LDL Cancer Research Results

LDL, LDL-cholesterol: Click to Expand ⟱
Source:
Type:
The relationship between LDL (low-density lipoprotein) cholesterol and cancer is a complex and evolving area of research. LDL cholesterol is often referred to as "bad" cholesterol because high levels are associated with an increased risk of cardiovascular diseases.

Protumorigenic: High levels of LDL cholesterol can promote tumor growth by providing lipids that are essential for cell membrane synthesis and energy production. Additionally, LDL can influence inflammation and angiogenesis, further supporting tumor development.
Antitumorigenic: Some studies suggest that lowering LDL cholesterol through lifestyle changes or medications (like statins) may have a protective effect against certain cancers, although the evidence is not uniform across all cancer types.
Scientific Papers found: Click to Expand⟱
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7646- IP6,  Ins,    Protection against cancer by dietary IP6 and inositol
- Review, Var, NA
*antiOx↑, TumCG↓, TumMeta↓, Imm↑, kidSt↓, LDL↓, TumCCA↑, TumCP↓, Diff↑, ChemoSen↑, QoL↑,
1791- LEC,    Vegetable lecithins: A review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention
- Review, Nor, NA
*BioEnh↑, *antiOx↑, *BioEnh↑, *LDL↓, *HDL∅, *Obesity↓, eff↑, GutMicro↝,
1796- LEC,    A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin
- Review, NA, NA
BioAv↑, antiOx↑, LDL↓, memory↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
1713- Lyco,    Lycopene: A Potent Antioxidant with Multiple Health Benefits
- Review, Nor, NA
*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,
1710- Lyco,    Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
- Review, CardioV, NA
antiOx↓, ROS↓, BP↓, LDL↓, *toxicity∅, eff↑, ROS↑, *Half-Life↑, *BioAv↓, *BioAv↑, *antiOx↑,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
1802- NarG,  ATV,    Bioenhancing effects of naringin on atorvastatin
- in-vivo, Nor, NA
BioEnh↑, LDL↓, P450↓, P-gp↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
2035- PB,    Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- in-vitro, Nor, glial - in-vivo, NA, NA
*ROS↓, *Inflam↑, *P21↓, *antiOx↑, *GSH↑, *NF-kB↓, *neuroP↑, *HDAC↓, *iNOS↓, *TNF-α↓, *IL1β↓, *LDL↓, ROS↓,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2/PTGS2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1/CCL2↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3601- QC,    Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid
- Review, Var, NA - Review, AD, NA
*Inflam↓, *cardioP↑, AntiCan↑, AntiTum↑, *neuroP↑, *cognitive↑, *ROS↓, *BP↓, *LDL↓,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *antiOx↑, *LDL↓, *ADAM10↑,
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2/PTGS2↓, angioG↓, *AST↓, *ALAT?,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, NA, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
2087- TQ,    Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
- in-vivo, Nor, NA
*LDL↓, *SOD1↑, *Catalase↑, *GPx↑, *antiOx↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4860- Uro,    Urolithins–gut Microbial Metabolites with Potential Health Benefits
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*ROS↓, *Inflam↓, TumCG↓, *neuroP↑, *cardioP↑, *LDL↓, *BioAv↝, *BioAv↓, *BioAv↑, *SIRT1↑, *mTOR↑, *BDNF↑, *cognitive↑,
4336- VitB5,    Effectiveness of long-term treatment with pantethine in patients with dyslipidemia
- Trial, NA, NA
*LDL↓, *HDL↑,
4335- VitB5,    Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation
- Trial, NA, NA
*LDL↓,
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,

Showing Research Papers: 51 to 75 of 75
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 75

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

kidSt↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   H2O2↑, 1,   lipid-P↑, 1,   ROS↓, 3,   ROS↑, 3,   i-ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,   Glycolysis↓, 1,   LDL↓, 5,   PPARγ↑, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 2,   BAX↑, 3,   Bcl-2↓, 2,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   MAPK↓, 1,   p27/CDKN1B↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   EMT↓, 1,   ERK↓, 2,   IGF-1↓, 1,   mTOR↓, 2,   PI3K↓, 3,   STAT3↓, 1,   TumCG↓, 4,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   MMP2↓, 2,   MMP9↓, 1,   MMP9↑, 1,   PDGF↓, 1,   PKCδ↓, 1,   Rho↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 3,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,  

Barriers & Transport(tgid=15) ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   Imm↑, 1,   NF-kB↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 3,   eff↑, 5,   P450↓, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   GutMicro↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 2,   chemoP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,  
Total Targets: 89

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   FFA/NEFA↓, 1,   IRes↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   Catalase↑, 7,   GPx↑, 6,   GSH↑, 5,   GSTs↑, 2,   H2O2↓, 1,   HDL↓, 1,   HDL↑, 3,   HDL∅, 1,   HO-1↑, 2,   lipid-P↓, 4,   MDA↓, 3,   NADH↓, 1,   NQO1↑, 1,   NRF2↑, 3,   RNS↓, 1,   ROS?, 1,   ROS↓, 10,   ROS⇅, 1,   SOD↑, 6,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 1,   TrxR1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT?, 1,   ALAT↓, 3,   AMPK↑, 1,   CRM↑, 1,   FASN↓, 1,   glucose↓, 1,   glucose↝, 1,   LDL↓, 20,   NADPH↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   MAPK↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↓, 1,   NQO2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   HDAC↓, 1,   mTOR↑, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   E-sel↓, 1,   MMP9↓, 1,   MMPs↓, 2,   RAGE↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↝, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   IFN-γ↓, 1,   IL17↓, 1,   IL1β↓, 4,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 12,   Inflam↑, 2,   MCP1/CCL2↓, 2,   NF-kB↓, 5,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   ADAM10↑, 1,   BChE↓, 1,   BDNF↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 7,   BioAv↝, 2,   BioEnh↑, 2,   Dose↝, 3,   eff↑, 4,   Half-Life↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BP↓, 2,   GutMicro↑, 1,   IL6↓, 2,   NOS2↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 4,   cardioP↑, 7,   cognitive↑, 5,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 6,   Obesity↓, 2,   RenoP↑, 1,   Risk↓, 1,   Risk↑, 1,   Strength↑, 1,   toxicity↓, 1,   toxicity⇅, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 122

Scientific Paper Hit Count for: LDL, LDL-cholesterol
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Atorvastatin
4 EGCG (Epigallocatechin Gallate)
4 bempedoic acid
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Lycopene
3 Allicin (mainly Garlic)
3 Curcumin
3 Hydrogen Gas
3 Hibiscus sabdariffa
3 Vitamin B5,Pantothenic Acid
2 Berberine
2 chitosan
2 Cinnamon
2 diet Fermented Foods
2 diet Short Term Fasting
2 Inositol
2 Lecithin
1 Anthocyanins
1 beta-glucans
1 immunotherapy
1 Huperzine A/Huperzia serrata
1 Bruteridin(bergamot juice)
1 Carvacrol
1 Chocolate
1 Chrysin
1 Chyawanprash
1 Coenzyme Q10
1 Selenium
1 Ellagic acid
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)
1 Metformin
1 Naringin
1 Nimbolide
1 Phenylbutyrate
1 Pterostilbene
1 Quercetin
1 Resveratrol
1 Salvia officinalis
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 Thymoquinone
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:71  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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