast cancer
- in-vitro, BC, NA
β-catenin/ZEB1↓, Wnt↓, TCF7/TCF1↓, GPx4↝, Ferroptosis↑, EMT↓,
8549- Matr,    Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
- in-vitro, Var, NA
toxicity↑, *hepatoP↓, *SOD↓, *GSH↓, *MDA↑, *ROS↑, *lipid-P↑, *Iron↝, *Ferroptosis↑, *FTH1↓, *NRF2↓, *xCT/SLC7A11↓, *GPx4↓, *HO-1↓, *toxicity↝,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
8545- Matr,    Matrine enhances RLS3-induced ferroptosis at non-toxic doses in acute myeloid leukemia cells with MLL rearrangement
- in-vitro, AML, MV411 - in-vitro, ALL, MOLM-13
Ferroptosis↑, Synergy↑, i-Iron↑, ROS↑, MMP↓, GSH↓, xCT/SLC7A11↓, GPx4↓, P53↑,
1204- MET,    Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT/SLC7A11↓, NRF2↓, HO-1↓,
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
8489- MF,    Pulsed electromagnetic fields induce ferroptosis in osteosarcoma cells and promote osteogenic differentiation
- in-vitro, OS, U2OS - in-vitro, OS, MG63
TumCP↓, TumCMig↓, Ferroptosis↑, GPx4↓, xCT/SLC7A11↓, BMD↑, selectivity↑, Dose↝, TumCG↓, Dose↝, OS↑, ROS↑, MDA↑, Iron↑, ChemoSen↑, TOP2↑, radioP↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
8479- MFrot,  doxoR,    Dual-targeting by rotating magnetic field-driven superparamagnetic bionic nanorobots for enhanced triple-negative breast cancer therapy
- vitro+vivo, BC, 4T1
Dose?, EPR↑, BioEnh↑, GSH↓, GPx4↓, Iron↑, ROS↑, lipid-P↑, Ferroptosis↑, TumVol↓, Fenton↑,
3567- MFrot,  MF,    The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review
- Review, Stroke, NA
*Stroke↓, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,
582- MNPs,  immuno,  VitC,    Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
- in-vitro, Pca, TRAMP-C1 - in-vivo, NA, NA
Fenton↑, Ferroptosis↑, ROS↑, TumCG↓, Iron↑, GPx4↓,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,
8770- MSM,  Cisplatin,    Methylsulfonylmethane (MSM) Mitigates Cisplatin-Induced Early Oxidative Testicular Dysfunction Through Modulation of Antioxidant Defense and GPX4 Response
- in-vivo, Nor, NA
*Dose?, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *testos↑, *GPx4↓, *chemoP↑,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,
4965- PSO,  Cisplatin,    The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis
- vitro+vivo, GC, HGC27 - vitro+vivo, GC, MKN45
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, Synergy↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,
5026- QC,    Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes
- in-vitro, GC, NA
SLC1A5↓, ROS↑, Iron↓, NRF2↓, GPx4↓, Ferroptosis↑,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT/SLC7A11↓, GPx4↓, *BioAv↑, COX2/PTGS2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
3023- RosA,    Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis
- in-vivo, Sepsis, NA
*GPx4↑, *Inflam↓, *ER Stress↓, *Ferroptosis↓, *Sepsis↓, *GRP78/BiP↓, *IRE1↓, JNK↓,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
- in-vitro, Var, NA
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT/SLC7A11↓, GPx4↓, FTH1↓,
4613- Se,  Rad,    Effect of Selenium and Selenoproteins on Radiation Resistance
- Review, Nor, NA
*selenoP↑, *GPx1↑, *GPx4↑, *lipid-P↓, *DNAdam↓, *ROS↓, *radioP↑,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2200- SK,    Shikonin inhibits the growth of anaplastic thyroid carcinoma cells by promoting ferroptosis and inhibiting glycolysis
- in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, 8505C
NF-kB↓, GPx4↓, TrxR1↓, PKM2↓, GLUT1↓, Glycolysis↓, Ferroptosis↑, GlucoseCon↓, lactateProd↓, ROS↑,
2199- SK,    Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
- in-vitro, GC, NA
ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,

Showing Research Papers: 51 to 100 of 119
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 119

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 3,   Catalase↑, 1,   Copper↑, 1,   Fenton↑, 7,   GCLM↑, 1,   GPx↓, 3,   GPx1↓, 1,   GPx1⇅, 1,   GPx4↓, 88,   GPx4↑, 3,   GPx4↝, 1,   GPx4∅, 1,   GSH↓, 46,   GSH↑, 1,   GSH/GSSG↓, 5,   GSSG↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 6,   HO-1↑, 9,   Iron↓, 2,   Iron↑, 37,   Iron↝, 1,   i-Iron↑, 8,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 37,   MDA↓, 2,   MDA↑, 28,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NQO1↑, 1,   NRF2↓, 19,   NRF2↑, 8,   NRF2↝, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 76,   SOD↓, 6,   SOD↑, 1,   T-SOD↓, 1,   TrxR↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 18,   xCT/SLC7A11∅, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 5,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   LIP↑, 1,   NCOA4↑, 3,   Tf↑, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↝, 1,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   ETC↓, 2,   mtDam↑, 5,   OXPHOS↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 6,   ACSL4∅, 1,   AMPK↑, 6,   ATP↓, 4,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 6,   GSK‐3β↓, 1,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 2,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 1,   PFKP↓, 1,   PKM2↓, 3,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SLC1A5↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 25,   BAD↑, 1,   p‑BAD↓, 1,   BAX↑, 11,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 5,   cl‑Casp3↑, 5,   Casp7↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 2,   Cyt‑c↑, 7,   DR5↑, 4,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 79,   GranB/GZMB↝, 1,   iNOS↓, 1,   MOMP↑, 2,   p38↑, 3,   Paraptosis↑, 1,   Perforin↝, 1,   Pyro↑, 1,   survivin↓, 1,   TumCD↑, 3,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 14,   p‑Akt↓, 2,   CaMKII ↓, 1,   cMET↓, 1,   EGFR↓, 1,   ERK↓, 3,   ERK↑, 2,   p‑ERK↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↓, 2,   JNK↑, 4,   p‑MAP2K1/MEK1↓, 1,   MAPK↑, 4,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   mTOR↓, 9,   p‑mTOR↓, 2,   PI3K↓, 11,   p‑PI3K↓, 1,   PTEN↑, 3,   RET↓, 1,   STAT3↓, 8,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 4,   ATFs↑, 1,   DLEU1↓, 1,   DNMT1↑, 1,   DNMTs↓, 1,   FOXO1↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-21↓, 2,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   miR-592↑, 1,   OCT4↓, 1,   other↓, 1,   other↑, 2,   other↝, 3,   sonoS↑, 1,   SOX2↓, 1,   SOX4↓, 2,   tumCV↓, 10,   tumCV↑, 1,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 6,   eIF2α↓, 1,   eIF2α↑, 2,   ER Stress↑, 7,   Erlin1↑, 1,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 3,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 4,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 2,   p62↓, 2,   p62↑, 2,   TumAuto↑, 13,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 5,   DNArepair↓, 1,   ERCC3↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 8,   cl‑PARP↑, 3,   PCNA↓, 1,   SIRT6↓, 1,   TOP2↑, 1,   XRCC1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↝, 1,   CDK4↓, 1,   CDK7↓, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 3,   Ki-67↓, 7,   P21↑, 2,   p27/CDKN1B↑, 1,   TumCCA↑, 24,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs?, 1,   CSCs↓, 5,   GDF15↓, 1,   Ki-67↓, 7,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   Piezo1↑, 2,   TumCG↓, 21,   TumCP?, 1,   TumCP↓, 32,   TumCP↑, 1,   Wnt↓, 9,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ASAP2↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 3,   CAFs/TAFs↓, 1,   E-cadherin↑, 4,   EMT↓, 9,   FAK↓, 1,   MALAT1↓, 1,   MMP16↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP9↓, 6,   MMPs↓, 1,   N-cadherin↓, 3,   PCBP1↓, 1,   ROCK1↓, 1,   Sharpin↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 1,   TumCI↓, 13,   TumCMig↓, 11,   TumMeta↓, 5,   TumPF↓, 1,   Twist↓, 1,   uPA↓, 2,   Vim↓, 6,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   EGR1↓, 1,   Hif1a↓, 5,   Hif1a↑, 1,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   GLUT1↓, 3,   MMP↓, 17,   MPT↑, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   COX2/PTGS2↓, 4,   CXCR4↓, 1,   DR4↑, 1,   FOXP3↓, 1,   HLA↑, 1,   HMGB1↓, 3,   IL12↑, 1,   IL2↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm↝, 1,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   NF-kB↓, 9,   p‑NF-kB↓, 1,   NK cell↑, 1,   PD-L1↓, 5,   TCF7/TCF1↓, 1,   TLR1↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 1,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 24,   CYP3A4↓, 1,   Dose?, 1,   Dose↝, 6,   eff↓, 12,   eff↑, 9,   eff↝, 3,   Half-Life↓, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 2,   RadioS↑, 5,   selectivity↑, 6,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   Ferritin↓, 2,   Ferritin↑, 1,   LDH↓, 1,   PD-L1↓, 5,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↑, 3,   chemoP↑, 3,   hepatoP↑, 1,   OS↑, 2,   QoL↑, 2,   radioP↑, 1,   toxicity↓, 3,   toxicity↑, 2,   TumVol↓, 4,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 375

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 10,   Catalase↑, 6,   GPx↑, 3,   GPx1↑, 6,   GPx4↓, 3,   GPx4↑, 23,   GPx4∅, 1,   GSH↓, 1,   GSH↑, 8,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 7,   HO-1↝, 1,   HO-1∅, 1,   Iron↓, 2,   Iron↝, 1,   i-Iron↓, 3,   lipid-P↓, 5,   lipid-P↑, 2,   MDA↓, 7,   MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 16,   NRF2∅, 1,   ROS↓, 17,   ROS↑, 1,   i-ROS↑, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 10,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 2,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   IronCh↑, 2,   NCOA4↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↓, 3,   OXPHOS↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACSL4↓, 4,   ACSL4∅, 1,   ALAT↓, 1,   AMPK↑, 1,   ATP↑, 1,   GlucoseCon↑, 1,   Glycolysis↑, 2,   GSK‐3β↑, 1,   HK2↑, 2,   PFKL↑, 2,   PFKM↑, 2,   PFKP↑, 1,   PKM2↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp3↓, 3,   Cyt‑c↓, 1,   Ferroptosis↓, 18,   Ferroptosis↑, 1,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↓, 1,   JNK↓, 2,   MAPK↓, 1,   p‑mTOR↓, 1,   PKCδ↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   FOXO3↑, 1,   other↓, 1,   other↑, 1,   other↝, 2,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 2,   GRP78/BiP↓, 2,   IRE1↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   neuroG↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

EMT↑, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumCMig↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↑, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   BBB∅, 2,   CLDN4↑, 1,   GLUT1↑, 2,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   MMP↑, 2,   MMP↝, 1,   OCLN↑, 1,   TJ↑, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 4,   IL1β↑, 1,   IL6↓, 3,   Inflam?, 1,   Inflam↓, 11,   NeuroI↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   NLRP3↓, 1,   RAGE↓, 1,   TLR4↓, 2,   TNF-α↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   Dose?, 2,   Dose↝, 1,   eff↓, 1,   eff↑, 4,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BloodF↑, 1,   BUN↓, 1,   creat↓, 1,   Ferritin↑, 1,   IL6↓, 3,   IRes↝, 1,   LDH↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 2,   cardioP↑, 5,   chemoP↑, 2,   cognitive↑, 4,   hepatoP↓, 1,   hepatoP↑, 2,   Learn↑, 2,   memory↑, 3,   neuroP↑, 8,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 2,   RenoP↝, 1,   Stroke↓, 5,   toxicity?, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 2,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 195

Scientific Paper Hit Count for: GPx4, Glutathione Peroxidase 4
9 Shikonin
7 Artemisinin
7 Curcumin
7 Matrine
7 Selenite (Sodium)
6 Luteolin
6 Magnetic Fields
5 Cisplatin
4 Baicalein
3 immunotherapy
3 Honokiol
3 doxorubicin
3 Vitamin C (Ascorbic Acid)
2 Astragalus
2 Ashwagandha(Withaferin A)
2 Radiotherapy/Radiation
2 Boron
2 Formononetin
2 Ginkgetin
2 Hyperoside
2 Isoliquiritigenin
2 Phenethyl isothiocyanate
2 Sulforaphane (mainly Broccoli)
2 Juglone
2 Kaempferol
2 Magnetic Field Rotating
2 Rosmarinic acid
2 Thymoquinone
1 Auranofin
1 Silver-NanoParticles
1 Andrographis
1 Docetaxel
1 Astaxanthin
1 Betulinic acid
1 Boswellia (frankincense)
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 chemodynamic therapy
1 Celastrol
1 Citric Acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diindolylmethane
1 EGCG (Epigallocatechin Gallate)
1 erastin
1 ferumoxytol
1 Gallic acid
1 Gambogic Acid
1 Ginkgo biloba
1 HydroxyTyrosol
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Licochalcone A
1 Metformin
1 magnetic nanoparticles
1 Morin
1 Zeolite
1 Methylsulfonylmethane
1 Myricetin
1 Piperlongumine
1 Psoralidin
1 Quercetin
1 Resveratrol
1 salinomycin
1 Sulfasalazine
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:643  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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