CREB Cancer Research Results

CREB, cAMP Response Element Binding Protein: Click to Expand ⟱
Source:
Type: transcription factor
CREB is a transcription factor that binds to specific DNA sequences, known as cAMP response elements (CRE), in the promoter regions of target genes.
CREB is activated by phosphorylation, which allows it to bind to CRE and recruit other transcriptional coactivators.
CREB regulates the expression of genes involved in various cellular processes, including:
    Cell growth and differentiation
    Apoptosis
    Metabolism
    Neurotransmission

CREB is also involved in the regulation of genes involved in cancer, including:
    Cell cycle progression
    Angiogenesis
    Invasion and metastasis

CREB is often overexpressed in cancer tissues.
High levels of CREB expression are associated with poor prognosis, increased tumor aggressiveness, and resistance to therapy. CREB can promote the expression of genes involved in cell survival and proliferation.
Scientific Papers found: Click to Expand⟱
4296- QC,    A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
- Review, AD, NA
*Inflam↓, *COX2/PTGS2↓, *5LO↓, *antiOx↑, *BioAv↝, *GPx↑, *SOD↑, *Ach↑, *4-HNE↓, *CREB↑, *BDNF↑, *ROS↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
4198- SFN,    Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways
- vitro+vivo, AD, NA
*TrkB↑, *CREB↑, CaMKII ↑, *ERK↑, *ac‑H3↑, *ac‑H4↑, *HDAC↓, *HDAC2↓, *BDNF↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, Nor, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
4172- TQ,    Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
- in-vivo, AD, NA
*cognitive↑, *BDNF↑, *p‑CREB↑, *ROS↓, *memory↑,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
3921- VitD3,  RES,    Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE/β-secretase↓, *p‑tau↓, *p‑CREB↑, *p‑NF-kB↓, *neuroP↑,

Showing Research Papers: 51 to 60 of 60
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 60

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   H2O2↑, 1,   MDA↓, 1,   ROS↓, 1,   ROS↑, 3,   ROS⇅, 1,   SOD↓, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CS↓, 1,   mtDam↑, 1,   PDH↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   AMPK↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   glut↓, 1,   GlutaM↓, 1,   lactateProd↓, 1,   PFK1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 1,   Casp3↑, 4,   Casp7↑, 1,   Casp9↑, 1,   CellShr↑, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   FADD↑, 1,   MDM2↑, 1,   MOMP↑, 1,   p38↓, 1,   p‑p38↓, 1,   survivin↓, 1,   TNFR 1↑, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   CaMKII ↑, 2,   CREB↓, 6,   CREB↑, 1,   p‑CREB↓, 2,   p‑CREB↑, 2,   EGFR↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   JNK↓, 1,   mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 3,   PTEN↑, 2,   p‑RSK↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   STAT↓, 1,   p‑STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF2↓, 3,   H3↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   p‑CDK2↓, 1,   CDK4↓, 1,   p‑Chk2↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   Ki-67↓, 2,   Securin↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 2,   Ki-67↓, 2,   TumCG↓, 6,   TumCP↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   Furin↓, 2,   MMP1↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 1,   Slug↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   HIF-1↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD8+↑, 1,   COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IL1β↓, 1,   Imm↑, 2,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   p50↓, 1,   p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   SOCS1↑, 1,   TCF↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   TAMS↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 2,   eff↑, 2,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   Synergy?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   Remission↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 155

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 15,   Catalase↑, 5,   GPx↑, 8,   GSH↑, 6,   GSR↑, 2,   H2O2↓, 2,   HNE↓, 1,   HO-1↑, 7,   Iron↓, 1,   lipid-P↓, 5,   MDA↓, 4,   Nrf1↑, 1,   NRF2↑, 7,   ROS↓, 24,   SOD↓, 1,   SOD↑, 13,   TAC↑, 1,   TBARS↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   AMPK↑, 1,   ATP↑, 1,   cAMP↑, 3,   GSK‐3β↓, 5,   p‑GSK‐3β↑, 1,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 4,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 3,   Casp3↓, 6,   cl‑Casp3↓, 1,   Casp9↑, 1,   iNOS↓, 1,   iNOS↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 2,   CREB↓, 3,   CREB↑, 31,   CREB∅, 1,   p‑CREB↑, 16,   ERK↓, 1,   ERK↑, 9,   p‑ERK↓, 1,   p‑ERK↑, 2,   IκB↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   PI3K↑, 2,   PKA↑, 5,   PKCδ↑, 1,   PP2A↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC↓, 1,   HDAC2↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↑, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   Ki-67↑, 1,   neuroG↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

Ca+2?, 1,   Ca+2↓, 1,   MMP9↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,   p‑eNOS↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL1β↓, 5,   IL33↓, 1,   IL6↓, 7,   IL8↓, 1,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 13,   NeuroI↓, 3,   NF-kB↓, 7,   p‑NF-kB↓, 2,   NLRP3↓, 4,   TLR3↓, 1,   TLR4↓, 1,   TNF-α↓, 6,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 3,   AChE↓, 8,   ADAM10↑, 1,   BDNF↑, 41,   BDNF⇅, 1,   BDNF∅, 1,   ChAT↑, 2,   CHRM1↑, 1,   GABA↑, 1,   NGF↑, 2,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 1,   TrkB↑, 8,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 2,   Aβ↓, 12,   Aβ↑, 1,   BACE/β-secretase↓, 8,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 7,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

END↑, 1,   ERβ/ESR2↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 3,   Dose↑, 2,   eff↑, 1,   Half-Life↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 7,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 23,   hepatoP↑, 2,   Learn↑, 2,   memory↑, 26,   Mood↑, 4,   motorD↑, 1,   neuroP↑, 26,   Obesity↓, 1,   OS↑, 1,   Sleep↑, 2,   Stress↓, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,  
Total Targets: 177

Scientific Paper Hit Count for: CREB, cAMP Response Element Binding Protein
3 Apigenin (mainly Parsley)
2 Bacopa monnieri
2 Crocetin
2 Curcumin
2 Docosahexaenoic Acid
2 Ginseng
2 isoorientin
2 Melatonin
2 Piperine
2 Pterostilbene
2 Resveratrol
2 Thymoquinone
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Berberine
1 Beta-Caryophyllene
1 Benzyl isothiocyanate
1 Boswellia (frankincense)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Chrysin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Zinc
1 Emodin
1 Fisetin
1 flavonoids
1 Ginkgo biloba
1 Hydrogen Gas
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Kaempferol
1 Mung Bean Sprouts
1 Lapachol
1 SDG/lignans
1 Luteolin
1 Magnolol
1 Magnetic Fields
1 Magnesium
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 L-Theanine
1 Bicarbonate(Sodium)
1 Naringin
1 Phenylbutyrate
1 Polyphenols
1 Quercetin
1 Salvia officinalis
1 Rosmarinic acid
1 Aromatherapy
1 Sulforaphane (mainly Broccoli)
1 Spirulina(Arthrospira/Limnospira)
1 Safflower yellow
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:798  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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