OCR Cancer Research Results

OCR, Oxygen consumption rate: Click to Expand ⟱
Source:
Type:
Oxygen consumption rate (OCR) is a measure of the rate at which cells consume oxygen, and it has been found to be altered in cancer cells. Cancer cells often exhibit increased glycolysis, a process in which glucose is converted into energy without the use of oxygen, even in the presence of oxygen. This is known as the Warburg effect.
Cancer cells often exhibit increased glycolysis, which leads to a decrease in OCR.
-When mitochondrial function is impaired (resulting in lower OCR), cells may compensate by upregulating glycolysis to meet their energy needs (known as the Pasteur effect).
-Instruments such as the Seahorse Analyzer allow simultaneous measurement of OCR (reflecting mitochondrial respiration) and Extracellular Acidification Rate (ECAR, which is commonly used as a proxy for glycolysis). This dual measurement helps researchers understand how shifts in one pathway correlate with compensatory changes in the other.
Scientific Papers found: Click to Expand⟱
8067- KAE,  Cisplatin,    Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin
- in-vitro, HNSCC, NA
AntiCan↑, OCR↓, i-ATP↓, TumCMig↓, TumCP↓, Apoptosis↑, ChemoSen↑,
8162- LapC,    Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- in-vitro, Melanoma, MEL526 - in-vitro, Melanoma, MEL697 - in-vitro, Melanoma, MEL103
Glycolysis↓, OCR↑, PKM2↓, ATP↓, TumCP↓, Apoptosis↑, OXPHOS↑, Dose↝,
8330- LIN,    SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
- in-vitro, GBM, U87MG
tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,
4779- Lyco,    Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, PANC1
ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4789- Lyco,    Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *NF-kB↓, *neuroP↑, *MMP↓, *mtDam↓, *OCR↓,
8734- M-Blu,    From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue
- Review, AD, NA
*ETC↑, *compIV↑, *ROS↓, *NeuroI↓, *neuroP↑, *Stroke↓, *cognitive↑, *BBB↑, *BloodF↑, *NOS2↓, *lipid-P↓, *Inflam↓, *Synergy↑, *OCR↑, *compIV↑, *ATP↑, *Casp↓, *MMP↑, *tau↓,
8728- M-Blu,    Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
- Review, AD, NA
*Dose↝, *antiOx↑, *mitResp↑, *neuroP↑, *memory↑, *CellMemb↑, *BBB↑, *other↝, *compV↑, *OCR↑, *ROS↓, *Sepsis↓, *NO↓, *RNS↓, *memory↑, *tau↓, *CX43/GJA1↑, *THBD↑, *CARTPT↑,
8733- M-Blu,    Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Review, AD, NA - Review, Stroke, NA
*ETC↑, *ROS↓, *Inflam↓, *memfluid↑, *BloodF↑, *BBB↑, *OCR↑, *ATP↑, *BioAv↑, *Aβ↓, *compIV↑, *Stroke↓, *compI↑, *compII↑, *compIII↑, *GlucoseCon↑, *neuroG↑,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2543- M-Blu,    The use of methylene blue to control the tumor oxygenation level
- in-vivo, Lung, NA
OCR↑, OXPHOS↑, Half-Life↝, AntiTum↑,
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
8752- MeSA,  Rad,    Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells
- in-vitro, HNSCC, CAL27 - in-vitro, SCC, SCC25
selectivity↑, RadioS↑, GSH↓, lipid-P↑, OCR↑,
8711- MET,    https://pubmed.ncbi.nlm.nih.gov/42725610/
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, OCR↑, Hypoxia↓, RadioS↑, ChemoSen↑,
2260- MF,    Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229 - in-vivo, NA, NA
TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,
4568- MF,    Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria
- Study, Var, NA
*ETC↓, *OCR↑, *MMP↑, *ROS⇅, *MMP⇅,
4355- MF,    Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism
- in-vitro, Nor, C2C12
*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
2041- PB,    The Effect of Glucose Concentration and Sodium Phenylbutyrate Treatment on Mitochondrial Bioenergetics and ER Stress in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*mitResp↓, *ER Stress↓, MMP↓, GlucoseCon↓, OCR↓, CHOP/DDIT3↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
2190- SK,    Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway
- in-vitro, HCC, HCCLM3
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↓, ROS↑, OCR↓, ATP↓, PKM2↓,
4334- VitB5,    Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model
- in-vivo, AD, NA
*neuroP↑, *motorD↑, *MMP↑, *OCR↑,
2414- β‐Ele,    Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumMeta↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, EGFR↓, GLUT1↓, LDHA↓, ECAR↓, OCR↓,

Showing Research Papers: 51 to 78 of 78
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 78

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ARE↑, 1,   Catalase↓, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↓, 5,   GSH/GSSG↓, 1,   GSTs↑, 1,   H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 2,   lipid-P↑, 1,   mt-NADH↑, 1,   NRF2↑, 1,   ROS↓, 3,   ROS↑, 36,   ROS⇅, 1,   mt-ROS↑, 4,   SOD↓, 2,   mt-SOD↑, 1,   SOD2↑, 3,   mt-SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↑, 1,   TrxR↓, 2,   TrxR↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 5,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 1,   ETC↓, 4,   ETC↝, 1,   mitResp↓, 8,   mtDam↑, 6,   OCR↓, 43,   OCR↑, 18,   mt-OCR↓, 1,   mt-OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 9,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   p‑PDH↑, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACLY↓, 1,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 4,   p‑AMPK↑, 2,   ATP↓, 18,   ATP↑, 2,   i-ATP↓, 1,   i-ATP↑, 1,   ATP:AMP↓, 1,   CRM↑, 1,   ECAR↓, 15,   ECAR↑, 1,   ECAR∅, 1,   ENO1↓, 1,   FAO↓, 1,   GAPDH↓, 2,   GlucoseCon↓, 8,   GlucoseCon↑, 2,   GlutaM↓, 1,   Glycolysis↓, 25,   Glycolysis↑, 1,   HK2↓, 6,   HMG-CoA↓, 2,   lactateProd↓, 17,   LDHA↓, 6,   lipoGen↓, 2,   NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 2,   PDKs↓, 3,   PFK↓, 2,   PFK1↓, 1,   PFKFB3↓, 1,   PKM2↓, 7,   PPP↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 25,   mt-Apoptosis↑, 1,   BAD↓, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↓, 1,   BIM↑, 1,   Casp↑, 3,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 12,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 3,   cFLIP↓, 3,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   DR5↑, 1,   Fas↑, 1,   ICD↑, 2,   iNOS↑, 1,   Mcl-1↓, 1,   MOMP↓, 1,   p38↓, 1,   survivin↓, 5,   TumCD↑, 3,   TumCD∅, 1,   XIAP↓, 3,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 10,   p‑Akt↓, 4,   CIP2A↓, 2,   EGFR↓, 4,   ERK↓, 2,   ERK↝, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 2,   Hippo↓, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   MAPK↓, 1,   MAPK↝, 1,   mTOR↓, 12,   p‑mTOR↓, 2,   p‑P70S6K↓, 1,   PI3K↓, 9,   PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PTEN↑, 3,   RAS↓, 2,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT3↓, 7,   STAT3↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 2,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 1,   HDAC↓, 1,   HDAC8↓, 1,   miR-375↑, 1,   Myc↓, 1,   OCT4↓, 1,   other↓, 1,   other↑, 1,   other↝, 6,   SOX2↓, 2,   TFE3↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B-II↑, 1,   LC3II↑, 2,   MitoP↓, 1,   p62↓, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

DNA-PK↑, 1,   DNAdam↑, 3,   hTERT/TERT↓, 2,   P53↑, 5,   cl‑PARP↑, 4,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,   TP53↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 2,   CDK6↓, 3,   Cyc↓, 1,   cycA1/CCNA1↑, 1,   cycD1/CCND1↓, 5,   cycD1/CCND1↑, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 2,   MAD↓, 1,   mitA↓, 1,   P21↓, 1,   P21↑, 3,   p27/CDKN1B↑, 3,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   BMPs↑, 1,   CD24↓, 2,   CEBPB?, 1,   CSCs↓, 6,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   Ki-67↓, 2,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 3,   NOTCH2↑, 1,   TumCG↓, 14,   TumCG↑, 2,   TumCP↓, 22,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   Ca+2↝, 1,   i-Ca+2↑, 1,   Cav1↑, 1,   E-cadherin↑, 4,   EMT↓, 4,   ITGB1↓, 1,   ITGB6↓, 1,   MMP2↓, 7,   MMP9↓, 4,   MMP9:TIMP1↓, 1,   MMPs↓, 2,   N-cadherin↓, 2,   PAK1↓, 1,   PAK1↑, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Snail↓, 3,   SPARC↑, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TumCA↓, 1,   TumCI↓, 8,   TumCMig↓, 9,   TumMeta↓, 5,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   Hif1a↓, 12,   Hypoxia↓, 2,   NO↝, 1,   VEGF↓, 6,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   CellMemb↑, 2,   GLUT1↓, 7,   GLUT2↓, 1,   MMP?, 1,   MMP↓, 19,   MMP↑, 2,   MPT↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   DR4↑, 2,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL4↓, 1,   IL6↓, 1,   Inflam↓, 2,   pol-M1↑, 1,   pol-M2 MC↓, 1,   NF-kB↓, 9,   p65↓, 2,   PD-1↓, 1,   PGE2↓, 1,   T-Cell↑, 1,   TCF↓, 1,   TCF↝, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 2,   ChemoSen↓, 1,   ChemoSen↑, 12,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose↓, 1,   Dose↝, 8,   Dose∅, 4,   eff↓, 14,   eff↑, 12,   GSTZ1↓, 1,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 10,   selectivity↑, 16,   selectivity↝, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   EGFR↓, 4,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 2,   IL6↓, 1,   LDH↓, 5,   Myc↓, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 2,   chemoPv↑, 2,   ChemoSideEff↓, 1,   fatigue↓, 1,   neuroP↑, 2,   OS↑, 2,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 1,   Weight∅, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 351

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   mt-antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GPx1↑, 1,   GSH↑, 1,   HO-1↑, 1,   Keap1↑, 1,   lipid-P↓, 1,   lipidDe↓, 1,   MDA↓, 2,   NQO1↑, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 11,   ROS⇅, 1,   ROS∅, 1,   mt-ROS↑, 1,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compI↑, 1,   compII↑, 1,   compIII↑, 1,   compIV↑, 3,   compV↑, 1,   ETC↓, 1,   ETC↑, 2,   ETC↝, 1,   mitResp↓, 1,   mitResp↑, 1,   mtDam↓, 1,   OCR↓, 4,   OCR↑, 10,   mt-OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   p‑ACC↑, 1,   ALAT↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   ATP↑, 4,   ECAR↓, 2,   ECAR↑, 2,   ECAR∅, 1,   FAO↑, 1,   glucose↓, 1,   GlucoseCon↑, 2,   Glycolysis↓, 1,   Glycolysis↑, 2,   GSK‐3β↓, 1,   HK2↑, 1,   LDHA↓, 1,   LDHA↑, 1,   PDKs↓, 1,   PFK↓, 1,   PKM2↓, 1,   PKM2↑, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,   mTOR↓, 1,   PI3K↑, 1,   PP2A↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↑, 3,   other↝, 2,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   Rho↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CellMemb↑, 1,   CX43/GJA1↑, 1,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 3,   MMP⇅, 1,   THBD↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 5,   NeuroI↓, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   CARTPT↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 2,   Dose↝, 4,   eff↓, 1,   eff↝, 2,   Half-Life↝, 2,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BloodF↑, 2,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 3,   memory↑, 5,   motorD↑, 1,   neuroP↑, 7,   Obesity↓, 1,   Stroke↓, 2,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 3,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 2,   GutMicro↑, 1,   Sepsis↓, 3,  
Total Targets: 136

Scientific Paper Hit Count for: OCR, Oxygen consumption rate
8 Methylene blue
4 Dichloroacetate
4 Honokiol
4 Magnetic Fields
3 Betulinic acid
3 Citric Acid
3 Electrical Pulses
3 Metformin
3 Ivermectin
2 α-Bisabolol / Chamomile oil
2 Phenethyl isothiocyanate
2 Lycopene
1 3-bromopyruvate
1 5-Aminolevulinic acid
1 Auranofin
1 Alpha-Lipoic-Acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Baicalin
1 Berberine
1 Brutieridin–Melitidin Mixture
1 Capsaicin
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 CUSP9
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Formononetin
1 Gambogic Acid
1 Ginkgo biloba
1 HydroxyCitric Acid
1 Hyperthermia
1 Oxygen, Hyperbaric
1 Isorhamnetin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Sulforaphane (mainly Broccoli)
1 itraconazole
1 Juglone
1 doxorubicin
1 Kaempferol
1 Cisplatin
1 Lapachol
1 Linalool
1 methylseleninic acid
1 Radiotherapy/Radiation
1 Magnetic Field Rotating
1 Melatonin
1 Phenylbutyrate
1 Propolis -bee glue
1 Quercetin
1 Resveratrol
1 Shikonin
1 Vitamin B5,Pantothenic Acid
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:846  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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