γH2AX Cancer Research Results

γH2AX, gamma-H2AX: Click to Expand ⟱
Source:
Type:
γH2AX (gamma-H2AX) is a histone protein that plays a crucial role in the repair of DNA double-strand breaks (DSBs). It is a phosphorylated form of the H2AX protein, which is a component of chromatin.

γH2AX is often used as a biomarker for DNA damage and genomic instability. When DNA is damaged, the H2AX protein is phosphorylated, forming γH2AX, which recruits and activates DNA repair proteins to the site of damage.
γ-H2AX, a marker for DNA double-strand breaks.

Cancer cells often exhibit increased levels of γH2AX due to their high rate of DNA replication and repair errors.

Gamma-H2AX, on the other hand, refers to a phosphorylated form of H2AX.
Scientific Papers found: Click to Expand⟱
8427- OM,    Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53
- in-vitro, BC, MDA-MB-231
tumCV↓, Dose↝, mitA↑, Apoptosis↑, TNF-α↑, Casp3↑, Casp8↑, cl‑PARP↑, survivin↓, p53 Wildtype↓, P21↑, ac‑H3↑, ac‑H4↑, γH2AX↑, DNAdam↑, TumCCA↑,
9048- PatchO,    Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage
- in-vitro, Lung, A549
ROS↑, CHK1↑, Chk2↑, TumCP↓, Tumccf↓, TumCCA↑, P53↑, P21↑, cycE/CCNE↝, P-gp/ABCB1↓, CD44↓, CD133↓, ChemoSen↑, Dose↝, p‑γH2AX↑, CSCs↓,
9017- Phyco,    Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
eff↑, TumCP↓, Tumccf↓, TumCCA↑, cycE/CCNE↓, CDK2↓, P21↑, Apoptosis↑, γH2AX↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, TumCMig↓, TumCA↑, angioG↓, COX2/PTGS2↓, PGE2↓, MAPK↓, toxicity↓,
3355- QC,    Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks
- in-vitro, Cerv, HeLa
DNAdam↑, ROS↑, *antiOx↑, TOP2↓, γH2AX↑,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
TIMP2↑, TumCG↓, TumCMig↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, Bax:Bcl2↑, cl‑Casp9↑, cl‑Casp3↑, DNAdam↑, γH2AX↑, MGMT↓, cl‑PARP↑,
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,
2329- RES,    Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
- in-vitro, Melanoma, A375
P53↑, Bcl-2↓, BAX↑, Cyt‑c↑, ERK↓, PKM2↓, Apoptosis↑, γH2AX↑, Casp3↑, cl‑PARP1↑,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27/CDKN1B↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
1460- SFN,    High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells
- in-vitro, Lung, NA
ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,
1456- SFN,    Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
2129- TQ,  doxoR,    Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
- in-vitro, BC, MCF7
ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,

Showing Research Papers: 51 to 65 of 65
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 65

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   GSR↑, 2,   HO-1↑, 3,   lipid-P↑, 4,   NQO1↑, 2,   NRF2↑, 3,   ROS↓, 3,   ROS↑, 38,   i-ROS↓, 1,   SOD↓, 3,   SOD↑, 1,   TAC?, 1,   Trx↑, 1,   Trx1↓, 1,   TrxR↓, 1,   TrxR↑, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 4,   CDC25↝, 1,   compI↓, 2,   compIII↓, 1,   EGF↓, 1,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 2,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   p‑PDH↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   ALAT↓, 1,   ALDOB↑, 1,   ATP↓, 5,   ENO1↓, 1,   ENO3↑, 1,   FBP1↑, 1,   GlucoseCon↓, 3,   Glycolysis↓, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HK2↓, 1,   HK3↑, 1,   lactateProd↓, 3,   LDHA↓, 1,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↑, 1,   PDK1 / PDPK1↓, 3,   PDKs↓, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM2↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 31,   BAD↑, 1,   Bak↑, 2,   BAX↓, 2,   BAX↑, 12,   Bax:Bcl2↑, 5,   Bcl-2↓, 12,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BID↑, 1,   p‑BID↓, 1,   BIM↑, 2,   Casp↑, 4,   cl‑Casp↑, 1,   Casp3↑, 14,   cl‑Casp3↑, 11,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 7,   cl‑Casp9↑, 6,   Cyt‑c↑, 9,   Diablo↑, 1,   DR5↑, 3,   Fas↑, 2,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   Mcl-1↓, 2,   p‑Mcl-1↓, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 3,   PUMA↑, 1,   survivin↓, 7,   TumCD↑, 6,   XIAP↓, 2,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   p‑Akt↓, 6,   CK2↓, 1,   EGFR↓, 3,   p‑EGFR↓, 1,   ERK↓, 5,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 1,   JAK↓, 1,   JAK1↓, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 5,   PDGFR-BB↓, 1,   PHKG1↑, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↑, 2,   Sp1/3/4↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 1,   cMyc↓, 4,   DNMT1↓, 2,   DNMT3B↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   H3↑, 1,   ac‑H3↑, 3,   H3K9↓, 1,   ac‑H4↑, 2,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 2,   HMTs↓, 1,   KLF4↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↓, 1,   other↝, 3,   OV6↓, 1,   SOX2↓, 1,   SOX4↓, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   ER Stress↑, 3,   HSP90↓, 1,   SERPINH1/HSP47↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   TumAuto↑, 4,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↑, 3,   p‑ATM↑, 2,   ATR↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DNA-PK↑, 2,   DNAdam↓, 2,   DNAdam↑, 34,   hTERT/TERT↓, 1,   MGMT↓, 1,   P53↓, 2,   P53↑, 14,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↑, 4,   cl‑PARP↑, 12,   cl‑PARP1↑, 2,   PCNA↓, 5,   RAD51↓, 1,   RAD51↑, 1,   TOP2↓, 1,   γH2AX↓, 1,   γH2AX↑, 50,   γH2AX↝, 1,   p‑γH2AX↑, 11,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↝, 1,   CDK2↓, 3,   CDK4↓, 4,   p‑CDK4↓, 1,   CDK6↓, 1,   cellSen↑, 1,   CHK1↓, 4,   CHK1↑, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 9,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 3,   cycE/CCNE↝, 1,   GADD45A↑, 1,   Ki-67↓, 6,   mitA↑, 2,   P21↓, 1,   P21↑, 15,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 34,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CSCs↓, 6,   FGF↓, 1,   Gli1↓, 2,   HH↓, 1,   Ki-67↓, 6,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH⇅, 1,   NOTCH1↓, 1,   NOTCH2↓, 1,   NOTCH2↑, 1,   PTCH1↓, 2,   Smo↓, 2,   TumCG↓, 11,   TumCG↑, 1,   TumCP↓, 20,   tyrosinase↓, 1,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   EMT↓, 7,   EMT↑, 1,   EpCAM↓, 1,   GLI2↓, 1,   IQGAP3↓, 1,   MMP2↓, 11,   MMP9↓, 11,   MMPs↓, 1,   MTA1↓, 1,   N-cadherin↓, 5,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 5,   TIMP1↑, 2,   TIMP2↑, 1,   TumCA↑, 1,   TumCI↓, 6,   TumCMig↓, 12,   TumMeta↓, 6,   TumMeta↑, 1,   uPA↓, 1,   Vim↓, 6,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   CD31/PECAM-1↓, 1,   Hif1a↓, 2,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   EPR↑, 1,   GLUT1↓, 1,   MMP↓, 14,   SVCT-2∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 7,   CXCR2↑, 1,   DR4↑, 1,   IL1↑, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 9,   NF-kB↑, 1,   NOD1↓, 1,   p65↓, 1,   PGE2↓, 2,   PSA↓, 1,   TNF-α↓, 3,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER-α36↓, 2,   PPARγ↓, 1,   PPARγ↑, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 4,   ChemoSen↑, 17,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 8,   Dose∅, 2,   eff↓, 13,   eff↑, 9,   eff↝, 1,   GSTA1↑, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   RadioS↑, 11,   selectivity?, 1,   selectivity↑, 10,   selectivity↝, 1,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 2,   AST↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   p‑EGFR↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Myc↓, 1,   PSA↓, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   neuroP↑, 1,   NKG2D↑, 1,   OS↑, 4,   Pin1↓, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 2,   toxicity↑, 1,   TumVol↓, 6,   TumW↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 373

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   Prx↑, 1,   ROS↓, 3,   ROS∅, 1,   SOD↑, 2,   SOD2↑, 2,   TBARS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3?, 1,   Casp3↓, 1,   Casp9↓, 1,   p38↑, 1,   p‑p38↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   Dose↝, 2,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiCan↑, 1,   cardioP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   Obesity↓, 1,   Stress↓, 1,   toxicity↓, 5,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 43

Scientific Paper Hit Count for: γH2AX, gamma-H2AX
4 Quercetin
4 Sulforaphane (mainly Broccoli)
3 doxorubicin
3 Ashwagandha(Withaferin A)
3 Curcumin
3 Resveratrol
2 Silver-NanoParticles
2 Radiotherapy/Radiation
2 Allyl isothiocyanate
2 Baicalein
2 Benzyl isothiocyanate
2 Dichloroacetate
2 Fisetin
2 Isothiocyanates
2 Kaempferol
2 Lycopene
2 Magnetic Fields
2 Magnetic Field Rotating
2 salinomycin
1 Astragalus
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Berberine
1 Beta-Caryophyllene
1 Carnosic acid
1 Capsaicin
1 chaetocin
1 Metformin
1 EGCG (Epigallocatechin Gallate)
1 Butyrate
1 Evodiamine
1 Ferulic acid
1 Formononetin
1 Flaxseed Oil
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 isoorientin
1 Phenethyl isothiocyanate
1 Juglone
1 Licochalcone A
1 Licorice
1 Cisplatin
1 Luteolin
1 Matrine
1 mebendazole
1 Melatonin
1 Morin
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Phycocyanin
1 Aflavin-3,3′-digallate
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:667  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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