AntiCan Cancer Research Results

AntiCan, Anticancer Effect: Click to Expand ⟱
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Type: general indicator
Anticancer Effect


Scientific Papers found: Click to Expand⟱
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5369- AV,    Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
- in-vitro, Liver, HepG2
tumCV↓, AntiCan↑, P53↑, Bcl-2↓,
5570- B-Gluc,    Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
- Review, Var, NA
Imm↑, BioAv↝, eff↑, AntiCan↑, Dectin1↝, Dose↝, BioAv↓,
874- B-Gluc,    Potential promising anticancer applications of β-glucans: a review
- Review, NA, NA
AntiCan↑, TumCG↓, BAX↑, Bcl-2↓, IFN-γ↑, PI3K/Akt↑, MAPK↑, NFAT↑, NF-kB↑, ROS↑, NK cell↑, TumCCA↑, ERK↓, Telomerase↓,
875- B-Gluc,    Chemistry, physico-chemistry and applications linked to biological activities of β-glucans
- Review, NA, NA
AntiCan↑,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
5497- Ba,    Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics
- Review, Var, NA
*Inflam↓, AntiCan↑, BioAv↝, BioAv⇅, BioAv↓, CYP3A2↓, P-gp↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5635- BCA,    Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
- vitro+vivo, Lung, NA
AntiCan↑, ChemoSen↑, Zeb1↓, TumMeta↓,
2716- BetA,    Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment
- Review, Var, NA
AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1↓,
5678- BML,    Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
- in-vivo, CRC, NA
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1↑, p62↑, PARP↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
746- Bor,    Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
- Review, NA, NA
eff↑, *toxicity↓, ROS↑, LAT↓, AntiCan↑, AR↓, PSMB5↓, IGF-1↓, PSA↓, TumVol↓, eff↑, Rho↓, Cdc42↓, Ca+2↓, eff↑,
4619- Bor,    Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article
- Review, Var, NA
Dose↝, Risk↓, *antiOx↓, *Inflam↓, ChemoSen↑, AntiCan↑, *PCNA↓, *ROS↓, other↝,
4623- Bor,    Proteomic insights into the anti-cancer mechanisms of boron-based compounds in prostate cancer
- Review, Pca, NA
AntiCan↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1447- Bos,    Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vivo, BC, 4T1 - in-vitro, Nor, MCF10
tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,
5706- Brut,    Bergamot juice extract inhibits proliferation by inducing apoptosis in human colon cancer cells
- in-vitro, CRC, HT29
TumCG↓, MAPK↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, AntiCan↑,
5743- Buty,    Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status
- Review, Var, NA
*GutMicro↑, *other↑, *Inflam↓, *ROS↓, AntiCan↑, HCAR2↑, HDAC↓,
5733- Buty,  VitB3,    Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
- in-vivo, CRC, NA
GutMicro↑, HCAR2↑, AntiCan↑, Inflam↓, IL18↑,
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
1653- Caff,    Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study
- Review, Melanoma, NA
AntiCan↑, eff↓,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
5202- CAP,    Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways
- vitro+vivo, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
antiOx↑, Inflam↓, AntiCan↓, TRPV1↑, TumCP↓, TumCCA↑, ROS↑, FOXO3↑, TumCMig↓,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- NA, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2↓, CRP↓,
4654- CUR,    Stem Cell Therapy: Curcumin Does the Trick
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, chemoPv↑, *AntiAge↑, *neuroP↑, *Wound Healing↑,
4673- CUR,    Curcumin and colorectal cancer: An update and current perspective on this natural medicine
- Review, CRC, NA
AntiCan↑, GutMicro↝,
4708- CUR,    Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers
- Review, GC, NA
chemoPv↑, AntiCan↑, *antiOx↑, *Inflam↓, miR-21↓, miR-34a↑, miR-200b↑, miR-27a-3p↓,
1875- DCA,    Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells
- in-vitro, neuroblastoma, NA - in-vivo, NA, NA
selectivity↑, AntiCan↑, TumVol↓, PDKs↓, mt-OXPHOS↑, MMP↓, Glycolysis↓, toxicity↓, Warburg↓, ROS↑, eff↑,
1865- DCA,    Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
- in-vivo, BC, NA - in-vitro, BC, MCF-7 - in-vitro, BC, T47D
TumCG↓, TumCP↓, AntiCan↑,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
2155- dietP,    Transepithelial Anti-Neuroblastoma Response to Kale among Four Vegetable Juices Using In Vitro Model Co-Culture System
- in-vivo, neuroblastoma, Caco-2 - NA, NA, SH-SY5Y
AntiCan↑, ROS↑, eff↑, eff↑, eff↑,
4253- EA,    The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple sclerosis patients with mild to moderate depressive symptoms: A randomized, triple-blind, placebo-controlled trial
- Human, MS, NA - NA, IBD, NA
*Mood↑, *BDNF↑, *5HT↑, *antiOx↑, *Inflam↓, *AntiCan↑, *QoL↑, *neuroP↑, *cognitive↑, *memory↑,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,

Showing Research Papers: 51 to 100 of 244
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 244

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 1,   GSH↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 1,   i-Iron↑, 1,   lipid-P?, 1,   lipid-P↑, 1,   MAD↓, 1,   MDA↓, 1,   MDA↑, 1,   NRF2↝, 1,   mt-OXPHOS↑, 1,   ROS↑, 25,   SOD↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 2,   Insulin↓, 2,   MEK↓, 1,   MMP↓, 8,   MMP↑, 1,   mtDam↑, 1,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AMPK↑, 5,   cMyc↓, 3,   CYP3A2↓, 1,   Glycolysis↓, 2,   LAT↓, 1,   LDH↓, 1,   NADPH↑, 1,   PDH↝, 1,   PDK1↓, 1,   PDKs↓, 1,   PI3K/Akt↑, 1,   polyA↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   PSMB5↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   TS↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 1,   Apoptosis↑, 15,   BAD↓, 1,   Bak↑, 2,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Casp3↓, 1,   Casp3↑, 6,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 6,   CK2↓, 1,   Cyt‑c↑, 4,   DR4↑, 2,   DR5↑, 3,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   JNK↑, 1,   MAPK↓, 3,   MAPK↑, 2,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TRPV1↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 2,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,   miR-27a-3p↓, 1,   other↓, 2,   other↝, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↑, 1,   ERStress↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   BNIP3↑, 1,   LC3II↑, 3,   LC3s↑, 1,   p62↑, 2,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 3,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 3,   PARP1↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   Cyc↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↑, 2,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State ⓘ

CIP2A↓, 1,   EIF4E↓, 1,   EMT↓, 2,   EMT↑, 1,   ERK↓, 4,   p‑ERK↓, 1,   FOXO3↑, 2,   GSK‐3β↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC8↓, 2,   IGF-1↓, 4,   IGFR↓, 1,   Let-7↑, 1,   miR-34a↑, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   mTORC1↓, 1,   NOTCH↓, 2,   PI3K↓, 5,   PI3K↑, 1,   PTEN↑, 1,   RAS↓, 1,   STAT3↓, 4,   STAT3↑, 2,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 11,   Wnt↓, 4,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↑, 2,   Cdc42↓, 1,   E-cadherin↑, 1,   FAK↓, 3,   Ki-67↓, 2,   miR-200b↑, 2,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 9,   MMP3↓, 1,   MMP9↓, 8,   MMPs↓, 3,   NFAT↑, 1,   PDGF↓, 1,   PKCδ↓, 1,   Rho↓, 2,   ROCK1↓, 1,   SMAD4↓, 2,   Snail↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 9,   TumMeta↓, 9,   TXNIP↑, 1,   uPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 9,   EGFR↓, 1,   Endoglin↑, 1,   EPR↑, 1,   HIF-1↓, 2,   Hif1a↓, 4,   LOX1↓, 1,   p‑PDGFR-BB↓, 1,   PHDs↓, 1,   VEGF↓, 8,   VEGF↑, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 2,   P-gp↓, 1,   P-gp⇅, 1,  

Immune & Inflammatory Signaling ⓘ

CD14↓, 1,   CD4+↓, 1,   COX2↓, 7,   CRP↓, 1,   CXCR4↓, 1,   Dectin1↝, 1,   HCAR2↑, 2,   IFN-γ↑, 2,   IKKα↓, 1,   IL1↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 5,   JAK2↓, 1,   MCP1↓, 2,   MIP2↓, 1,   NF-kB↓, 13,   NF-kB↑, 1,   NK cell↑, 3,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 10,   BioAv↑, 6,   BioAv⇅, 1,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 14,   ChemoSen∅, 2,   Dose?, 1,   Dose↑, 1,   Dose↝, 5,   Dose∅, 4,   eff↓, 5,   eff↑, 19,   Half-Life↓, 2,   Half-Life↝, 1,   Half-Life∅, 1,   RadioS↑, 5,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AR↓, 2,   ascitic↓, 1,   BG↓, 1,   CRP↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   GutMicro↝, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 2,   LDH↓, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↓, 3,   AntiCan↑, 41,   AntiTum↑, 2,   cardioP↑, 1,   chemoPv↑, 6,   ChemoSideEff↓, 1,   RenoP↑, 1,   Risk↓, 3,   toxicity↓, 2,   toxicity↝, 1,   TumVol↓, 3,  

Infection & Microbiome ⓘ

CD8+↑, 1,   Dectin1↝, 1,   Sepsis↓, 1,  
Total Targets: 275

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 14,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 3,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 11,   SAM-e↑, 1,   SOD↑, 3,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,   Insulin↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   p‑AMPK↑, 1,   GlucoseCon↑, 1,   NAD↝, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↝, 2,   MMP9↓, 1,   serineP↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 15,   NF-kB↓, 3,   PGE2↓, 2,   TLR2↓, 1,   TNF-α↓, 4,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   BDNF↑, 1,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   GutMicro↑, 2,   hs-CRP↓, 1,   IL6↓, 2,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 4,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 3,   memory↑, 2,   Mood↑, 1,   neuroP↑, 8,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   Wound Healing↑, 2,  
Total Targets: 87

Scientific Paper Hit Count for: AntiCan, Anticancer Effect
16 Silver-NanoParticles
12 Lycopene
10 Thymoquinone
10 Selenium NanoParticles
8 Magnolol
7 Allicin (mainly Garlic)
7 Phenethyl isothiocyanate
7 Quercetin
7 Sulforaphane (mainly Broccoli)
6 Astaxanthin
6 Baicalein
6 Curcumin
6 Gambogic Acid
6 Selenite (Sodium)
5 Artemisinin
5 Vitamin C (Ascorbic Acid)
4 Coenzyme Q10
4 chitosan
4 Apigenin (mainly Parsley)
4 Boron
4 Capsaicin
4 Honokiol
4 Naringin
4 Selenium
3 Melatonin
3 Aloe anthraquinones
3 beta-glucans
3 Biochanin A
3 Ellagic acid
3 Propolis -bee glue
3 Pterostilbene
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Vitamin D3
3 Vitamin K2
2 3-bromopyruvate
2 Auranofin
2 doxorubicin
2 Alpha-Lipoic-Acid
2 Baicalin
2 Boswellia (frankincense)
2 Butyrate
2 Dichloroacetate
2 Ferulic acid
2 HydroxyTyrosol
2 Magnetic Fields
2 Bicarbonate(Sodium)
2 Piperine
2 Resveratrol
2 Rosmarinic acid
2 Shikonin
2 Ursolic acid
2 Urolithin
2 VitK3,menadione
1 5-fluorouracil
1 Astragalus
1 Citric Acid
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Berberine
1 Betulinic acid
1 Bromelain
1 borneol
1 Bruteridin(bergamot juice)
1 Vitamin B3,Niacin
1 Caffeic acid
1 Caffeine
1 urea
1 Chrysin
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 diet Plant based
1 EGCG (Epigallocatechin Gallate)
1 Electrical Pulses
1 Gallic acid
1 γ-linolenic acid (Borage Oil)
1 alpha Linolenic acid
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Licorice
1 Lecithin
1 Luteolin
1 Methylene blue
1 Photodynamic Therapy
1 mebendazole
1 Magnetic Field Rotating
1 Methylglyoxal
1 Oleocanthal
1 Piperlongumine
1 Psoralidin
1 Parthenolide
1 Salvia officinalis
1 Radiotherapy/Radiation
1 Date Fruit Extract
1 Spermidine
1 Calcium
1 Aflavin-3,3′-digallate
1 Magnesium
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:813  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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