lactateProd Cancer Research Results

lactateProd, lactate production: Click to Expand ⟱
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Lactate production has been linked to cancer development and progression. In normal conditions, lactate is produced in cells through a process called glycolysis, which breaks down glucose to generate energy. However, in cancer cells, this process is often upregulated, leading to increased lactate production, even in the presence of oxygen. This phenomenon is known as the Warburg effect.

-Lactate is the end product of glycolysis and induces TGFβ1 upregulation and the acidic microenvironment.
Scientific Papers found: Click to Expand⟱
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
2459- EGCG,    Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2‑mediated glycolysis
- in-vitro, Tong, Tca8113 - in-vitro, Tong, TSCCa
EGFR↓, Akt↓, ERK↓, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
937- EGCG,    Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells
- in-vitro, Pca, MIA PaCa-2
lactateProd↓, Glycolysis↓, GlucoseCon↓, LDHA↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1/ATG6↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
6856- FBZ,    Fenbendazole Suppresses Growth and Induces Apoptosis of Actively Growing H4IIE Hepatocellular Carcinoma Cells via p21-Mediated Cell-Cycle Arrest
- in-vitro, Liver, H4IIE
TumCCA↑, P21↑, cycD1/CCND1↓, CycB/CCNB1↓, GlucoseCon∅, lactateProd∅, ROS∅, selectivity↑,
6853- FBZ,    Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp/ABCB1∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, Synergy↑, Dose↝, TumCG↓,
7297- GlaB,    H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma
- vitro+vivo, GBM, NA
TumCG↓, Glycolysis↑, lactateProd↑, Warburg↑, eff↑, Gli1↓,
7298- GlaB,    Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, NA
Gli1↓, GlucoseCon↑, lactateProd↝, Warburg↑,
941- Gos,  Rad,    The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis
- in-vivo, Var, NA
lactateProd↓, other↓, TGF-β↓,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, Asthma, NA
*selectivity↑, *lactateProd↓, *ATP↑, *HK2↓, *PFK↓, *Hif1a↓, *PGC-1α↑, *Glycolysis↓, *OXPHOS↑, *Dose↝, *antiAll↑,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1 / PDPK1↓, Apoptosis↑, LDHA↓,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
9244- ISO, IH,    Isorhamnetin inhibits bladder cancer progression by mediating glycolysis through targeting the SRC/PI3K/Akt axis
- in-vitro, Bladder, 5637
TumCP↓, TumCMig↓, TumCI↓, TumCA↓, Glycolysis↓, TumCCA↑, Apoptosis↑, p‑Src↓, PI3K↓, Akt↓, mTOR↓, HK2↓, GLUT1↓, PFKFB3↓, ECAR↓, OCR↓, GlucoseCon↓, lactateProd↓,
7910- IVT,    Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1975
TumCG↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, ChemoSen↑,
8089- KAE,    Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, B16-F10
TumCMig↓, TumCI↓, TumMeta↓, ECAR↓, GlucoseCon↓, ATP↓, Pyruv↓, lactateProd↓, HK2↓, VDAC1↓, Akt↓, GSK‐3β↝, Glycolysis↓,
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
2390- KAE,    Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis
- in-vitro, CRC, HCT8
eff↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, glucose↑,
8158- lamb,    Effect of Pinus koraiensis leaf extract on fatigue reduction and exercise performance: study protocol for a randomized, double-blind, placebo-controlled clinical trial
- Trial, Nor, NA
*Strength↑, *lactateProd↓, *LDH↓, *CK2↓,
2351- lamb,    Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓, Warburg↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
8528- Matr,  Cisplatin,    Matrine targets Enolase 1 and regulates the glycolysis-lactylation axis to enhance cisplatin sensitivity in triple-negative breast cancer
- vitro+vivo, BC, NA
ChemoSen↑, ENO1↓, Glycolysis↓, lactateProd↓,
8725- MeJa,    Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
- vitro+vivo, HCC, HCCLM3 - in-vitro, Liver, Bel-7402 - in-vitro, Liver, Hep3B - in-vitro, HCC, SMMC-7721 cell
HK2↓, MMP↓, Cyt‑c↑, AIF↑, Glycolysis↓, ChemoSen↑, selectivity↑, lactateProd↓, GlucoseCon↓, Synergy↑, Synergy↑,
2245- MF,    Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysis
- in-vitro, Nor, NIH-3T3
Warburg↓, Hif1a↓, *Hif1a∅, Glycolysis↓, *lactateProd↓, *ADP:ATP↓, Pyruv↓, ADP:ATP↓, *PPP↓, *mt-ROS↑, *ROS↓, RPM↑, *ECAR↓,
2259- MFrot,  MF,    Method and apparatus for oncomagnetic treatment
- in-vitro, GBM, NA
MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, ChemoSen↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,
8736- MGO,    Selective inhibition of mitochondrial respiration and glycolysis in human leukaemic leucocytes by methylglyoxal
- in-vitro, AML, NA
mitResp↓, selectivity↑, lactateProd↓, ATP↓, Glycolysis↓, compI↓,
8740- MGO,    Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation
- in-vitro, Liver, HepG2
GLO-I↓, HAGH/GLO2↓, RAGE↑, AGEs↑, Hypoxia↑, ROS↑, GlucoseCon↑, GLUT1↑, HK2↑, PFK1↑, LDH↑, lactateProd↑, Glycolysis↑, Hif1a↑, Warburg↑,
8681- MLT,    Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
HIF-1↓, G6PD↓, GAPDH↓, PDH↓, CS↓, PFK1↓, LDH↓, PDH↑, lactateProd↓, glut↓, CREB↓, JNK↓, NF-kB↓, p38↓, ERK↓, Akt↓, P70S6K↓, STAT↓, Warburg↓, GlutaM↓,
995- MLT,    Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
- vitro+vivo, GBM, NA
LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,
991- OA,    Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
- in-vivo, NA, NA - in-vivo, Nor, NA
*Glycolysis↓, *GlucoseCon↓, *lactateProd↓, *ECAR↓, *HK2↓, *PFK↓, *PKM2↓, *LDHA↓,
2452- PA,    Targeting Pyruvate Kinase M2 and Hexokinase II, Pachymic Acid Impairs Glucose Metabolism and Induces Mitochondrial Apoptosis
- in-vitro, BC, SkBr3
HK2↓, GlucoseCon↓, lactateProd↓, mtDam↑, ATP↓, ROS↑, PKM2↑,
2396- PACs,    PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
- in-vitro, HCC, HCCLM3 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2 - in-vitro, Nor, L02
TumCP↓, TumCCA↓, Apoptosis↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, HK2↓, PFK↓, OXPHOS↑, ChemoSen↑, HSP90↓, Hif1a↓,
2421- PB,    Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
- in-vitro, HCC, HCCLM3 - in-vivo, NA, NA - in-vitro, HCC, Bel-7402 - in-vitro, HCC, SMMC-7721 cell - in-vitro, Nor, L02
Glycolysis↓, Apoptosis↑, TumCP↓, lactateProd↓, GlucoseCon↓, HK2↓, ChemoSen↑, *toxicity↓, cMyc↓, PFK1↓, LDHA↓, cMyc↓, ChemoSen↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
2382- PBG,    Integration with Transcriptomic and Metabolomic Analyses Reveals the In Vitro Cytotoxic Mechanisms of Chinese Poplar Propolis by Triggering the Glucose Metabolism in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, HepG2
TumCP↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GLUT1↓, GLUT2↓, LDHA↓, HK2↓, PKM2↓, PFK↓, Dose↝,
2408- PTS,    Pterostilbene suppresses the growth of esophageal squamous cell carcinoma by inhibiting glycolysis and PKM2/STAT3/c-MYC signaling pathway
- in-vitro, ESCC, NA
TumCP↓, TumCMig↓, PKA↓, GlucoseCon↓, lactateProd↓, PKM2↓, STAT3↓, cMyc↓,
2409- PTS,    Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway
- in-vitro, BC, EMT6 - in-vitro, BC, 4T1 - in-vitro, Nor, HC11
Pyro↑, Glycolysis↓, *toxicity∅, selectivity↑, GSDMC↑, PKM2↓, PKM1↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCG↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp/ABCB1↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP/DDIT3↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
2340- QC,    Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2)
- in-vitro, OS, NA
TumCG↓, GlucoseCon↓, TumCI↓, GLUT1↓, PKM2↓, LDHA↓, Glycolysis↓, lactateProd↓, HK2↓, eff↑,
2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
*HK2↓, *PFKP↓, *PKM2↓, *hepatoP↑, *ALAT↓, *AST↓, *Glycolysis↓, *lactateProd↓, *GlucoseCon↓, *CXCL1↓, *Inflam↓,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,

Showing Research Papers: 51 to 100 of 153
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 153

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 2,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 4,   GSH↓, 3,   GSH↑, 1,   GSH∅, 1,   GSH/GSSG↓, 1,   H2O2↑, 4,   HO-1↓, 1,   HO-1↑, 3,   HO-2↓, 1,   HO-2↑, 1,   Iron↑, 3,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↑, 2,   i-MDA↑, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NRF2↓, 2,   NRF2↑, 4,   ROS↓, 3,   ROS↑, 54,   ROS⇅, 2,   ROS↝, 1,   ROS∅, 2,   mt-ROS↑, 3,   RPM↑, 1,   SOD2↓, 1,   Trx1↓, 2,   TrxR↓, 2,   TrxR1↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   compI↓, 2,   CS↓, 1,   ETC↓, 1,   KIF2C↓, 1,   mitResp↓, 3,   mitResp↑, 2,   mtDam↑, 5,   OCR↓, 9,   OCR↑, 7,   OXPHOS↓, 3,   OXPHOS↑, 8,   mt-OXPHOS↑, 1,   PDH↓, 3,   PDH↑, 4,   PDH∅, 1,   p‑PDH↓, 2,   p‑PDH↑, 1,   SDH↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 2,   ACSL1↓, 1,   ALAT↓, 1,   ALDOA↓, 2,   ALDOB↑, 1,   AminoA↓, 1,   AMPK↓, 1,   AMPK↑, 9,   p‑AMPK↑, 2,   ATP↓, 34,   ATP↑, 2,   ATP↝, 1,   i-ATP↓, 1,   ATP:AMP↓, 1,   CAIX/CA9↓, 1,   i-citrate↑, 1,   CPT1A↓, 1,   ECAR↓, 16,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   ENO3↑, 1,   FAO↓, 1,   FAO↑, 2,   FASN↓, 5,   FBP1↑, 2,   FDG↓, 1,   G6PD↓, 2,   GAPDH↓, 2,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 2,   glucose↑, 1,   GlucoseCon↓, 80,   GlucoseCon↑, 5,   GlucoseCon∅, 2,   glut↓, 1,   GlutaM↓, 1,   Glycolysis↓, 90,   Glycolysis↑, 5,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 1,   HAGH/GLO2↓, 1,   HK1↓, 2,   HK2↓, 48,   HK2↑, 2,   HK3↑, 1,   HMG-CoA↓, 1,   lact/pyru↓, 1,   lactateProd↓, 136,   lactateProd↑, 7,   lactateProd↝, 1,   lactateProd∅, 2,   e-lactateProd↓, 1,   LAR↓, 1,   LDHA↓, 34,   LDHA↑, 1,   LDHA∅, 1,   lipoGen↓, 1,   MCT4↓, 5,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   PCK1↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 12,   p‑PDK1 / PDPK1↓, 2,   PDKs↓, 6,   PDKs↑, 1,   PFK↓, 5,   PFK1↓, 7,   PFK1↑, 1,   PFK2↓, 1,   PFKFB3↓, 1,   PFKP↓, 1,   PGK1↓, 2,   PGK2↑, 1,   PGM1↓, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM1↑, 2,   PKM2↓, 49,   PKM2↑, 1,   PKM2∅, 2,   p‑PKM2↓, 1,   PPP↓, 3,   PYGL↓, 1,   Pyruv↓, 3,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 2,   Warburg↓, 19,   Warburg↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   Apoptosis↓, 1,   Apoptosis↑, 35,   ASC↑, 1,   BAD↑, 3,   Bak↑, 2,   BAX↑, 9,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   Bcl-xL↓, 3,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 5,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 23,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp8↓, 1,   Casp8↑, 5,   Casp9↑, 10,   cFLIP↓, 1,   Cyt‑c↑, 12,   Cyt‑c↝, 2,   Diablo↑, 1,   DR5↑, 2,   Endon↑, 1,   FADD↑, 1,   Fas↑, 2,   Ferroptosis↑, 5,   GSDMC↑, 1,   GSDME-N↑, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MDM2↓, 2,   MEG3↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 4,   proApCas↑, 1,   PUMA↑, 1,   Pyro↑, 2,   survivin↓, 3,   TumCD↑, 2,   TumCD∅, 1,   XIAP↓, 1,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 22,   Akt↑, 3,   p‑Akt↓, 4,   p‑Akt↑, 1,   AKT1↓, 1,   AMPKα↓, 1,   CaMKII ↓, 1,   cMET↓, 1,   CREB↓, 1,   EGFR↓, 7,   ERK↓, 4,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   IGF-1R↑, 1,   IκB↑, 1,   p‑IκB↑, 1,   JAK↓, 1,   JNK↓, 1,   JNK↑, 5,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   MAPK↝, 1,   MARK4↓, 1,   mTOR↓, 19,   p‑mTOR↓, 2,   P70S6K↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K↓, 11,   PI3K↑, 2,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKA↓, 4,   PKCδ↓, 1,   PTEN↑, 5,   RET↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 11,   STAT3↑, 1,   p‑STAT3↓, 7,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cMyc↓, 15,   DNMTs↓, 1,   FOXM1↓, 1,   H3↓, 1,   H3K9↓, 1,   HDAC↓, 2,   HDAC2↓, 2,   HMTs↓, 2,   miR-155↓, 1,   miR-339-5p↑, 1,   miR-375↑, 1,   Myc↓, 4,   other↓, 2,   other↑, 1,   other↝, 4,   other∅, 1,   SOX2↓, 1,   SUV39H↓, 1,   TBX15↑, 1,   tumCV↓, 13,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 2,   PERK↑, 3,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG5↝, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   Beclin-1/ATG6↝, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3B-II↑, 2,   LC3II↑, 2,   LC3s↓, 1,   p62↑, 1,   TumAuto↑, 13,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 2,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 10,   hTERT/TERT↓, 2,   P53↑, 7,   p73↑, 1,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 9,   proPARP↓, 1,   PCNA↓, 1,   SIRT6↑, 2,   Telomerase↓, 1,   TOP1↓, 1,   TP53↓, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 4,   CDK4↓, 2,   CDK6↓, 3,   CDK8↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 8,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 7,   P21↓, 1,   P21↑, 5,   p27/CDKN1B↑, 2,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 25,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD24↓, 1,   CSCs↓, 5,   Gli1↓, 2,   GTPBP4↓, 1,   HH↓, 1,   Ki-67↓, 7,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH3↓, 1,   TumCG↓, 33,   TumCG↑, 1,   TumCP↓, 41,   Wnt↓, 3,   Wnt↑, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 4,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   Cav1↑, 1,   E-cadherin↑, 5,   EMT↓, 9,   p‑FAK↓, 1,   GIT1↓, 1,   MMP2↓, 8,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 8,   MMP9:TIMP1↓, 1,   MMPs↓, 6,   N-cadherin↓, 3,   Rho↓, 1,   Slug↓, 2,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 5,   TIMP1↑, 1,   TumCA↓, 1,   TumCI↓, 13,   TumCMig↓, 14,   TumMeta↓, 10,   TumPF↓, 1,   Twist↓, 4,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 1,   Zeb1↓, 2,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 26,   Hif1a↑, 3,   Hypoxia↓, 1,   Hypoxia↑, 1,   LOX1↓, 1,   NO↓, 1,   NO↑, 4,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 1,   VM↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 32,   GLUT1↑, 2,   GLUT1∅, 1,   GLUT2↓, 3,   GLUT3↓, 2,   GLUT3∅, 1,   GLUT4↓, 2,   MMP↓, 21,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 9,   COX2/PTGS2↑, 2,   HCAR1↓, 2,   ICAM-1↓, 1,   Igs↑, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 5,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 5,   M2 MC↓, 1,   MCT1↓, 6,   NF-kB↓, 13,   NK cell↑, 2,   NLRP3↓, 1,   p‑p65↓, 1,   p‑p65↑, 1,   PD-L1↓, 2,   PGE2↓, 1,   RAGE↑, 1,   TLR4↓, 2,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 3,   e-pH↑, 1,   i-pH↓, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 9,   BioAv↝, 1,   BioEnh?, 1,   ChemoSen↑, 25,   Dose?, 1,   Dose↝, 15,   Dose∅, 3,   eff↓, 18,   eff↑, 22,   eff↝, 3,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,   Half-Life∅, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 1,   P-gp/ABCB1↑, 1,   P-gp/ABCB1∅, 1,   RadioS↑, 10,   selectivity↓, 1,   selectivity↑, 21,   selectivity∅, 1,   Synergy↑, 26,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BG↓, 1,   BMD↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 5,   IL6↑, 1,   LDH↓, 3,   LDH↑, 3,   LDH∅, 1,   Myc↓, 4,   PD-L1↓, 2,   RAGE↑, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   fatigue↓, 1,   neuroP↑, 4,   NP/CIPN↑, 1,   OS↑, 4,   OS∅, 1,   Remission↑, 1,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 2,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 7,   TumW↓, 5,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 525

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   mt-antiOx↑, 1,   Catalase↑, 4,   Copper↓, 1,   GPx↑, 4,   GSH↑, 6,   GSR↑, 2,   GSTs↑, 2,   HO-1↑, 2,   Iron↓, 1,   lipid-P↓, 2,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 3,   Prx↑, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 1,   mt-ROS↑, 1,   SOD↑, 4,   Trx↑, 1,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 3,   ECAR↓, 3,   ECAR∅, 1,   glucose↓, 1,   GlucoseCon↓, 3,   GlucoseCon↑, 1,   Glycolysis↓, 4,   Glycolysis↑, 1,   Glycolysis↝, 1,   HK2↓, 4,   lactateProd↓, 7,   LDHA↓, 2,   LDL↓, 1,   lipidLev↓, 1,   NADPH↓, 2,   PFK↓, 2,   PFK2↓, 1,   PFKP↓, 1,   PKM2↓, 4,   PPP↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CK2↓, 1,   p‑JNK↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2?, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   Hif1a∅, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↓, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 4,   CXCL1↓, 1,   HMGB1↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 2,   Inflam↓, 8,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 2,   eff↑, 1,   eff↝, 1,   Half-Life↓, 1,   P450↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BG↓, 1,   IL6↓, 2,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 5,   cognitive↑, 2,   hepatoP↑, 6,   memory↑, 3,   motorD↓, 1,   motorD↑, 1,   neuroP↑, 9,   Pain↓, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 113

Scientific Paper Hit Count for: lactateProd, lactate production
18 Shikonin
12 Dichloroacetate
8 Quercetin
8 Diclofenac
7 Resveratrol
5 EGCG (Epigallocatechin Gallate)
4 Artemisinin
4 Curcumin
4 Metformin
4 Kaempferol
4 Rosmarinic acid
3 Betulinic acid
3 Chrysin
3 Cisplatin
3 Methylene blue
3 Ursolic acid
3 Vitamin K2
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 5-fluorouracil
2 chaetocin
2 Citric Acid
2 Radiotherapy/Radiation
2 Fenbendazole
2 Glabrescione B
2 lambertianic acid
2 Magnetic Fields
2 Methylglyoxal
2 Melatonin
2 Propolis -bee glue
2 Pterostilbene
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
1 3-bromopyruvate
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Apigenin (mainly Parsley)
1 2-DeoxyGlucose
1 tamoxifen
1 Capsaicin
1 Catechins
1 Cichoric acid / Chicoric acid
1 Dichloroacetophenone(2,2-)
1 Bortezomib
1 salinomycin
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ellagic acid
1 Gossypol/AT-101
1 Hydrogen Gas
1 Honokiol
1 Isoliquiritigenin
1 Isorhamnetin
1 Isovitexin
1 Matrine
1 Methyl Jasmonate
1 Magnetic Field Rotating
1 Oroxylin-A
1 Pachymic acid
1 Proanthocyanidins
1 Phenylbutyrate
1 Sulforaphane (mainly Broccoli)
1 Selenite (Sodium)
1 triptolide
1 Vitamin B1/Thiamine
1 Arsenic trioxide
1 Wogonin
1 Worenine
1 β‐Elemene
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:739  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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