LDL Cancer Research Results

LDL, LDL-cholesterol: Click to Expand ⟱
Source:
Type:
The relationship between LDL (low-density lipoprotein) cholesterol and cancer is a complex and evolving area of research. LDL cholesterol is often referred to as "bad" cholesterol because high levels are associated with an increased risk of cardiovascular diseases.

Protumorigenic: High levels of LDL cholesterol can promote tumor growth by providing lipids that are essential for cell membrane synthesis and energy production. Additionally, LDL can influence inflammation and angiogenesis, further supporting tumor development.
Antitumorigenic: Some studies suggest that lowering LDL cholesterol through lifestyle changes or medications (like statins) may have a protective effect against certain cancers, although the evidence is not uniform across all cancer types.
Scientific Papers found: Click to Expand⟱
8579- FS,  IP6,    Flaxseed: a potential source of food, feed and fiber
- Review, Nor, NA - Review, IBD, NA
*Ingr↑, *AntiCan↑, *Ingr↑, *AntiCan↑, *eff↑, *LDL↓, *HDL∅, *antiOx↑, *lipid-P↓, Synergy↑, *other↝, *BioAv↝, *eff↑, *other↝, *other↝, *other↝, *other↝, *other↝, *CompStab↑,
8578- FS,    High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans
- Human, Nor, NA
*LDL↓, *Dose↝, *glucose↑,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
7104- GEN,    Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial
- Trial, Pca, NA
Dose↝, PSA↓, *LDL↓,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓, *antiAll↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7361- HibSad,    Hibiscus sabdariffa L. - a phytochemical and pharmacological review
- Review, Var, NA
*Bacteria↓, *hepatoP↑, *diuretic↑, *LDL↓, *antiOx↑, *ACE/ACE1↓, *Ca+2↝, *toxicity↓, *ROS↓, *RenoP↑,
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7646- IP6,  Ins,    Protection against cancer by dietary IP6 and inositol
- Review, Var, NA
*antiOx↑, TumCG↓, TumMeta↓, Imm↑, kidSt↓, LDL↓, TumCCA↑, TumCP↓, Diff↑, ChemoSen↑, QoL↑,
7737- isoFl,    An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health
- Review, Nor, NA
*cardioP↑, Risk↓, *BMD↑, *eff↑, *antiOx↑, *lipid-P↓, *LDL↓, AntiThr↑, AntiAg↑, PSA↓, TumCCA↑, cognitive↑, memory↑,
9232- ITCs,  SFN,    The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update
- Review, AD, NA
*ROS↓, *Inflam↓, *eff↑, *toxicity↓, *HDAC?, *neuroP↑, *NRF2↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑, *CHIP↑, *memory↑, *NeuroI↓, *ROS↓, *BACE/β-secretase↓, *BDNF↑, *GSH↑, *GPx↑, *AChE↓, *BChE↓, *TC↓, *TG/TAG↓, *LDL↓, ROS↑,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,
1791- LEC,    Vegetable lecithins: A review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention
- Review, Nor, NA
*BioEnh↑, *antiOx↑, *BioEnh↑, *LDL↓, *HDL∅, *Obesity↓, eff↑, GutMicro↝,
1796- LEC,    A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin
- Review, Var, NA
BioAv↑, antiOx↑, LDL↓, memory↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
1710- Lyco,    Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
- Review, CardioV, NA
antiOx↓, ROS↓, BP↓, LDL↓, *toxicity∅, eff↑, ROS↑, *Half-Life↑, *BioAv↓, *BioAv↑, *antiOx↑,
1713- Lyco,    Lycopene: A Potent Antioxidant with Multiple Health Benefits
- Review, Nor, NA
*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,
8924- MBS,    Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
- Review, Var, NA
*hepatoP↑, *AntiCan↑, *Ingr↝, *NO↓, *TNF-α↓, *IL6↓, *IL1β↓, *TG/TAG↓, *BG↓, *LDL↓, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *mt-ROS↓, *Ingr?, Risk↓,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
8909- MO,    Effect of Moringa oleifera on inflammatory diseases: an umbrella review of 26 systematic reviews
- Review, Nor, NA
*Ingr↝, *LDL↓, *TG/TAG↓, *TC↓, *HDL↑, *VLDL↓, *ROS↓, *TAC↑, *HK2↑, *Glycolysis↑, *GLUT4↑, Apoptosis↑, P53↑, ROS↑, NF-kB↓, TumCP↓, TumCCA↑, COX2/PTGS2↓, NO↓, MAP2K1/MEK1↓, *GSTs↑, *NQO1↑, *NRF2↑, *ARE↑,
1802- NarG,  ATV,    Bioenhancing effects of naringin on atorvastatin
- in-vivo, Nor, NA
BioEnh↑, LDL↓, P450↓, P-gp/ABCB1↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
2035- PB,    Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- in-vitro, Nor, glial - in-vivo, NA, NA
*ROS↓, *Inflam↑, *P21↓, *antiOx↑, *GSH↑, *NF-kB↓, *neuroP↑, *HDAC↓, *iNOS↓, *TNF-α↓, *IL1β↓, *LDL↓, ROS↓,
9289- PSY,    Psyllium supplementation and lipid profiles: systematic review and dose-response meta-analysis of randomized controlled trials
- Review, Nor, NA
*LDL↓, *TC↓,
9288- PSY,    Structural and Functional Properties of Fiber From Psyllium (Plantago ovata) Husk: Current Knowledge and Strategies to Expand Its Application in Food and Beyond
- Review, Nor, NA
*other↑, *other↝, *other↝, *BioAv↑, *cardioP↑, *TC↓, *Obesity↓, *GastroP↑, *BowelM↑, *LDL↓,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2/PTGS2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1/CCL2↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3601- QC,    Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid
- Review, Var, NA - Review, AD, NA
*Inflam↓, *cardioP↑, AntiCan↑, AntiTum↑, *neuroP↑, *cognitive↑, *ROS↓, *BP↓, *LDL↓,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *antiOx↑, *LDL↓, *ADAM10↑,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2/PTGS2↓, angioG↓, *AST↓, *ALAT?,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
2087- TQ,    Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
- in-vivo, Nor, NA
*LDL↓, *SOD1↑, *Catalase↑, *GPx↑, *antiOx↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4860- Uro,    Urolithins–gut Microbial Metabolites with Potential Health Benefits
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*ROS↓, *Inflam↓, TumCG↓, *neuroP↑, *cardioP↑, *LDL↓, *BioAv↝, *BioAv↓, *BioAv↑, *SIRT1↑, *mTOR↑, *BDNF↑, *cognitive↑,
4336- VitB5,    Effectiveness of long-term treatment with pantethine in patients with dyslipidemia
- Trial, Var, NA
*LDL↓, *HDL↑,
4335- VitB5,    Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation
- Trial, Nor, NA
*LDL↓, *TC↓,
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,
9147- WN,    Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults: A Randomized Controlled Trial
- Trial, Nor, NA
*Dose↝, *GutMicro↑, *LDL↓,

Showing Research Papers: 51 to 97 of 97
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 97

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   H2O2↑, 1,   HO-1↓, 1,   lipid-P↓, 1,   lipid-P↑, 3,   NRF2↓, 2,   ROS↓, 3,   ROS↑, 9,   i-ROS↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   mtDam↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 3,   ALAT↓, 1,   AMPK↑, 2,   FASN↓, 1,   glucose↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 12,   LDL↑, 1,   PDK1 / PDPK1↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis↑, 15,   BAD↑, 2,   Bak↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 4,   Casp9↑, 4,   Cyt‑c↑, 4,   Fas↑, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↑, 1,   p38↑, 1,   TumCD↑, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   p‑Akt↓, 1,   EGFR↓, 3,   ERK↓, 3,   ERK↑, 1,   HER2/EBBR2↓, 1,   IGF-1R↑, 1,   JAK1↓, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 2,   mTOR↓, 4,   PI3K↓, 6,   PKCδ↓, 1,   PTEN↑, 1,   RAS↓, 3,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 3,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 1,   EZH2↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC3↓, 1,   miR-124-3p↓, 1,   miR-25-5p↓, 1,   Myc↓, 1,   other↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 7,   hTERT/TERT↓, 1,   P53↑, 5,   PARP↑, 3,   cl‑PARP↑, 3,   PCNA↓, 1,   TOP1↓, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 5,   CDK6↓, 1,   CDK6↑, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 4,   CycD3↓, 1,   cycE/CCNE↓, 3,   Ki-67↓, 2,   P21↑, 5,   p27/CDKN1B↑, 2,   TumCCA↓, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   HMGCR↓, 2,   IGF-1↓, 4,   Ki-67↓, 2,   mTORC1↓, 1,   NOTCH1↑, 1,   NOTCH3↓, 1,   TumCG↓, 8,   TumCP↓, 12,   Wnt↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 3,   E-cadherin↑, 1,   EMT↓, 3,   Fibronectin↓, 1,   MALAT1↓, 1,   MMP-10↓, 1,   MMP2↓, 4,   MMP9↓, 2,   MMP9↑, 1,   MMPs↓, 1,   PDGF↓, 1,   Rho↓, 1,   Rho↝, 1,   Slug↓, 1,   Smad1↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 6,   TumCMig↓, 6,   TumMeta↓, 5,   Twist↓, 1,   Vim↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   Hif1a↓, 3,   NO↓, 1,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT1↓, 1,   GLUT2↓, 1,   MMP↓, 4,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   cGAS–STING↑, 1,   COX2/PTGS2↓, 4,   COX2/PTGS2↑, 2,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 4,   Inflam↓, 2,   NF-kB↓, 6,   NK cell↑, 2,   PD-L1↑, 1,   PGE2↓, 2,   PSA↓, 3,   TLR4↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,   PPARα↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioEnh↑, 1,   ChemoSen↑, 13,   CYP1A1↑, 1,   Dose↑, 1,   Dose↝, 5,   eff↑, 9,   eff↝, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 6,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   BP↓, 1,   CRP↓, 1,   EGFR↓, 3,   EZH2↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   LDH↓, 1,   Myc↓, 1,   PD-L1↑, 1,   PSA↓, 3,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 4,   cardioP↑, 3,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 1,   kidSt↓, 1,   memory↑, 2,   neuroP↑, 2,   NP/CIPN↓, 1,   OS↑, 1,   PFS↑, 1,   QoL↑, 5,   radioP↑, 2,   Remission↑, 1,   RenoP↑, 2,   Risk↓, 7,   Risk↑, 1,   toxicity↓, 3,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 242

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 44,   ARE↑, 1,   Bil↓, 1,   Catalase↑, 15,   Fenton↓, 1,   GPx↑, 15,   GPx1↑, 1,   GSH↓, 2,   GSH↑, 17,   GSTs↑, 3,   H2O2↓, 1,   HDL↓, 2,   HDL↑, 18,   HDL∅, 4,   HO-1↑, 6,   HO-2↓, 1,   lipid-P↓, 16,   MDA↓, 10,   MPO↓, 5,   NADH↓, 1,   NQO1↑, 3,   NRF2↑, 12,   RNS↓, 3,   ROS?, 1,   ROS↓, 38,   ROS↑, 1,   ROS⇅, 1,   mt-ROS↓, 2,   SOD↑, 18,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 3,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↓, 2,   mtDam↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   adiP↓, 2,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 7,   AMPK↑, 2,   p‑AMPK↑, 1,   ATP↑, 2,   BHB↑, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 2,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↑, 1,   HMG-CoA↓, 2,   LDL↓, 84,   lipidLev↓, 4,   NADPH↓, 3,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 2,   Cyt‑c↓, 1,   Fas↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 2,   p38↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   Akt2↓, 1,   AMPKα↑, 1,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↝, 1,   mTOR↓, 4,   mTOR↑, 1,   PI3K↑, 3,   PTEN↓, 2,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   FOXO3↑, 1,   HDAC?, 1,   HDAC↓, 1,   other↓, 4,   other↑, 7,   other↝, 15,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   NQO2↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   CHIP↑, 1,   HMGCR↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AntiAg∅, 1,   Ca+2?, 1,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   MMP9↓, 1,   MMPs↓, 2,   MUC1↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 8,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB↝, 1,   GastroP↑, 6,   GLUT4↑, 1,   IBI↑, 2,   ketosis↑, 1,   MMP↑, 2,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPV3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   COX1↓, 2,   COX2/PTGS2↓, 9,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 1,   IFN-γ↝, 1,   IL10↑, 2,   IL17↓, 3,   IL1β↓, 11,   IL23↓, 2,   IL4↓, 2,   IL4↑, 1,   IL4↝, 1,   IL5↝, 1,   IL6↓, 12,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 41,   Inflam↑, 2,   LPS↓, 1,   MCP1/CCL2↓, 3,   NeuroI↓, 1,   NF-kB↓, 13,   NK cell↑, 1,   NLRP3↓, 4,   PGE2↓, 1,   RAGE↓, 1,   TLR4↓, 3,   TNF-α↓, 18,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 2,   AChE↓, 10,   AChE∅, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↑, 7,   ChAT↑, 1,   MAOA↓, 1,   MAOB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 11,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 5,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 13,   BioAv↝, 7,   BioEnh↑, 2,   CompStab↑, 2,   CompStab↝, 2,   Dose?, 1,   Dose↑, 2,   Dose↝, 24,   eff↓, 4,   eff↑, 10,   eff↝, 1,   Half-Life↑, 3,   Half-Life↝, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 7,   ALP↓, 1,   AST↓, 8,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 13,   BP↝, 1,   creat↓, 1,   CRP↓, 8,   Ferritin↑, 1,   HOMA↓, 1,   hs-CRP↓, 3,   IL6↓, 12,   IRes↓, 2,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 11,   TG/TAG↓, 13,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 18,   antiPs↑, 1,   AntiTum↑, 1,   BOLD↑, 1,   BowelM↑, 1,   cardioP↑, 29,   chemoP↑, 1,   cognitive↑, 19,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↑, 16,   memory↑, 13,   motorD↑, 1,   MusCon↓, 1,   neuroP↑, 23,   Obesity↓, 9,   OS↑, 3,   QoL↑, 2,   RenoP↑, 5,   Risk↓, 4,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 2,   toxicity↓, 8,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 1,   Weight↓, 3,   Weight↝, 1,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 1,   AntiViral↑, 4,   Bacteria↓, 6,   GutMicro↑, 16,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 3,   Ingr↑, 3,   Ingr↝, 10,  
Total Targets: 286

Scientific Paper Hit Count for: LDL, LDL-cholesterol
6 Flaxseed/Linseed
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Atorvastatin
4 EGCG (Epigallocatechin Gallate)
4 bempedoic acid
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Lycopene
3 Allicin (mainly Garlic)
3 Curcumin
3 Hydrogen Gas
3 Hibiscus sabdariffa
3 Vitamin B5,Pantothenic Acid
2 Berberine
2 buckwheat sprouts
2 Rutin
2 chitosan
2 Cinnamon
2 Chlorella (Chlorella vulgaris)
2 diet Fermented Foods
2 diet Short Term Fasting
2 phytic acid, Inositol hexakisphosphate
2 Inositol
2 Lecithin
2 Psyllium husk
1 Anthocyanins
1 beta-glucans
1 immunotherapy
1 Huperzine A/Huperzia serrata
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Carvacrol
1 Chocolate
1 Chrysin
1 Chyawanprash
1 Coenzyme Q10
1 Selenium
1 Spirulina(Arthrospira/Limnospira)
1 diet Ketogenic
1 Ellagic acid
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 isoflavones
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 lambertianic acid
1 Lactoferrin/Talactoferrin
1 Mung Bean Sprouts
1 Metformin
1 Moringa oleifera
1 Naringin
1 Nimbolide
1 Phenylbutyrate
1 Pterostilbene
1 Quercetin
1 Resveratrol
1 Salvia officinalis
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 Thymoquinone
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin E
1 Walnut
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:71  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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